LINGO1 Variants in the French-Canadian Population

Essential tremor (ET) is a complex genetic disorder for which no causative gene has been found. Recently, a genome-wide association study reported that two variants in the LINGO1 locus were associated to this disease. The aim of the present study was to test if this specific association could be replicated using a French-Canadian cohort of 259 ET patients and 479 ethnically matched controls. Our genotyping results lead us to conclude that no association exists between the key variant rs9652490 and ET (Pcorr = 1.00).

[1]  K. Xia,et al.  Screening for two SNPs of LINGO1 gene in patients with essential tremor or sporadic Parkinson's disease in Chinese population , 2010, Neuroscience Letters.

[2]  G. Deuschl,et al.  LINGO1 polymorphisms are associated with essential tremor in Europeans , 2010, Movement disorders : official journal of the Movement Disorder Society.

[3]  N. Park,et al.  Replication of the LINGO1 gene association with essential tremor in a North American population , 2010, European Journal of Human Genetics.

[4]  Matthew J. Farrer,et al.  LINGO1 and LINGO2 variants are associated with essential tremor and Parkinson disease , 2010, neurogenetics.

[5]  M. Farrer,et al.  LINGO1 rs9652490 is associated with essential tremor and Parkinson disease. , 2010, Parkinsonism & related disorders.

[6]  David B. Goldstein,et al.  Rare Variants Create Synthetic Genome-Wide Associations , 2010, PLoS biology.

[7]  Y. Teo,et al.  LINGO1 VARIANT INCREASES RISK OF FAMILIAL ESSENTIAL TREMOR , 2009, Neurology.

[8]  H. Stefánsson,et al.  Variant in the sequence of the LINGO1 gene confers risk of essential tremor , 2009, Nature Genetics.

[9]  Manuel A. R. Ferreira,et al.  PLINK: a tool set for whole-genome association and population-based linkage analyses. , 2007, American journal of human genetics.

[10]  Eden R Martin,et al.  No gene is an island: the flip-flop phenomenon. , 2007, American journal of human genetics.

[11]  E D Louis,et al.  Clinical practice. Essential tremor. , 2001, The New England journal of medicine.

[12]  C. Wider,et al.  Genetics of essential tremor. , 2012, Parkinsonism & related disorders.

[13]  Pak Chung Sham,et al.  Genetic Power Calculator: design of linkage and association genetic mapping studies of complex traits , 2003, Bioinform..