Novel intelligent systems to assist energy transition and improve sustainability can be deployed at different scales, ranging from a house to an entire region. University campuses are an interesting intermediate size (big enough to matter and small enough to be tractable) for research, development, test and training on the integration of smartness at all levels, which has led to the emergence of the concept of “smart campus” over the last few years. This review article proposes an extensive analysis of the scientific literature on smart campuses from the last decade (2010-2020). The 182 selected publications are distributed into seven categories of smartness: smart building, smart environment, smart mobility, smart living, smart people, smart governance and smart data. The main open questions and challenges regarding smart campuses are presented at the end of the review and deal with sustainability and energy transition, acceptability and ethics, learning models, open data policies and interoperability. The present work was carried out within the framework of the Energy Network of the Regional Leaders Summit (RLS-Energy) as part of its multilateral research efforts on smart regions.