Discovery and resupply of pharmacologically active plant-derived natural products: A review
暂无分享,去创建一个
Daniela Schuster | Hermann Stuppner | Veronika Temml | Birgit Waltenberger | Stefan Schwaiger | Christoph Wawrosch | Elke H. Heiss | Verena M. Dirsch | Judith M. Rollinger | Atanas G. Atanasov | Marko D. Mihovilovic | Rudolf Bauer | R. Bauer | A. Atanasov | D. Schuster | E. Heiss | J. Rollinger | H. Stuppner | V. Dirsch | B. Waltenberger | J. Breuss | V. Temml | V. Bochkov | P. Uhrin | S. Schwaiger | Eva-Maria Pferschy-Wenzig | M. Mihovilovic | Thomas Linder | C. Wawrosch | Limei Wang | B. Kopp | Thomas Linder | Pavel Uhrin | Valery Bochkov | Brigitte Kopp | Eva-Maria Pferschy-Wenzig | Limei Wang | Johannes M. Breuss
[1] Albert S. Matlack,et al. Introduction to Green Chemistry , 2022 .
[2] Jisook Park,et al. Total Synthesis of Strychnine. , 2017, Chemistry.
[3] T. Hudlický,et al. The quest for a practical synthesis of morphine alkaloids and their derivatives by chemoenzymatic methods. , 2015, Accounts of chemical research.
[4] D. Dias,et al. The pharmaceutical industry and natural products: historical status and new trends , 2015, Phytochemistry Reviews.
[5] Aurélien Thomas,et al. Current approaches and challenges for the metabolite profiling of complex natural extracts. , 2015, Journal of chromatography. A.
[6] Pablo Carbonell,et al. Computer-aided design for metabolic engineering. , 2014, Journal of biotechnology.
[7] R. Bauer,et al. Plant extracts in cell-based anti-inflammatory assays—Pitfalls and considerations related to removal of activity masking bulk components , 2014 .
[8] M. Heinrich,et al. Alkaloids as drug leads – A predictive structural and biodiversity-based analysis , 2014 .
[9] R. Bauer,et al. The therapeutic value of natural products derived from Chinese medicine—A systems based perspective , 2014 .
[10] R. Saller,et al. Alteration of anti‐inflammatory activity of Harpagophytum procumbens (devil's claw) extract after external metabolic activation with S9 mix , 2014, The Journal of pharmacy and pharmacology.
[11] D. Llères,et al. Monitoring Keap1–Nrf2 interactions in single live cells , 2014, Biotechnology advances.
[12] M. Cooper,et al. Natural product and natural product derived drugs in clinical trials. , 2014, Natural product reports.
[13] E. Kim,et al. Microbial biosynthesis of medicinally important plant secondary metabolites. , 2014, Natural product reports.
[14] Chuang‐Chuang Li,et al. Collective synthesis of humulanolides using a metathesis cascade reaction. , 2014, Journal of the American Chemical Society.
[15] S. Gairola,et al. A cross-cultural analysis of Jammu, Kashmir and Ladakh (India) medicinal plant use. , 2014, Journal of ethnopharmacology.
[16] Melissa M. Harrison,et al. A CRISPR view of development , 2014, Genes & development.
[17] A. Fallarero,et al. How to Translate a Bioassay Into a Screening Assay for Natural Products: General Considerations and Implementation of Antimicrobial Screens , 2014, Planta Medica.
[18] H. Stuppner,et al. Lignan formation in hairy root cultures of Edelweiss (Leontopodium nivale ssp. alpinum (Cass.) Greuter) , 2014, Fitoterapia.
[19] L. Yu,et al. Utility of hesperidinase for food function research: enzymatic digestion of botanical extracts alters cellular antioxidant capacities and anti-inflammatory properties. , 2014, Journal of agricultural and food chemistry.
[20] Jiyong Hong. Natural product synthesis at the interface of chemistry and biology. , 2014, Chemistry.
[21] J. Keasling,et al. Recent applications of synthetic biology tools for yeast metabolic engineering. , 2014, FEMS yeast research.
[22] M. Diederich,et al. Plumbagin Modulates Leukemia Cell Redox Status , 2014, Molecules.
[23] Robert Verpoorte,et al. Metabolomics: what you see is what you extract. , 2014, Phytochemical analysis : PCA.
[24] J. Espín,et al. Ellagic acid metabolism by human gut microbiota: consistent observation of three urolithin phenotypes in intervention trials, independent of food source, age, and health status. , 2014, Journal of agricultural and food chemistry.
[25] Martin D. Eastgate,et al. Natural Product Synthesis in the Age of Scalability , 2014 .
[26] B. Pfeifer,et al. Heterologous production of plant-derived isoprenoid products in microbes and the application of metabolic engineering and synthetic biology. , 2014, Current opinion in plant biology.
[27] I. Zündorf,et al. Plant-Derived Anti-Inflammatory Compounds: Hopes and Disappointments regarding the Translation of Preclinical Knowledge into Clinical Progress , 2014, Mediators of inflammation.
[28] Helen O. Masson,et al. Hairy Root Transformation Using Agrobacterium rhizogenes as a Tool for Exploring Cell Type-Specific Gene Expression and Function Using Tomato as a Model1[W][OPEN] , 2014, Plant Physiology.
[29] J. Reed,et al. Ultra-High-Throughput Screening of Natural Product Extracts to Identify Proapoptotic Inhibitors of Bcl-2 Family Proteins , 2014, Journal of biomolecular screening.
[30] G. Loake,et al. Paclitaxel: biosynthesis, production and future prospects. , 2014, New biotechnology.
[31] S. Gibbons,et al. Flavonoid glycosides from the stem bark of Margaritaria discoidea demonstrate antibacterial and free radical scavenging activities , 2014, Phytotherapy research : PTR.
[32] C. Harrison. Patenting natural products just got harder , 2014, Nature Biotechnology.
[33] G. Silverman,et al. C. elegans in high-throughput drug discovery. , 2014, Advanced drug delivery reviews.
[34] C. Zheng,et al. Monoterpenoids from the whole herb of Veronicastrum axillare , 2014, Pharmaceutical biology.
[35] P. Baran,et al. Development of a concise synthesis of (+)-ingenol. , 2014, Journal of the American Chemical Society.
[36] H. Bouwmeester,et al. The seco-iridoid pathway from Catharanthus roseus , 2014, Nature Communications.
[37] S. A. Wilson,et al. Metabolic engineering approaches for production of biochemicals in food and medicinal plants. , 2014, Current opinion in biotechnology.
[38] J. Keasling,et al. Semi-synthetic artemisinin: a model for the use of synthetic biology in pharmaceutical development , 2014, Nature Reviews Microbiology.
[39] M. Zehl,et al. Activity-guided isolation of NF-κB inhibitors and PPARγ agonists from the root bark of Lycium chinense Miller. , 2014, Journal of ethnopharmacology.
[40] G. Burton,et al. Emerging R and D law: the Nagoya Protocol and its implications for researchers. , 2014, ACS chemical biology.
[41] S. Noha,et al. Identification of plumericin as a potent new inhibitor of the NF-κB pathway with anti-inflammatory activity in vitro and in vivo , 2014, British journal of pharmacology.
[42] H. N. Murthy,et al. Production of secondary metabolites from cell and organ cultures: strategies and approaches for biomass improvement and metabolite accumulation , 2014, Plant Cell, Tissue and Organ Culture (PCTOC).
[43] H. N. Murthy,et al. Production of secondary metabolites from cell and organ cultures: strategies and approaches for biomass improvement and metabolite accumulation , 2014, Plant Cell, Tissue and Organ Culture (PCTOC).
[44] Franklin Riet-Correa,et al. Detection of toxic monofluoroacetate in Palicourea species. , 2014, Toxicon : official journal of the International Society on Toxinology.
[45] Martin D. Eastgate,et al. Natural product synthesis in the age of scalability. , 2014, Natural product reports.
[46] P. Hu,et al. Transformation of ginsenosides from notoginseng by artificial gastric juice can increase cytotoxicity toward cancer cells. , 2014, Journal of agricultural and food chemistry.
[47] K C Nicolaou,et al. Organic synthesis: the art and science of replicating the molecules of living nature and creating others like them in the laboratory , 2014, Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences.
[48] D. Schuster,et al. Polypharmacology and Adverse Bioactivity Profiles Predict Potential Toxicity and Drug‐Related Adrs , 2014 .
[49] P. Magnus,et al. Total synthesis of 8,14-dihydromorphinandienone alkaloids. , 2014, Organic letters.
[50] O. Kayser,et al. Natural products – learning chemistry from plants , 2014, Biotechnology journal.
[51] D. Sherman,et al. The role of HTS in drug discovery at the University of Michigan. , 2014, Combinatorial chemistry & high throughput screening.
[52] V. Kadirkamanathan,et al. A Zebrafish Compound Screen Reveals Modulation of Neutrophil Reverse Migration as an Anti-Inflammatory Mechanism , 2014, Science Translational Medicine.
[53] D. Ramasamy,et al. Vitiquinolone--a quinolone alkaloid from Hibiscus vitifolius Linn. , 2014, Food chemistry.
[54] H. Bouwmeester,et al. Comparison of plant-based expression platforms for the heterologous production of geraniol , 2014, Plant Cell, Tissue and Organ Culture (PCTOC).
[55] R. Linhardt,et al. Biochemical strategies for enhancing the in vivo production of natural products with pharmaceutical potential. , 2014, Current opinion in biotechnology.
[56] P. D’souza,et al. Use of in vitro bioassays for assessing botanicals. , 2014, Current opinion in biotechnology.
[57] Jian Chen,et al. Novel fermentation processes for manufacturing plant natural products. , 2014, Current opinion in biotechnology.
[58] Fei Wang,et al. Investigation of Antioxidant Interactions between Radix Astragali and Cimicifuga foetida and Identification of Synergistic Antioxidant Compounds , 2014, PloS one.
[59] A. Atanasov,et al. Identification of Chromomoric Acid C-I as an Nrf2 Activator in Chromolaena odorata , 2014, Journal of natural products.
[60] D. Tyrrell,et al. Chimeric rodents with humanized liver: bridging the preclinical/clinical trial gap in ADME/toxicity studies , 2014, Xenobiotica; the fate of foreign compounds in biological systems.
[61] P. Baran,et al. 14-Step Synthesis of (+)-Ingenol from (+)-3-Carene. , 2014 .
[62] G. Appendino. Omnia praeclara rara. The quest for ingenol heats up. , 2014, Angewandte Chemie.
[63] G. Massolini,et al. Isolation and characterization of bioactive compounds from plant resources: the role of analysis in the ethnopharmacological approach. , 2014, Journal of pharmaceutical and biomedical analysis.
[64] S. Gibbons,et al. The application of GC–MS combined with chemometrics for the identification of antimicrobial compounds from selected commercial essential oils , 2014 .
[65] C. Geethu,et al. Metabolic Profiling of Zingiber zerumbet Following Pythium myriotylum Infection: Investigations on the Defensive Role of the Principal Secondary Metabolite, Zerumbone , 2014, Applied Biochemistry and Biotechnology.
[66] R. Pandey,et al. Establishment of hairy root culture and production of secondary metabolites in Coleus (Coleus forskohlii) , 2014 .
[67] O. Werz,et al. Indirubin-3′-monoxime exerts a dual mode of inhibition towards leukotriene-mediated vascular smooth muscle cell migration , 2013, Cardiovascular research.
[68] J. Rollinger,et al. Computer-Guided Approach to Access the Anti-influenza Activity of Licorice Constituents , 2013, Journal of natural products.
[69] Judith M. Rollinger,et al. Virtual Screening and Target Fishing for Natural Products Using 3D Pharmacophores , 2013 .
[70] E. Lander,et al. Genetic Screens in Human Cells Using the CRISPR-Cas9 System , 2013, Science.
[71] Zhengxiang Wang,et al. Metabolic engineering of Escherichia coli: a sustainable industrial platform for bio-based chemical production. , 2013, Biotechnology advances.
[72] Jyoti Sahu,et al. A Review on Low Cost Methods for In Vitro Micropropagation of Plant Through Tissue Culture Technique , 2013 .
[73] L. Arola,et al. Serum metabolites of proanthocyanidin-administered rats decrease lipid synthesis in HepG2 cells. , 2013, The Journal of nutritional biochemistry.
[74] B. Graz. What is "clinical data"? Why and how can they be collected during field surveys on medicinal plants? , 2013, Journal of Ethnopharmacology.
[75] G. Schneider,et al. Aminothiazole-featured pirinixic acid derivatives as dual 5-lipoxygenase and microsomal prostaglandin E2 synthase-1 inhibitors with improved potency and efficiency in vivo. , 2013, Journal of medicinal chemistry.
[76] Steven V Ley,et al. Flow chemistry syntheses of natural products. , 2013, Chemical Society reviews.
[77] Wei Zheng,et al. Phenotypic screens as a renewed approach for drug discovery. , 2013, Drug discovery today.
[78] Binbin Chen,et al. Microbial engineering strategies to improve cell viability for biochemical production. , 2013, Biotechnology advances.
[79] S. Noha,et al. Honokiol: A non-adipogenic PPARγ agonist from nature☆ , 2013, Biochimica et biophysica acta.
[80] R. Edrada-Ebel,et al. Metabolomics and dereplication strategies in natural products. , 2013, Methods in molecular biology.
[81] S. Alqahtani,et al. Experimental models for predicting drug absorption and metabolism , 2013, Expert opinion on drug metabolism & toxicology.
[82] Curtis J Henrich,et al. Matching the power of high throughput screening to the chemical diversity of natural products. , 2013, Natural product reports.
[83] D. Fuchs,et al. Interaction of Carthamus tinctorius lignan arctigenin with the binding site of tryptophan-degrading enzyme indoleamine 2,3-dioxygenase☆ , 2013, FEBS open bio.
[84] Lei Zhang,et al. Ex vivo and in situ approaches used to study intestinal absorption. , 2013, Journal of pharmacological and toxicological methods.
[85] Peng Gao,et al. A novel strategy to evaluate the quality of traditional Chinese medicine based on the correlation analysis of chemical fingerprint and biological effect. , 2013, Journal of pharmaceutical and biomedical analysis.
[86] Robert J Linhardt,et al. Metabolic engineering and in vitro biosynthesis of phytochemicals and non-natural analogues. , 2013, Plant science : an international journal of experimental plant biology.
[87] M. Diederich,et al. Styryl-lactone goniothalamin inhibits TNF-α-induced NF-κB activation. , 2013, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
[88] P. Christou,et al. Metabolic engineering of plant secondary products: which way forward? , 2013, Current pharmaceutical design.
[89] P. Baran,et al. 14-Step Synthesis of (+)-Ingenol from (+)-3-Carene , 2013, Science.
[90] M. Farhi,et al. Metabolic engineering of plants for artemisinin synthesis , 2013, Biotechnology & genetic engineering reviews.
[91] M. Pellegatti. Dogs and monkeys in preclinical drug development: the challenge of reducing and replacing , 2013, Expert opinion on drug metabolism & toxicology.
[92] Shu Liu,et al. Coumestrol from the national cancer Institute’s natural product library is a novel inhibitor of protein kinase CK2 , 2013, BMC Pharmacology and Toxicology.
[93] Rolf Müller,et al. Recent advances in the heterologous expression of microbial natural product biosynthetic pathways. , 2013, Natural product reports.
[94] Deok-Chun Yang,et al. Computer-aided identification of EGFR tyrosine kinase inhibitors using ginsenosides from Panax ginseng , 2013, Comput. Biol. Medicine.
[95] A. Marston,et al. Antimicrobial activity of southern African medicinal plants with dermatological relevance , 2014 .
[96] David J Newman,et al. Natural products: a continuing source of novel drug leads. , 2013, Biochimica et biophysica acta.
[97] P. Duez,et al. Metabolomic-Based Study of the Leafy Gall, the Ecological Niche of the Phytopathogen Rhodococcus Fascians, as a Potential Source of Bioactive Compounds , 2013, International journal of molecular sciences.
[98] A. Ward,et al. Zebrafish as a genetic model in pre-clinical drug testing and screening. , 2013, Current medicinal chemistry.
[99] P. Zhu,et al. Artemisinic acid: A promising molecule potentially suitable for the semi-synthesis of artemisinin , 2013 .
[100] R. Brun,et al. Antiprotozoal activity of Khaya anthotheca, (Welv.) C.D.C. a plant used by chimpanzees for self-medication. , 2013, Journal of ethnopharmacology.
[101] Jianbo Xiao,et al. Metabolism of dietary flavonoids in liver microsomes. , 2013, Current drug metabolism.
[102] A. Bogdanove,et al. TALEN-mediated editing of the Mouse Y Chromosome , 2013, Nature Biotechnology.
[103] L. Kang,et al. Two novel furostanol saponins from the tubers of Ophiopogon japonicus , 2013, Journal of Asian natural products research.
[104] R. Bauer,et al. Polyacetylenes from Notopterygium incisum–New Selective Partial Agonists of Peroxisome Proliferator-Activated Receptor-Gamma , 2013, PloS one.
[105] E. Nevo,et al. Antitumor activities of extracts from selected desert plants against HepG2 human hepatocellular carcinoma cells , 2013, Pharmaceutical biology.
[106] P. Liu,et al. Biotransformation and metabolic profile of American ginseng saponins with human intestinal microflora by liquid chromatography quadrupole time-of-flight mass spectrometry. , 2013, Journal of chromatography. A.
[107] J. Keasling,et al. High-level semi-synthetic production of the potent antimalarial artemisinin , 2013, Nature.
[108] P. Clemons,et al. Target identification and mechanism of action in chemical biology and drug discovery. , 2013, Nature chemical biology.
[109] S. O’Connor,et al. Recent progress in the metabolic engineering of alkaloids in plant systems. , 2013, Current opinion in biotechnology.
[110] P. Forster,et al. Multiple metal accumulation within a manganese-specific genus. , 2013, American journal of botany.
[111] F. Bucar,et al. Natural product isolation--how to get from biological material to pure compounds. , 2013, Natural product reports.
[112] W. Folk,et al. 21st century natural product research and drug development and traditional medicines. , 2013, Natural product reports.
[113] Herbert Waldmann,et al. Target identification for small bioactive molecules: finding the needle in the haystack. , 2013, Angewandte Chemie.
[114] Serge Rudaz,et al. Plant metabolomics: from holistic data to relevant biomarkers. , 2013, Current medicinal chemistry.
[115] M. Zehl,et al. The Herbal Drug Melampyrum pratense L. (Koch): Isolation and Identification of Its Bioactive Compounds Targeting Mediators of Inflammation , 2013, Evidence-based complementary and alternative medicine : eCAM.
[116] Stephen Gabriel,et al. Metal impurities cause false positives in high-throughput screening campaigns. , 2013, ACS medicinal chemistry letters.
[117] K. Tasheva,et al. Role of Biotechnology for Protection of Endangered Medicinal Plants , 2013 .
[118] B. M. Lange,et al. Metabolic engineering of plant monoterpenes, sesquiterpenes and diterpenes--current status and future opportunities. , 2013, Plant biotechnology journal.
[119] B. Ncube,et al. Anti-Oxidative and Cholinesterase Inhibitory Effects of Leaf Extracts and Their Isolated Compounds from Two Closely Related Croton Species , 2013, Molecules.
[120] A. Napolitano,et al. Oleanane glycosides from Astragalus tauricolus: isolation and structural elucidation based on a preliminary liquid chromatography-electrospray ionization tandem mass spectrometry profiling. , 2013, Phytochemistry.
[121] M. Bogyo,et al. Target deconvolution techniques in modern phenotypic profiling. , 2013, Current opinion in chemical biology.
[122] Xiaoguang Lei,et al. Collective Synthesis of Lycopodium Alkaloids and Tautomer Locking Strategy for the Total Synthesis of (−)-lycojapodine A , 2022 .
[123] T. Verbiest,et al. Polyphenols can inhibit furin in vitro as a result of the reactivity of their auto-oxidation products to proteins. , 2013, Current medicinal chemistry.
[124] N. Scheer,et al. Xenobiotic receptor humanized mice and their utility , 2013, Drug metabolism reviews.
[125] M. Bott,et al. Metabolic engineering of microorganisms for the synthesis of plant natural products. , 2013, Journal of biotechnology.
[126] Dario R Alessi,et al. Kinase drug discovery--what's next in the field? , 2013, ACS chemical biology.
[127] J. Keasling,et al. Synthesis: A constructive debate , 2012, Nature.
[128] Chuang Lu,et al. Preclinical experimental models of drug metabolism and disposition in drug discovery and development , 2012 .
[129] M. Sandasi,et al. An untargeted metabolomic approach in the chemotaxonomic assessment of two Salvia species as a potential source of α-bisabolol. , 2012, Phytochemistry.
[130] J. Rosenthal,et al. The impact of the United Nations Convention on Biological Diversity on natural products research. , 2012, Natural product reports.
[131] T. Högberg,et al. Semisynthesis of Ingenol 3-Angelate (PEP005): Efficient Stereoconservative Angeloylation of Alcohols , 2012, Synlett.
[132] Jan Maes,et al. Evaluation of 14 Organic Solvents and Carriers for Screening Applications in Zebrafish Embryos and Larvae , 2012, PloS one.
[133] X. Qiao,et al. Analytical strategy to reveal the in vivo process of multi-component herbal medicine: a pharmacokinetic study of licorice using liquid chromatography coupled with triple quadrupole mass spectrometry. , 2012, Journal of chromatography. A.
[134] S. Franzblau,et al. Unbiased evaluation of bioactive secondary metabolites in complex matrices. , 2012, Fitoterapia.
[135] Milen I Georgiev,et al. Genetically transformed roots: from plant disease to biotechnological resource. , 2012, Trends in biotechnology.
[136] Adrià Cereto-Massagué,et al. Identification of Novel Human Dipeptidyl Peptidase-IV Inhibitors of Natural Origin (Part I): Virtual Screening and Activity Assays , 2012, PloS one.
[137] C. Saslis-Lagoudakis,et al. Phylogenies reveal predictive power of traditional medicine in bioprospecting , 2012, Proceedings of the National Academy of Sciences.
[138] Ming-cang Chen,et al. Systematic screening and characterization of the major bioactive components of Poria cocos and their metabolites in rats by LC-ESI-MS(n). , 2012, Biomedical chromatography : BMC.
[139] M. Hamburger,et al. Epilepsy in the Renaissance: a survey of remedies from 16th and 17th century German herbals. , 2012, Journal of ethnopharmacology.
[140] Steven V Ley,et al. On being green: can flow chemistry help? , 2012, Chemical record.
[141] D. Barron,et al. Elucidation of (-)-epicatechin metabolites after ingestion of chocolate by healthy humans. , 2012, Free radical biology & medicine.
[142] Chunyin Zhu,et al. A concise synthesis of (+)-artemisinin. , 2012, Journal of the American Chemical Society.
[143] Jianxin Chen,et al. The Active Ingredients of Jiang-Zhi-Ning: Study of the Nelumbo nucifera Alkaloids and Their Main Bioactive Metabolites , 2012, Molecules.
[144] P. B. Kavi Kishor,et al. Carbohydrate and elicitor enhanced withanolide (withaferin A and withanolide A) accumulation in hairy root cultures of Withania somnifera (L.). , 2012, Indian journal of experimental biology.
[145] V. De Luca,et al. Mining the Biodiversity of Plants: A Revolution in the Making , 2012, Science.
[146] P. Egan,et al. Coproduction and Ecological Significance of Naphthoquinones in Carnivorous Sundews (Drosera) , 2012, Chemistry & biodiversity.
[147] K. Booker‐Milburn. Flow chemistry: a light touch to a deadly problem. , 2012, Nature chemistry.
[148] E. Werner,et al. Ascorbate stimulates endothelial nitric oxide synthase enzyme activity by rapid modulation of its phosphorylation status , 2012, Free radical biology & medicine.
[149] Manabendra Dutta Choudhury,et al. Challenges in developing medicinal plant databases for sharing ethnopharmacological knowledge. , 2012, Journal of ethnopharmacology.
[150] L. Overman,et al. Is there no end to the total syntheses of strychnine? Lessons learned in strategy and tactics in total synthesis. , 2012, Angewandte Chemie.
[151] K. Helin,et al. Identification of catechols as histone–lysine demethylase inhibitors , 2012, FEBS Letters.
[152] Il Seok Oh,et al. In vivo anti-oxidant and anti-inflammatory activities of cambial meristematic cells established from Ginkgo biloba L. , 2012 .
[153] A. Nahrstedt,et al. What Is the Best Strategy for Preclinical Testing of Botanicals? A Critical Perspective , 2012, Planta Medica.
[154] A. Atanasov,et al. Synergy Study of the Inhibitory Potential of Red Wine Polyphenols on Vascular Smooth Muscle Cell Proliferation , 2012, Planta Medica.
[155] R. Bauer,et al. Traditional Chinese medicine research in the post-genomic era: good practice, priorities, challenges and opportunities. , 2012, Journal of ethnopharmacology.
[156] S. A. Wilson,et al. Recent advances towards development and commercialization of plant cell culture processes for the synthesis of biomolecules. , 2012, Plant biotechnology journal.
[157] D. Sall,et al. Modern phenotypic drug discovery is a viable, neoclassic pharma strategy. , 2012, Journal of medicinal chemistry.
[158] J. Scannell,et al. Diagnosing the decline in pharmaceutical R&D efficiency , 2012, Nature Reviews Drug Discovery.
[159] C. Smolke,et al. Advancing secondary metabolite biosynthesis in yeast with synthetic biology tools. , 2012, FEMS yeast research.
[160] F. Clubb,et al. Swine as Models in Biomedical Research and Toxicology Testing , 2012, Veterinary pathology.
[161] I. Gülçin. Antioxidant activity of food constituents: an overview , 2012, Archives of Toxicology.
[162] Peter H Seeberger,et al. Continuous-flow synthesis of the anti-malaria drug artemisinin. , 2012, Angewandte Chemie.
[163] David J Newman,et al. Natural products as sources of new drugs over the 30 years from 1981 to 2010. , 2012, Journal of natural products.
[164] Lufeng Hu,et al. Molecular determinants of magnolol targeting both RXR(alpha) and PPAR(gamma). , 2012 .
[165] Q. Wang,et al. Target separation of a new anti-tumor saponin and metabolic profiling of leaves of Panax notoginseng by liquid chromatography with eletrospray ionization quadrupole time-of-flight mass spectrometry. , 2012, Journal of pharmaceutical and biomedical analysis.
[166] Rohan A Davis,et al. Drug-like properties: guiding principles for the design of natural product libraries. , 2012, Journal of natural products.
[167] W. Barbosa,et al. Selecting Medicinal Plants for Development of Phytomedicine and Use in Primary Health Care , 2012 .
[168] D D Soejarto,et al. Ethnobotanical approach versus random approach in the search for new bioactive compounds: Support of a hypothesis , 2012, Pharmaceutical biology.
[169] G. Loake,et al. Plant natural products: history, limitations and the potential of cambial meristematic cells , 2012, Biotechnology & genetic engineering reviews.
[170] Lin Zhang,et al. New triterpenoid saponins from Patrinia scabiosaefolia. , 2011, Carbohydrate research.
[171] Kyria Boundy-Mills,et al. Natural product libraries to accelerate the high-throughput discovery of therapeutic leads. , 2011, Journal of natural products.
[172] B. Spitzer-Rimon,et al. Generation of the potent anti-malarial drug artemisinin in tobacco , 2011, Nature Biotechnology.
[173] Bochu Wang,et al. The screening toolbox of bioactive substances from natural products: a review. , 2011, Fitoterapia.
[174] Hualiang Jiang,et al. Molecular Determinants of Magnolol Targeting Both RXRα and PPARγ , 2011, PloS one.
[175] R. Breitling,et al. Toward global metabolomics analysis with hydrophilic interaction liquid chromatography-mass spectrometry: improved metabolite identification by retention time prediction. , 2011, Analytical chemistry.
[176] Daniela Schuster,et al. Pharmacophore-based discovery of FXR-agonists. Part II: Identification of bioactive triterpenes from Ganoderma lucidum , 2011, Bioorganic & medicinal chemistry.
[177] D. Bernhard,et al. Leoligin, the major lignan from Edelweiss, activates cholesteryl ester transfer protein , 2011, Atherosclerosis.
[178] Gokare A. Ravishankar,et al. Influence of abiotic stress signals on secondary metabolites in plants , 2011, Plant signaling & behavior.
[179] A. Fuerstner. Metathesis in Total Synthesis , 2011 .
[180] M. Lourenço,et al. Ethnopharmacological versus random plant selection methods for the evaluation of the antimycobacterial activity , 2011 .
[181] B. Aggarwal,et al. Identification of novel anti-inflammatory agents from Ayurvedic medicine for prevention of chronic diseases: "reverse pharmacology" and "bedside to bench" approach. , 2011, Current drug targets.
[182] Yuguo Du,et al. Total Synthesis of Solamargine (I). , 2011 .
[183] John P. Overington,et al. ChEMBL: a large-scale bioactivity database for drug discovery , 2011, Nucleic Acids Res..
[184] Xianli Wu,et al. Phenolic acids are in vivo atheroprotective compounds appearing in the serum of rats after blueberry consumption. , 2011, Journal of agricultural and food chemistry.
[185] M. Rask-Andersen,et al. Trends in the exploitation of novel drug targets , 2011, Nature Reviews Drug Discovery.
[186] An Xiao,et al. Heritable gene targeting in zebrafish using customized TALENs , 2011, Nature Biotechnology.
[187] Guodong Zhang,et al. Isolation and synergism of in vitro anti-inflammatory and quinone reductase (QR) inducing agents from the fruits of Morinda citrifolia (noni) , 2011 .
[188] Rainer Breitling,et al. Separating the wheat from the chaff: a prioritisation pipeline for the analysis of metabolomics datasets , 2011, Metabolomics.
[189] N. Oberlies,et al. Synergy-directed fractionation of botanical medicines: a case study with goldenseal (Hydrastis canadensis). , 2011, Journal of natural products.
[190] C. Saslis-Lagoudakis,et al. The Use of Phylogeny to Interpret Cross-Cultural Patterns in Plant Use and Guide Medicinal Plant Discovery: An Example from Pterocarpus (Leguminosae) , 2011, PloS one.
[191] Elo Leung,et al. Targeted Genome Editing Across Species Using ZFNs and TALENs , 2011, Science.
[192] D. MacMillan,et al. Collective synthesis of natural products by means of organocascade catalysis , 2011, Nature.
[193] I. Maclean,et al. Recent ecological responses to climate change support predictions of high extinction risk , 2011, Proceedings of the National Academy of Sciences.
[194] O. Yu,et al. Metabolic engineering of flavonoids in plants and microorganisms , 2011, Applied Microbiology and Biotechnology.
[195] D. Swinney,et al. How were new medicines discovered? , 2011, Nature Reviews Drug Discovery.
[196] Robert Verpoorte,et al. Cultivation of medicinal and aromatic plants for specialty industrial materials , 2011 .
[197] M. Oliva. Sharing the benefits of biodiversity: a new international protocol and its implications for research and development. , 2011, Planta medica.
[198] A. Kinghorn,et al. The relevance of higher plants in lead compound discovery programs. , 2011, Journal of natural products.
[199] Alois Fürstner,et al. Metathesis in total synthesis. , 2011, Chemical communications.
[200] D. Passarella,et al. Synthesis of (+)-dumetorine and congeners by using flow chemistry technologies. , 2011, Chemistry.
[201] H. Azaizeh,et al. Synergistic Antibacterial Effects of Polyphenolic Compounds from Olive Mill Wastewater , 2011, Evidence-based complementary and alternative medicine : eCAM.
[202] M. Heinrich,et al. The Thai Medicinal Plant Gynura Pseudochina var. hispida: Chemical Composition and in vitro NF-κB Inhibitory Activity , 2011, Natural product communications.
[203] M. Leonti. The future is written: impact of scripts on the cognition, selection, knowledge and transmission of medicinal plant use and its implications for ethnobotany and ethnopharmacology. , 2011, Journal of ethnopharmacology.
[204] M. Simmons,et al. Scale‐Up of Chemical Reactions , 2011 .
[205] David J. Ager,et al. Route and Process Selection , 2011 .
[206] Jun-ichi Yoshida,et al. A flow-microreactor approach to protecting-group-free synthesis using organolithium compounds. , 2011, Nature communications.
[207] D. Kingston. Modern natural products drug discovery and its relevance to biodiversity conservation. , 2011, Journal of natural products.
[208] Johannes Ottl,et al. Non-stoichiometric inhibition in biochemical high-throughput screening , 2011, Expert opinion on drug discovery.
[209] J. Gertsch,et al. Botanical drugs, synergy, and network pharmacology: forth and back to intelligent mixtures. , 2011, Planta medica.
[210] G. Sileshi,et al. Applications of phytochemical and in vitro techniques for reducing over-harvesting of medicinal and pesticidal plants and generating income for the rural poor , 2011, Plant Cell Reports.
[211] Shu-Dong Wei,et al. Antioxidant condensed tannins from Machilus pauhoi leaves , 2011 .
[212] S. Leelavathi,et al. Advances in plant molecular farming. , 2011, Biotechnology advances.
[213] L. Tian,et al. The multiplicity of hairy root cultures: prolific possibilities. , 2011, Plant science : an international journal of experimental plant biology.
[214] John P. Overington,et al. Probing the links between in vitro potency, ADMET and physicochemical parameters , 2011, Nature Reviews Drug Discovery.
[215] D. E. Clark,et al. Outstanding challenges in protein–ligand docking and structure‐based virtual screening , 2011 .
[216] J. Vederas,et al. [Drug discovery and natural products: end of era or an endless frontier?]. , 2011, Biomeditsinskaia khimiia.
[217] R. Ketting. The many faces of RNAi. , 2011, Developmental cell.
[218] G. Cordell,et al. Sustainable Medicines and Global Health Care , 2011, Planta medica.
[219] Gerhard G. Thallinger,et al. Lipid Data Analyzer: unattended identification and quantitation of lipids in LC-MS data , 2011, Bioinform..
[220] Y. Choi,et al. Metabolomics for bioactivity assessment of natural products , 2011, Phytotherapy research : PTR.
[221] Archana Sharma,et al. Enhancement of Secondary Metabolites in Cultured Plant Cells Through Stress Stimulus , 2011 .
[222] Elo Leung,et al. A TALE nuclease architecture for efficient genome editing , 2011, Nature Biotechnology.
[223] V. Pence. Evaluating costs for the in vitro propagation and preservation of endangered plants , 2011, In Vitro Cellular & Developmental Biology - Plant.
[224] Daniela Schuster,et al. Predicting cyclooxygenase inhibition by three-dimensional pharmacophoric profiling. Part II: Identification of enzyme inhibitors from Prasaplai, a Thai traditional medicine , 2011, Phytomedicine : international journal of phytotherapy and phytopharmacology.
[225] A. Vollmar,et al. In silico discovery of acylated flavonol monorhamnosides from Eriobotrya japonica as natural, small-molecular weight inhibitors of XIAP BIR3. , 2011, Bioorganic & medicinal chemistry.
[226] S. Bryant,et al. PubChem as a public resource for drug discovery. , 2010, Drug discovery today.
[227] A. Atanasov,et al. Indirubin-3′-Monoxime Blocks Vascular Smooth Muscle Cell Proliferation by Inhibition of Signal Transducer and Activator of Transcription 3 Signaling and Reduces Neointima Formation In Vivo , 2010, Arteriosclerosis, thrombosis, and vascular biology.
[228] C. Sotriffer,et al. Docking compared to 3D-pharmacophores: the scoring function challenge , 2010 .
[229] Daniela Schuster,et al. 3D pharmacophores as tools for activity profiling. , 2010, Drug discovery today. Technologies.
[230] A. Atanasov,et al. Resveratrol blocks Akt activation in angiotensin II- or EGF-stimulated vascular smooth muscle cells in a redox-independent manner , 2010, Cardiovascular research.
[231] Chun-Houh Chen,et al. Comparative metabolomics approach coupled with cell- and gene-based assays for species classification and anti-inflammatory bioactivity validation of Echinacea plants. , 2010, The Journal of nutritional biochemistry.
[232] J. W. van der Laan,et al. Regulatory acceptability of the minipig in the development of pharmaceuticals, chemicals and other products. , 2010, Journal of pharmacological and toxicological methods.
[233] Susan C. Roberts,et al. Plant natural products from cultured multipotent cells , 2010, Nature Biotechnology.
[234] G. Loake,et al. Cultured cambial meristematic cells as a source of plant natural products , 2010, Nature Biotechnology.
[235] J. Spurlino,et al. Potency variation of small-molecule chymase inhibitors across species. , 2010, Biochemical pharmacology.
[236] A. Davis,et al. Using a phylogenetic approach to selection of target plants in drug discovery of acetylcholinesterase inhibiting alkaloids in Amaryllidaceae tribe Galantheae , 2010 .
[237] Keith E. J. Tyo,et al. Isoprenoid Pathway Optimization for Taxol Precursor Overproduction in Escherichia coli , 2010, Science.
[238] J. Keasling,et al. Cloning of casbene and neocembrene synthases from Euphorbiaceae plants and expression in Saccharomyces cerevisiae. , 2010, Phytochemistry.
[239] A. Atanasov,et al. Bioactivity-guided isolation of 1,2,3,4,6-Penta-O-galloyl-D-glucopyranose from Paeonia lactiflora roots as a PTP1B inhibitor. , 2010, Journal of natural products.
[240] Matej Oresic,et al. MZmine 2: Modular framework for processing, visualizing, and analyzing mass spectrometry-based molecular profile data , 2010, BMC Bioinformatics.
[241] M. Heinrich. Ethnopharmacology in the 21st Century – Grand Challenges , 2010, Front. Pharm..
[242] A. Sakamoto,et al. Pattern Recognition Analysis of Proton Nuclear Magnetic Resonance Spectra of Brain Tissue Extracts from Rats Anesthetized with Propofol or Isoflurane , 2010, PloS one.
[243] Philip Gribbon,et al. Exemplification of the challenges associated with utilising fluorescence intensity based assays in discovery , 2010, Expert opinion on drug discovery.
[244] Paul Anastas,et al. Green chemistry: principles and practice. , 2010, Chemical Society reviews.
[245] K. Altmann,et al. Identification of serotonin 5-HT1A receptor partial agonists in ginger. , 2010, Bioorganic & medicinal chemistry.
[246] Daniela Schuster,et al. Computer-Aided Discovery, Validation, and Mechanistic Characterization of Novel Neolignan Activators of Peroxisome Proliferator-Activated Receptor γ , 2010, Molecular Pharmacology.
[247] Kip Guy,et al. Automated high-throughput system to fractionate plant natural products for drug discovery. , 2010, Journal of natural products.
[248] A. Kortenkamp,et al. Metabolomic profiling of liquid Echinacea medicinal products with in vitro inhibitory effects on cytochrome P450 3A4 (CYP3A4). , 2010, Planta medica.
[249] A. Vaidya,et al. Natural products drug discovery: accelerating the clinical candidate development using reverse pharmacology approaches. , 2010, Indian journal of experimental biology.
[250] K. Shilpa,et al. An alternate method of natural drug production: eliciting secondary metabolite production using plant cell culture. , 2010 .
[251] P. Proksch,et al. Methods for isolation of marine-derived endophytic fungi and their bioactive secondary products , 2010, Nature Protocols.
[252] N. Gilbert. Biodiversity law could stymie research , 2010, Nature.
[253] M. Ratner. Pfizer stakes a claim in plant cell–made biopharmaceuticals , 2010, Nature Biotechnology.
[254] Jianfeng Xu,et al. Bench to batch: advances in plant cell culture for producing useful products , 2010, Applied Microbiology and Biotechnology.
[255] Cecilia Alsmark,et al. Natural products in modern life science , 2010, Phytochemistry Reviews.
[256] Tomas Hudlicky,et al. Short Chemoenzymatic Azide‐Free Synthesis of Oseltamivir (Tamiflu): Approaching the Potential for Process Efficiency , 2010 .
[257] Liang-liang Zhang,et al. Condensed Tannins from Mangrove Species Kandelia candel and Rhizophora mangle and Their Antioxidant Activity , 2010, Molecules.
[258] Guillermo Gosset,et al. Production of aromatic compounds in bacteria. , 2009, Current opinion in biotechnology.
[259] John Calvin Reed,et al. Versatile Assays for High Throughput Screening for Activators or Inhibitors of Intracellular Proteases and Their Cellular Regulators , 2009, PloS one.
[260] Fatima Alkhalfioui,et al. From purified GPCRs to drug discovery: the promise of protein-based methodologies. , 2009, Current opinion in pharmacology.
[261] J. Beutler,et al. Natural Products as a Foundation for Drug Discovery , 2009, Current protocols in pharmacology.
[262] J. Forbey,et al. Exploitation of secondary metabolites by animals: A response to homeostatic challenges. , 2009, Integrative and comparative biology.
[263] M. Diederich,et al. Effect of Curcumin on Nuclear Factor κB Signaling Pathways in Human Chronic Myelogenous K562 Leukemia Cells , 2009 .
[264] T. Hudlický,et al. Celebrating 20 Years of SYNLETT — Special Account on the Merits of Biocatalysis and the Impact of Arene cis‐Dihydrodiols on Enantioselective Synthesis , 2009 .
[265] Thierry Kogej,et al. ChemGPS-NPWeb: chemical space navigation online , 2009, J. Comput. Aided Mol. Des..
[266] G. Appendino,et al. Genepolide, a sesterpene gamma-lactone with a novel carbon skeleton from mountain wormwood (Artemisia umbelliformis). , 2009, Journal of natural products.
[267] John Andraos,et al. Global Green Chemistry Metrics Analysis Algorithm and Spreadsheets: Evaluation of the Material Efficiency Performances of Synthesis Plans for Oseltamivir Phosphate (Tamiflu) as a Test Case , 2009 .
[268] H. Wagner,et al. Synergy research: approaching a new generation of phytopharmaceuticals. , 2009, Phytomedicine : international journal of phytotherapy and phytopharmacology.
[269] R. Quatrano,et al. Production of taxa-4(5),11(12)-diene by transgenic Physcomitrella patens , 2009, Transgenic Research.
[270] Tomas Hudlicky,et al. Celebrating 20 Years of SYNLETT - Special Account Onthe Merits of Biocatalysis and the Impact of Arene cis-Dihydrodiolson Enantioselective Synthesis , 2009 .
[271] Thierry Langer,et al. In silico Target Fishing for Rationalized Ligand Discovery Exemplified on Constituents of Ruta graveolens , 2008, Planta medica.
[272] De-Xin Kong,et al. Where is the hope for drug discovery? Let history tell the future. , 2009, Drug discovery today.
[273] T. Shibamoto,et al. Antioxidant assays for plant and food components. , 2009, Journal of agricultural and food chemistry.
[274] Y. Uprety,et al. Indigenous Use and Ethnopharmacology of Medicinal Plants in Far-West Nepal , 2009 .
[275] B. Teicher,et al. In Vivo/Ex Vivo and In Situ Assays Used in Cancer Research: A Brief Review , 2009, Toxicologic pathology.
[276] M. Koffas,et al. Metabolic engineering for plant natural product biosynthesis in microbes. , 2008, Current opinion in biotechnology.
[277] R. Ramchandran,et al. A Whole-Animal Microplate Assay for Metabolic Rate Using Zebrafish , 2008, Journal of biomolecular screening.
[278] P. Proksch,et al. Methods for isolation, purification and structural elucidation of bioactive secondary metabolites from marine invertebrates , 2008, Nature Protocols.
[279] Corey Nislow,et al. Yeast chemical genomics and drug discovery: an update. , 2008, Trends in pharmacological sciences.
[280] Hanlee P. Ji,et al. Next-generation DNA sequencing , 2008, Nature Biotechnology.
[281] Nicholas H Oberlies,et al. Colchicinoids from Colchicum crocifolium Boiss.: a case study in dereplication strategies for (-)-colchicine and related analogues using LC-MS and LC-PDA techniques. , 2008, Phytochemical analysis : PCA.
[282] Alan Talevi,et al. A Combined Virtual Screening 2D and 3D QSAR Methodology for the Selection of New Anticonvulsant Candidates from a Natural Product Library , 2008 .
[283] Y. Choi,et al. Metabolic profiling of the Mexican anxiolytic and sedative plant Galphimia glauca using nuclear magnetic resonance spectroscopy and multivariate data analysis. , 2008, Planta medica.
[284] R. Gabel,et al. Streamlined process for the esterification and ketalization of shikimic acid en route to the key precursor for oseltamivir phosphate (Tamiflu , 2008 .
[285] I. Raskin,et al. A natural history of botanical therapeutics. , 2008, Metabolism: clinical and experimental.
[286] S. Bagal,et al. Recent Advances in Biomimetic Natural Product Synthesis , 2008 .
[287] M. Barrett,et al. Metabolomic profiling using Orbitrap Fourier transform mass spectrometry with hydrophilic interaction chromatography: a method with wide applicability to analysis of biomolecules. , 2008, Rapid communications in mass spectrometry : RCM.
[288] H. Otsuka,et al. Chemical and biologically active constituents of Pteris multifida , 2008, Journal of Natural Medicines.
[289] Zhijun Liu. Preparation of botanical samples for biomedical research. , 2008, Endocrine, metabolic & immune disorders drug targets.
[290] C. Antczak,et al. Synthesis of antiproliferative Cephalotaxus esters and their evaluation against several human hematopoietic and solid tumor cell lines: uncovering differential susceptibilities to multidrug resistance. , 2008, Chemistry.
[291] S. Jennewein,et al. Metabolic engineering of taxadiene biosynthesis in yeast as a first step towards Taxol (Paclitaxel) production. , 2008, Metabolic engineering.
[292] V. Savolainen,et al. Phylogenetic selection of Narcissus species for drug discovery , 2008 .
[293] H. Kaiser,et al. Von der Pflanze zur Chemie – Die Frühgeschichte der „Rheumamittel“ , 2008, Zeitschrift für Rheumatologie.
[294] N. White,et al. Qinghaosu (Artemisinin): The Price of Success , 2008, Science.
[295] Susan C. Roberts,et al. Pharmaceutically active natural product synthesis and supply via plant cell culture technology. , 2008, Molecular pharmaceutics.
[296] Paul G Bulger,et al. Recent advances in biomimetic natural product synthesis. , 2008, Natural product reports.
[297] Ming-Wei Wang,et al. Botanical drugs: challenges and opportunities: contribution to Linnaeus Memorial Symposium 2007. , 2008, Life sciences.
[298] J. Pezzuto,et al. In Vitro Metabolism of Isoliquiritigenin by Human Liver Microsomes , 2008, Drug Metabolism and Disposition.
[299] B. Pfeifer,et al. Bacterial hosts for natural product production. , 2008, Molecular pharmaceutics.
[300] C. G. Curtis,et al. Ex Vivo Metrics™, a preclinical tool in new drug development , 2008, Journal of Translational Medicine.
[301] Roger A. Sheldon,et al. The E Factor: fifteen years on , 2007 .
[302] Pankaj Oberoi,et al. Identification of Inhibitors for MDM2 Ubiquitin Ligase Activity from Natural Product Extracts by a Novel High-Throughput Electrochemiluminescent Screen , 2008, Journal of biomolecular screening.
[303] S. Gibbons,et al. Polyisoprenylated benzoylphloroglucinol derivatives from Hypericum sampsonii. , 2007, Journal of natural products.
[304] H. Chaturvedi,et al. Cloning of medicinal plants through tissue culture--a review. , 2007, Indian journal of experimental biology.
[305] M. Zenk,et al. Evolution and current status of the phytochemistry of nitrogenous compounds. , 2007, Phytochemistry.
[306] Craig M. Crews,et al. Molecular Understanding and Modern Application of Traditional Medicines: Triumphs and Trials , 2007, Cell.
[307] T. Hudlický,et al. The Way of Synthesis: Evolution of Design and Methods for Natural Products , 2007 .
[308] Shih-Hsiung Wu,et al. Anti-platelet aggregation triterpene saponins from the galls of Sapindus mukorossi. , 2007, Chemical & pharmaceutical bulletin.
[309] R. Bandichhor,et al. Enantioselective synthesis of arglabin. , 2007, Angewandte Chemie.
[310] P. Read. MICROPROPAGATION: PAST, PRESENT AND FUTURE , 2007 .
[311] A. K. Kukreja,et al. Efficiency of liquid culture systems over conventional micropropagation: A progress towards commercialization , 2007 .
[312] Paul T Anastas,et al. Innovations and green chemistry. , 2007, Chemical reviews.
[313] John Andraos,et al. On the Use of "Green" Metrics in the Undergraduate Organic Chemistry Lecture and Lab to Assess the Mass Efficiency of Organic Reactions , 2007 .
[314] Poul R. Kruse. Geschichte der Pharmazie. Vol. II: Von der Frühen Neuzeit bis zur Gegenwart ‐ by Rudolf Schmitz , 2007 .
[315] M. Furmanowa,et al. Phytochemical and analytical studies of extracts from Rhodiola rosea and Rhodiola quadrifida. , 2007, Die Pharmazie.
[316] C. Cho,et al. The Protective Effect of Chlorophyll a Against Oxidative Stress and Inflammatory Processes in LPS-stimulated Macrophages , 2007 .
[317] B. Trost,et al. Synthesis of (-)-Delta9-trans-tetrahydrocannabinol: stereocontrol via Mo-catalyzed asymmetric allylic alkylation reaction. , 2007, Organic letters.
[318] D. Newman,et al. Natural products as sources of new drugs over the last 25 years. , 2007, Journal of natural products.
[319] Milen I Georgiev,et al. Hairy root type plant in vitro systems as sources of bioactive substances , 2007, Applied Microbiology and Biotechnology.
[320] R. Linforth,et al. Redirection of carotenoid metabolism for the efficient production of taxadiene [taxa-4(5),11(12)-diene] in transgenic tomato fruit , 2007, Transgenic Research.
[321] Thierry Langer,et al. Parallel Screening and Activity Profiling with HIV Protease Inhibitor Pharmacophore Models , 2007, J. Chem. Inf. Model..
[322] D. Frense. Taxanes: perspectives for biotechnological production , 2007, Applied Microbiology and Biotechnology.
[323] A. Cunningham,et al. A comparison of cultivation and wild collection of medicinal and aromatic plants under sustainability aspects , 2006 .
[324] K. F. Wiersum,et al. CULTIVATION OF MEDICINAL PLANTS AS A TOOL FOR BIODIVERSITY CONSERVATION AND POVERTY ALLEVIATION IN THE AMATOLA REGION, SOUTH AFRICA , 2006 .
[325] P. Imming,et al. Drugs, their targets and the nature and number of drug targets , 2006, Nature Reviews Drug Discovery.
[326] M. Hardy,et al. Natural products that reduce rotavirus infectivity identified by a cell-based moderate-throughput screening assay , 2006, Virology Journal.
[327] Pascal Gantet,et al. Harnessing the potential of hairy roots: dawn of a new era. , 2006, Trends in biotechnology.
[328] Thierry Langer,et al. Parallel Screening: A Novel Concept in Pharmacophore Modeling and Virtual Screening , 2006, J. Chem. Inf. Model..
[329] J. Serkedjieva,et al. Biologically Active Constituents of a Polyphenol Extract from Geranium sanguineum L. with Anti-Influenza Activity , 2006, Zeitschrift fur Naturforschung. C, Journal of biosciences.
[330] Sorel Muresan,et al. ChemGPS-NP: tuned for navigation in biologically relevant chemical space. , 2006, Journal of natural products.
[331] L. Maes,et al. Anti-infective potential of natural products: how to develop a stronger in vitro 'proof-of-concept'. , 2006, Journal of ethnopharmacology.
[332] S. Ley,et al. A flow process for the multi-step synthesis of the alkaloid natural product oxomaritidine: a new paradigm for molecular assembly. , 2006, Chemical communications.
[333] Matthias Hamburger,et al. Natural products in drug discovery –concepts and approaches for tracking bioactivity , 2006 .
[334] Marcy J. Balunas,et al. Interference by naturally occurring fatty acids in a noncellular enzyme-based aromatase bioassay. , 2006, Journal of natural products.
[335] Michael Dean,et al. A High-Throughput Cell-Based Assay for Inhibitors of ABCG2 Activity , 2006, Journal of biomolecular screening.
[336] Steven V. Ley,et al. Preparation of the neolignan natural product grossamide by a continuous-flow process , 2006 .
[337] M. Debnath,et al. Micropropagation: a tool for the production of high quality plant-based medicines. , 2006, Current pharmaceutical biotechnology.
[338] T. Hudlický. Chemoenzymatic synthesis of complex natural and unnatural products: morphine, pancratistatin, and their analogs , 2006 .
[339] R. Abagyan,et al. XCMS: processing mass spectrometry data for metabolite profiling using nonlinear peak alignment, matching, and identification. , 2006, Analytical chemistry.
[340] R. Wrangham,et al. Bioactive properties of plant species ingested by chimpanzees (Pan troglodytes schweinfurthii) in the Kibale National Park, Uganda , 2006, American journal of primatology.
[341] R. Müller,et al. Recent developments towards the heterologous expression of complex bacterial natural product biosynthetic pathways. , 2005, Current opinion in biotechnology.
[342] Ian Paterson,et al. The Renaissance of Natural Products as Drug Candidates , 2005, Science.
[343] C. Laggner,et al. Why drugs fail--a study on side effects in new chemical entities. , 2005, Current pharmaceutical design.
[344] B. Patwardhan. Ethnopharmacology and drug discovery. , 2005, Journal of ethnopharmacology.
[345] R. Verpoorte,et al. Elicitor signal transduction leading to production of plant secondary metabolites. , 2005, Biotechnology advances.
[346] Walter Sneader,et al. Drug Discovery (The History) , 2005 .
[347] Jaindra Nath Tripathi,et al. Role of biotechnology in medicinal plants , 2005, Tropical Journal of Pharmaceutical Research.
[348] R. Brinton,et al. Structure-based virtual screening for plant-based ERbeta-selective ligands as potential preventative therapy against age-related neurodegenerative diseases. , 2005, Journal of medicinal chemistry.
[349] W. Dunn,et al. Measuring the metabolome: current analytical technologies. , 2005, The Analyst.
[350] E. Ernst,et al. Bringing medicinal plants into cultivation: opportunities and challenges for biotechnology. , 2005, Trends in biotechnology.
[351] H. El‐Seedi,et al. Aryl Ketones from Acronychia pedunculata with Cyclooxygenase‐2 Inhibitory Effects , 2005, Chemistry & biodiversity.
[352] D. Guo,et al. Note: A novel cyanogenic glycoside from Semiaquilegia adoxoides , 2005 .
[353] M. Butler. Natural products to drugs: natural product-derived compounds in clinical trials. , 2005, Natural product reports.
[354] J. Minic,et al. Yeast system as a screening tool for pharmacological assessment of g protein coupled receptors. , 2005, Current medicinal chemistry.
[355] F. Koehn,et al. The evolving role of natural products in drug discovery , 2005, Nature Reviews Drug Discovery.
[356] John Andraos,et al. Unification of Reaction Metrics for Green Chemistry: Applications to Reaction Analysis , 2005 .
[357] Nicholas H Oberlies,et al. New colchicinoids from a native Jordanian meadow saffron, colchicum brachyphyllum: isolation of the first naturally occurring dextrorotatory colchicinoid. , 2005, Journal of natural products.
[358] A. Hopkins,et al. Navigating chemical space for biology and medicine , 2004, Nature.
[359] Christopher T. Walsh,et al. Lessons from natural molecules , 2004, Nature.
[360] Mark S Butler,et al. The role of natural product chemistry in drug discovery. , 2004, Journal of natural products.
[361] S. Sauret-Güeto,et al. Metabolic engineering of isoprenoid biosynthesis in Arabidopsis for the production of taxadiene, the first committed precursor of Taxol , 2004, Biotechnology and bioengineering.
[362] D. Moore,et al. Meclizine is an agonist ligand for mouse constitutive androstane receptor (CAR) and an inverse agonist for human CAR. , 2004, Molecular endocrinology.
[363] I. Kola,et al. Can the pharmaceutical industry reduce attrition rates? , 2004, Nature Reviews Drug Discovery.
[364] P. Grellier,et al. Novel Antimalarial Compounds Isolated in a Survey of Self-Medicative Behavior of Wild Chimpanzees in Uganda , 2004, Antimicrobial Agents and Chemotherapy.
[365] H. Tokuyama,et al. Total synthesis of (-)-strychnine. , 2004, Journal of the American Chemical Society.
[366] A Ganesan,et al. Natural products and combinatorial chemistry: back to the future. , 2004, Current opinion in chemical biology.
[367] J. Conrad,et al. A novel furostanol saponin from Tribulus terrestris of Bulgarian origin. , 2004, Fitoterapia.
[368] J. Lampe,et al. In vitro incubation of human feces with daidzein and antibiotics suggests interindividual differences in the bacteria responsible for equol production. , 2004, The Journal of nutrition.
[369] C Gyllenhaal,et al. The UIC ICBG (University of Illinois at Chicago International Cooperative Biodiversity Group) Memorandum of Agreement: a model of benefit-sharing arrangement in natural products drug discovery and development. , 2004, Journal of natural products.
[370] Thierry Langer,et al. Combining Ethnopharmacology and Virtual Screening for Lead Structure Discovery: COX-Inhibitors as Application Example , 2004, J. Chem. Inf. Model..
[371] O. Phillips,et al. Extinction risk from climate change , 2004, Nature.
[372] Mahabir P. Gupta,et al. Using ecological criteria to design plant collection strategies for drug discovery , 2003 .
[373] T. de Boer,et al. Fluorescence assays for high-throughput screening of protein kinases. , 2003, Combinatorial chemistry & high throughput screening.
[374] M. Huffman,et al. Animal self-medication and ethno-medicine: exploration and exploitation of the medicinal properties of plants , 2003, Proceedings of the Nutrition Society.
[375] H. Adlercreutz,et al. Metabolism of isoflavones and lignans by the gut microflora: a study in germ-free and human flora associated rats. , 2003, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
[376] H. Nishino,et al. Crown gall – a plant tumour with biological activities , 2003, Phytotherapy research : PTR.
[377] T. Kuzuyama,et al. Diversity of the biosynthesis of the isoprene units. , 2003, Natural product reports.
[378] Ivan A. Ross. Curcuma longa L. , 2003 .
[379] M. Miyashita,et al. Total synthesis of ingenol. , 2003, Journal of the American Chemical Society.
[380] David J. C. Constable,et al. Metrics to ‘green’ chemistry—which are the best? , 2002 .
[381] K. Kobashi,et al. Evaluation of salicin as an antipyretic prodrug that does not cause gastric injury. , 2002, Planta medica.
[382] M. O'Neil-Johnson,et al. High-throughput method for the production and analysis of large natural product libraries for drug discovery. , 2002, Analytical chemistry.
[383] T. Hudlický,et al. Medium-Scale Preparation of Useful Metabolites of Aromatic Compounds via Whole-Cell Fermentation with Recombinant Organisms , 2002 .
[384] S. Rao,et al. Plant cell cultures: Chemical factories of secondary metabolites. , 2002, Biotechnology advances.
[385] Cecil R. Smith,et al. Isolation of Antitumor Alkaloids from Cephalotaxus harringtonia , 2002 .
[386] B. Timmermann,et al. A Short Synthetic Route to Nordihydroguaiaretic Acid (NDGA) and Its Stereoisomer Using Ti‐Induced Carbonyl‐Coupling Reaction. , 2002 .
[387] Y. Konishi,et al. Taxines from the needles of Taxus wallichiana. , 2001, Phytochemistry.
[388] T. Takenaka,et al. Classical vs reverse pharmacology in drug discovery , 2001, BJU international.
[389] J. Pezzuto,et al. Antimalarial compounds from Rhaphidophora decursiva. , 2001, Journal of natural products.
[390] G. Schneider,et al. Scaffold architecture and pharmacophoric properties of natural products and trade drugs: application in the design of natural product-based combinatorial libraries. , 2001, Journal of combinatorial chemistry.
[391] S. Gibbons,et al. Ethnopharmacology in drug discovery: an analysis of its role and potential contribution , 2001, The Journal of pharmacy and pharmacology.
[392] N. Farnsworth,et al. The value of plants used in traditional medicine for drug discovery. , 2001, Environmental health perspectives.
[393] Tudor I. Oprea,et al. Chemography: the Art of Navigating in Chemical Space , 2000 .
[394] Jürgen Bajorath,et al. Distinguishing between Natural Products and Synthetic Molecules by Descriptor Shannon Entropy Analysis and Binary QSAR Calculations , 2000, J. Chem. Inf. Comput. Sci..
[395] A. Beresford,et al. ADME/PK as part of a rational approach to drug discovery. , 2000, Drug discovery today.
[396] J. Bonjoch,et al. Synthesis of Strychnine. , 2000, Chemical reviews.
[397] I. Khafagi,et al. The efficiency of random versus ethno-directed research in the evaluation of Sinai medicinal plants for bioactive compounds. , 2000, Journal of ethnopharmacology.
[398] K. K. Park,et al. Chlorophyllin suppression of lipopolysaccharide-induced nitric oxide production in RAW 264.7 cells. , 2000, Toxicology and applied pharmacology.
[399] G. Schwartsmann,et al. Anti-cancer drug discovery and development in Brazil: targeted plant collection as a rational strategy to acquire candidate anti-cancer compounds. , 2000, The oncologist.
[400] Juei-Tang Cheng,et al. Review: Drug Therapy in Chinese Traditional Medicine , 2000, Journal of clinical pharmacology.
[401] J. Hohmann,et al. Diterpenoids from Euphorbia peplus. , 2000, Planta medica.
[402] P. Das,et al. In vitro manipulation and propagation of medicinal plants. , 2000, Biotechnology advances.
[403] R. Verpoorte. Pharmacognosy in the New Millennium: Leadfinding and Biotechnology , 2000, The Journal of pharmacy and pharmacology.
[404] U. Jordis,et al. Development of a Pilot Scale Process for the Anti-Alzheimer Drug (−)-Galanthamine Using Large-Scale Phenolic Oxidative Coupling and Crystallisation-Induced Chiral Conversion , 1999 .
[405] I. Sattler,et al. Natural Products in High Throughput Screening: Automated High-Quality Sample Preparation , 1999, Journal of biomolecular screening.
[406] M. Zenk,et al. Biosynthesis of the amaryllidaceae alkaloid Galanthamine , 1998 .
[407] K. Nicolaou,et al. The Art and Science of Organic and Natural Products Synthesis , 1998 .
[408] G. Cragg. Paclitaxel (Taxol®): A success story with valuable lessons for natural product drug discovery and development , 1998, Medicinal research reviews.
[409] Jae Chol Lee,et al. Total Synthesis of Colchicine. α‐Methoxy‐Substituted Oxyallyl [4 + 3] Cycloaddition Approach. , 1998 .
[410] C. C. Wan,et al. Removal of polyphenolic compounds from aqueous plant extracts using polyamide minicolumns , 1998, Biochemistry and molecular biology international.
[411] You-Ping Zhu,et al. Chinese Materia Medica: Chemistry, Pharmacology and Applications , 1998 .
[412] R. Verpoorte. Exploration of nature's chemodiversity: the role of secondary metabolites as leads in drug development , 1998 .
[413] G. Reaven,et al. Masoprocol (nordihydroguaiaretic acid): a new antihyperglycemic agent isolated from the creosote bush (Larrea tridentata). , 1998, European journal of pharmacology.
[414] H. El‐Seedi,et al. Two New Isoflavones from Ceiba pentandra and Their Effect on Cyclooxygenase-Catalyzed Prostaglandin Biosynthesis , 1998 .
[415] S. Hosztafi. The discovery of alkaloids. , 1997, Die Pharmazie.
[416] J. Phillipson,et al. Plant polyphenols: biologically active compounds or non-selective binders to protein? , 1997, Phytochemistry.
[417] H. G. Vogel. Drug Discovery and Evaluation: Pharmacological Assays , 1997 .
[418] D. Knorr,et al. Strategies for the improvement of secondary metabolite production in plant cell cultures , 1995 .
[419] L. Caporale,et al. Chemical ecology: a view from the pharmaceutical industry. , 1995, Proceedings of the National Academy of Sciences of the United States of America.
[420] Li Ws,et al. Enzymic preparation of (3R‐cis)‐3‐(acetyloxy)‐4‐phenyl‐2‐azetidinone: a taxol side‐chain synthon , 1994, Biotechnology and applied biochemistry.
[421] C. Nessler. Metabolic engineering of plant secondary products , 1994, Transgenic Research.
[422] K. Nicolaou,et al. Total synthesis of taxol , 1994, Nature.
[423] R. Breslow. Biomimetic chemistry , 1994 .
[424] M. Grever,et al. The taxol supply crisis. New NCI policies for handling the large-scale production of novel natural product anticancer and anti-HIV agents. , 1993, Journal of natural products.
[425] D. Guénard,et al. Taxol and Taxotere: Discovery, Chemistry, and Structure‐Activity Relationships , 1993 .
[426] K. Gustafson,et al. A chemical screening strategy for the dereplication and prioritization of HIV-inhibitory aqueous natural products extracts. , 1993, Journal of natural products.
[427] D. Guénard,et al. Taxol and taxotere: discovery, chemistry, and structure-activity relationships , 1993 .
[428] N. Burres,et al. Isolation of 9-Dihydro-13-acetylbaccatin III from Taxus canadensis , 1992 .
[429] B. Trost,et al. The atom economy--a search for synthetic efficiency. , 1991, Science.
[430] J M Pezzuto,et al. Evaluation of natural products as inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase. , 1991, Journal of natural products.
[431] H. Kaga,et al. A facile procedure for synthesis of capsaicin , 1989 .
[432] A. Greene,et al. Highly efficient, practical approach to natural taxol , 1988 .
[433] Marianne Winder,et al. Medicine in China. A history of pharmaceutics , 1988, Medical History.
[434] A. Bingel,et al. Medicinal plants in therapy , 1987 .
[435] D. L. Klayman,et al. Qinghaosu (artemisinin): an antimalarial drug from China. , 1985, Science.
[436] R. Spjut. Limitations of a random screen: Search for new anticancer drugs in higher plants , 1985, Economic Botany.
[437] T. Matsuzaki,et al. Detection and chemical identification of natural bio-antimutagens. A case of the green tea factor. , 1985, Mutation research.
[438] N. Acton,et al. Isolation of artemisinin (qinghaosu) from Artemisia annua growing in the United States. , 1984, Journal of natural products.
[439] G. M. Sapers,et al. Varietal differences in distribution of quercetin and kaempferol in onion (Allium cepa L.) tissue , 1984 .
[440] S. Adekenov,et al. Arglabin — A new sesquiterpene lactone fromArtemisia glabella , 1982, Chemistry of Natural Compounds.
[441] P. Schiff,et al. Taxol stabilizes microtubules in mouse fibroblast cells. , 1980, Proceedings of the National Academy of Sciences of the United States of America.
[442] K. Joshi,et al. Quinones and other Constituents from Haplophragma adenophyllum , 1979 .
[443] W. Lewis,et al. Medical botany. Plants affecting man's health , 1979, Medical History.
[444] P. Schiff,et al. Promotion of microtubule assembly in vitro by taxol , 1979, Nature.
[445] P. Langcake,et al. The production of resveratrol by Vitis vinifera and other members of the Vitaceae as a response to infection or injury , 1976 .
[446] T. Vree,et al. Identification in hashish of tetrahydrocannabinol, cannabidiol and cannabinol analogues with a methyl side‐chain , 1972, The Journal of pharmacy and pharmacology.
[447] D. Liljegren. Glucosylation of solasodine by extracts from Solanum laciniatum , 1971 .
[448] A. McPhail,et al. Plant antitumor agents. VI. The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia. , 1971, Journal of the American Chemical Society.
[449] S. Y. Yunusov,et al. Alkaloids ofGalanthus caucasicus , 1969, Chemistry of Natural Compounds.
[450] E. Leete,et al. The Biogenesis of the Alkaloids of Colchicum. I. The Incorporation of Phenylalanine into Colchicine1 , 1960 .
[451] T. S. Lee,et al. The pharmacological actions of capsaicin and analogues. , 1955, British Journal of Pharmacology and Chemotherapy.
[452] W. D. Ollis,et al. The total synthesis of strychnine. , 1954, Experientia.
[453] Andrei Hent,et al. Green Chemistry Metrics: A Guide to Determining and Evaluating Process Greenness , 2015 .
[454] R. Yu,et al. Optimal inductive and cultural conditions of Polygonum multiflorum transgenic hairy roots mediated with Agrobacterium rhizogenes R1601 and an analysis of their anthraquinone constituents , 2014, Pharmacognosy magazine.
[455] M. Mirjalili,et al. Production and Genetic Engineering of Terpenoids Production in Plant Cell and Organ Cultures , 2013 .
[456] J. Gras. Ingenol mebutate: a new option for actinic keratosis treatment. , 2013, Drugs of today.
[457] W. Jones,et al. Extraction of plant secondary metabolites. , 2012, Methods in molecular biology.
[458] Jane A. Craycroft,et al. Developing a library of authenticated Traditional Chinese Medicinal (TCM) plants for systematic biological evaluation--rationale, methods and preliminary results from a Sino-American collaboration. , 2011, Fitoterapia.
[459] M. Rahimi,et al. APPLICATION OF BIOTECHNOLOGY IN PRODUCTION OF MEDICINAL PLANTS , 2011 .
[460] Meriel G. Jones,et al. Drugs from daffodils , 2011 .
[461] M. Mirjalili,et al. Production of the anticancer drug taxol in Taxus baccata suspension cultures: A review , 2011 .
[462] G. Appendino. 3 . 08 Natural Products Drug Discovery , 2010 .
[463] M. Heinrich. 3.12 Ethnopharmacology and Drug Discovery , 2010 .
[464] G. Appendino,et al. Natural Products Drug Discovery , 2010 .
[465] A. Mathur,et al. Emerging trends in medicinal plant biotechnology. , 2010 .
[466] C. Wawrosch,et al. In vitro propagation of medicinal plants for conservation and quality assurance. , 2010 .
[467] L. Cseke,et al. The use of plant cell biotechnology for the production of phytochemicals , 2009 .
[468] J. Brinckmann,et al. COMMITTEE ON HERBAL MEDICINAL PRODUCTS (HMPC) , 2008 .
[469] Thierry Langer,et al. Virtual screening for the discovery of bioactive natural products , 2008, Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques.
[470] J. Bohlmann,et al. Terpenoid biomaterials. , 2008, The Plant journal : for cell and molecular biology.
[471] G. Cordell,et al. Studies on the antifertility components from Marsdenia koi , 2008, Journal of Tongji Medical University.
[472] R. Breinbauer. The Way of Synthesis: Evolution of Design and Methods for Natural Products , 2008 .
[473] J. Lehár,et al. Multi-target therapeutics: when the whole is greater than the sum of the parts. , 2007, Drug discovery today.
[474] A. Namdeo. Plant cell elicitation for production of secondary metabolites: A review , 2007 .
[475] A. Vaidya. Reverse pharmacological correlates of ayurvedic drug actions , 2006 .
[476] R. Pulak,et al. Techniques for analysis, sorting, and dispensing of C. elegans on the COPAS flow-sorting system. , 2006, Methods in molecular biology.
[477] D. Guo,et al. A nobel cyanogenic glycoside from Semiaquilegia adoxoides. , 2005, Journal of Asian natural products research.
[478] J. AfolayanA.,et al. In vitro propagation : A biotechnological tool capable of solving the problem of medicinal plants decimation in South Africa , 2005 .
[479] T. Foderaro,et al. Research and Development of a Second-Generation Process for Oseltamivir Phosphate, Prodrug for a Neuraminidase Inhibitor , 2004 .
[480] Miklos Feher,et al. Property Distributions: Differences between Drugs, Natural Products, and Molecules from Combinatorial Chemistry , 2003, J. Chem. Inf. Comput. Sci..
[481] A. Sands,et al. Knockouts model the 100 best-selling drugs—will they model the next 100? , 2003, Nature Reviews Drug Discovery.
[482] G. Haberlandt. Culturversuche mit isolierten Pflanzenzellen , 2003 .
[483] W. Lewis,et al. Medical botany : plants affecting human health , 2003 .
[484] M. Harkey,et al. Effects of intrinsic fluorescence and quenching on fluorescence-based screening of natural products. , 2002, Phytomedicine : international journal of phytotherapy and phytopharmacology.
[485] John K Borchardt,et al. The Beginnings of Drug Therapy: Ancient Mesopotamian Medicine. , 2002, Drug news & perspectives.
[486] Peter Gwynne,et al. Drug Discovery: 5 , 2002 .
[487] Alan D. Curzons,et al. So you think your process is green, how do you know?—Using principles of sustainability to determine what is green–a corporate perspective , 2001 .
[488] R. Verpoorte,et al. Metabolic Engineering of Plant Secondary Metabolism , 2000, Springer Netherlands.
[489] Palmisano,et al. An expeditious procedure for the isolation of ingenol from the seeds of euphorbia lathyris , 1999, Journal of natural products.
[490] H. El‐Seedi,et al. Two new isoflavones from Ceiba pentandra and their effect on cyclooxygenase-catalyzed prostaglandin biosynthesis. , 1998, Journal of natural products.
[491] P. Doran,et al. Effect of inoculum size on growth of Atropa belladonna hairy roots in shake flasks , 1997 .
[492] T. Huynh-Dinh,et al. The logic of chemical synthesis , 1996 .
[493] R. Bauer. [Chinese drugs as a source of new drug materials in western medicine]. , 1994, Pharmazie in unserer Zeit.
[494] R. Bauer. Chinesische Arzneidrogen als Quelle neuer Arzneistoffe für die westliche Medizin , 1994 .
[495] K. Yoshimatsu,et al. Further Approaches in the Production of Secondary Metabolites by Plant Tissue Cultures , 1992 .
[496] P. Dewick,et al. Biosynthesis of Podophyllum lignans—II. Interconversions of aryltetralin lignans in Podophyllum hexandrum , 1984 .
[497] G Zbinden,et al. Toxicological screening. , 1984, Regulatory toxicology and pharmacology : RTP.
[498] P. Heinstein,et al. Formation of Gossypol by Gossypium hirsutum L. Cell Suspension Cultures , 1981 .
[499] R. Breslow. Centenary Lecture. Biomimetic chemistry , 1972 .
[500] P. Anastas,et al. Green Chemistry , 2018, Environmental Science.
[501] T. Petrzilka,et al. Synthese von Haschisch-Inhaltsstoffen. 4. Mitteilung , 1969 .
[502] D. Barton,et al. 153. Phenol oxidation and biosynthesis. Part V. The synthesis of galanthamine , 1962 .
[503] T. A. H.,et al. Chinese Materia Medica , 1939, Nature.
[504] Robert Robinson,et al. LXIII.—A synthesis of tropinone , 1917 .
[505] T. H.. Geschichte der Pharmazie , 1905, Nature.
[506] A. G. Perkin,et al. LXXIX.—The colouring matters contained in dyer's broom (Genista tinctoria) and heather (Calluna vulgaris) , 1899 .
[507] Sertuerner. Ueber das Morphium, eine neue salzfähige Grundlage, und die Mekonsäure, als Hauptbestandtheile des Opiums , 1817 .