Small diameter microchannel of PDMS and complex three-dimensional microchannel network

Abstract Polydimethylsiloxane (PDMS) is an important functional material that has been intensively applied in science research, industry, medical devices, plastic surgery, etc. We presented here a new method of fabricating small diameter microchannels in PDMS without using standard cleanroom techniques such as lithography and etching. The as-fabricated microchannels had a round cross-sectional shape, smooth inner surface, and a diameter from 100 μm down to 9 μm. We demonstrated that these microchannels could be applied to construct complicated, three-dimensional (3D) structures of double helix, knots, as well as interconnection along different directions. Together with the merits of PDMS itself, this flexible and versatile technique showed a promising potential for applications in advanced 3D microfluidic devices, and embedded devices in biosystems.

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