Exposure to particulate air pollution and cognitive decline in older women.

BACKGROUND Chronic exposure to particulate air pollution may accelerate cognitive decline in older adults, although data on this association are limited. Our objective was to examine long-term exposure to particulate matter (PM) air pollution, both coarse ([PM 2.5-10 μm in diameter [PM(2.5-10)]) and fine (PM <2.5 μm in diameter [PM(2.5)]), in relation to cognitive decline. METHODS The study population comprised the Nurses' Health Study Cognitive Cohort, which included 19,409 US women aged 70 to 81 years. We used geographic information system-based spatiotemporal smoothing models to estimate recent (1 month) and long-term (7-14 years) exposures to PM(2.5-10), and PM(2.5) preceding baseline cognitive testing (1995-2001) of participants residing in the contiguous United States. We used generalized estimating equation regression to estimate differences in the rate of cognitive decline across levels of PM(2.5-10) and PM(2.5) exposures. The main outcome measure was cognition, via validated telephone assessments, administered 3 times at approximately 2-year intervals, including tests of general cognition, verbal memory, category fluency, working memory, and attention. RESULTS Higher levels of long-term exposure to both PM(2.5-10) and PM(2.5) were associated with significantly faster cognitive decline. Two-year decline on a global score was 0.020 (95% CI, -0.032 to -0.008) standard units worse per 10 μg/m(3) increment in PM(2.5-10) exposure and 0.018 (95% CI, -0.035 to -0.002) units worse per 10 μg/m(3) increment in PM(2.5) exposure. These differences in cognitive trajectory were similar to those between women in our cohort who were approximately 2 years apart in age, indicating that the effect of a 10-μg/m(3) increment in long-term PM exposure is cognitively equivalent to aging by approximately 2 years. CONCLUSION Long-term exposure to PM(2.5-10) and PM(2.5) at levels typically experienced by many individuals in the United States is associated with significantly worse cognitive decline in older women.

[1]  Melinda E. Lull,et al.  Diesel Exhaust Activates and Primes Microglia: Air Pollution, Neuroinflammation, and Regulation of Dopaminergic Neurotoxicity , 2011, Environmental health perspectives.

[2]  M. Baudry,et al.  Glutamatergic Neurons in Rodent Models Respond to Nanoscale Particulate Urban Air Pollutants in Vivo and in Vitro , 2011, Environmental health perspectives.

[3]  J. Schwartz,et al.  Traffic-Related Air Pollution and Cognitive Function in a Cohort of Older Men , 2010, Environmental health perspectives.

[4]  Donald Silberberg,et al.  National Institutes of Health State-of-the-Science Conference Statement: Preventing Alzheimer Disease* and Cognitive Decline , 2010, Annals of Internal Medicine.

[5]  Linus Jönsson,et al.  The worldwide societal costs of dementia: Estimates for 2009 , 2010, Alzheimer's & Dementia.

[6]  N. Christakis,et al.  Associations of environmental factors with elderly health and mortality in China. , 2010, American journal of public health.

[7]  M. Miller.  Agency , 2010 .

[8]  Oscar L. Lopez,et al.  Telephone Interview for Cognitive Status , 2009, Neuroepidemiology.

[9]  Jean Krutmann,et al.  Long-term exposure to traffic-related particulate matter impairs cognitive function in the elderly. , 2009, Environmental research.

[10]  D. Harvey,et al.  Longitudinal Changes in Memory and Executive Functioning are Associated with longitudinal change in instrumental activities of daily living in older Adults , 2009, The Clinical neuropsychologist.

[11]  J. Schwartz,et al.  Neurobehavioral effects of ambient air pollution on cognitive performance in US adults. , 2009, Neurotoxicology.

[12]  Francine Laden,et al.  Submitted to the Annals of Applied Statistics PRACTICAL LARGE-SCALE SPATIO-TEMPORAL MODELING OF PARTICULATE MATTER CONCENTRATIONS By , 2016 .

[13]  Christopher J. Paciorek,et al.  Predicting Chronic Fine and Coarse Particulate Exposures Using Spatiotemporal Models for the Northeastern and Midwestern United States , 2008, Environmental health perspectives.

[14]  Joel Schwartz,et al.  Chronic Fine and Coarse Particulate Exposure, Mortality, and Coronary Heart Disease in the Nurses’ Health Study , 2008, Environmental health perspectives.

[15]  Joel Schwartz,et al.  Chronic particulate exposure, mortality, and coronary heart disease in the nurses' health study. , 2008, American journal of epidemiology.

[16]  Joel Schwartz,et al.  Spatio-temporal modeling of chronic PM10 exposure for the Nurses' Health Study. , 2008, Atmospheric environment.

[17]  Rosalind J Wright,et al.  Association of black carbon with cognition among children in a prospective birth cohort study. , 2007, American journal of epidemiology.

[18]  Daniel Krewski,et al.  Health Effects Associated With Exposure to Ambient Air Pollution , 2007, Journal of toxicology and environmental health. Part A.

[19]  L. Sheppard,et al.  Long-term exposure to air pollution and incidence of cardiovascular events in women. , 2007, The New England journal of medicine.

[20]  Joel Schwartz,et al.  Focused Exposures to Airborne Traffic Particles and Heart Rate Variability in the Elderly , 2007, Epidemiology.

[21]  W. Sturm,et al.  Neuropsychological assessment , 2007, Journal of Neurology.

[22]  D. Dockery,et al.  Health Effects of Fine Particulate Air Pollution: Lines that Connect , 2006, Journal of the Air & Waste Management Association.

[23]  Annette Peters,et al.  Translocation and potential neurological effects of fine and ultrafine particles a critical update , 2006, Particle and Fibre Toxicology.

[24]  M. Stampfer,et al.  Cardiovascular disease and Alzheimer's disease: common links , 2006, Journal of internal medicine.

[25]  D. Dockery,et al.  Health Effects of Fine Particulate Air Pollution: Lines that Connect , 2006, Journal of the Air & Waste Management Association.

[26]  J. Schwartz,et al.  Reduction in fine particulate air pollution and mortality: Extended follow-up of the Harvard Six Cities study. , 2006, American journal of respiratory and critical care medicine.

[27]  F. Dominici,et al.  Fine particulate air pollution and hospital admission for cardiovascular and respiratory diseases. , 2006, JAMA.

[28]  Loyda B. Mendez,et al.  Particulate matter in polluted air may increase biomarkers of inflammation in mouse brain. , 2005, Neurotoxicology.

[29]  R. Maronpot,et al.  Brain Inflammation and Alzheimer's-Like Pathology in Individuals Exposed to Severe Air Pollution , 2004, Toxicologic pathology.

[30]  J. Manson,et al.  Physical activity, including walking, and cognitive function in older women. , 2004, JAMA.

[31]  E. Keeler,et al.  Cognitive Decline in High‐Functioning Older Persons Is Associated with an Increased Risk of Hospitalization , 2004, Journal of the American Geriatrics Society.

[32]  J. Samet,et al.  Air Pollution and Cardiovascular Disease: A Statement for Healthcare Professionals From the Expert Panel on Population and Prevention Science of the American Heart Association , 2004, Circulation.

[33]  D. Howard.  Assessment of aphasia , 2004 .

[34]  W. Kreyling,et al.  Translocation of Inhaled Ultrafine Particles to the Brain , 2004, Inhalation toxicology.

[35]  D. Bennett,et al.  Alzheimer disease in the US population: prevalence estimates using the 2000 census. , 2003, Archives of neurology.

[36]  J. M. Guralnik,et al.  The role of APOE-&egr;4 in longitudinal cognitive decline: MacArthur Studies of Successful Aging , 2003 .

[37]  L. Bäckman,et al.  Cognitive deficits in preclinical Alzheimer's disease , 2003, Acta neurologica Scandinavica. Supplementum.

[38]  M. Albert,et al.  The role of APOE-epsilon4 in longitudinal cognitive decline: MacArthur Studies of Successful Aging. , 2003, Neurology.

[39]  D. Dockery,et al.  Effect of air-pollution control on death rates in Dublin, Ireland: an intervention study , 2002, The Lancet.

[40]  Günter Oberdörster,et al.  Ultrafine particles in the urban air: to the respiratory tract--and beyond? , 2002, Environmental health perspectives.

[41]  D. A. Bennett,et al.  Natural history of mild cognitive impairment in older persons , 2002, Neurology.

[42]  J. Carson,et al.  Air Pollution and Brain Damage , 2002, Toxicologic pathology.

[43]  B. Winblad,et al.  The course of cognitive impairment in preclinical Alzheimer disease: three- and 6-year follow-up of a population-based sample. , 2000, Archives of neurology.

[44]  M. Breteler.  Vascular Involvement in Cognitive Decline and Dementia: Epidemiologic Evidence from the Rotterdam Study and the Rotterdam Scan Study , 2000, Annals of the New York Academy of Sciences.

[45]  R Brookmeyer,et al.  Projections of Alzheimer's disease in the United States and the public health impact of delaying disease onset. , 1998, American journal of public health.

[46]  M. Katze,et al.  Functional Genomics Highlights Differential Induction of Antiviral Pathways in the Lungs of SARS-CoV–Infected Macaques , 2007, PLoS pathogens.

[47]  J. Manson,et al.  The Nurses' Health Study: 20-year contribution to the understanding of health among women. , 1997, Journal of women's health.

[48]  J. Lewtas,et al.  Teplice program--the impact of air pollution on human health. , 1996, Environmental health perspectives.

[49]  D. Dockery,et al.  Health effects of acid aerosols on North American children: air pollution exposures. , 1996, Environmental health perspectives.

[50]  E. Kaplan,et al.  The 'preclinical phase' of probable Alzheimer's disease. A 13-year prospective study of the Framingham cohort. , 1995, Archives of neurology.

[51]  M. Albert,et al.  Use of brief cognitive tests to identify individuals in the community with clinically diagnosed Alzheimer's disease. , 1991, The International journal of neuroscience.

[52]  L R White,et al.  Correlates of cognitive function in an elderly community population. , 1988, American journal of epidemiology.

[53]  R. Nass,et al.  The assessment of aphasia and related disorders By Harold Goodglass and edith kaplan philadelphia, lea & febiger, 1983 illustrated, $27.50 (package) , 1984 .

[54]  Grinding Facility,et al.  Office Of Air Quality Planning And Standards , 1976 .