The Effect of Body Fat Tissue Distribution in Obese and Premenopausal Patients Complicated with Endometrial Hyperplasia

Objective: There is a close association between obesity and menstrual irregularity.This study is aimed to investigate lipoid tissue accumulation between overweight or obese premenopausal patients with endometrial hyperplasia and overweight or obese volunteers with benign pathologic lesions via using bioimpedance method. Materyal and methods: Obese or overweight volunteers with abnormal uterine bleeding were examined.88 volunteers meet inclusion criteria.We obtained fat mass, fat percentage and impedance of body parts by using Multi-Frequency Body Composition Analyzer.Blood lipid profile and ultrasonographic measurement of endometrial thickness were performed for all volunteers. Results:33 volunteers were in the hyperplasia group and 55 were in the control group. 28 of the 33 volunteers (84.8 %) had at least one increased fatty acids in endometrial hyperplasia group. 41 of the 55 patients (74.5 %) had at least one increased fatty acids in control group. Total cholesterol levels are higher in the hyperplasia group than the control group (p=0,006). There was no significant difference between hyperplasia and control group for bioimpedance analyses. Conclusion:Hyperlipidemia remains an important factor that contributes endometrial pathologies. Serum cholesterols were significantly high in endometrial hyperplasia group. Rather than lipoid tissue distribution, increased cholesterol may contribute gynecologic pathology occurrence in obese individuals complicated with endometrial hyperplasia.