Lipid droplets: a classic organelle with new outfits

Lipid droplets are depots of neutral lipids that exist virtually in any kind of cell. Recent studies have revealed that the lipid droplet is not a mere lipid blob, but a major contributor not only to lipid homeostasis but also to diverse cellular functions. Because of the unique structure as well as the functional importance in relation to obesity, steatosis, and other prevailing diseases, the lipid droplet is now reborn as a brand new organelle, attracting interests from researchers of many disciplines.

[1]  S. Fowler,et al.  Nile red: a selective fluorescent stain for intracellular lipid droplets , 1985, The Journal of cell biology.

[2]  A. Penn,et al.  Combustion-derived hydrocarbons localize to lipid droplets in respiratory cells. , 2008, American journal of respiratory cell and molecular biology.

[3]  J. Borén,et al.  Adipocyte Differentiation-Related Protein Promotes Fatty Acid Storage in Cytosolic Triglycerides and Inhibits Secretion of Very Low–Density Lipoproteins , 2006, Arteriosclerosis, thrombosis, and vascular biology.

[4]  H. Robenek,et al.  PAT family proteins pervade lipid droplet cores Published, JLR Papers in Press, March 1, 2005. DOI 10.1194/jlr.M400323-JLR200 , 2005, Journal of Lipid Research.

[5]  D. Eliezer,et al.  A structural and functional role for 11-mer repeats in alpha-synuclein and other exchangeable lipid binding proteins. , 2003, Journal of molecular biology.

[6]  R. Kauppinen,et al.  1H NMR visible lipids in the life and death of cells. , 2000, Trends in biochemical sciences.

[7]  Y. Kraan,et al.  Single-cell Raman and fluorescence microscopy reveal the association of lipid bodies with phagosomes in leukocytes. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[8]  K. Gaus,et al.  Identification and Characterization of Associated with Lipid Droplet Protein 1: A Novel Membrane‐Associated Protein That Resides on Hepatic Lipid Droplets , 2006, Traffic.

[9]  A. Chawla,et al.  Fat-specific Protein 27, a Novel Lipid Droplet Protein That Enhances Triglyceride Storage* , 2007, Journal of Biological Chemistry.

[10]  C. Sztalryd,et al.  LSDP5 is a PAT protein specifically expressed in fatty acid oxidizing tissues. , 2007, Biochimica et biophysica acta.

[11]  A. Kimmel,et al.  Role of PAT proteins in lipid metabolism. , 2005, Biochimie.

[12]  K. Mahajan,et al.  Role of human Pso4 in mammalian DNA repair and association with terminal deoxynucleotidyl transferase , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[13]  A. Garg,et al.  Genetic disorders of adipose tissue development, differentiation, and death. , 2006, Annual review of genomics and human genetics.

[14]  T. Uchida,et al.  Temporal and spatial variations of lipid droplets during adipocyte division and differentiations⃞ Published, JLR Papers in Press, October 21, 2006. , 2007, Journal of Lipid Research.

[15]  G. Daum,et al.  Characterization of lipid particles of the yeast, Saccharomyces cerevisiae , 1994, Yeast.

[16]  T. Osumi,et al.  MLDP, a Novel PAT Family Protein Localized to Lipid Droplets and Enriched in the Heart, Is Regulated by Peroxisome Proliferator-activated Receptor α* , 2006, Journal of Biological Chemistry.

[17]  S. Patton,et al.  Morphometric evaluation of lipid droplet associations with secretory vesicles, mitochondria and other components in the lactating cell , 2004, Cell and Tissue Research.

[18]  T. Fujimoto,et al.  Deformation of lipid droplets in fixed samples , 2002, Histochemistry and Cell Biology.

[19]  M. Osumi,et al.  Analysis of the membrane structures involved in autophagy in yeast by freeze-replica method. , 1995, Cell structure and function.

[20]  E. Deharven Ultrastructural Pathology of the Cell and Matrix. , 1982 .

[21]  B. Chang,et al.  Protection against Fatty Liver but Normal Adipogenesis in Mice Lacking Adipose Differentiation-Related Protein , 2006, Molecular and Cellular Biology.

[22]  A. Kimmel,et al.  Perilipins, ADRP, and other proteins that associate with intracellular neutral lipid droplets in animal cells. , 1999, Seminars in cell & developmental biology.

[23]  J. Schaffer,et al.  Lipotoxicity: when tissues overeat , 2003, Current opinion in lipidology.

[24]  A. Kimmel,et al.  Functional Compensation for Adipose Differentiation-related Protein (ADFP) by Tip47 in an ADFP Null Embryonic Cell Line* , 2006, Journal of Biological Chemistry.

[25]  F. Wieland,et al.  VIP21/caveolin is a cholesterol-binding protein. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[26]  R. Zechner,et al.  Intracellular distribution and mobilization of unesterified cholesterol in adipocytes: triglyceride droplets are surrounded by cholesterol-rich ER-like surface layer structures. , 2000, Journal of cell science.

[27]  A. Luini,et al.  The multiple activities of CtBP/BARS proteins: the Golgi view. , 2006, Trends in cell biology.

[28]  A. Steinbüchel,et al.  Neutral Lipid Bodies in Prokaryotes: Recent Insights into Structure, Formation, and Relationship to Eukaryotic Lipid Depots , 2005, Journal of bacteriology.

[29]  L. Shapiro,et al.  Proteomic Analysis of Proteins Associated with Lipid Droplets of Basal and Lipolytically Stimulated 3T3-L1 Adipocytes* , 2004, Journal of Biological Chemistry.

[30]  G. Wanner,et al.  Possible Role in Fat Utilization in Germinating Oil Seeds , 1978 .

[31]  H. Kogo,et al.  Caveolin-2 Is Targeted to Lipid Droplets, a New “Membrane Domain” in the Cell , 2001, The Journal of cell biology.

[32]  R. Nussbaum,et al.  Lipid Droplet Binding and Oligomerization Properties of the Parkinson's Disease Protein α-Synuclein* , 2002, The Journal of Biological Chemistry.

[33]  J. Borén,et al.  SNARE proteins mediate fusion between cytosolic lipid droplets and are implicated in insulin sensitivity , 2007, Nature Cell Biology.

[34]  H. Ploegh A lipid-based model for the creation of an escape hatch from the endoplasmic reticulum , 2007, Nature.

[35]  X. Xie,et al.  Nonperturbative chemical imaging of organelle transport in living cells with coherent anti-stokes Raman scattering microscopy. , 2006, Biophysical journal.

[36]  M. Masserini,et al.  A photo‐reactive derivative of ganglioside GM1 specifically cross‐links VIP21‐caveolin on the cell surface , 1995, FEBS letters.

[37]  M. Welte Proteins under new management: lipid droplets deliver. , 2007, Trends in cell biology.

[38]  J. Papp,et al.  Identification of the gene altered in Berardinelli–Seip congenital lipodystrophy on chromosome 11q13 , 2001, Nature Genetics.

[39]  A. Uittenbogaard,et al.  Cholesteryl Ester Is Transported from Caveolae to Internal Membranes as Part of a Caveolin-Annexin II Lipid-Protein Complex* , 2002, The Journal of Biological Chemistry.

[40]  G. Daum,et al.  Synthesis of Triacylglycerols by the Acyl-Coenzyme A:Diacyl-Glycerol Acyltransferase Dga1p in Lipid Particles of the Yeast Saccharomyces cerevisiae , 2002, Journal of bacteriology.

[41]  Richard G. W. Anderson,et al.  Chinese Hamster Ovary K2 Cell Lipid Droplets Appear to Be Metabolic Organelles Involved in Membrane Traffic* , 2004, Journal of Biological Chemistry.

[42]  R. Parton,et al.  Caveolin, cholesterol, and lipid bodies. , 2005, Seminars in cell & developmental biology.

[43]  A. Greenberg,et al.  Perilipin, a major hormonally regulated adipocyte-specific phosphoprotein associated with the periphery of lipid storage droplets. , 1991, The Journal of biological chemistry.

[44]  A. Ostermeyer,et al.  Role of the hydrophobic domain in targeting caveolin-1 to lipid droplets , 2004, The Journal of cell biology.

[45]  R. Pease,et al.  Mobilisation of triacylglycerol stores. , 2000, Biochimica et biophysica acta.

[46]  E. Tai,et al.  The role of perilipin in human obesity and insulin resistance , 2007, Current opinion in lipidology.

[47]  A. Dvorak,et al.  RNA is closely associated with human mast cell lipid bodies. , 2003, Histology and histopathology.

[48]  Steven P Gross,et al.  Developmental Regulation of Vesicle Transport in Drosophila Embryos: Forces and Kinetics , 1998, Cell.

[49]  R. Valdivia,et al.  The Obligate Intracellular Pathogen Chlamydia trachomatis Targets Host Lipid Droplets , 2006, Current Biology.

[50]  I. Mills,et al.  COP and clathrin-coated vesicle budding: different pathways, common approaches. , 2004, Current opinion in cell biology.

[51]  R. Volpé Ultrastructural Pathology of the Cell and Matrix , 1982 .

[52]  G. Wanner,et al.  The ontogeny of lipid bodies (spherosomes) in plant cells , 1981, Planta.

[53]  O. Rosen,et al.  Organelle relationships in cultured 3T3-L1 preadipocytes , 1980, The Journal of cell biology.

[54]  Robert V Farese,et al.  Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking Dgat , 2000, Nature Genetics.

[55]  T. Osumi,et al.  CGI-58 Interacts with Perilipin and Is Localized to Lipid Droplets , 2004, Journal of Biological Chemistry.

[56]  C. Mountford,et al.  Organization of lipids in the plasma membranes of malignant and stimulated cells: a new model. , 1988, Trends in biochemical sciences.

[57]  M. Lai,et al.  Hepatitis C virus NS5A colocalizes with the core protein on lipid droplets and interacts with apolipoproteins. , 2002, Virology.

[58]  D. Brasaemle,et al.  TIP47 Associates with Lipid Droplets* , 2001, The Journal of Biological Chemistry.

[59]  A. Kimmel,et al.  Perilipin A is essential for the translocation of hormone-sensitive lipase during lipolytic activation , 2003, The Journal of cell biology.

[60]  Y. Ohsaki,et al.  Recruitment of TIP47 to lipid droplets is controlled by the putative hydrophobic cleft. , 2006, Biochemical and biophysical research communications.

[61]  Richard G. W. Anderson,et al.  Rab-regulated interaction of early endosomes with lipid droplets. , 2007, Biochimica et biophysica acta.

[62]  R. Bartenschlager,et al.  The lipid droplet is an important organelle for hepatitis C virus production , 2007, Nature Cell Biology.

[63]  Y. Ohsaki,et al.  Cytoplasmic Lipid Droplets , 2006, Annals of the New York Academy of Sciences.

[64]  D. Brasaemle Thematic review series: Adipocyte Biology. The perilipin family of structural lipid droplet proteins: stabilization of lipid droplets and control of lipolysis Published, JLR Papers in Press, September 18, 2007. , 2007, Journal of Lipid Research.

[65]  H. Robenek,et al.  Lipids partition caveolin‐1 from ER membranes into lipid droplets: updating the model of lipid droplet biogenesis , 2004, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[66]  J. Schaffer,et al.  Lipotoxicity: when tissues overeat , 2003, Current opinion in lipidology.

[67]  J. Borén,et al.  A Phospholipase D-dependent Process Forms Lipid Droplets Containing Caveolin, Adipocyte Differentiation-related Protein, and Vimentin in a Cell-free System* , 2003, Journal of Biological Chemistry.

[68]  H. Fahimi,et al.  Imidazole-buffered osmium tetroxide: an excellent stain for visualization of lipids in transmission electron microscopy , 1982, The Histochemical Journal.

[69]  N. Wolins,et al.  S3-12, Adipophilin, and TIP47 Package Lipid in Adipocytes* , 2005, Journal of Biological Chemistry.

[70]  Jeremy N. Skepper,et al.  α-Synuclein Is Degraded by Both Autophagy and the Proteasome* , 2003, Journal of Biological Chemistry.

[71]  J. Weissenbach,et al.  Mutations in CGI-58, the gene encoding a new protein of the esterase/lipase/thioesterase subfamily, in Chanarin-Dorfman syndrome. , 2001, American journal of human genetics.

[72]  R. Taguchi,et al.  The Surface of Lipid Droplets Is a Phospholipid Monolayer with a Unique Fatty Acid Composition* , 2002, The Journal of Biological Chemistry.

[73]  E. Ikonen,et al.  A Caveolin Dominant Negative Mutant Associates with Lipid Bodies and Induces Intracellular Cholesterol Imbalance , 2001, The Journal of cell biology.

[74]  F. N. Ghadially Ultrastructural pathology of the cell and matrix , 1988 .

[75]  Steven P. Gross,et al.  Regulation of Lipid-Droplet Transport by the Perilipin Homolog LSD2 , 2005, Current Biology.

[76]  L. Lichtenstein,et al.  Ultrastructural immunogold localization of prostaglandin endoperoxide synthase (cyclooxygenase) to non-membrane-bound cytoplasmic lipid bodies in human lung mast cells, alveolar macrophages, type II pneumocytes, and neutrophils. , 1992, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[77]  S. Gross,et al.  The Lipid-Droplet Proteome Reveals that Droplets Are a Protein-Storage Depot , 2006, Current Biology.

[78]  N. Wolins,et al.  OXPAT/PAT-1 Is a PPAR-Induced Lipid Droplet Protein That Promotes Fatty Acid Utilization , 2006, Diabetes.

[79]  David S. Park,et al.  Caveolin-1-deficient Mice Are Lean, Resistant to Diet-induced Obesity, and Show Hypertriglyceridemia with Adipocyte Abnormalities* , 2002, The Journal of Biological Chemistry.

[80]  Richard G. W. Anderson,et al.  The lipodystrophy protein seipin is found at endoplasmic reticulum lipid droplet junctions and is important for droplet morphology , 2007, Proceedings of the National Academy of Sciences.

[81]  J Q Trojanowski,et al.  A Hydrophobic Stretch of 12 Amino Acid Residues in the Middle of α-Synuclein Is Essential for Filament Assembly* , 2001, The Journal of Biological Chemistry.

[82]  M. Lindsay,et al.  Cholesterol‐Induced Caveolin Targeting to Lipid Droplets in Adipocytes: A Role for Caveolar Endocytosis , 2006, Traffic.

[83]  David E. James,et al.  Insulin and Oleate Promote Translocation of Inosine‐5′ Monophosphate Dehydrogenase to Lipid Bodies , 2004, Traffic.

[84]  Y. Ohsaki,et al.  Lipid droplets are arrested in the ER membrane by tight binding of lipidated apolipoprotein B-100 , 2008, Journal of Cell Science.

[85]  A. Cohen,et al.  ON THE PRIMARY SITE OF NUCLEAR RNA SYNTHESIS , 1966, The Journal of cell biology.

[86]  S. Gledhill,et al.  Live Cell Analysis and Targeting of the Lipid Droplet-binding Adipocyte Differentiation-related Protein* 210 , 2003, The Journal of Biological Chemistry.

[87]  Y. Ohsaki,et al.  Cytoplasmic lipid droplets are sites of convergence of proteasomal and autophagic degradation of apolipoprotein B. , 2006, Molecular biology of the cell.

[88]  H. Brockerhoff,et al.  Lysophosphatidylcholine-cholesterol complex. , 1982, The Journal of biological chemistry.

[89]  C. Thiele,et al.  Imaging of Lipid Biosynthesis: How a Neutral Lipid Enters Lipid Droplets , 2008, Traffic.

[90]  Vladislav S. Markin,et al.  An intimate collaboration between peroxisomes and lipid bodies , 2006, The Journal of cell biology.

[91]  Petra C. Kienesberger,et al.  Adipose triglyceride lipase-mediated lipolysis of cellular fat stores is activated by CGI-58 and defective in Chanarin-Dorfman Syndrome. , 2006, Cell metabolism.

[92]  Robert V Farese,et al.  Membrane Topology and Identification of Key Functional Amino Acid Residues of Murine Acyl-CoA:Diacylglycerol Acyltransferase-2* , 2006, Journal of Biological Chemistry.

[93]  S. Munro,et al.  Accumulation of Caveolin in the Endoplasmic Reticulum Redirects the Protein to Lipid Storage Droplets , 2001, The Journal of cell biology.

[94]  T. Barber,et al.  Adipose differentiation-related protein is an ubiquitously expressed lipid storage droplet-associated protein. , 1997, Journal of lipid research.

[95]  A. Steinbüchel,et al.  Mechanism of lipid‐body formation in prokaryotes: how bacteria fatten up , 2004, Molecular microbiology.

[96]  M. Drab,et al.  Loss of Caveolae, Vascular Dysfunction, and Pulmonary Defects in Caveolin-1 Gene-Disrupted Mice , 2001, Science.

[97]  Vidya Subramanian,et al.  Perilipin A Mediates the Reversible Binding of CGI-58 to Lipid Droplets in 3T3-L1 Adipocytes* , 2004, Journal of Biological Chemistry.

[98]  D. Murphy The biogenesis and functions of lipid bodies in animals, plants and microorganisms. , 2001, Progress in lipid research.

[99]  N. Nakamura,et al.  Adipose differentiation-related protein has two independent domains for targeting to lipid droplets. , 2003, Biochemical and biophysical research communications.

[100]  J. Hurley,et al.  Structure of a lipid droplet protein; the PAT family member TIP47. , 2004, Structure.

[101]  J. Segrest,et al.  Structure of apolipoprotein B-100 in low density lipoproteins. , 2001, Journal of lipid research.

[102]  A. Fabre,et al.  Imaging lipid bodies in cells and tissues using third-harmonic generation microscopy , 2005, Nature Methods.

[103]  Chunjiang Yu,et al.  Roles of acyl-coenzyme A : cholesterol acyltransferase-1 and -2 , 2001, Current opinion in lipidology.

[104]  P. Shewry,et al.  The accumulation of triacylglycerols within the endoplasmic reticulum of developing seeds of Helianthus annuus , 1999 .

[105]  T. Barber,et al.  Perilipin is located on the surface layer of intracellular lipid droplets in adipocytes. , 1995, Journal of lipid research.

[106]  H. Robenek,et al.  Adipophilin-enriched domains in the ER membrane are sites of lipid droplet biogenesis , 2006, Journal of Cell Science.

[107]  M. Schrader Tubulo-Reticular Clusters of Peroxisomes in Living COS-7 Cells , 2001, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[108]  J. Borén,et al.  PLD1 and ERK2 regulate cytosolic lipid droplet formation , 2006, Journal of Cell Science.

[109]  S. O’Rahilly,et al.  Association of a homozygous nonsense caveolin-1 mutation with Berardinelli-Seip congenital lipodystrophy. , 2008, The Journal of clinical endocrinology and metabolism.

[110]  C. Deng,et al.  Perilipin ablation results in a lean mouse with aberrant adipocyte lipolysis, enhanced leptin production, and resistance to diet-induced obesity , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[111]  R. Parton,et al.  Fld1p, a functional homologue of human seipin, regulates the size of lipid droplets in yeast , 2008, The Journal of cell biology.

[112]  B. Oliver,et al.  Functional Conservation for Lipid Storage Droplet Association among Perilipin, ADRP, and TIP47 (PAT)-related Proteins in Mammals,Drosophila, and Dictyostelium * , 2002, The Journal of Biological Chemistry.

[113]  J. Riemersma Osmium tetroxide fixation of lipids for electron microscopy. A possible reaction mechanism. , 1968, Biochimica et biophysica acta.

[114]  K. Athenstaedt,et al.  Intracellular lipid particles of eukaryotic cells. , 2000, Biochimica et biophysica acta.

[115]  Vidya Subramanian,et al.  The Central Domain Is Required to Target and Anchor Perilipin A to Lipid Droplets* , 2003, The Journal of Biological Chemistry.

[116]  R. Simari,et al.  Selective stimulation of caveolar endocytosis by glycosphingolipids and cholesterol. , 2004, Molecular biology of the cell.

[117]  Nicole A. Ducharme,et al.  Lipid droplets in lipogenesis and lipolysis. , 2008, Endocrinology.

[118]  S. Boulant,et al.  Disrupting the association of hepatitis C virus core protein with lipid droplets correlates with a loss in production of infectious virus. , 2007, The Journal of general virology.

[119]  M. Ala-Korpela,et al.  Structure of low density lipoprotein (LDL) particles: basis for understanding molecular changes in modified LDL. , 2000, Biochimica et biophysica acta.

[120]  J. McManaman,et al.  Lipid droplet targeting domains of adipophilin Published, JLR Papers in Press, January 16, 2003. DOI 10.1194/jlr.C200021-JLR200 , 2003, Journal of Lipid Research.

[121]  P. Weller,et al.  Phosphatidylinositide 3-kinase localizes to cytoplasmic lipid bodies in human polymorphonuclear leukocytes and other myeloid-derived cells. , 2000, Blood.

[122]  R. Lehner,et al.  Biosynthesis of triacylglycerols. , 1996, Progress in lipid research.

[123]  C. Grund,et al.  Rearrangement of the vimentin cytoskeleton during adipose conversion: Formation of an intermediate filament cage around lipid globules , 1987, Cell.

[124]  Hyoung Ho Lee,et al.  Identification of Mouse Prp19p as a Lipid Droplet-associated Protein and Its Possible Involvement in the Biogenesis of Lipid Droplets* , 2007, Journal of Biological Chemistry.

[125]  Kate S. Carroll,et al.  Role of Rab9 GTPase in Facilitating Receptor Recruitment by TIP47 , 2001, Science.

[126]  Robert G. Parton,et al.  Opinion: Lipid droplets: a unified view of a dynamic organelle , 2006, Nature Reviews Molecular Cell Biology.

[127]  M. Zerial,et al.  Regulated Localization of Rab18 to Lipid Droplets , 2005, Journal of Biological Chemistry.

[128]  Y. Higashi,et al.  Identification of major proteins in the lipid droplet-enriched fraction isolated from the human hepatocyte cell line HuH7. , 2004, Biochimica et biophysica acta.

[129]  G. Gerber,et al.  Identification of caveolin-1 as a fatty acid binding protein. , 1999, Biochemical and biophysical research communications.

[130]  R. G. Anderson,et al.  Morphological characterization of the cholesteryl ester cycle in cultured mouse macrophage foam cells , 1983, The Journal of cell biology.

[131]  D. Bernlohr,et al.  Perilipin Targets a Novel Pool of Lipid Droplets for Lipolytic Attack by Hormone-sensitive Lipase* , 2005, Journal of Biological Chemistry.

[132]  A. Kimmel,et al.  Post-translational Regulation of Adipose Differentiation-related Protein by the Ubiquitin/Proteasome Pathway* , 2005, Journal of Biological Chemistry.

[133]  M. Kohara,et al.  Hepatitis C virus core protein shows a cytoplasmic localization and associates to cellular lipid storage droplets. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[134]  J. Vance,et al.  Mechanisms of lipid-body formation. , 1999, Trends in biochemical sciences.

[135]  J. Borén,et al.  Cytosolic Lipid Droplets Increase in Size by Microtubule-Dependent Complex Formation , 2005, Arteriosclerosis, thrombosis, and vascular biology.

[136]  H. Taniguchi,et al.  Rab18 localizes to lipid droplets and induces their close apposition to the endoplasmic reticulum-derived membrane , 2005, Journal of Cell Science.

[137]  P. Gőcze,et al.  Factors underlying the variability of lipid droplet fluorescence in MA-10 Leydig tumor cells. , 1994, Cytometry.

[138]  A. Dvorak,et al.  Roles and origins of leukocyte lipid bodies: proteomic and ultrastructural studies , 2007, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[139]  D. Brasaemle,et al.  The Phosphorylation of Serine 492 of Perilipin A Directs Lipid Droplet Fragmentation and Dispersion* , 2006, Journal of Biological Chemistry.

[140]  M. Schnölzer,et al.  Adipocyte differentiation-related protein is secreted into milk as a constituent of milk lipid globule membrane. , 1996, The Biochemical journal.

[141]  T. Natsume,et al.  Proteomic profiling of lipid droplet proteins in hepatoma cell lines expressing hepatitis C virus core protein. , 2006, Journal of biochemistry.

[142]  R. Parton,et al.  Association of Stomatin with Lipid Bodies* , 2004, Journal of Biological Chemistry.

[143]  Robert V Farese,et al.  Triglyceride accumulation protects against fatty acid-induced lipotoxicity , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[144]  Robert V Farese,et al.  Mammalian acyl-CoA:cholesterol acyltransferases. , 2000, Biochimica et biophysica acta.

[145]  A. Dvorak,et al.  Eosinophil Lipid Bodies: Specific, Inducible Intracellular Sites for Enhanced Eicosanoid Formation , 1997, The Journal of experimental medicine.

[146]  R. Parton,et al.  Caveolin-1 Is Essential for Liver Regeneration , 2006, Science.

[147]  D. Brasaemle,et al.  A proposed model of fat packaging by exchangeable lipid droplet proteins , 2006, FEBS letters.

[148]  Harvey T. McMahon,et al.  The dynamin superfamily: universal membrane tubulation and fission molecules? , 2004, Nature Reviews Molecular Cell Biology.