论文信息 - An Improved Control Algorithm for an Artificial ß-Cell

An Improved Control Algorithm for an Artificial ß-Cell

With the successful implementation of a computer analog for (ß-cell function to restore normal glucose tolerance in diabetic patients, one of the major obstacles to the ultimate development of an implantable ``artificial pancreas'' was overcome. The next step was to optimize the original algorithm and simplify the operation of the blood sugar control system to make it more amenable to miniaturization.

Charles K. Botz

[1] G. Grodsky,et al. “Staircase” Glucose Stimulation of Insulin Secretion in Obesity: Measure of Beta-cell Sensitivity and Capacity , 1974, Diabetes.

[2] K. Moxness,et al. Continuous blood glucose analysis in ambulatory fed subjects. I. General methodology. , 1968, Mayo Clinic proceedings.

[3] P. Felig. Pathophysiology of diabetes mellitus. , 1971, The Medical clinics of North America.

[4] W. Zingg,et al. An Artificial Endocrine Pancreas , 1974, Diabetes.

[5] G. Grodsky,et al. A threshold distribution hypothesis for packet storage of insulin and its mathematical modeling. , 1972, The Journal of clinical investigation.

[6] W Zingg,et al. Clinical Control of Diabetes by the Artificial Pancreas , 1974, Diabetes.