Organic Electrochemical Transistors Integrated in Flexible Microfluidic Systems and Used for Label‐Free DNA Sensing

enzyme sensors, [ 9 ] DNA sensors, [ 10 ] dopamine sensor, [ 11 ] and cell-based biosensors. [ 12 ] A transistor-based sensor is the combination of a sensor and an amplifi er since a small potential change at an interface can induce a substantial variation of the channel current. [ 16–18 ] Therefore such devices are highly sensitive and potentially low cost. More importantly, OECT can be easily miniaturized and fabricated on fl exible substrates, which is essential for some applications in living systems. OECTs have been integrated in microfl uidic channels and used as ion sensors and enzyme sensors. [ 5 , 6 , 9 ] As for fl exible devices, OECTs were fabricated on fi bers and showed excellent transistor performance. [ 19 , 20 ] However, the application of the fi ber-supported devices in biosensors is limited by solid electrolytes used in the devices. Therefore, we study the OECT integrated in a fl exible microfl uidic system and explore its applications in biosensors, such as DNA sensors. Nucleic acid diagnostics has attracted much interest due to its great scientifi c and economic importance, and it has signifi cant applications in gene expression monitoring, viral and bacterial identifi cation, biowarfare and bioterrorism agents detecting, and clinical medicine. [ 21 ] Besides the traditional technique that is based on the confocal fl uorescence microscope, several different label-free technologies have been developed for the analysis of DNA microarrays, including atomic force microscopy, [ 22 ] electrochemical detection, [ 23 ] surface vibration spectroscopy, [ 24 ] scanning Kelvin probe microscopy (SKPM), [ 25 ]

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