A Genetic Variant Associated with Five Vascular Diseases Is a Distal Regulator of Endothelin-1 Gene Expression
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Jesse M. Engreitz | Bradley E. Bernstein | Charles B. Epstein | Wouter de Laat | Sekar Kathiresan | Valerio Bianchi | Noam Shoresh | Renate B. Schnabel | A. Khera | R. Schnabel | B. Bernstein | S. Kathiresan | N. Shoresh | C. Epstein | R. Issner | J. Engreitz | W. D. Laat | Russell J. H. Ryan | S. Zekavat | D. Klarin | C. Emdin | C. Roselli | Rajat M. Gupta | Valerio Bianchi | Robbyn Issner | Connor A. Emdin | Derek Klarin | Seyedeh M. Zekavat | Carolina Roselli | Aditi Trehan | Amit Khera | Jonathan D. Brown | Rajat M. Gupta | Joseph Hadaya | Catharina R.E. Hilvering | Christian Mueller | Russell J.H. Ryan | C. R. Hilvering | Joseph E. Hadaya | Aditi Trehan | Christian Mueller | Rajat M. Gupta | Jonathan D Brown | Rajat M. Gupta | W. Laat | Robbyn Issner | Joseph Hadaya
[1] He Zhang,et al. Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease , 2017, Journal of the American College of Cardiology.
[2] P. Ellinor,et al. PHACTR1 Is a Genetic Susceptibility Locus for Fibromuscular Dysplasia Supporting Its Complex Genetic Pattern of Inheritance , 2016, PLoS genetics.
[3] He Zhang,et al. Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension , 2016, Nature Genetics.
[4] Eleazar Eskin,et al. Local genetic effects on gene expression across 44 human tissues , 2016, bioRxiv.
[5] Ian C. McDowell,et al. Direct GR Binding Sites Potentiate Clusters of TF Binding across the Human Genome , 2016, Cell.
[6] M. Levine,et al. Enhancer Control of Transcriptional Bursting , 2016, Cell.
[7] A. Chalisey,et al. Genetic and environmental risk factors for atherosclerosis regulate transcription of phosphatase and actin regulating gene PHACTR1 , 2016, Atherosclerosis.
[8] Eric S. Lander,et al. Direct Identification of Hundreds of Expression-Modulating Variants using a Multiplexed Reporter Assay , 2016, Cell.
[9] Marc Tessier-Lavigne,et al. Efficient introduction of specific homozygous and heterozygous mutations using CRISPR/Cas9 , 2016, Nature.
[10] Lior Pachter,et al. Near-optimal probabilistic RNA-seq quantification , 2016, Nature Biotechnology.
[11] Linzhao Cheng,et al. Genome Editing in Human Pluripotent Stem Cells. , 2016, Cold Spring Harbor protocols.
[12] Rajiv,et al. Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease. , 2016, The New England journal of medicine.
[13] Shawn M. Gillespie,et al. Insulator dysfunction and oncogene activation in IDH mutant gliomas , 2015, Nature.
[14] O. Hermine,et al. Disruption of phactr-1 pathway triggers pro-inflammatory and pro-atherogenic factors: New insights in atherosclerosis development. , 2015, Biochimie.
[15] A. Regev,et al. Cpf1 Is a Single RNA-Guided Endonuclease of a Class 2 CRISPR-Cas System , 2015, Cell.
[16] Sebastian M. Armasu,et al. A comprehensive 1000 Genomes-based genome-wide association meta-analysis of coronary artery disease , 2015, Nature Genetics.
[17] Tobias Heckel,et al. Generation of vascular endothelial and smooth muscle cells from human pluripotent stem cells , 2015, Nature Cell Biology.
[18] S. Kathiresan,et al. Myocardial Infarction–Associated SNP at 6p24 Interferes With MEF2 Binding and Associates With PHACTR1 Expression Levels in Human Coronary Arteries , 2015, Arteriosclerosis, thrombosis, and vascular biology.
[19] Clint L. Miller,et al. Coronary artery disease associated transcription factor TCF21 regulates smooth muscle precursor cells that contribute to the fibrous cap , 2015, Genomics data.
[20] Felix A. Klein,et al. FourCSeq: analysis of 4C sequencing data , 2015, bioRxiv.
[21] K. Pollard,et al. Human Disease Modeling Reveals Integrated Transcriptional and Epigenetic Mechanisms of NOTCH1 Haploinsufficiency , 2015, Cell.
[22] H. Ploegh,et al. Inhibition of non-homologous end joining increases the efficiency of CRISPR/Cas9-mediated precise [TM: inserted] genome editing , 2015, Nature Biotechnology.
[23] M. Reilly,et al. Knockout of Adamts7, a Novel Coronary Artery Disease Locus in Humans, Reduces Atherosclerosis in Mice , 2015, Circulation.
[24] Michael Q. Zhang,et al. Integrative analysis of 111 reference human epigenomes , 2015, Nature.
[25] Andrew D. Johnson,et al. Common variation in PHACTR1 is associated with susceptibility to cervical artery dissection , 2014, Nature Genetics.
[26] Andrew L. Kung,et al. NF-κB directs dynamic super enhancer formation in inflammation and atherogenesis. , 2014, Molecular cell.
[27] Jill M Dowen,et al. Control of Cell Identity Genes Occurs in Insulated Neighborhoods in Mammalian Chromosomes , 2014, Cell.
[28] M. Daly,et al. Genetic and Epigenetic Fine-Mapping of Causal Autoimmune Disease Variants , 2014, Nature.
[29] John P. Overington,et al. An atlas of genetic influences on human blood metabolites , 2014, Nature Genetics.
[30] S. Malcolm. Faculty Opinions recommendation of Obesity-associated variants within FTO form long-range functional connections with IRX3. , 2014 .
[31] Faha,et al. Fibromuscular dysplasia: state of the science and critical unanswered questions: a scientific statement from the American Heart Association. , 2014, Circulation.
[32] Stephen C. J. Parker,et al. Chromatin stretch enhancer states drive cell-specific gene regulation and harbor human disease risk variants , 2013, Proceedings of the National Academy of Sciences.
[33] Matthew C. Canver,et al. An Erythroid Enhancer of BCL11A Subject to Genetic Variation Determines Fetal Hemoglobin Level , 2013, Science.
[34] E. Schiffrin,et al. Endothelin-1 Overexpression Exacerbates Atherosclerosis and Induces Aortic Aneurysms in Apolipoprotein E Knockout Mice , 2013, Arteriosclerosis, thrombosis, and vascular biology.
[35] Jason S. Park,et al. A robust method to derive functional neural crest cells from human pluripotent stem cells. , 2013, American journal of stem cells.
[36] Thomas Meitinger,et al. Genome-wide meta-analysis identifies new susceptibility loci for migraine , 2013, Nature Genetics.
[37] Ellen T. Gelfand,et al. The Genotype-Tissue Expression (GTEx) project , 2013, Nature Genetics.
[38] David A. Orlando,et al. Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes , 2013, Cell.
[39] L. Aaltonen,et al. Mice Lacking a Myc Enhancer That Includes Human SNP rs6983267 Are Resistant to Intestinal Tumors , 2012, Science.
[40] J. Danesh,et al. Large-scale association analysis identifies new risk loci for coronary artery disease , 2012, Nature Genetics.
[41] Amos Tanay,et al. Robust 4C-seq data analysis to screen for regulatory DNA interactions , 2012, Nature Methods.
[42] Shane J. Neph,et al. Systematic Localization of Common Disease-Associated Variation in Regulatory DNA , 2012, Science.
[43] S. Batzoglou,et al. Linking disease associations with regulatory information in the human genome , 2012, Genome research.
[44] Raymond K. Auerbach,et al. An Integrated Encyclopedia of DNA Elements in the Human Genome , 2012, Nature.
[45] P. Gregory,et al. Controlling Long-Range Genomic Interactions at a Native Locus by Targeted Tethering of a Looping Factor , 2012, Cell.
[46] P. Visscher,et al. Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits , 2012, Nature Genetics.
[47] Udo Hoffmann,et al. Genome-Wide Association Study for Coronary Artery Calcification With Follow-Up in Myocardial Infarction , 2011, Circulation.
[48] J. Larghero,et al. Depletion of the novel protein PHACTR-1 from human endothelial cells abolishes tube formation and induces cell death receptor apoptosis. , 2011, Biochimie.
[49] J. Olesen,et al. Evidence for a vascular factor in migraine , 2011, Annals of neurology.
[50] Olle Melander,et al. From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus , 2010, Nature.
[51] D. Pollock. Dissecting the complex physiology of endothelin: new lessons from genetic models. , 2010, Hypertension.
[52] Joshua M. Korn,et al. Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants , 2009, Nature Genetics.
[53] A. Padovani,et al. History of Migraine and the Risk of Spontaneous Cervical Artery Dissection , 2005, Cephalalgia : an international journal of headache.
[54] I. Riphagen,et al. A Systematic Review of the Risk Factors for Cervical Artery Dissection , 2005, Stroke.
[55] E. Schiffrin. Vascular endothelin in hypertension. , 2005, Vascular pharmacology.
[56] J. Verbalis,et al. Collecting duct-specific knockout of endothelin-1 alters vasopressin regulation of urine osmolality. , 2005, American journal of physiology. Renal physiology.
[57] Mario Fritsch Neves,et al. Endothelium-Restricted Overexpression of Human Endothelin-1 Causes Vascular Remodeling and Endothelial Dysfunction , 2004, Circulation.
[58] R. D. du Bois,et al. Endothelin-1 Induces Expression of Matrix-associated Genes in Lung Fibroblasts through MEK/ERK* , 2004, Journal of Biological Chemistry.
[59] Andrew K. Dunn,et al. Intrinsic brain activity triggers trigeminal meningeal afferents in a migraine model , 2002, Nature Medicine.
[60] E. Benjamin,et al. Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: a report of the International Brachial Artery Reactivity Task Force. , 2002, Journal of the American College of Cardiology.
[61] J. Pearson,et al. Fibroblast matrix gene expression and connective tissue remodeling: role of endothelin-1. , 2001, The Journal of investigative dermatology.
[62] T. Warner,et al. Endothelin-1 is induced by cytokines in human vascular smooth muscle cells: evidence for intracellular endothelin-converting enzyme. , 1999, Molecular pharmacology.
[63] T. Lüscher,et al. Endothelin ETA receptor blockade restores NO-mediated endothelial function and inhibits atherosclerosis in apolipoprotein E-deficient mice. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[64] A. Davenport,et al. Endothelin peptide and receptors in human atherosclerotic coronary artery and aorta. , 1996, Circulation research.
[65] D. Spiegelhalter,et al. Non-invasive measurement of human endothelium dependent arterial responses: accuracy and reproducibility. , 1995, British heart journal.
[66] M. Kowala,et al. Selective blockade of the endothelin subtype A receptor decreases early atherosclerosis in hamsters fed cholesterol. , 1995, The American journal of pathology.
[67] E. Schiffrin,et al. Effect of a nonselective endothelin antagonist on vascular remodeling in deoxycorticosterone acetate-salt hypertensive rats. Evidence for a role of endothelin in vascular hypertrophy. , 1994, Hypertension.
[68] Y. Ouchi,et al. Elevated blood pressure and craniofaclal abnormalities in mice deficient in endothelin-1 , 1994, Nature.
[69] Y. Hirata,et al. Endothelin receptor subtype B mediates synthesis of nitric oxide by cultured bovine endothelial cells. , 1993, The Journal of clinical investigation.
[70] B. Binder,et al. Polar secretion of endothelin-1 by cultured endothelial cells. , 1992, The Journal of biological chemistry.
[71] Y. Yazaki,et al. Interleukin 1 increases the production of endothelin-1 by cultured endothelial cells. , 1990, Biochemical and biophysical research communications.
[72] Y. Hirata,et al. Endothelin is a potent mitogen for rat vascular smooth muscle cells. , 1989, Atherosclerosis.
[73] Feng Yue,et al. Transcriptional Enhancers: Bridging the Genome and Phenome. , 2015, Cold Spring Harbor symposia on quantitative biology.
[74] Derek T. Peters,et al. Genome editing in human pluripotent stem cells , 2014 .
[75] D. Kohan,et al. Regulation of blood pressure and salt homeostasis by endothelin. , 2011, Physiological reviews.