T-type calcium channels blockers as new tools in cancer therapies

[1]  S. Kwon,et al.  Neuroendocrine differentiation correlates with hormone receptor expression and decreased survival in patients with invasive breast carcinoma , 2014, Histopathology.

[2]  J. Larner,et al.  T-Type Ca2+ Channel Inhibition Induces p53-Dependent Cell Growth Arrest and Apoptosis through Activation of p38-MAPK in Colon Cancer Cells , 2013, Molecular Cancer Research.

[3]  H. Rhim,et al.  In vitro cytotoxicity on human ovarian cancer cells by T-type calcium channel blockers. , 2013, Bioorganic & medicinal chemistry letters.

[4]  X. Matías-Guiu,et al.  T‐type calcium channel blockers inhibit autophagy and promote apoptosis of malignant melanoma cells , 2013, Pigment cell & melanoma research.

[5]  A. Kawabata,et al.  T-type calcium channels: functional regulation and implication in pain signaling. , 2013, Journal of pharmacological sciences.

[6]  L. Gray,et al.  Exploiting MCF-7 Cells’ Calcium Dependence with Interlaced Therapy , 2013 .

[7]  M. Fallon,et al.  Neuropathic pain in cancer. , 2013, British journal of anaesthesia.

[8]  D. Schiff,et al.  A model for the regulation of T-type Ca2+ channels in proliferation: roles in stem cells and cancer , 2013, Expert review of anticancer therapy.

[9]  H. Wigren,et al.  Role of low voltage activated calcium channels in neuritogenesis and active migration of embryonic neural progenitor cells. , 2013, Stem cells and development.

[10]  J. Larner,et al.  Inhibition of T-type calcium channels disrupts Akt signaling and promotes apoptosis in glioblastoma cells. , 2013, Biochemical pharmacology.

[11]  J. Sheehan,et al.  Inhibition of glioblastoma and enhancement of survival via the use of mibefradil in conjunction with radiosurgery. , 2013, Journal of neurosurgery.

[12]  Jung-Hye Choi,et al.  T-type Ca2+ channel blocker, KYS05047 induces G1 phase cell cycle arrest by decreasing intracellular Ca2+ levels in human lung adenocarcinoma A549 cells. , 2012, Bioorganic & medicinal chemistry letters.

[13]  L. Nicholson,et al.  Cancer stem cells: in the line of fire. , 2012, Cancer treatment reviews.

[14]  Dominique Ardail,et al.  Targeting a cornerstone of radiation resistance: cancer stem cell. , 2012, Cancer letters.

[15]  A. Fisseler‐Eckhoff,et al.  Neuroendocrine Tumors of the Lung , 2012, Cancers.

[16]  F. Davis,et al.  Calcium Channels and Pumps in Cancer: Changes and Consequences* , 2012, The Journal of Biological Chemistry.

[17]  J. Yamazaki,et al.  T-type voltage-activated calcium channel Cav3.1, but not Cav3.2, is involved in the inhibition of proliferation and apoptosis in MCF-7 human breast cancer cells. , 2012, International journal of oncology.

[18]  G. Santoni,et al.  Functional role of T‐type calcium channels in tumour growth and progression: prospective in cancer therapy , 2012, British journal of pharmacology.

[19]  Y. Zhang,et al.  Inhibition of T‐type Ca2+ channels by endostatin attenuates human glioblastoma cell proliferation and migration , 2012, British journal of pharmacology.

[20]  X. Matías-Guiu,et al.  Functional expression of voltage‐gated calcium channels in human melanoma , 2012, Pigment cell & melanoma research.

[21]  J. López-Barneo,et al.  T-type Ca2+ channels in mouse embryonic stem cells: modulation during cell cycle and contribution to self-renewal. , 2012, American journal of physiology. Cell physiology.

[22]  Nirmal Singh,et al.  Mechanisms in cancer-chemotherapeutic drugs-induced peripheral neuropathy. , 2012, Toxicology.

[23]  Ji-Hyung Seo,et al.  In vivo evaluation of oral anti-tumoral effect of 3,4-dihydroquinazoline derivative on solid tumor. , 2012, Bioorganic & medicinal chemistry letters.

[24]  S. Keir,et al.  Mibefradil, a novel therapy for glioblastoma multiforme: cell cycle synchronization and interlaced therapy in a murine model , 2012, Journal of Neuro-Oncology.

[25]  T. Capiod Cell proliferation, calcium influx and calcium channels. , 2011, Biochimie.

[26]  Holger Gerhardt,et al.  Basic and Therapeutic Aspects of Angiogenesis , 2011, Cell.

[27]  Lei Xu,et al.  Normalization of the vasculature for treatment of cancer and other diseases. , 2011, Physiological reviews.

[28]  W. Wilson,et al.  Targeting hypoxia in cancer therapy , 2011, Nature Reviews Cancer.

[29]  Ning Wang,et al.  Blockade of T-Type Ca2+ Channels Inhibits Human Ovarian Cancer Cell Proliferation , 2011, Cancer investigation.

[30]  D. Atlas Signaling role of the voltage-gated calcium channel as the molecular on/off-switch of secretion. , 2010, Cellular signalling.

[31]  R. Nagai,et al.  Involvement of CaV3.1 T-type calcium channels in cell proliferation in mouse preadipocytes. , 2010, American journal of physiology. Cell physiology.

[32]  H. Zhuang,et al.  A role of functional T-type Ca2+ channel in hepatocellular carcinoma cell proliferation. , 2009, Oncology reports.

[33]  L. Cribbs,et al.  T-type calcium channels are regulated by hypoxia/reoxygenation in ventricular myocytes. , 2009, American journal of physiology. Heart and circulatory physiology.

[34]  E. Perez-Reyes,et al.  Molecular Pharmacology of Human Cav3.2 T-Type Ca2+ Channels: Block by Antihypertensives, Antiarrhythmics, and Their Analogs , 2009, Journal of Pharmacology and Experimental Therapeutics.

[35]  K. Jauch,et al.  Cancer stem cells: how can we target them? , 2008, Current medicinal chemistry.

[36]  Ming Li,et al.  Calcium signaling and T-type calcium channels in cancer cell cycling. , 2008, World journal of gastroenterology.

[37]  Luping Z. Huang,et al.  Selective blockade of T-type Ca2+ channels suppresses human breast cancer cell proliferation. , 2008, Cancer letters.

[38]  H. Rhim,et al.  T-type Ca2+ channel blockers suppress the growth of human cancer cells. , 2008, Bioorganic & medicinal chemistry letters.

[39]  J. K. Kundu,et al.  Inflammation: gearing the journey to cancer. , 2008, Mutation research.

[40]  F. Gackière,et al.  CaV3.2 T-type Calcium Channels Are Involved in Calcium-dependent Secretion of Neuroendocrine Prostate Cancer Cells* , 2008, Journal of Biological Chemistry.

[41]  Min Guo,et al.  T‐type Ca2+ Channel Expression in Human Esophageal Carcinomas: A Functional Role in Proliferation , 2007, Cell calcium.

[42]  D. Clapham,et al.  Calcium Signaling , 2007, Cell.

[43]  Sarah J. Roberts-Thomson,et al.  Calcium and cancer: targeting Ca2+ transport , 2007, Nature Reviews Cancer.

[44]  A. Hackam,et al.  Human embryonic and neuronal stem cell markers in retinoblastoma , 2007, Molecular vision.

[45]  K. Node,et al.  Atorvastatin inhibits angiotensin II-induced T-type Ca2+ channel expression in endothelial cells. , 2006, Biochemical and biophysical research communications.

[46]  A. Panner,et al.  T-type calcium channels and tumor proliferation. , 2006, Cell calcium.

[47]  P. Lory,et al.  T-type calcium channels in differentiation and proliferation. , 2006, Cell calcium.

[48]  T. Macdonald,et al.  The pharmacology and regulation of T type calcium channels: new opportunities for unique therapeutics for cancer. , 2006, Cell calcium.

[49]  A. Verkhratsky,et al.  T-type calcium channels: the never ending story. , 2006, Cell calcium.

[50]  K. Campbell,et al.  CaV3.2 is the major molecular substrate for redox regulation of T‐type Ca2+ channels in the rat and mouse thalamus , 2006, The Journal of physiology.

[51]  Hairu Chen,et al.  Is there a role for T-type Ca2+ channel in glioma cell proliferation? , 2005, Cell calcium.

[52]  L. Cribbs,et al.  Variation of T-type calcium channel protein expression affects cell division of cultured tumor cells. , 2005, Cell calcium.

[53]  G. Bennett,et al.  Ethosuximide reverses paclitaxel- and vincristine-induced painful peripheral neuropathy , 2004, Pain.

[54]  B. Nebe,et al.  Induction of apoptosis by the calcium antagonist mibefradil correlates with depolarization of the membrane potential and decreased integrin expression in human lens epithelial cells , 2004, Graefe's Archive for Clinical and Experimental Ophthalmology.

[55]  H. Zhuang,et al.  NNC 55-0396 [(1S,2S)-2-(2-(N-[(3-Benzimidazol-2-yl)propyl]-N-methylamino)ethyl)-6-fluoro-1,2,3,4-tetrahydro-1-isopropyl-2-naphtyl cyclopropanecarboxylate dihydrochloride]: A New Selective Inhibitor of T-Type Calcium Channels , 2004, Journal of Pharmacology and Experimental Therapeutics.

[56]  P. Lory,et al.  Cav3.2 calcium channels control an autocrine mechanism that promotes neuroblastoma cell differentiation , 2004, Neuroreport.

[57]  M. Roudbaraki,et al.  Ca2+ homeostasis and apoptotic resistance of neuroendocrine-differentiated prostate cancer cells , 2004, Cell Death and Differentiation.

[58]  F. Bühler,et al.  Prevention of neointima formation by mibefradil after vascular injury in rats: Comparison with ACE inhibition , 1996, Cardiovascular Drugs and Therapy.

[59]  G. Amorino,et al.  Neuroendocrine cells in prostate cancer. , 2004, Critical reviews in eukaryotic gene expression.

[60]  J. Trepel Ion channels as molecular targets in prostate cancer. , 2003, Clinical prostate cancer.

[61]  A. Means,et al.  Regulation of cell cycle progression by calcium/calmodulin-dependent pathways. , 2003, Endocrine reviews.

[62]  J. López-Barneo,et al.  Induction of T-type Calcium Channel Gene Expression by Chronic Hypoxia* , 2003, Journal of Biological Chemistry.

[63]  S. Barnes,et al.  Regulation of α1G T‐type calcium channel gene (CACNA1G) expression during neuronal differentiation , 2003, The European journal of neuroscience.

[64]  E. Perez-Reyes Molecular physiology of low-voltage-activated t-type calcium channels. , 2003, Physiological reviews.

[65]  H. Bonkhoff,et al.  Apoptosis resistance of neuroendocrine phenotypes in prostatic adenocarcinoma , 2002, The Prostate.

[66]  G. Rozenberg,et al.  The Ca(2+) channel antagonists mibefradil and pimozide inhibit cell growth via different cytotoxic mechanisms. , 2002, Molecular pharmacology.

[67]  S. Barnes,et al.  T-Type Calcium Channel α1G and α1H Subunits in Human Retinoblastoma Cells and Their Loss After Differentiation , 2002 .

[68]  N. Prevarskaya,et al.  Overexpression of an α1H (Cav3.2) T-type Calcium Channel during Neuroendocrine Differentiation of Human Prostate Cancer Cells* , 2002, The Journal of Biological Chemistry.

[69]  S. Barnes,et al.  T-Type calcium channel alpha1G and alpha1H subunits in human retinoblastoma cells and their loss after differentiation. , 2002, Journal of neurophysiology.

[70]  N. Prevarskaya,et al.  Overexpression of an alpha 1H (Cav3.2) T-type calcium channel during neuroendocrine differentiation of human prostate cancer cells. , 2002, The Journal of biological chemistry.

[71]  D. Bilici,et al.  Protective effect of T-type calcium channel blocker in histamine-induced paw inflammation in rat. , 2001, Pharmacological research.

[72]  J. Welsh,et al.  Molecular classification of human carcinomas by use of gene expression signatures. , 2001, Cancer research.

[73]  T. Macdonald,et al.  Molecular pharmacology of T-type Ca2+ channels. , 2001, Japanese journal of pharmacology.

[74]  Alberto Mantovani,et al.  Inflammation and cancer: back to Virchow? , 2001, The Lancet.

[75]  P. di Sant'Agnese,et al.  Neuroendocrine differentiation in prostatic carcinoma: an update on recent developments. , 2001, Annals of oncology : official journal of the European Society for Medical Oncology.

[76]  C. Peers,et al.  Modulation of recombinant T-type Ca2+ channels by hypoxia and glutathione , 2000, Pflügers Archiv.

[77]  A. Reichenbach,et al.  Developmental regulation of calcium channel-mediated currents in retinal glial (Müller) cells. , 2000, Journal of neurophysiology.

[78]  S. D. Kimball,et al.  High affinity interaction of mibefradil with voltage‐gated calcium and sodium channels , 2000, British journal of pharmacology.

[79]  T. Macdonald,et al.  Inhibition of human prostate cancer proliferation in vitro and in a mouse model by a compound synthesized to block Ca2+ entry. , 2000, Cancer research.

[80]  Y. Zhang,et al.  Arachidonic acid modulation of alpha1H, a cloned human T-type calcium channel. , 2000, American journal of physiology. Heart and circulatory physiology.

[81]  L. Cribbs,et al.  Arachidonic acid modulation of α1H, a cloned human T-type calcium channel , 2000 .

[82]  S. Baylin,et al.  Inactivation of CACNA1G, a T-type calcium channel gene, by aberrant methylation of its 5' CpG island in human tumors. , 1999, Cancer research.

[83]  R. Fagard,et al.  Mibefradil-induced inhibition of proliferation of human peripheral blood mononuclear cells. , 1999, Journal of cardiovascular pharmacology.

[84]  A. Bhattacharjee,et al.  A Low Voltage-Activated Ca2+ Current Mediates Cytokine-Induced Pancreatic β-Cell Death. , 1999, Endocrinology.

[85]  A. Bhattacharjee,et al.  A low voltage-activated Ca2+ current mediates cytokine-induced pancreatic beta-cell death. , 1999, Endocrinology.

[86]  W. Robberecht,et al.  Mibefradil (Ro 40-5967) blocks multiple types of voltage-gated calcium channels in cultured rat spinal motoneurones. , 1997, Cell calcium.

[87]  D. Clapham,et al.  Calcium signaling , 1995, Cell.

[88]  F. Hofmann,et al.  The Ca(++)-channel blocker Ro 40-5967 blocks differently T-type and L-type Ca++ channels. , 1994, The Journal of pharmacology and experimental therapeutics.

[89]  S. Mishra,et al.  Selective inhibition of T-type Ca2+ channels by Ro 40-5967. , 1994, Circulation research.

[90]  R. Tsien,et al.  Three types of neuronal calcium channel with different calcium agonist sensitivity , 1985, Nature.

[91]  R. Tsien,et al.  A novel type of cardiac calcium channel in ventricular cells. , 1985, Nature.

[92]  H. Lux,et al.  A low voltage-activated, fully inactivating Ca channel in vertebrate sensory neurones , 1984, Nature.

[93]  R. Isaacs,et al.  Different extracellular calcium requirements for proliferation of nonneoplastic, preneoplastic, and neoplastic mouse cells. , 1977, Cancer research.

[94]  S. Balk Calcium as a regulator of the proliferation of normal, but not of transformed, chicken fibroblasts in a plasma-containing medium. , 1971, Proceedings of the National Academy of Sciences of the United States of America.