Bioinspired colorimetric detection of calcium(II) ions in serum using calsequestrin-functionalized gold nanoparticles.

Seeing is sensing: Calsequestrin (CSQ) functionalized gold nanoparticles undergo calcium-dependent CSQ polymerization, which results in a clear color change (see picture) together with precipitation. The sensing system is specific for Ca(2+) ions and the differences between normal and disease-associated abnormal (hypercalcemia) Ca(2+) ion levels in serum can be distinguished with the naked eye.

[1]  Weihong Tan,et al.  Aptamer-modified gold nanoparticles for colorimetric determination of platelet-derived growth factors and their receptors. , 2005, Analytical chemistry.

[2]  D. Seligson,et al.  APPLICATION OF ATOMIC ABSORPTION SPECTROPHOTOMETRY IN THE DETERMINATION OF CALCIUM IN SERUM. , 1964, Clinical chemistry.

[3]  Chih-Ching Huang,et al.  Parameters for selective colorimetric sensing of mercury(II) in aqueous solutions using mercaptopropionic acid-modified gold nanoparticles. , 2007, Chemical communications.

[4]  D. Young,et al.  A referee method for the determination of total calcium in serum. , 1973, Clinical chemistry.

[5]  P. Duggan,et al.  Single stable reagent (Arsenazo III) for optically robust measurement of calcium in serum and plasma. , 1992, Clinical chemistry.

[6]  D. A. Russell,et al.  Gold glyconanoparticles for mimics and measurement of metal ion-mediated carbohydrate-carbohydrate interactions. , 2006, Langmuir : the ACS journal of surfaces and colloids.

[7]  H. Gitelman.  An improved automated procedure for the determination of calcium in biological specimens. , 1967 .

[8]  Jin Kyeong Kim,et al.  Direct immobilization of protein g variants with various numbers of cysteine residues on a gold surface. , 2007, Analytical chemistry.

[9]  David A Russell,et al.  Silver and gold glyconanoparticles for colorimetric bioassays. , 2006, Langmuir : the ACS journal of surfaces and colloids.

[10]  Chad A Mirkin,et al.  Multiplexed detection of protein cancer markers with biobarcoded nanoparticle probes. , 2006, Journal of the American Chemical Society.

[11]  C. Mirkin,et al.  Nanoparticle-Based Bio-Bar Codes for the Ultrasensitive Detection of Proteins , 2003, Science.

[12]  J. Gergely,et al.  Interaction of divalent cations with the 55,000-dalton protein component of the sarcoplasmic reticulum. Studies of fluorescence and circular dichroism. , 1972, The Journal of biological chemistry.

[13]  Yi Lu,et al.  Optimization of a Pb2+-Directed Gold Nanoparticle/DNAzyme Assembly and Its Application as a Colorimetric Biosensor for Pb2+ , 2004 .

[14]  M. Walser,et al.  Calcium measurements in serum and plasma--total and ionized. , 1979, CRC critical reviews in clinical laboratory sciences.

[15]  C. Mirkin,et al.  Nanoparticle-based detection in cerebral spinal fluid of a soluble pathogenic biomarker for Alzheimer's disease. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[16]  D. Maclennan,et al.  Isolation of a calcium-sequestering protein from sarcoplasmic reticulum. , 1971, Proceedings of the National Academy of Sciences of the United States of America.

[17]  Yi Xiao,et al.  Aptamer-functionalized Au nanoparticles for the amplified optical detection of thrombin. , 2004, Journal of the American Chemical Society.

[18]  Chad A Mirkin,et al.  Colorimetric screening of DNA-binding molecules with gold nanoparticle probes. , 2006, Angewandte Chemie.

[19]  A. Kumar,et al.  New reagent for colorimetric assay of calcium in serum. , 1993, Clinical chemistry.

[20]  George C Schatz,et al.  What controls the melting properties of DNA-linked gold nanoparticle assemblies? , 2000, Journal of the American Chemical Society.

[21]  A. Dunker,et al.  Crystal structure of calsequestrin from rabbit skeletal muscle sarcoplasmic reticulum , 1998, Nature Structural Biology.

[22]  Chad A Mirkin,et al.  Colorimetric detection of mercuric ion (Hg2+) in aqueous media using DNA-functionalized gold nanoparticles. , 2007, Angewandte Chemie.

[23]  Xingyu Jiang,et al.  Visual detection of copper(II) by azide- and alkyne-functionalized gold nanoparticles using click chemistry. , 2008, Angewandte Chemie.

[24]  R. Reithmeier,et al.  Size and shape of rabbit skeletal muscle calsequestrin. , 1984, The Journal of biological chemistry.

[25]  H. V. Connerty,et al.  Determination of serum calcium by means of orthocresolphthalein complexone. , 1966, American journal of clinical pathology.

[26]  C. Corns.  A New Colorimetric Method for the Measurement of Serum Calcium Using a Zinc-Zincon Indicator , 1987, Annals of clinical biochemistry.

[27]  J. Rojo,et al.  Gold Glyconanoparticles as Water-Soluble Polyvalent Models To Study Carbohydrate Interactions. , 2001, Angewandte Chemie.

[28]  A. Dulhunty,et al.  Calsequestrin and the calcium release channel of skeletal and cardiac muscle. , 2004, Progress in biophysics and molecular biology.

[29]  Yingfu Li,et al.  Simple and rapid colorimetric enzyme sensing assays using non-crosslinking gold nanoparticle aggregation. , 2007, Chemical communications.

[30]  D. A. Russell,et al.  Glyconanoparticles for the colorimetric detection of cholera toxin. , 2007, Analytical chemistry.

[31]  C. Corns,et al.  Some Observations on the Nature of the Calcium-Cresolphthalein Complexone Reaction and its Relevance to the Clinical Laboratory , 1987, Annals of clinical biochemistry.

[32]  B. Liedberg,et al.  Folding induced assembly of polypeptide decorated gold nanoparticles. , 2008, Journal of the American Chemical Society.

[33]  A. Dunker,et al.  Polymerization of Calsequestrin , 2003, The Journal of Biological Chemistry.

[34]  S. Yun,et al.  Characteristics of Nanocomposite ZrO 2 /Al 2 O 3 Films Deposited by Plasma-Enhanced Atomic Layer Deposition , 2007 .

[35]  Chad A. Mirkin,et al.  One-Pot Colorimetric Differentiation of Polynucleotides with Single Base Imperfections Using Gold Nanoparticle Probes , 1998 .

[36]  Joseph T. Hupp,et al.  Gold Nanoparticle-Based Sensing of “Spectroscopically Silent” Heavy Metal Ions , 2001 .

[37]  D. Schade,et al.  A practical approach to hypercalcemia. , 2003, American family physician.

[38]  J. Bilezikian,et al.  Rare causes of hypercalcemia , 2005 .

[39]  Joseph M Slocik,et al.  Colorimetric response of peptide-functionalized gold nanoparticles to metal ions. , 2008, Small.

[40]  C. Tung,et al.  Sensing phosphatase activity by using gold nanoparticles. , 2007, Angewandte Chemie.

[41]  Guonan Chen,et al.  Fast colorimetric detection of copper ions using L-cysteine functionalized gold nanoparticles. , 2007, Journal of nanoscience and nanotechnology.