Discovery and resupply of pharmacologically active plant-derived natural products: A review

[1]  Albert S. Matlack,et al.  Introduction to Green Chemistry , 2022 .

[2]  Jisook Park,et al.  Total Synthesis of Strychnine. , 2017, Chemistry.

[3]  T. Hudlický,et al.  The quest for a practical synthesis of morphine alkaloids and their derivatives by chemoenzymatic methods. , 2015, Accounts of chemical research.

[4]  D. Dias,et al.  The pharmaceutical industry and natural products: historical status and new trends , 2015, Phytochemistry Reviews.

[5]  Aurélien Thomas,et al.  Current approaches and challenges for the metabolite profiling of complex natural extracts. , 2015, Journal of chromatography. A.

[6]  Pablo Carbonell,et al.  Computer-aided design for metabolic engineering. , 2014, Journal of biotechnology.

[7]  R. Bauer,et al.  Plant extracts in cell-based anti-inflammatory assays—Pitfalls and considerations related to removal of activity masking bulk components , 2014 .

[8]  M. Heinrich,et al.  Alkaloids as drug leads – A predictive structural and biodiversity-based analysis , 2014 .

[9]  R. Bauer,et al.  The therapeutic value of natural products derived from Chinese medicine—A systems based perspective , 2014 .

[10]  R. Saller,et al.  Alteration of anti‐inflammatory activity of Harpagophytum procumbens (devil's claw) extract after external metabolic activation with S9 mix , 2014, The Journal of pharmacy and pharmacology.

[11]  D. Llères,et al.  Monitoring Keap1–Nrf2 interactions in single live cells , 2014, Biotechnology advances.

[12]  M. Cooper,et al.  Natural product and natural product derived drugs in clinical trials. , 2014, Natural product reports.

[13]  E. Kim,et al.  Microbial biosynthesis of medicinally important plant secondary metabolites. , 2014, Natural product reports.

[14]  Chuang‐Chuang Li,et al.  Collective synthesis of humulanolides using a metathesis cascade reaction. , 2014, Journal of the American Chemical Society.

[15]  S. Gairola,et al.  A cross-cultural analysis of Jammu, Kashmir and Ladakh (India) medicinal plant use. , 2014, Journal of ethnopharmacology.

[16]  Melissa M. Harrison,et al.  A CRISPR view of development , 2014, Genes & development.

[17]  A. Fallarero,et al.  How to Translate a Bioassay Into a Screening Assay for Natural Products: General Considerations and Implementation of Antimicrobial Screens , 2014, Planta Medica.

[18]  H. Stuppner,et al.  Lignan formation in hairy root cultures of Edelweiss (Leontopodium nivale ssp. alpinum (Cass.) Greuter) , 2014, Fitoterapia.

[19]  L. Yu,et al.  Utility of hesperidinase for food function research: enzymatic digestion of botanical extracts alters cellular antioxidant capacities and anti-inflammatory properties. , 2014, Journal of agricultural and food chemistry.

[20]  Jiyong Hong Natural product synthesis at the interface of chemistry and biology. , 2014, Chemistry.

[21]  J. Keasling,et al.  Recent applications of synthetic biology tools for yeast metabolic engineering. , 2014, FEMS yeast research.

[22]  M. Diederich,et al.  Plumbagin Modulates Leukemia Cell Redox Status , 2014, Molecules.

[23]  Robert Verpoorte,et al.  Metabolomics: what you see is what you extract. , 2014, Phytochemical analysis : PCA.

[24]  J. Espín,et al.  Ellagic acid metabolism by human gut microbiota: consistent observation of three urolithin phenotypes in intervention trials, independent of food source, age, and health status. , 2014, Journal of agricultural and food chemistry.

[25]  Martin D. Eastgate,et al.  Natural Product Synthesis in the Age of Scalability , 2014 .

[26]  B. Pfeifer,et al.  Heterologous production of plant-derived isoprenoid products in microbes and the application of metabolic engineering and synthetic biology. , 2014, Current opinion in plant biology.

[27]  I. Zündorf,et al.  Plant-Derived Anti-Inflammatory Compounds: Hopes and Disappointments regarding the Translation of Preclinical Knowledge into Clinical Progress , 2014, Mediators of inflammation.

[28]  Helen O. Masson,et al.  Hairy Root Transformation Using Agrobacterium rhizogenes as a Tool for Exploring Cell Type-Specific Gene Expression and Function Using Tomato as a Model1[W][OPEN] , 2014, Plant Physiology.

[29]  J. Reed,et al.  Ultra-High-Throughput Screening of Natural Product Extracts to Identify Proapoptotic Inhibitors of Bcl-2 Family Proteins , 2014, Journal of biomolecular screening.

[30]  G. Loake,et al.  Paclitaxel: biosynthesis, production and future prospects. , 2014, New biotechnology.

[31]  S. Gibbons,et al.  Flavonoid glycosides from the stem bark of Margaritaria discoidea demonstrate antibacterial and free radical scavenging activities , 2014, Phytotherapy research : PTR.

[32]  C. Harrison Patenting natural products just got harder , 2014, Nature Biotechnology.

[33]  G. Silverman,et al.  C. elegans in high-throughput drug discovery. , 2014, Advanced drug delivery reviews.

[34]  C. Zheng,et al.  Monoterpenoids from the whole herb of Veronicastrum axillare , 2014, Pharmaceutical biology.

[35]  P. Baran,et al.  Development of a concise synthesis of (+)-ingenol. , 2014, Journal of the American Chemical Society.

[36]  H. Bouwmeester,et al.  The seco-iridoid pathway from Catharanthus roseus , 2014, Nature Communications.

[37]  S. A. Wilson,et al.  Metabolic engineering approaches for production of biochemicals in food and medicinal plants. , 2014, Current opinion in biotechnology.

[38]  J. Keasling,et al.  Semi-synthetic artemisinin: a model for the use of synthetic biology in pharmaceutical development , 2014, Nature Reviews Microbiology.

[39]  M. Zehl,et al.  Activity-guided isolation of NF-κB inhibitors and PPARγ agonists from the root bark of Lycium chinense Miller. , 2014, Journal of ethnopharmacology.

[40]  G. Burton,et al.  Emerging R and D law: the Nagoya Protocol and its implications for researchers. , 2014, ACS chemical biology.

[41]  S. Noha,et al.  Identification of plumericin as a potent new inhibitor of the NF-κB pathway with anti-inflammatory activity in vitro and in vivo , 2014, British journal of pharmacology.

[42]  H. N. Murthy,et al.  Production of secondary metabolites from cell and organ cultures: strategies and approaches for biomass improvement and metabolite accumulation , 2014, Plant Cell, Tissue and Organ Culture (PCTOC).

[43]  H. N. Murthy,et al.  Production of secondary metabolites from cell and organ cultures: strategies and approaches for biomass improvement and metabolite accumulation , 2014, Plant Cell, Tissue and Organ Culture (PCTOC).

[44]  Franklin Riet-Correa,et al.  Detection of toxic monofluoroacetate in Palicourea species. , 2014, Toxicon : official journal of the International Society on Toxinology.

[45]  Martin D. Eastgate,et al.  Natural product synthesis in the age of scalability. , 2014, Natural product reports.

[46]  P. Hu,et al.  Transformation of ginsenosides from notoginseng by artificial gastric juice can increase cytotoxicity toward cancer cells. , 2014, Journal of agricultural and food chemistry.

[47]  K C Nicolaou,et al.  Organic synthesis: the art and science of replicating the molecules of living nature and creating others like them in the laboratory , 2014, Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences.

[48]  D. Schuster,et al.  Polypharmacology and Adverse Bioactivity Profiles Predict Potential Toxicity and Drug‐Related Adrs , 2014 .

[49]  P. Magnus,et al.  Total synthesis of 8,14-dihydromorphinandienone alkaloids. , 2014, Organic letters.

[50]  O. Kayser,et al.  Natural products – learning chemistry from plants , 2014, Biotechnology journal.

[51]  D. Sherman,et al.  The role of HTS in drug discovery at the University of Michigan. , 2014, Combinatorial chemistry & high throughput screening.

[52]  V. Kadirkamanathan,et al.  A Zebrafish Compound Screen Reveals Modulation of Neutrophil Reverse Migration as an Anti-Inflammatory Mechanism , 2014, Science Translational Medicine.

[53]  D. Ramasamy,et al.  Vitiquinolone--a quinolone alkaloid from Hibiscus vitifolius Linn. , 2014, Food chemistry.

[54]  H. Bouwmeester,et al.  Comparison of plant-based expression platforms for the heterologous production of geraniol , 2014, Plant Cell, Tissue and Organ Culture (PCTOC).

[55]  R. Linhardt,et al.  Biochemical strategies for enhancing the in vivo production of natural products with pharmaceutical potential. , 2014, Current opinion in biotechnology.

[56]  P. D’souza,et al.  Use of in vitro bioassays for assessing botanicals. , 2014, Current opinion in biotechnology.

[57]  Jian Chen,et al.  Novel fermentation processes for manufacturing plant natural products. , 2014, Current opinion in biotechnology.

[58]  Fei Wang,et al.  Investigation of Antioxidant Interactions between Radix Astragali and Cimicifuga foetida and Identification of Synergistic Antioxidant Compounds , 2014, PloS one.

[59]  A. Atanasov,et al.  Identification of Chromomoric Acid C-I as an Nrf2 Activator in Chromolaena odorata , 2014, Journal of natural products.

[60]  D. Tyrrell,et al.  Chimeric rodents with humanized liver: bridging the preclinical/clinical trial gap in ADME/toxicity studies , 2014, Xenobiotica; the fate of foreign compounds in biological systems.

[61]  P. Baran,et al.  14-Step Synthesis of (+)-Ingenol from (+)-3-Carene. , 2014 .

[62]  G. Appendino Omnia praeclara rara. The quest for ingenol heats up. , 2014, Angewandte Chemie.

[63]  G. Massolini,et al.  Isolation and characterization of bioactive compounds from plant resources: the role of analysis in the ethnopharmacological approach. , 2014, Journal of pharmaceutical and biomedical analysis.

[64]  S. Gibbons,et al.  The application of GC–MS combined with chemometrics for the identification of antimicrobial compounds from selected commercial essential oils , 2014 .

[65]  C. Geethu,et al.  Metabolic Profiling of Zingiber zerumbet Following Pythium myriotylum Infection: Investigations on the Defensive Role of the Principal Secondary Metabolite, Zerumbone , 2014, Applied Biochemistry and Biotechnology.

[66]  R. Pandey,et al.  Establishment of hairy root culture and production of secondary metabolites in Coleus (Coleus forskohlii) , 2014 .

[67]  O. Werz,et al.  Indirubin-3′-monoxime exerts a dual mode of inhibition towards leukotriene-mediated vascular smooth muscle cell migration , 2013, Cardiovascular research.

[68]  J. Rollinger,et al.  Computer-Guided Approach to Access the Anti-influenza Activity of Licorice Constituents , 2013, Journal of natural products.

[69]  Judith M. Rollinger,et al.  Virtual Screening and Target Fishing for Natural Products Using 3D Pharmacophores , 2013 .

[70]  E. Lander,et al.  Genetic Screens in Human Cells Using the CRISPR-Cas9 System , 2013, Science.

[71]  Zhengxiang Wang,et al.  Metabolic engineering of Escherichia coli: a sustainable industrial platform for bio-based chemical production. , 2013, Biotechnology advances.

[72]  Jyoti Sahu,et al.  A Review on Low Cost Methods for In Vitro Micropropagation of Plant Through Tissue Culture Technique , 2013 .

[73]  L. Arola,et al.  Serum metabolites of proanthocyanidin-administered rats decrease lipid synthesis in HepG2 cells. , 2013, The Journal of nutritional biochemistry.

[74]  B. Graz What is "clinical data"? Why and how can they be collected during field surveys on medicinal plants? , 2013, Journal of Ethnopharmacology.

[75]  G. Schneider,et al.  Aminothiazole-featured pirinixic acid derivatives as dual 5-lipoxygenase and microsomal prostaglandin E2 synthase-1 inhibitors with improved potency and efficiency in vivo. , 2013, Journal of medicinal chemistry.

[76]  Steven V Ley,et al.  Flow chemistry syntheses of natural products. , 2013, Chemical Society reviews.

[77]  Wei Zheng,et al.  Phenotypic screens as a renewed approach for drug discovery. , 2013, Drug discovery today.

[78]  Binbin Chen,et al.  Microbial engineering strategies to improve cell viability for biochemical production. , 2013, Biotechnology advances.

[79]  S. Noha,et al.  Honokiol: A non-adipogenic PPARγ agonist from nature☆ , 2013, Biochimica et biophysica acta.

[80]  R. Edrada-Ebel,et al.  Metabolomics and dereplication strategies in natural products. , 2013, Methods in molecular biology.

[81]  S. Alqahtani,et al.  Experimental models for predicting drug absorption and metabolism , 2013, Expert opinion on drug metabolism & toxicology.

[82]  Curtis J Henrich,et al.  Matching the power of high throughput screening to the chemical diversity of natural products. , 2013, Natural product reports.

[83]  D. Fuchs,et al.  Interaction of Carthamus tinctorius lignan arctigenin with the binding site of tryptophan-degrading enzyme indoleamine 2,3-dioxygenase☆ , 2013, FEBS open bio.

[84]  Lei Zhang,et al.  Ex vivo and in situ approaches used to study intestinal absorption. , 2013, Journal of pharmacological and toxicological methods.

[85]  Peng Gao,et al.  A novel strategy to evaluate the quality of traditional Chinese medicine based on the correlation analysis of chemical fingerprint and biological effect. , 2013, Journal of pharmaceutical and biomedical analysis.

[86]  Robert J Linhardt,et al.  Metabolic engineering and in vitro biosynthesis of phytochemicals and non-natural analogues. , 2013, Plant science : an international journal of experimental plant biology.

[87]  M. Diederich,et al.  Styryl-lactone goniothalamin inhibits TNF-α-induced NF-κB activation. , 2013, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[88]  P. Christou,et al.  Metabolic engineering of plant secondary products: which way forward? , 2013, Current pharmaceutical design.

[89]  P. Baran,et al.  14-Step Synthesis of (+)-Ingenol from (+)-3-Carene , 2013, Science.

[90]  M. Farhi,et al.  Metabolic engineering of plants for artemisinin synthesis , 2013, Biotechnology & genetic engineering reviews.

[91]  M. Pellegatti Dogs and monkeys in preclinical drug development: the challenge of reducing and replacing , 2013, Expert opinion on drug metabolism & toxicology.

[92]  Shu Liu,et al.  Coumestrol from the national cancer Institute’s natural product library is a novel inhibitor of protein kinase CK2 , 2013, BMC Pharmacology and Toxicology.

[93]  Rolf Müller,et al.  Recent advances in the heterologous expression of microbial natural product biosynthetic pathways. , 2013, Natural product reports.

[94]  Deok-Chun Yang,et al.  Computer-aided identification of EGFR tyrosine kinase inhibitors using ginsenosides from Panax ginseng , 2013, Comput. Biol. Medicine.

[95]  A. Marston,et al.  Antimicrobial activity of southern African medicinal plants with dermatological relevance , 2014 .

[96]  David J Newman,et al.  Natural products: a continuing source of novel drug leads. , 2013, Biochimica et biophysica acta.

[97]  P. Duez,et al.  Metabolomic-Based Study of the Leafy Gall, the Ecological Niche of the Phytopathogen Rhodococcus Fascians, as a Potential Source of Bioactive Compounds , 2013, International journal of molecular sciences.

[98]  A. Ward,et al.  Zebrafish as a genetic model in pre-clinical drug testing and screening. , 2013, Current medicinal chemistry.

[99]  P. Zhu,et al.  Artemisinic acid: A promising molecule potentially suitable for the semi-synthesis of artemisinin , 2013 .

[100]  R. Brun,et al.  Antiprotozoal activity of Khaya anthotheca, (Welv.) C.D.C. a plant used by chimpanzees for self-medication. , 2013, Journal of ethnopharmacology.

[101]  Jianbo Xiao,et al.  Metabolism of dietary flavonoids in liver microsomes. , 2013, Current drug metabolism.

[102]  A. Bogdanove,et al.  TALEN-mediated editing of the Mouse Y Chromosome , 2013, Nature Biotechnology.

[103]  L. Kang,et al.  Two novel furostanol saponins from the tubers of Ophiopogon japonicus , 2013, Journal of Asian natural products research.

[104]  R. Bauer,et al.  Polyacetylenes from Notopterygium incisum–New Selective Partial Agonists of Peroxisome Proliferator-Activated Receptor-Gamma , 2013, PloS one.

[105]  E. Nevo,et al.  Antitumor activities of extracts from selected desert plants against HepG2 human hepatocellular carcinoma cells , 2013, Pharmaceutical biology.

[106]  P. Liu,et al.  Biotransformation and metabolic profile of American ginseng saponins with human intestinal microflora by liquid chromatography quadrupole time-of-flight mass spectrometry. , 2013, Journal of chromatography. A.

[107]  J. Keasling,et al.  High-level semi-synthetic production of the potent antimalarial artemisinin , 2013, Nature.

[108]  P. Clemons,et al.  Target identification and mechanism of action in chemical biology and drug discovery. , 2013, Nature chemical biology.

[109]  S. O’Connor,et al.  Recent progress in the metabolic engineering of alkaloids in plant systems. , 2013, Current opinion in biotechnology.

[110]  P. Forster,et al.  Multiple metal accumulation within a manganese-specific genus. , 2013, American journal of botany.

[111]  F. Bucar,et al.  Natural product isolation--how to get from biological material to pure compounds. , 2013, Natural product reports.

[112]  W. Folk,et al.  21st century natural product research and drug development and traditional medicines. , 2013, Natural product reports.

[113]  Herbert Waldmann,et al.  Target identification for small bioactive molecules: finding the needle in the haystack. , 2013, Angewandte Chemie.

[114]  Serge Rudaz,et al.  Plant metabolomics: from holistic data to relevant biomarkers. , 2013, Current medicinal chemistry.

[115]  M. Zehl,et al.  The Herbal Drug Melampyrum pratense L. (Koch): Isolation and Identification of Its Bioactive Compounds Targeting Mediators of Inflammation , 2013, Evidence-based complementary and alternative medicine : eCAM.

[116]  Stephen Gabriel,et al.  Metal impurities cause false positives in high-throughput screening campaigns. , 2013, ACS medicinal chemistry letters.

[117]  K. Tasheva,et al.  Role of Biotechnology for Protection of Endangered Medicinal Plants , 2013 .

[118]  B. M. Lange,et al.  Metabolic engineering of plant monoterpenes, sesquiterpenes and diterpenes--current status and future opportunities. , 2013, Plant biotechnology journal.

[119]  B. Ncube,et al.  Anti-Oxidative and Cholinesterase Inhibitory Effects of Leaf Extracts and Their Isolated Compounds from Two Closely Related Croton Species , 2013, Molecules.

[120]  A. Napolitano,et al.  Oleanane glycosides from Astragalus tauricolus: isolation and structural elucidation based on a preliminary liquid chromatography-electrospray ionization tandem mass spectrometry profiling. , 2013, Phytochemistry.

[121]  M. Bogyo,et al.  Target deconvolution techniques in modern phenotypic profiling. , 2013, Current opinion in chemical biology.

[122]  Xiaoguang Lei,et al.  Collective Synthesis of Lycopodium Alkaloids and Tautomer Locking Strategy for the Total Synthesis of (−)-lycojapodine A , 2022 .

[123]  T. Verbiest,et al.  Polyphenols can inhibit furin in vitro as a result of the reactivity of their auto-oxidation products to proteins. , 2013, Current medicinal chemistry.

[124]  N. Scheer,et al.  Xenobiotic receptor humanized mice and their utility , 2013, Drug metabolism reviews.

[125]  M. Bott,et al.  Metabolic engineering of microorganisms for the synthesis of plant natural products. , 2013, Journal of biotechnology.

[126]  Dario R Alessi,et al.  Kinase drug discovery--what's next in the field? , 2013, ACS chemical biology.

[127]  J. Keasling,et al.  Synthesis: A constructive debate , 2012, Nature.

[128]  Chuang Lu,et al.  Preclinical experimental models of drug metabolism and disposition in drug discovery and development , 2012 .

[129]  M. Sandasi,et al.  An untargeted metabolomic approach in the chemotaxonomic assessment of two Salvia species as a potential source of α-bisabolol. , 2012, Phytochemistry.

[130]  J. Rosenthal,et al.  The impact of the United Nations Convention on Biological Diversity on natural products research. , 2012, Natural product reports.

[131]  T. Högberg,et al.  Semisynthesis of Ingenol 3-Angelate (PEP005): Efficient Stereoconservative Angeloylation of Alcohols , 2012, Synlett.

[132]  Jan Maes,et al.  Evaluation of 14 Organic Solvents and Carriers for Screening Applications in Zebrafish Embryos and Larvae , 2012, PloS one.

[133]  X. Qiao,et al.  Analytical strategy to reveal the in vivo process of multi-component herbal medicine: a pharmacokinetic study of licorice using liquid chromatography coupled with triple quadrupole mass spectrometry. , 2012, Journal of chromatography. A.

[134]  S. Franzblau,et al.  Unbiased evaluation of bioactive secondary metabolites in complex matrices. , 2012, Fitoterapia.

[135]  Milen I Georgiev,et al.  Genetically transformed roots: from plant disease to biotechnological resource. , 2012, Trends in biotechnology.

[136]  Adrià Cereto-Massagué,et al.  Identification of Novel Human Dipeptidyl Peptidase-IV Inhibitors of Natural Origin (Part I): Virtual Screening and Activity Assays , 2012, PloS one.

[137]  C. Saslis-Lagoudakis,et al.  Phylogenies reveal predictive power of traditional medicine in bioprospecting , 2012, Proceedings of the National Academy of Sciences.

[138]  Ming-cang Chen,et al.  Systematic screening and characterization of the major bioactive components of Poria cocos and their metabolites in rats by LC-ESI-MS(n). , 2012, Biomedical chromatography : BMC.

[139]  M. Hamburger,et al.  Epilepsy in the Renaissance: a survey of remedies from 16th and 17th century German herbals. , 2012, Journal of ethnopharmacology.

[140]  Steven V Ley,et al.  On being green: can flow chemistry help? , 2012, Chemical record.

[141]  D. Barron,et al.  Elucidation of (-)-epicatechin metabolites after ingestion of chocolate by healthy humans. , 2012, Free radical biology & medicine.

[142]  Chunyin Zhu,et al.  A concise synthesis of (+)-artemisinin. , 2012, Journal of the American Chemical Society.

[143]  Jianxin Chen,et al.  The Active Ingredients of Jiang-Zhi-Ning: Study of the Nelumbo nucifera Alkaloids and Their Main Bioactive Metabolites , 2012, Molecules.

[144]  P. B. Kavi Kishor,et al.  Carbohydrate and elicitor enhanced withanolide (withaferin A and withanolide A) accumulation in hairy root cultures of Withania somnifera (L.). , 2012, Indian journal of experimental biology.

[145]  V. De Luca,et al.  Mining the Biodiversity of Plants: A Revolution in the Making , 2012, Science.

[146]  P. Egan,et al.  Coproduction and Ecological Significance of Naphthoquinones in Carnivorous Sundews (Drosera) , 2012, Chemistry & biodiversity.

[147]  K. Booker‐Milburn Flow chemistry: a light touch to a deadly problem. , 2012, Nature chemistry.

[148]  E. Werner,et al.  Ascorbate stimulates endothelial nitric oxide synthase enzyme activity by rapid modulation of its phosphorylation status , 2012, Free radical biology & medicine.

[149]  Manabendra Dutta Choudhury,et al.  Challenges in developing medicinal plant databases for sharing ethnopharmacological knowledge. , 2012, Journal of ethnopharmacology.

[150]  L. Overman,et al.  Is there no end to the total syntheses of strychnine? Lessons learned in strategy and tactics in total synthesis. , 2012, Angewandte Chemie.

[151]  K. Helin,et al.  Identification of catechols as histone–lysine demethylase inhibitors , 2012, FEBS Letters.

[152]  Il Seok Oh,et al.  In vivo anti-oxidant and anti-inflammatory activities of cambial meristematic cells established from Ginkgo biloba L. , 2012 .

[153]  A. Nahrstedt,et al.  What Is the Best Strategy for Preclinical Testing of Botanicals? A Critical Perspective , 2012, Planta Medica.

[154]  A. Atanasov,et al.  Synergy Study of the Inhibitory Potential of Red Wine Polyphenols on Vascular Smooth Muscle Cell Proliferation , 2012, Planta Medica.

[155]  R. Bauer,et al.  Traditional Chinese medicine research in the post-genomic era: good practice, priorities, challenges and opportunities. , 2012, Journal of ethnopharmacology.

[156]  S. A. Wilson,et al.  Recent advances towards development and commercialization of plant cell culture processes for the synthesis of biomolecules. , 2012, Plant biotechnology journal.

[157]  D. Sall,et al.  Modern phenotypic drug discovery is a viable, neoclassic pharma strategy. , 2012, Journal of medicinal chemistry.

[158]  J. Scannell,et al.  Diagnosing the decline in pharmaceutical R&D efficiency , 2012, Nature Reviews Drug Discovery.

[159]  C. Smolke,et al.  Advancing secondary metabolite biosynthesis in yeast with synthetic biology tools. , 2012, FEMS yeast research.

[160]  F. Clubb,et al.  Swine as Models in Biomedical Research and Toxicology Testing , 2012, Veterinary pathology.

[161]  I. Gülçin Antioxidant activity of food constituents: an overview , 2012, Archives of Toxicology.

[162]  Peter H Seeberger,et al.  Continuous-flow synthesis of the anti-malaria drug artemisinin. , 2012, Angewandte Chemie.

[163]  David J Newman,et al.  Natural products as sources of new drugs over the 30 years from 1981 to 2010. , 2012, Journal of natural products.

[164]  Lufeng Hu,et al.  Molecular determinants of magnolol targeting both RXR(alpha) and PPAR(gamma). , 2012 .

[165]  Q. Wang,et al.  Target separation of a new anti-tumor saponin and metabolic profiling of leaves of Panax notoginseng by liquid chromatography with eletrospray ionization quadrupole time-of-flight mass spectrometry. , 2012, Journal of pharmaceutical and biomedical analysis.

[166]  Rohan A Davis,et al.  Drug-like properties: guiding principles for the design of natural product libraries. , 2012, Journal of natural products.

[167]  W. Barbosa,et al.  Selecting Medicinal Plants for Development of Phytomedicine and Use in Primary Health Care , 2012 .

[168]  D D Soejarto,et al.  Ethnobotanical approach versus random approach in the search for new bioactive compounds: Support of a hypothesis , 2012, Pharmaceutical biology.

[169]  G. Loake,et al.  Plant natural products: history, limitations and the potential of cambial meristematic cells , 2012, Biotechnology & genetic engineering reviews.

[170]  Lin Zhang,et al.  New triterpenoid saponins from Patrinia scabiosaefolia. , 2011, Carbohydrate research.

[171]  Kyria Boundy-Mills,et al.  Natural product libraries to accelerate the high-throughput discovery of therapeutic leads. , 2011, Journal of natural products.

[172]  B. Spitzer-Rimon,et al.  Generation of the potent anti-malarial drug artemisinin in tobacco , 2011, Nature Biotechnology.

[173]  Bochu Wang,et al.  The screening toolbox of bioactive substances from natural products: a review. , 2011, Fitoterapia.

[174]  Hualiang Jiang,et al.  Molecular Determinants of Magnolol Targeting Both RXRα and PPARγ , 2011, PloS one.

[175]  R. Breitling,et al.  Toward global metabolomics analysis with hydrophilic interaction liquid chromatography-mass spectrometry: improved metabolite identification by retention time prediction. , 2011, Analytical chemistry.

[176]  Daniela Schuster,et al.  Pharmacophore-based discovery of FXR-agonists. Part II: Identification of bioactive triterpenes from Ganoderma lucidum , 2011, Bioorganic & medicinal chemistry.

[177]  D. Bernhard,et al.  Leoligin, the major lignan from Edelweiss, activates cholesteryl ester transfer protein , 2011, Atherosclerosis.

[178]  Gokare A. Ravishankar,et al.  Influence of abiotic stress signals on secondary metabolites in plants , 2011, Plant signaling & behavior.

[179]  A. Fuerstner Metathesis in Total Synthesis , 2011 .

[180]  M. Lourenço,et al.  Ethnopharmacological versus random plant selection methods for the evaluation of the antimycobacterial activity , 2011 .

[181]  B. Aggarwal,et al.  Identification of novel anti-inflammatory agents from Ayurvedic medicine for prevention of chronic diseases: "reverse pharmacology" and "bedside to bench" approach. , 2011, Current drug targets.

[182]  Yuguo Du,et al.  Total Synthesis of Solamargine (I). , 2011 .

[183]  John P. Overington,et al.  ChEMBL: a large-scale bioactivity database for drug discovery , 2011, Nucleic Acids Res..

[184]  Xianli Wu,et al.  Phenolic acids are in vivo atheroprotective compounds appearing in the serum of rats after blueberry consumption. , 2011, Journal of agricultural and food chemistry.

[185]  M. Rask-Andersen,et al.  Trends in the exploitation of novel drug targets , 2011, Nature Reviews Drug Discovery.

[186]  An Xiao,et al.  Heritable gene targeting in zebrafish using customized TALENs , 2011, Nature Biotechnology.

[187]  Guodong Zhang,et al.  Isolation and synergism of in vitro anti-inflammatory and quinone reductase (QR) inducing agents from the fruits of Morinda citrifolia (noni) , 2011 .

[188]  Rainer Breitling,et al.  Separating the wheat from the chaff: a prioritisation pipeline for the analysis of metabolomics datasets , 2011, Metabolomics.

[189]  N. Oberlies,et al.  Synergy-directed fractionation of botanical medicines: a case study with goldenseal (Hydrastis canadensis). , 2011, Journal of natural products.

[190]  C. Saslis-Lagoudakis,et al.  The Use of Phylogeny to Interpret Cross-Cultural Patterns in Plant Use and Guide Medicinal Plant Discovery: An Example from Pterocarpus (Leguminosae) , 2011, PloS one.

[191]  Elo Leung,et al.  Targeted Genome Editing Across Species Using ZFNs and TALENs , 2011, Science.

[192]  D. MacMillan,et al.  Collective synthesis of natural products by means of organocascade catalysis , 2011, Nature.

[193]  I. Maclean,et al.  Recent ecological responses to climate change support predictions of high extinction risk , 2011, Proceedings of the National Academy of Sciences.

[194]  O. Yu,et al.  Metabolic engineering of flavonoids in plants and microorganisms , 2011, Applied Microbiology and Biotechnology.

[195]  D. Swinney,et al.  How were new medicines discovered? , 2011, Nature Reviews Drug Discovery.

[196]  Robert Verpoorte,et al.  Cultivation of medicinal and aromatic plants for specialty industrial materials , 2011 .

[197]  M. Oliva Sharing the benefits of biodiversity: a new international protocol and its implications for research and development. , 2011, Planta medica.

[198]  A. Kinghorn,et al.  The relevance of higher plants in lead compound discovery programs. , 2011, Journal of natural products.

[199]  Alois Fürstner,et al.  Metathesis in total synthesis. , 2011, Chemical communications.

[200]  D. Passarella,et al.  Synthesis of (+)-dumetorine and congeners by using flow chemistry technologies. , 2011, Chemistry.

[201]  H. Azaizeh,et al.  Synergistic Antibacterial Effects of Polyphenolic Compounds from Olive Mill Wastewater , 2011, Evidence-based complementary and alternative medicine : eCAM.

[202]  M. Heinrich,et al.  The Thai Medicinal Plant Gynura Pseudochina var. hispida: Chemical Composition and in vitro NF-κB Inhibitory Activity , 2011, Natural product communications.

[203]  M. Leonti The future is written: impact of scripts on the cognition, selection, knowledge and transmission of medicinal plant use and its implications for ethnobotany and ethnopharmacology. , 2011, Journal of ethnopharmacology.

[204]  M. Simmons,et al.  Scale‐Up of Chemical Reactions , 2011 .

[205]  David J. Ager,et al.  Route and Process Selection , 2011 .

[206]  Jun-ichi Yoshida,et al.  A flow-microreactor approach to protecting-group-free synthesis using organolithium compounds. , 2011, Nature communications.

[207]  D. Kingston Modern natural products drug discovery and its relevance to biodiversity conservation. , 2011, Journal of natural products.

[208]  Johannes Ottl,et al.  Non-stoichiometric inhibition in biochemical high-throughput screening , 2011, Expert opinion on drug discovery.

[209]  J. Gertsch,et al.  Botanical drugs, synergy, and network pharmacology: forth and back to intelligent mixtures. , 2011, Planta medica.

[210]  G. Sileshi,et al.  Applications of phytochemical and in vitro techniques for reducing over-harvesting of medicinal and pesticidal plants and generating income for the rural poor , 2011, Plant Cell Reports.

[211]  Shu-Dong Wei,et al.  Antioxidant condensed tannins from Machilus pauhoi leaves , 2011 .

[212]  S. Leelavathi,et al.  Advances in plant molecular farming. , 2011, Biotechnology advances.

[213]  L. Tian,et al.  The multiplicity of hairy root cultures: prolific possibilities. , 2011, Plant science : an international journal of experimental plant biology.

[214]  John P. Overington,et al.  Probing the links between in vitro potency, ADMET and physicochemical parameters , 2011, Nature Reviews Drug Discovery.

[215]  D. E. Clark,et al.  Outstanding challenges in protein–ligand docking and structure‐based virtual screening , 2011 .

[216]  J. Vederas,et al.  [Drug discovery and natural products: end of era or an endless frontier?]. , 2011, Biomeditsinskaia khimiia.

[217]  R. Ketting The many faces of RNAi. , 2011, Developmental cell.

[218]  G. Cordell,et al.  Sustainable Medicines and Global Health Care , 2011, Planta medica.

[219]  Gerhard G. Thallinger,et al.  Lipid Data Analyzer: unattended identification and quantitation of lipids in LC-MS data , 2011, Bioinform..

[220]  Y. Choi,et al.  Metabolomics for bioactivity assessment of natural products , 2011, Phytotherapy research : PTR.

[221]  Archana Sharma,et al.  Enhancement of Secondary Metabolites in Cultured Plant Cells Through Stress Stimulus , 2011 .

[222]  Elo Leung,et al.  A TALE nuclease architecture for efficient genome editing , 2011, Nature Biotechnology.

[223]  V. Pence Evaluating costs for the in vitro propagation and preservation of endangered plants , 2011, In Vitro Cellular & Developmental Biology - Plant.

[224]  Daniela Schuster,et al.  Predicting cyclooxygenase inhibition by three-dimensional pharmacophoric profiling. Part II: Identification of enzyme inhibitors from Prasaplai, a Thai traditional medicine , 2011, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[225]  A. Vollmar,et al.  In silico discovery of acylated flavonol monorhamnosides from Eriobotrya japonica as natural, small-molecular weight inhibitors of XIAP BIR3. , 2011, Bioorganic & medicinal chemistry.

[226]  S. Bryant,et al.  PubChem as a public resource for drug discovery. , 2010, Drug discovery today.

[227]  A. Atanasov,et al.  Indirubin-3′-Monoxime Blocks Vascular Smooth Muscle Cell Proliferation by Inhibition of Signal Transducer and Activator of Transcription 3 Signaling and Reduces Neointima Formation In Vivo , 2010, Arteriosclerosis, thrombosis, and vascular biology.

[228]  C. Sotriffer,et al.  Docking compared to 3D-pharmacophores: the scoring function challenge , 2010 .

[229]  Daniela Schuster,et al.  3D pharmacophores as tools for activity profiling. , 2010, Drug discovery today. Technologies.

[230]  A. Atanasov,et al.  Resveratrol blocks Akt activation in angiotensin II- or EGF-stimulated vascular smooth muscle cells in a redox-independent manner , 2010, Cardiovascular research.

[231]  Chun-Houh Chen,et al.  Comparative metabolomics approach coupled with cell- and gene-based assays for species classification and anti-inflammatory bioactivity validation of Echinacea plants. , 2010, The Journal of nutritional biochemistry.

[232]  J. W. van der Laan,et al.  Regulatory acceptability of the minipig in the development of pharmaceuticals, chemicals and other products. , 2010, Journal of pharmacological and toxicological methods.

[233]  Susan C. Roberts,et al.  Plant natural products from cultured multipotent cells , 2010, Nature Biotechnology.

[234]  G. Loake,et al.  Cultured cambial meristematic cells as a source of plant natural products , 2010, Nature Biotechnology.

[235]  J. Spurlino,et al.  Potency variation of small-molecule chymase inhibitors across species. , 2010, Biochemical pharmacology.

[236]  A. Davis,et al.  Using a phylogenetic approach to selection of target plants in drug discovery of acetylcholinesterase inhibiting alkaloids in Amaryllidaceae tribe Galantheae , 2010 .

[237]  Keith E. J. Tyo,et al.  Isoprenoid Pathway Optimization for Taxol Precursor Overproduction in Escherichia coli , 2010, Science.

[238]  J. Keasling,et al.  Cloning of casbene and neocembrene synthases from Euphorbiaceae plants and expression in Saccharomyces cerevisiae. , 2010, Phytochemistry.

[239]  A. Atanasov,et al.  Bioactivity-guided isolation of 1,2,3,4,6-Penta-O-galloyl-D-glucopyranose from Paeonia lactiflora roots as a PTP1B inhibitor. , 2010, Journal of natural products.

[240]  Matej Oresic,et al.  MZmine 2: Modular framework for processing, visualizing, and analyzing mass spectrometry-based molecular profile data , 2010, BMC Bioinformatics.

[241]  M. Heinrich Ethnopharmacology in the 21st Century – Grand Challenges , 2010, Front. Pharm..

[242]  A. Sakamoto,et al.  Pattern Recognition Analysis of Proton Nuclear Magnetic Resonance Spectra of Brain Tissue Extracts from Rats Anesthetized with Propofol or Isoflurane , 2010, PloS one.

[243]  Philip Gribbon,et al.  Exemplification of the challenges associated with utilising fluorescence intensity based assays in discovery , 2010, Expert opinion on drug discovery.

[244]  Paul Anastas,et al.  Green chemistry: principles and practice. , 2010, Chemical Society reviews.

[245]  K. Altmann,et al.  Identification of serotonin 5-HT1A receptor partial agonists in ginger. , 2010, Bioorganic & medicinal chemistry.

[246]  Daniela Schuster,et al.  Computer-Aided Discovery, Validation, and Mechanistic Characterization of Novel Neolignan Activators of Peroxisome Proliferator-Activated Receptor γ , 2010, Molecular Pharmacology.

[247]  Kip Guy,et al.  Automated high-throughput system to fractionate plant natural products for drug discovery. , 2010, Journal of natural products.

[248]  A. Kortenkamp,et al.  Metabolomic profiling of liquid Echinacea medicinal products with in vitro inhibitory effects on cytochrome P450 3A4 (CYP3A4). , 2010, Planta medica.

[249]  A. Vaidya,et al.  Natural products drug discovery: accelerating the clinical candidate development using reverse pharmacology approaches. , 2010, Indian journal of experimental biology.

[250]  K. Shilpa,et al.  An alternate method of natural drug production: eliciting secondary metabolite production using plant cell culture. , 2010 .

[251]  P. Proksch,et al.  Methods for isolation of marine-derived endophytic fungi and their bioactive secondary products , 2010, Nature Protocols.

[252]  N. Gilbert Biodiversity law could stymie research , 2010, Nature.

[253]  M. Ratner Pfizer stakes a claim in plant cell–made biopharmaceuticals , 2010, Nature Biotechnology.

[254]  Jianfeng Xu,et al.  Bench to batch: advances in plant cell culture for producing useful products , 2010, Applied Microbiology and Biotechnology.

[255]  Cecilia Alsmark,et al.  Natural products in modern life science , 2010, Phytochemistry Reviews.

[256]  Tomas Hudlicky,et al.  Short Chemoenzymatic Azide‐Free Synthesis of Oseltamivir (Tamiflu): Approaching the Potential for Process Efficiency , 2010 .

[257]  Liang-liang Zhang,et al.  Condensed Tannins from Mangrove Species Kandelia candel and Rhizophora mangle and Their Antioxidant Activity , 2010, Molecules.

[258]  Guillermo Gosset,et al.  Production of aromatic compounds in bacteria. , 2009, Current opinion in biotechnology.

[259]  John Calvin Reed,et al.  Versatile Assays for High Throughput Screening for Activators or Inhibitors of Intracellular Proteases and Their Cellular Regulators , 2009, PloS one.

[260]  Fatima Alkhalfioui,et al.  From purified GPCRs to drug discovery: the promise of protein-based methodologies. , 2009, Current opinion in pharmacology.

[261]  J. Beutler,et al.  Natural Products as a Foundation for Drug Discovery , 2009, Current protocols in pharmacology.

[262]  J. Forbey,et al.  Exploitation of secondary metabolites by animals: A response to homeostatic challenges. , 2009, Integrative and comparative biology.

[263]  M. Diederich,et al.  Effect of Curcumin on Nuclear Factor κB Signaling Pathways in Human Chronic Myelogenous K562 Leukemia Cells , 2009 .

[264]  T. Hudlický,et al.  Celebrating 20 Years of SYNLETT — Special Account on the Merits of Biocatalysis and the Impact of Arene cis‐Dihydrodiols on Enantioselective Synthesis , 2009 .

[265]  Thierry Kogej,et al.  ChemGPS-NPWeb: chemical space navigation online , 2009, J. Comput. Aided Mol. Des..

[266]  G. Appendino,et al.  Genepolide, a sesterpene gamma-lactone with a novel carbon skeleton from mountain wormwood (Artemisia umbelliformis). , 2009, Journal of natural products.

[267]  John Andraos,et al.  Global Green Chemistry Metrics Analysis Algorithm and Spreadsheets: Evaluation of the Material Efficiency Performances of Synthesis Plans for Oseltamivir Phosphate (Tamiflu) as a Test Case , 2009 .

[268]  H. Wagner,et al.  Synergy research: approaching a new generation of phytopharmaceuticals. , 2009, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[269]  R. Quatrano,et al.  Production of taxa-4(5),11(12)-diene by transgenic Physcomitrella patens , 2009, Transgenic Research.

[270]  Tomas Hudlicky,et al.  Celebrating 20 Years of SYNLETT - Special Account Onthe Merits of Biocatalysis and the Impact of Arene cis-Dihydrodiolson Enantioselective Synthesis , 2009 .

[271]  Thierry Langer,et al.  In silico Target Fishing for Rationalized Ligand Discovery Exemplified on Constituents of Ruta graveolens , 2008, Planta medica.

[272]  De-Xin Kong,et al.  Where is the hope for drug discovery? Let history tell the future. , 2009, Drug discovery today.

[273]  T. Shibamoto,et al.  Antioxidant assays for plant and food components. , 2009, Journal of agricultural and food chemistry.

[274]  Y. Uprety,et al.  Indigenous Use and Ethnopharmacology of Medicinal Plants in Far-West Nepal , 2009 .

[275]  B. Teicher,et al.  In Vivo/Ex Vivo and In Situ Assays Used in Cancer Research: A Brief Review , 2009, Toxicologic pathology.

[276]  M. Koffas,et al.  Metabolic engineering for plant natural product biosynthesis in microbes. , 2008, Current opinion in biotechnology.

[277]  R. Ramchandran,et al.  A Whole-Animal Microplate Assay for Metabolic Rate Using Zebrafish , 2008, Journal of biomolecular screening.

[278]  P. Proksch,et al.  Methods for isolation, purification and structural elucidation of bioactive secondary metabolites from marine invertebrates , 2008, Nature Protocols.

[279]  Corey Nislow,et al.  Yeast chemical genomics and drug discovery: an update. , 2008, Trends in pharmacological sciences.

[280]  Hanlee P. Ji,et al.  Next-generation DNA sequencing , 2008, Nature Biotechnology.

[281]  Nicholas H Oberlies,et al.  Colchicinoids from Colchicum crocifolium Boiss.: a case study in dereplication strategies for (-)-colchicine and related analogues using LC-MS and LC-PDA techniques. , 2008, Phytochemical analysis : PCA.

[282]  Alan Talevi,et al.  A Combined Virtual Screening 2D and 3D QSAR Methodology for the Selection of New Anticonvulsant Candidates from a Natural Product Library , 2008 .

[283]  Y. Choi,et al.  Metabolic profiling of the Mexican anxiolytic and sedative plant Galphimia glauca using nuclear magnetic resonance spectroscopy and multivariate data analysis. , 2008, Planta medica.

[284]  R. Gabel,et al.  Streamlined process for the esterification and ketalization of shikimic acid en route to the key precursor for oseltamivir phosphate (Tamiflu , 2008 .

[285]  I. Raskin,et al.  A natural history of botanical therapeutics. , 2008, Metabolism: clinical and experimental.

[286]  S. Bagal,et al.  Recent Advances in Biomimetic Natural Product Synthesis , 2008 .

[287]  M. Barrett,et al.  Metabolomic profiling using Orbitrap Fourier transform mass spectrometry with hydrophilic interaction chromatography: a method with wide applicability to analysis of biomolecules. , 2008, Rapid communications in mass spectrometry : RCM.

[288]  H. Otsuka,et al.  Chemical and biologically active constituents of Pteris multifida , 2008, Journal of Natural Medicines.

[289]  Zhijun Liu Preparation of botanical samples for biomedical research. , 2008, Endocrine, metabolic & immune disorders drug targets.

[290]  C. Antczak,et al.  Synthesis of antiproliferative Cephalotaxus esters and their evaluation against several human hematopoietic and solid tumor cell lines: uncovering differential susceptibilities to multidrug resistance. , 2008, Chemistry.

[291]  S. Jennewein,et al.  Metabolic engineering of taxadiene biosynthesis in yeast as a first step towards Taxol (Paclitaxel) production. , 2008, Metabolic engineering.

[292]  V. Savolainen,et al.  Phylogenetic selection of Narcissus species for drug discovery , 2008 .

[293]  H. Kaiser,et al.  Von der Pflanze zur Chemie – Die Frühgeschichte der „Rheumamittel“ , 2008, Zeitschrift für Rheumatologie.

[294]  N. White,et al.  Qinghaosu (Artemisinin): The Price of Success , 2008, Science.

[295]  Susan C. Roberts,et al.  Pharmaceutically active natural product synthesis and supply via plant cell culture technology. , 2008, Molecular pharmaceutics.

[296]  Paul G Bulger,et al.  Recent advances in biomimetic natural product synthesis. , 2008, Natural product reports.

[297]  Ming-Wei Wang,et al.  Botanical drugs: challenges and opportunities: contribution to Linnaeus Memorial Symposium 2007. , 2008, Life sciences.

[298]  J. Pezzuto,et al.  In Vitro Metabolism of Isoliquiritigenin by Human Liver Microsomes , 2008, Drug Metabolism and Disposition.

[299]  B. Pfeifer,et al.  Bacterial hosts for natural product production. , 2008, Molecular pharmaceutics.

[300]  C. G. Curtis,et al.  Ex Vivo Metrics™, a preclinical tool in new drug development , 2008, Journal of Translational Medicine.

[301]  Roger A. Sheldon,et al.  The E Factor: fifteen years on , 2007 .

[302]  Pankaj Oberoi,et al.  Identification of Inhibitors for MDM2 Ubiquitin Ligase Activity from Natural Product Extracts by a Novel High-Throughput Electrochemiluminescent Screen , 2008, Journal of biomolecular screening.

[303]  S. Gibbons,et al.  Polyisoprenylated benzoylphloroglucinol derivatives from Hypericum sampsonii. , 2007, Journal of natural products.

[304]  H. Chaturvedi,et al.  Cloning of medicinal plants through tissue culture--a review. , 2007, Indian journal of experimental biology.

[305]  M. Zenk,et al.  Evolution and current status of the phytochemistry of nitrogenous compounds. , 2007, Phytochemistry.

[306]  Craig M. Crews,et al.  Molecular Understanding and Modern Application of Traditional Medicines: Triumphs and Trials , 2007, Cell.

[307]  T. Hudlický,et al.  The Way of Synthesis: Evolution of Design and Methods for Natural Products , 2007 .

[308]  Shih-Hsiung Wu,et al.  Anti-platelet aggregation triterpene saponins from the galls of Sapindus mukorossi. , 2007, Chemical & pharmaceutical bulletin.

[309]  R. Bandichhor,et al.  Enantioselective synthesis of arglabin. , 2007, Angewandte Chemie.

[310]  P. Read MICROPROPAGATION: PAST, PRESENT AND FUTURE , 2007 .

[311]  A. K. Kukreja,et al.  Efficiency of liquid culture systems over conventional micropropagation: A progress towards commercialization , 2007 .

[312]  Paul T Anastas,et al.  Innovations and green chemistry. , 2007, Chemical reviews.

[313]  John Andraos,et al.  On the Use of "Green" Metrics in the Undergraduate Organic Chemistry Lecture and Lab to Assess the Mass Efficiency of Organic Reactions , 2007 .

[314]  Poul R. Kruse Geschichte der Pharmazie. Vol. II: Von der Frühen Neuzeit bis zur Gegenwart ‐ by Rudolf Schmitz , 2007 .

[315]  M. Furmanowa,et al.  Phytochemical and analytical studies of extracts from Rhodiola rosea and Rhodiola quadrifida. , 2007, Die Pharmazie.

[316]  C. Cho,et al.  The Protective Effect of Chlorophyll a Against Oxidative Stress and Inflammatory Processes in LPS-stimulated Macrophages , 2007 .

[317]  B. Trost,et al.  Synthesis of (-)-Delta9-trans-tetrahydrocannabinol: stereocontrol via Mo-catalyzed asymmetric allylic alkylation reaction. , 2007, Organic letters.

[318]  D. Newman,et al.  Natural products as sources of new drugs over the last 25 years. , 2007, Journal of natural products.

[319]  Milen I Georgiev,et al.  Hairy root type plant in vitro systems as sources of bioactive substances , 2007, Applied Microbiology and Biotechnology.

[320]  R. Linforth,et al.  Redirection of carotenoid metabolism for the efficient production of taxadiene [taxa-4(5),11(12)-diene] in transgenic tomato fruit , 2007, Transgenic Research.

[321]  Thierry Langer,et al.  Parallel Screening and Activity Profiling with HIV Protease Inhibitor Pharmacophore Models , 2007, J. Chem. Inf. Model..

[322]  D. Frense Taxanes: perspectives for biotechnological production , 2007, Applied Microbiology and Biotechnology.

[323]  A. Cunningham,et al.  A comparison of cultivation and wild collection of medicinal and aromatic plants under sustainability aspects , 2006 .

[324]  K. F. Wiersum,et al.  CULTIVATION OF MEDICINAL PLANTS AS A TOOL FOR BIODIVERSITY CONSERVATION AND POVERTY ALLEVIATION IN THE AMATOLA REGION, SOUTH AFRICA , 2006 .

[325]  P. Imming,et al.  Drugs, their targets and the nature and number of drug targets , 2006, Nature Reviews Drug Discovery.

[326]  M. Hardy,et al.  Natural products that reduce rotavirus infectivity identified by a cell-based moderate-throughput screening assay , 2006, Virology Journal.

[327]  Pascal Gantet,et al.  Harnessing the potential of hairy roots: dawn of a new era. , 2006, Trends in biotechnology.

[328]  Thierry Langer,et al.  Parallel Screening: A Novel Concept in Pharmacophore Modeling and Virtual Screening , 2006, J. Chem. Inf. Model..

[329]  J. Serkedjieva,et al.  Biologically Active Constituents of a Polyphenol Extract from Geranium sanguineum L. with Anti-Influenza Activity , 2006, Zeitschrift fur Naturforschung. C, Journal of biosciences.

[330]  Sorel Muresan,et al.  ChemGPS-NP: tuned for navigation in biologically relevant chemical space. , 2006, Journal of natural products.

[331]  L. Maes,et al.  Anti-infective potential of natural products: how to develop a stronger in vitro 'proof-of-concept'. , 2006, Journal of ethnopharmacology.

[332]  S. Ley,et al.  A flow process for the multi-step synthesis of the alkaloid natural product oxomaritidine: a new paradigm for molecular assembly. , 2006, Chemical communications.

[333]  Matthias Hamburger,et al.  Natural products in drug discovery –concepts and approaches for tracking bioactivity , 2006 .

[334]  Marcy J. Balunas,et al.  Interference by naturally occurring fatty acids in a noncellular enzyme-based aromatase bioassay. , 2006, Journal of natural products.

[335]  Michael Dean,et al.  A High-Throughput Cell-Based Assay for Inhibitors of ABCG2 Activity , 2006, Journal of biomolecular screening.

[336]  Steven V. Ley,et al.  Preparation of the neolignan natural product grossamide by a continuous-flow process , 2006 .

[337]  M. Debnath,et al.  Micropropagation: a tool for the production of high quality plant-based medicines. , 2006, Current pharmaceutical biotechnology.

[338]  T. Hudlický Chemoenzymatic synthesis of complex natural and unnatural products: morphine, pancratistatin, and their analogs , 2006 .

[339]  R. Abagyan,et al.  XCMS: processing mass spectrometry data for metabolite profiling using nonlinear peak alignment, matching, and identification. , 2006, Analytical chemistry.

[340]  R. Wrangham,et al.  Bioactive properties of plant species ingested by chimpanzees (Pan troglodytes schweinfurthii) in the Kibale National Park, Uganda , 2006, American journal of primatology.

[341]  R. Müller,et al.  Recent developments towards the heterologous expression of complex bacterial natural product biosynthetic pathways. , 2005, Current opinion in biotechnology.

[342]  Ian Paterson,et al.  The Renaissance of Natural Products as Drug Candidates , 2005, Science.

[343]  C. Laggner,et al.  Why drugs fail--a study on side effects in new chemical entities. , 2005, Current pharmaceutical design.

[344]  B. Patwardhan Ethnopharmacology and drug discovery. , 2005, Journal of ethnopharmacology.

[345]  R. Verpoorte,et al.  Elicitor signal transduction leading to production of plant secondary metabolites. , 2005, Biotechnology advances.

[346]  Walter Sneader,et al.  Drug Discovery (The History) , 2005 .

[347]  Jaindra Nath Tripathi,et al.  Role of biotechnology in medicinal plants , 2005, Tropical Journal of Pharmaceutical Research.

[348]  R. Brinton,et al.  Structure-based virtual screening for plant-based ERbeta-selective ligands as potential preventative therapy against age-related neurodegenerative diseases. , 2005, Journal of medicinal chemistry.

[349]  W. Dunn,et al.  Measuring the metabolome: current analytical technologies. , 2005, The Analyst.

[350]  E. Ernst,et al.  Bringing medicinal plants into cultivation: opportunities and challenges for biotechnology. , 2005, Trends in biotechnology.

[351]  H. El‐Seedi,et al.  Aryl Ketones from Acronychia pedunculata with Cyclooxygenase‐2 Inhibitory Effects , 2005, Chemistry & biodiversity.

[352]  D. Guo,et al.  Note: A novel cyanogenic glycoside from Semiaquilegia adoxoides , 2005 .

[353]  M. Butler Natural products to drugs: natural product-derived compounds in clinical trials. , 2005, Natural product reports.

[354]  J. Minic,et al.  Yeast system as a screening tool for pharmacological assessment of g protein coupled receptors. , 2005, Current medicinal chemistry.

[355]  F. Koehn,et al.  The evolving role of natural products in drug discovery , 2005, Nature Reviews Drug Discovery.

[356]  John Andraos,et al.  Unification of Reaction Metrics for Green Chemistry: Applications to Reaction Analysis , 2005 .

[357]  Nicholas H Oberlies,et al.  New colchicinoids from a native Jordanian meadow saffron, colchicum brachyphyllum: isolation of the first naturally occurring dextrorotatory colchicinoid. , 2005, Journal of natural products.

[358]  A. Hopkins,et al.  Navigating chemical space for biology and medicine , 2004, Nature.

[359]  Christopher T. Walsh,et al.  Lessons from natural molecules , 2004, Nature.

[360]  Mark S Butler,et al.  The role of natural product chemistry in drug discovery. , 2004, Journal of natural products.

[361]  S. Sauret-Güeto,et al.  Metabolic engineering of isoprenoid biosynthesis in Arabidopsis for the production of taxadiene, the first committed precursor of Taxol , 2004, Biotechnology and bioengineering.

[362]  D. Moore,et al.  Meclizine is an agonist ligand for mouse constitutive androstane receptor (CAR) and an inverse agonist for human CAR. , 2004, Molecular endocrinology.

[363]  I. Kola,et al.  Can the pharmaceutical industry reduce attrition rates? , 2004, Nature Reviews Drug Discovery.

[364]  P. Grellier,et al.  Novel Antimalarial Compounds Isolated in a Survey of Self-Medicative Behavior of Wild Chimpanzees in Uganda , 2004, Antimicrobial Agents and Chemotherapy.

[365]  H. Tokuyama,et al.  Total synthesis of (-)-strychnine. , 2004, Journal of the American Chemical Society.

[366]  A Ganesan,et al.  Natural products and combinatorial chemistry: back to the future. , 2004, Current opinion in chemical biology.

[367]  J. Conrad,et al.  A novel furostanol saponin from Tribulus terrestris of Bulgarian origin. , 2004, Fitoterapia.

[368]  J. Lampe,et al.  In vitro incubation of human feces with daidzein and antibiotics suggests interindividual differences in the bacteria responsible for equol production. , 2004, The Journal of nutrition.

[369]  C Gyllenhaal,et al.  The UIC ICBG (University of Illinois at Chicago International Cooperative Biodiversity Group) Memorandum of Agreement: a model of benefit-sharing arrangement in natural products drug discovery and development. , 2004, Journal of natural products.

[370]  Thierry Langer,et al.  Combining Ethnopharmacology and Virtual Screening for Lead Structure Discovery: COX-Inhibitors as Application Example , 2004, J. Chem. Inf. Model..

[371]  O. Phillips,et al.  Extinction risk from climate change , 2004, Nature.

[372]  Mahabir P. Gupta,et al.  Using ecological criteria to design plant collection strategies for drug discovery , 2003 .

[373]  T. de Boer,et al.  Fluorescence assays for high-throughput screening of protein kinases. , 2003, Combinatorial chemistry & high throughput screening.

[374]  M. Huffman,et al.  Animal self-medication and ethno-medicine: exploration and exploitation of the medicinal properties of plants , 2003, Proceedings of the Nutrition Society.

[375]  H. Adlercreutz,et al.  Metabolism of isoflavones and lignans by the gut microflora: a study in germ-free and human flora associated rats. , 2003, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[376]  H. Nishino,et al.  Crown gall – a plant tumour with biological activities , 2003, Phytotherapy research : PTR.

[377]  T. Kuzuyama,et al.  Diversity of the biosynthesis of the isoprene units. , 2003, Natural product reports.

[378]  Ivan A. Ross Curcuma longa L. , 2003 .

[379]  M. Miyashita,et al.  Total synthesis of ingenol. , 2003, Journal of the American Chemical Society.

[380]  David J. C. Constable,et al.  Metrics to ‘green’ chemistry—which are the best? , 2002 .

[381]  K. Kobashi,et al.  Evaluation of salicin as an antipyretic prodrug that does not cause gastric injury. , 2002, Planta medica.

[382]  M. O'Neil-Johnson,et al.  High-throughput method for the production and analysis of large natural product libraries for drug discovery. , 2002, Analytical chemistry.

[383]  T. Hudlický,et al.  Medium-Scale Preparation of Useful Metabolites of Aromatic Compounds via Whole-Cell Fermentation with Recombinant Organisms , 2002 .

[384]  S. Rao,et al.  Plant cell cultures: Chemical factories of secondary metabolites. , 2002, Biotechnology advances.

[385]  Cecil R. Smith,et al.  Isolation of Antitumor Alkaloids from Cephalotaxus harringtonia , 2002 .

[386]  B. Timmermann,et al.  A Short Synthetic Route to Nordihydroguaiaretic Acid (NDGA) and Its Stereoisomer Using Ti‐Induced Carbonyl‐Coupling Reaction. , 2002 .

[387]  Y. Konishi,et al.  Taxines from the needles of Taxus wallichiana. , 2001, Phytochemistry.

[388]  T. Takenaka,et al.  Classical vs reverse pharmacology in drug discovery , 2001, BJU international.

[389]  J. Pezzuto,et al.  Antimalarial compounds from Rhaphidophora decursiva. , 2001, Journal of natural products.

[390]  G. Schneider,et al.  Scaffold architecture and pharmacophoric properties of natural products and trade drugs: application in the design of natural product-based combinatorial libraries. , 2001, Journal of combinatorial chemistry.

[391]  S. Gibbons,et al.  Ethnopharmacology in drug discovery: an analysis of its role and potential contribution , 2001, The Journal of pharmacy and pharmacology.

[392]  N. Farnsworth,et al.  The value of plants used in traditional medicine for drug discovery. , 2001, Environmental health perspectives.

[393]  Tudor I. Oprea,et al.  Chemography: the Art of Navigating in Chemical Space , 2000 .

[394]  Jürgen Bajorath,et al.  Distinguishing between Natural Products and Synthetic Molecules by Descriptor Shannon Entropy Analysis and Binary QSAR Calculations , 2000, J. Chem. Inf. Comput. Sci..

[395]  A. Beresford,et al.  ADME/PK as part of a rational approach to drug discovery. , 2000, Drug discovery today.

[396]  J. Bonjoch,et al.  Synthesis of Strychnine. , 2000, Chemical reviews.

[397]  I. Khafagi,et al.  The efficiency of random versus ethno-directed research in the evaluation of Sinai medicinal plants for bioactive compounds. , 2000, Journal of ethnopharmacology.

[398]  K. K. Park,et al.  Chlorophyllin suppression of lipopolysaccharide-induced nitric oxide production in RAW 264.7 cells. , 2000, Toxicology and applied pharmacology.

[399]  G. Schwartsmann,et al.  Anti-cancer drug discovery and development in Brazil: targeted plant collection as a rational strategy to acquire candidate anti-cancer compounds. , 2000, The oncologist.

[400]  Juei-Tang Cheng,et al.  Review: Drug Therapy in Chinese Traditional Medicine , 2000, Journal of clinical pharmacology.

[401]  J. Hohmann,et al.  Diterpenoids from Euphorbia peplus. , 2000, Planta medica.

[402]  P. Das,et al.  In vitro manipulation and propagation of medicinal plants. , 2000, Biotechnology advances.

[403]  R. Verpoorte Pharmacognosy in the New Millennium: Leadfinding and Biotechnology , 2000, The Journal of pharmacy and pharmacology.

[404]  U. Jordis,et al.  Development of a Pilot Scale Process for the Anti-Alzheimer Drug (−)-Galanthamine Using Large-Scale Phenolic Oxidative Coupling and Crystallisation-Induced Chiral Conversion , 1999 .

[405]  I. Sattler,et al.  Natural Products in High Throughput Screening: Automated High-Quality Sample Preparation , 1999, Journal of biomolecular screening.

[406]  M. Zenk,et al.  Biosynthesis of the amaryllidaceae alkaloid Galanthamine , 1998 .

[407]  K. Nicolaou,et al.  The Art and Science of Organic and Natural Products Synthesis , 1998 .

[408]  G. Cragg Paclitaxel (Taxol®): A success story with valuable lessons for natural product drug discovery and development , 1998, Medicinal research reviews.

[409]  Jae Chol Lee,et al.  Total Synthesis of Colchicine. α‐Methoxy‐Substituted Oxyallyl [4 + 3] Cycloaddition Approach. , 1998 .

[410]  C. C. Wan,et al.  Removal of polyphenolic compounds from aqueous plant extracts using polyamide minicolumns , 1998, Biochemistry and molecular biology international.

[411]  You-Ping Zhu,et al.  Chinese Materia Medica: Chemistry, Pharmacology and Applications , 1998 .

[412]  R. Verpoorte Exploration of nature's chemodiversity: the role of secondary metabolites as leads in drug development , 1998 .

[413]  G. Reaven,et al.  Masoprocol (nordihydroguaiaretic acid): a new antihyperglycemic agent isolated from the creosote bush (Larrea tridentata). , 1998, European journal of pharmacology.

[414]  H. El‐Seedi,et al.  Two New Isoflavones from Ceiba pentandra and Their Effect on Cyclooxygenase-Catalyzed Prostaglandin Biosynthesis , 1998 .

[415]  S. Hosztafi The discovery of alkaloids. , 1997, Die Pharmazie.

[416]  J. Phillipson,et al.  Plant polyphenols: biologically active compounds or non-selective binders to protein? , 1997, Phytochemistry.

[417]  H. G. Vogel Drug Discovery and Evaluation: Pharmacological Assays , 1997 .

[418]  D. Knorr,et al.  Strategies for the improvement of secondary metabolite production in plant cell cultures , 1995 .

[419]  L. Caporale,et al.  Chemical ecology: a view from the pharmaceutical industry. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[420]  Li Ws,et al.  Enzymic preparation of (3R‐cis)‐3‐(acetyloxy)‐4‐phenyl‐2‐azetidinone: a taxol side‐chain synthon , 1994, Biotechnology and applied biochemistry.

[421]  C. Nessler Metabolic engineering of plant secondary products , 1994, Transgenic Research.

[422]  K. Nicolaou,et al.  Total synthesis of taxol , 1994, Nature.

[423]  R. Breslow Biomimetic chemistry , 1994 .

[424]  M. Grever,et al.  The taxol supply crisis. New NCI policies for handling the large-scale production of novel natural product anticancer and anti-HIV agents. , 1993, Journal of natural products.

[425]  D. Guénard,et al.  Taxol and Taxotere: Discovery, Chemistry, and Structure‐Activity Relationships , 1993 .

[426]  K. Gustafson,et al.  A chemical screening strategy for the dereplication and prioritization of HIV-inhibitory aqueous natural products extracts. , 1993, Journal of natural products.

[427]  D. Guénard,et al.  Taxol and taxotere: discovery, chemistry, and structure-activity relationships , 1993 .

[428]  N. Burres,et al.  Isolation of 9-Dihydro-13-acetylbaccatin III from Taxus canadensis , 1992 .

[429]  B. Trost,et al.  The atom economy--a search for synthetic efficiency. , 1991, Science.

[430]  J M Pezzuto,et al.  Evaluation of natural products as inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase. , 1991, Journal of natural products.

[431]  H. Kaga,et al.  A facile procedure for synthesis of capsaicin , 1989 .

[432]  A. Greene,et al.  Highly efficient, practical approach to natural taxol , 1988 .

[433]  Marianne Winder,et al.  Medicine in China. A history of pharmaceutics , 1988, Medical History.

[434]  A. Bingel,et al.  Medicinal plants in therapy , 1987 .

[435]  D. L. Klayman,et al.  Qinghaosu (artemisinin): an antimalarial drug from China. , 1985, Science.

[436]  R. Spjut Limitations of a random screen: Search for new anticancer drugs in higher plants , 1985, Economic Botany.

[437]  T. Matsuzaki,et al.  Detection and chemical identification of natural bio-antimutagens. A case of the green tea factor. , 1985, Mutation research.

[438]  N. Acton,et al.  Isolation of artemisinin (qinghaosu) from Artemisia annua growing in the United States. , 1984, Journal of natural products.

[439]  G. M. Sapers,et al.  Varietal differences in distribution of quercetin and kaempferol in onion (Allium cepa L.) tissue , 1984 .

[440]  S. Adekenov,et al.  Arglabin — A new sesquiterpene lactone fromArtemisia glabella , 1982, Chemistry of Natural Compounds.

[441]  P. Schiff,et al.  Taxol stabilizes microtubules in mouse fibroblast cells. , 1980, Proceedings of the National Academy of Sciences of the United States of America.

[442]  K. Joshi,et al.  Quinones and other Constituents from Haplophragma adenophyllum , 1979 .

[443]  W. Lewis,et al.  Medical botany. Plants affecting man's health , 1979, Medical History.

[444]  P. Schiff,et al.  Promotion of microtubule assembly in vitro by taxol , 1979, Nature.

[445]  P. Langcake,et al.  The production of resveratrol by Vitis vinifera and other members of the Vitaceae as a response to infection or injury , 1976 .

[446]  T. Vree,et al.  Identification in hashish of tetrahydrocannabinol, cannabidiol and cannabinol analogues with a methyl side‐chain , 1972, The Journal of pharmacy and pharmacology.

[447]  D. Liljegren Glucosylation of solasodine by extracts from Solanum laciniatum , 1971 .

[448]  A. McPhail,et al.  Plant antitumor agents. VI. The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia. , 1971, Journal of the American Chemical Society.

[449]  S. Y. Yunusov,et al.  Alkaloids ofGalanthus caucasicus , 1969, Chemistry of Natural Compounds.

[450]  E. Leete,et al.  The Biogenesis of the Alkaloids of Colchicum. I. The Incorporation of Phenylalanine into Colchicine1 , 1960 .

[451]  T. S. Lee,et al.  The pharmacological actions of capsaicin and analogues. , 1955, British Journal of Pharmacology and Chemotherapy.

[452]  W. D. Ollis,et al.  The total synthesis of strychnine. , 1954, Experientia.

[453]  Andrei Hent,et al.  Green Chemistry Metrics: A Guide to Determining and Evaluating Process Greenness , 2015 .

[454]  R. Yu,et al.  Optimal inductive and cultural conditions of Polygonum multiflorum transgenic hairy roots mediated with Agrobacterium rhizogenes R1601 and an analysis of their anthraquinone constituents , 2014, Pharmacognosy magazine.

[455]  M. Mirjalili,et al.  Production and Genetic Engineering of Terpenoids Production in Plant Cell and Organ Cultures , 2013 .

[456]  J. Gras Ingenol mebutate: a new option for actinic keratosis treatment. , 2013, Drugs of today.

[457]  W. Jones,et al.  Extraction of plant secondary metabolites. , 2012, Methods in molecular biology.

[458]  Jane A. Craycroft,et al.  Developing a library of authenticated Traditional Chinese Medicinal (TCM) plants for systematic biological evaluation--rationale, methods and preliminary results from a Sino-American collaboration. , 2011, Fitoterapia.

[459]  M. Rahimi,et al.  APPLICATION OF BIOTECHNOLOGY IN PRODUCTION OF MEDICINAL PLANTS , 2011 .

[460]  Meriel G. Jones,et al.  Drugs from daffodils , 2011 .

[461]  M. Mirjalili,et al.  Production of the anticancer drug taxol in Taxus baccata suspension cultures: A review , 2011 .

[462]  G. Appendino 3 . 08 Natural Products Drug Discovery , 2010 .

[463]  M. Heinrich 3.12 Ethnopharmacology and Drug Discovery , 2010 .

[464]  G. Appendino,et al.  Natural Products Drug Discovery , 2010 .

[465]  A. Mathur,et al.  Emerging trends in medicinal plant biotechnology. , 2010 .

[466]  C. Wawrosch,et al.  In vitro propagation of medicinal plants for conservation and quality assurance. , 2010 .

[467]  L. Cseke,et al.  The use of plant cell biotechnology for the production of phytochemicals , 2009 .

[468]  J. Brinckmann,et al.  COMMITTEE ON HERBAL MEDICINAL PRODUCTS (HMPC) , 2008 .

[469]  Thierry Langer,et al.  Virtual screening for the discovery of bioactive natural products , 2008, Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques.

[470]  J. Bohlmann,et al.  Terpenoid biomaterials. , 2008, The Plant journal : for cell and molecular biology.

[471]  G. Cordell,et al.  Studies on the antifertility components from Marsdenia koi , 2008, Journal of Tongji Medical University.

[472]  R. Breinbauer The Way of Synthesis: Evolution of Design and Methods for Natural Products , 2008 .

[473]  J. Lehár,et al.  Multi-target therapeutics: when the whole is greater than the sum of the parts. , 2007, Drug discovery today.

[474]  A. Namdeo Plant cell elicitation for production of secondary metabolites: A review , 2007 .

[475]  A. Vaidya Reverse pharmacological correlates of ayurvedic drug actions , 2006 .

[476]  R. Pulak,et al.  Techniques for analysis, sorting, and dispensing of C. elegans on the COPAS flow-sorting system. , 2006, Methods in molecular biology.

[477]  D. Guo,et al.  A nobel cyanogenic glycoside from Semiaquilegia adoxoides. , 2005, Journal of Asian natural products research.

[478]  J. AfolayanA.,et al.  In vitro propagation : A biotechnological tool capable of solving the problem of medicinal plants decimation in South Africa , 2005 .

[479]  T. Foderaro,et al.  Research and Development of a Second-Generation Process for Oseltamivir Phosphate, Prodrug for a Neuraminidase Inhibitor , 2004 .

[480]  Miklos Feher,et al.  Property Distributions: Differences between Drugs, Natural Products, and Molecules from Combinatorial Chemistry , 2003, J. Chem. Inf. Comput. Sci..

[481]  A. Sands,et al.  Knockouts model the 100 best-selling drugs—will they model the next 100? , 2003, Nature Reviews Drug Discovery.

[482]  G. Haberlandt Culturversuche mit isolierten Pflanzenzellen , 2003 .

[483]  W. Lewis,et al.  Medical botany : plants affecting human health , 2003 .

[484]  M. Harkey,et al.  Effects of intrinsic fluorescence and quenching on fluorescence-based screening of natural products. , 2002, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[485]  John K Borchardt,et al.  The Beginnings of Drug Therapy: Ancient Mesopotamian Medicine. , 2002, Drug news & perspectives.

[486]  Peter Gwynne,et al.  Drug Discovery: 5 , 2002 .

[487]  Alan D. Curzons,et al.  So you think your process is green, how do you know?—Using principles of sustainability to determine what is green–a corporate perspective , 2001 .

[488]  R. Verpoorte,et al.  Metabolic Engineering of Plant Secondary Metabolism , 2000, Springer Netherlands.

[489]  Palmisano,et al.  An expeditious procedure for the isolation of ingenol from the seeds of euphorbia lathyris , 1999, Journal of natural products.

[490]  H. El‐Seedi,et al.  Two new isoflavones from Ceiba pentandra and their effect on cyclooxygenase-catalyzed prostaglandin biosynthesis. , 1998, Journal of natural products.

[491]  P. Doran,et al.  Effect of inoculum size on growth of Atropa belladonna hairy roots in shake flasks , 1997 .

[492]  T. Huynh-Dinh,et al.  The logic of chemical synthesis , 1996 .

[493]  R. Bauer [Chinese drugs as a source of new drug materials in western medicine]. , 1994, Pharmazie in unserer Zeit.

[494]  R. Bauer Chinesische Arzneidrogen als Quelle neuer Arzneistoffe für die westliche Medizin , 1994 .

[495]  K. Yoshimatsu,et al.  Further Approaches in the Production of Secondary Metabolites by Plant Tissue Cultures , 1992 .

[496]  P. Dewick,et al.  Biosynthesis of Podophyllum lignans—II. Interconversions of aryltetralin lignans in Podophyllum hexandrum , 1984 .

[497]  G Zbinden,et al.  Toxicological screening. , 1984, Regulatory toxicology and pharmacology : RTP.

[498]  P. Heinstein,et al.  Formation of Gossypol by Gossypium hirsutum L. Cell Suspension Cultures , 1981 .

[499]  R. Breslow Centenary Lecture. Biomimetic chemistry , 1972 .

[500]  P. Anastas,et al.  Green Chemistry , 2018, Environmental Science.

[501]  T. Petrzilka,et al.  Synthese von Haschisch-Inhaltsstoffen. 4. Mitteilung , 1969 .

[502]  D. Barton,et al.  153. Phenol oxidation and biosynthesis. Part V. The synthesis of galanthamine , 1962 .

[503]  T. A. H.,et al.  Chinese Materia Medica , 1939, Nature.

[504]  Robert Robinson,et al.  LXIII.—A synthesis of tropinone , 1917 .

[505]  T. H. Geschichte der Pharmazie , 1905, Nature.

[506]  A. G. Perkin,et al.  LXXIX.—The colouring matters contained in dyer's broom (Genista tinctoria) and heather (Calluna vulgaris) , 1899 .

[507]  Sertuerner Ueber das Morphium, eine neue salzfähige Grundlage, und die Mekonsäure, als Hauptbestandtheile des Opiums , 1817 .