Humanization of Murine Monoclonal anti-hTNF Antibody: The F10 Story

[1]  S. Danilov,et al.  ACE phenotyping in human heart , 2017, PloS one.

[2]  E. Letsiou,et al.  Lysozyme and bilirubin bind to ACE and regulate its conformation and shedding , 2016, Scientific Reports.

[3]  G. Gilliland,et al.  Engineering antibody therapeutics. , 2016, Current opinion in structural biology.

[4]  M. N. Petrov,et al.  Conformational fingerprinting of angiotensin-converting enzyme in the blood in health and disease , 2016, Moscow University Chemistry Bulletin.

[5]  D. Giannakis,et al.  Microvascular density and immunohistochemical expression of VEGF, VEGFR-1 and VEGFR-2 in benign prostatic hyperplasia, high-grade prostate intraepithelial neoplasia and prostate cancer , 2016, Central European journal of urology.

[6]  A. Gusakov,et al.  Tissue Specificity of Human Angiotensin I-Converting Enzyme , 2015, PloS one.

[7]  S. Ehlers,et al.  Control of Mycobacterial Infections in Mice Expressing Human Tumor Necrosis Factor (TNF) but Not Mouse TNF , 2015, Infection and Immunity.

[8]  Michael J. Osborn,et al.  Human Antibody Production in Transgenic Animals , 2014, Archivum Immunologiae et Therapiae Experimentalis.

[9]  Gert Vriend,et al.  YASARA View—molecular graphics for all devices—from smartphones to workstations , 2014, Bioinform..

[10]  Ross G. Douglas,et al.  A Novel Angiotensin I-Converting Enzyme Mutation (S333W) Impairs N-Domain Enzymatic Cleavage of the Anti-Fibrotic Peptide, AcSDKP , 2014, PloS one.

[11]  E. Sturrock,et al.  Peptidyl-Dipeptidase A/Angiotensin I-Converting Enzyme , 2013 .

[12]  S. Danilov,et al.  A Novel Splice-Site Mutation in Angiotensin I-Converting Enzyme (ACE) Gene, c.3691+1G>A (IVS25+1G>A), Causes a Dramatic Increase in Circulating ACE through Deletion of the Transmembrane Anchor , 2013, PloS one.

[13]  A. Koide,et al.  Generating conformation-specific synthetic antibodies to trap proteins in selected functional states. , 2013, Methods.

[14]  Melanie Y. White,et al.  Functional decorations: post-translational modifications and heart disease delineated by targeted proteomics , 2013, Genome Medicine.

[15]  K. Bernstein,et al.  A Modern Understanding of the Traditional and Nontraditional Biological Functions of Angiotensin-Converting Enzyme , 2013, Pharmacological Reviews.

[16]  M. N. Petrov,et al.  Conformational Changes of Blood ACE in Chronic Uremia , 2012, PloS one.

[17]  E. Sidransky.  Gaucher disease: insights from a rare Mendelian disorder. , 2012, Discovery medicine.

[18]  P. Reynolds,et al.  Gene therapy by targeted adenovirus-mediated knockdown of pulmonary endothelial Tph1 attenuates hypoxia-induced pulmonary hypertension. , 2012, Molecular therapy : the journal of the American Society of Gene Therapy.

[19]  S. Kalinin,et al.  An Angiotensin I-Converting Enzyme Mutation (Y465D) Causes a Dramatic Increase in Blood ACE via Accelerated ACE Shedding , 2011, PloS one.

[20]  P. Reynolds,et al.  Targeted gene delivery of BMPR2 attenuates pulmonary hypertension , 2011, European Respiratory Journal.

[21]  R. Bohle,et al.  Heterogeneous distribution of angiotensin I-converting enzyme (CD143) in the human and rat vascular systems: vessel, organ and species specificity. , 2011, Microvascular research.

[22]  L. Adamian,et al.  Cloning and characterization of a single-chain fragment of monoclonal antibody to ACE suitable for lung endothelial targeting. , 2010, Microvascular research.

[23]  I. V. Gachok,et al.  Conformational fingerprinting of the angiotensin I-converting enzyme (ACE). 1. Application in sarcoidosis. , 2010, Journal of proteome research.

[24]  H. Hecht,et al.  Porcine pulmonary angiotensin I-converting enzyme--biochemical characterization and spatial arrangement of the N- and C-domains by three-dimensional electron microscopic reconstruction. , 2010, Micron.

[25]  S. Kalinin,et al.  Angiotensin I-Converting Enzyme Gln1069Arg Mutation Impairs Trafficking to the Cell Surface Resulting in Selective Denaturation of the C-Domain , 2010, PloS one.

[26]  J. Schnitzer,et al.  Lung Vascular Targeting Using Antibody to Aminopeptidase P: CT-SPECT Imaging, Biodistribution and Pharmacokinetic Analysis , 2010, Journal of Vascular Research.

[27]  P. Hohenberger,et al.  Pre-ischaemic conditioning of the pulmonary endothelium by immunotargeting of catalase via angiotensin-converting-enzyme antibodies. , 2010, European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery.

[28]  E. Sturrock,et al.  Fine epitope mapping of monoclonal antibodies 9B9 and 3G8 to the N domain of angiotensin-converting enzyme (CD143) defines a region involved in regulating angiotensin-converting enzyme dimerization and shedding. , 2010, Tissue antigens.

[29]  S. Danilov,et al.  Angiotensin I-Converting Enzyme Mutation (Trp1197Stop) Causes a Dramatic Increase in Blood ACE , 2009, PloS one.

[30]  G. Efimov,et al.  Tumor Necrosis Factor and the consequences of its ablation in vivo. , 2009, Molecular immunology.

[31]  R. Dwek,et al.  Detailed N-glycan analysis of mannose receptor purified from murine spleen indicates tissue specific sialylation. , 2009, Biochemical and biophysical research communications.

[32]  E. Sasso,et al.  Comparisons of affinities, avidities, and complement activation of adalimumab, infliximab, and etanercept in binding to soluble and membrane tumor necrosis factor. , 2009, Clinical immunology.

[33]  E. Sturrock,et al.  Epitope mapping of mAbs to denatured human testicular ACE (CD143). , 2008, Tissue antigens.

[34]  G. Efimov,et al.  149 Mice in which human TNF is mediating both beneficial and deleterious functions: A model comparison of different blockade strategies , 2008 .

[35]  H. Chan.  What is the role of particle morphology in pharmaceutical powder aerosols? , 2008, Expert opinion on drug delivery.

[36]  E. Sturrock,et al.  Mapping of conformational mAb epitopes to the C domain of human angiotensin I-converting enzyme. , 2008, Journal of proteome research.

[37]  R. Albrecht,et al.  Fine epitope mapping of monoclonal antibody 5F1 reveals anticatalytic activity toward the N domain of human angiotensin-converting enzyme. , 2007, Biochemistry.

[38]  R. Albrecht,et al.  Immunotargeting of catalase to lung endothelium via anti-angiotensin-converting enzyme antibodies attenuates ischemia-reperfusion injury of the lung in vivo. , 2007, American journal of physiology. Lung cellular and molecular physiology.

[39]  D. Curiel,et al.  Bone morphogenetic protein type 2 receptor gene therapy attenuates hypoxic pulmonary hypertension. , 2007, American journal of physiology. Lung cellular and molecular physiology.

[40]  R. Albrecht,et al.  Monoclonal Antibodies 1G12 and 6A12 to the N-domain of human angiotensin-converting enzyme: fine epitope mapping and antibody-based detection of ACE inhibitors in human blood. , 2007, Journal of proteome research.

[41]  V. A. Palyulin,et al.  Inhibitory antibodies to human angiotensin-converting enzyme: fine epitope mapping and mechanism of action. , 2006, Biochemistry.

[42]  R. Albrecht,et al.  Testicular Isoform of Angiotensin I‐Converting Enzyme (ACE, CD143) on the Surface of Human Spermatozoa: Revelation and Quantification Using Monoclonal Antibodies , 2006, American journal of reproductive immunology.

[43]  V. Muzykantov.  Biomedical aspects of targeted delivery of drugs to pulmonary endothelium , 2005, Expert opinion on drug delivery.

[44]  Corinne Antignac,et al.  Mutations in genes in the renin-angiotensin system are associated with autosomal recessive renal tubular dysgenesis , 2005, Nature Genetics.

[45]  A. Dominiczak,et al.  Targeting endothelial cells with adenovirus expressing nitric oxide synthase prevents elevation of blood pressure in stroke-prone spontaneously hypertensive rats. , 2005, Molecular therapy : the journal of the American Society of Gene Therapy.

[46]  D. Curiel,et al.  Selective rat lung endothelial targeting with a new set of monoclonal antibodies to angiotensin I-converting enzyme. , 2005, Pulmonary pharmacology & therapeutics.

[47]  E. Sturrock,et al.  The N domain of somatic angiotensin-converting enzyme negatively regulates ectodomain shedding and catalytic activity. , 2005, The Biochemical journal.

[48]  R. Albrecht,et al.  Detection of mutated angiotensin I-converting enzyme by serum/plasma analysis using a pair of monoclonal antibodies. , 2005, Clinical chemistry.

[49]  R. Albrecht,et al.  Development and characterization of rat monoclonal antibodies to denatured mouse angiotensin-converting enzyme. , 2005, Tissue antigens.

[50]  R. Albrecht,et al.  Monoclonal antibodies 1B3 and 5C8 as probes for monitoring the integrity of the C-terminal end of soluble angiotensin-converting enzyme. , 2005, Hybridoma.

[51]  N. Hooper,et al.  Secretase-mediated cell surface shedding of the angiotensin-converting enzyme. , 2004, Protein and peptide letters.

[52]  M. Capecchi,et al.  Mice with cardiac-restricted angiotensin-converting enzyme (ACE) have atrial enlargement, cardiac arrhythmia, and sudden death. , 2004, The American journal of pathology.

[53]  Napoleone Ferrara,et al.  Vascular endothelial growth factor: basic science and clinical progress. , 2004, Endocrine reviews.

[54]  G. Adema,et al.  Angiotensin-converting enzyme (CD143) is abundantly expressed by dendritic cells and discriminates human monocyte-derived dendritic cells from acute myeloid leukemia-derived dendritic cells. , 2003, Experimental hematology.

[55]  R. Albrecht,et al.  Epitope-dependent blocking of the angiotensin-converting enzyme dimerization by monoclonal antibodies to the N-terminal domain of ACE: possible link of ACE dimerization and shedding from the cell surface. , 2003, Biochemistry.

[56]  G. Abelev,et al.  New Approaches for the Detection and Characterization of Alpha-Fetoprotein Epitope Variants , 2003, Tumor Biology.

[57]  S. Nedospasov,et al.  Characterization of the genes encoding variable light and heavy chains of the high-affinity monoclonal antibody against human tumor necrosis factor. , 2002, Russian journal of immunology : RJI : official journal of Russian Society of Immunology.

[58]  S. S. Levinson,et al.  Towards a better understanding of heterophile (and the like) antibody interference with modern immunoassays. , 2002, Clinica chimica acta; international journal of clinical chemistry.

[59]  R. Albrecht,et al.  Epitope-specific antibody-induced cleavage of angiotensin-converting enzyme from the cell surface. , 2002, The Biochemical journal.

[60]  E. Lonn,et al.  The relevance of tissue angiotensin-converting enzyme: manifestations in mechanistic and endpoint data. , 2001, The American journal of cardiology.

[61]  C. V. van Duijn,et al.  Point Mutation in the Stalk of Angiotensin-Converting Enzyme Causes a Dramatic Increase in Serum Angiotensin-Converting Enzyme But No Cardiovascular Disease , 2001, Circulation.

[62]  D. Curiel,et al.  Combined transductional and transcriptional targeting improves the specificity of transgene expression in vivo , 2001, Nature Biotechnology.

[63]  V. Muzykantov,et al.  Lung uptake of antibodies to endothelial antigens: key determinants of vascular immunotargeting. , 2001, American journal of physiology. Lung cellular and molecular physiology.

[64]  L. Cardon,et al.  Association study designs for complex diseases , 2001, Nature Reviews Genetics.

[65]  D. Curiel,et al.  A targetable, injectable adenoviral vector for selective gene delivery to pulmonary endothelium in vivo. , 2000, Molecular therapy : the journal of the American Society of Gene Therapy.

[66]  T. Klonisch,et al.  Somatic isoform of angiotensin I-converting enzyme in the pathology of testicular germ cell tumors. , 2000, Human pathology.

[67]  Inder M. Verma,et al.  Gene therapy: trials and tribulations , 2000, Nature Reviews Genetics.

[68]  A. Goette,et al.  Increased expression of extracellular signal-regulated kinase and angiotensin-converting enzyme in human atria during atrial fibrillation. , 2000, Journal of the American College of Cardiology.

[69]  V. Muzykantov,et al.  Immunotargeting of catalase to ACE or ICAM-1 protects perfused rat lungs against oxidative stress. , 1998, American journal of physiology. Lung cellular and molecular physiology.

[70]  V. Muzykantov,et al.  Targeting of antibody-conjugated plasminogen activators to the pulmonary vasculature. , 1996, The Journal of pharmacology and experimental therapeutics.

[71]  L. Tarnow,et al.  Development of enzyme-linked immunoassays for human angiotensin I converting enzyme suitable for large-scale studies , 1996, Journal of hypertension.

[72]  V. Muzykantov,et al.  Immunotargeting of antioxidant enzyme to the pulmonary endothelium. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[73]  S. Nedospasov,et al.  [Human tumor necrosis factor mutants: preparation and some properties]. , 1996, Bioorganicheskaia khimiia.

[74]  N. Voitenok,et al.  Homologous ELISA for detection of oligomeric human TNF: properties of the assay. , 1995, Journal of immunological methods.

[75]  G. Palade,et al.  Increased microvascular permeability and endothelial fenestration induced by vascular endothelial growth factor. , 1995, Journal of cell science.

[76]  R. Bohle,et al.  Cellular distribution of angiotensin-converting enzyme after myocardial infarction. , 1995, Hypertension.

[77]  H. Towbin,et al.  Structure-function analysis of angiotensin I-converting enzyme using monoclonal antibodies. Selective inhibition of the amino-terminal active site. , 1994, The Journal of biological chemistry.

[78]  V. Torchilin,et al.  Purification of radiolabeled monoclonal antibodies to angiotensin-converting enzyme significantly improves specificity and efficacy of its targeting into the lung. , 1993, Nuclear medicine and biology.

[79]  P Corvol,et al.  An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels. , 1990, The Journal of clinical investigation.

[80]  V. Muzykantov,et al.  Monoclonal antibodies to angiotensin-converting enzyme: a powerful tool for lung and vessel studies. , 1989, Journal of molecular and cellular cardiology.

[81]  P Corvol,et al.  Two putative active centers in human angiotensin I-converting enzyme revealed by molecular cloning. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[82]  S. Danilov,et al.  Isolation of human liver angiotensin-converting enzyme by chromatofocusing. , 1987, Analytical biochemistry.

[83]  S. Danilov,et al.  Monoclonal Antibody to Human Lung Angiotensin‐Converting Enzyme , 1987, Biotechnology and applied biochemistry.

[84]  S. Danilov,et al.  Affinity chromatography and some properties of the angiotensin-converting enzyme from human heart. , 1987, Biochimica et biophysica acta.

[85]  T. Espevik,et al.  A highly sensitive cell line, WEHI 164 clone 13, for measuring cytotoxic factor/tumor necrosis factor from human monocytes. , 1986, Journal of immunological methods.

[86]  I. I. Sakharov,et al.  [Isolation and properties of the angiotensin-converting enzyme from human lungs]. , 1986, Biokhimiia.

[87]  R. Auerbach,et al.  Expression of organ-specific antigens on capillary endothelial cells. , 1985, Microvascular research.

[88]  G. Hohlbrugger,et al.  Angiotensin I converting enzyme in the ejaculate of fertile and infertile men. , 1984, Fertility and sterility.

[89]  E. Silverstein,et al.  Angiotensin-converting enzyme in macrophages and Freund's adjuvant granuloma. , 1978, Israel journal of medical sciences.

[90]  E. Silverstein,et al.  Elevated serum and spleen angiotensin converting enzyme and serum lysozyme in Gaucher's disease. , 1977, Clinica chimica acta; international journal of clinical chemistry.

[91]  E. Silverstein,et al.  ELEVATION OF ANGIOTENSIN‐CONVERTING ENZYME IN GRANULOMATOUS LYMPH NODES AND SERUM IN SARCOIDOSIS: CLINICAL AND POSSIBLE PATHOGENIC SIGNIFICANCE * , 1976, Annals of the New York Academy of Sciences.

[92]  E. Beutler,et al.  Elevation of serum angiotensin-converting enzyme in Gaucher's disease. , 1976, The New England journal of medicine.

[93]  J. Lieberman.  Elevation of serum angiotensin-converting-enzyme (ACE) level in sarcoidosis. , 1975, The American journal of medicine.

[94]  C. Milstein,et al.  Continuous cultures of fused cells secreting antibody of predefined specificity , 1975, Nature.

[95]  S. Kalinin,et al.  Angiotensin I-converting enzyme mutation (Y465D) cause dramatic increase in blood ACE via accelerated ACE shedding due to changes of ACE dimerization , 2011 .

[96]  S. Kalinin,et al.  Gln1069Arg angiotensin I-converting enzyme mutation impairs transport to the cell surface resulting in selective denaturation of the C domain , 2010 .

[97]  S. Danilov,et al.  Point mutation of angiotensin I-converting enzyme (Trp1197Stop) determines a dramatic increase in blood ACE , 2009 .

[98]  P. Taylor,et al.  Monoclonal antibodies to native mouse angiotensin-converting enzyme (CD143): ACE expression quantification, lung endothelial cell targeting and gene delivery. , 2006, Tissue antigens.

[99]  I. Balyasnikova,et al.  Monoclonal antibodies to denatured human ACE (CD 143), broad species specificity, reactivity on paraffin sections, and detection of subtle conformational changes in the C-terminal domain of ACE. , 2003, Tissue antigens.

[100]  M. Feldmann,et al.  Anti-TNF alpha therapy of rheumatoid arthritis: what have we learned? , 2001, Annual review of immunology.

[101]  J. Ménard,et al.  Angiotensin-converting enzyme inhibitors. , 2001, Advances in protein chemistry.

[102]  P. Terasaki,et al.  The UNOS scientific renal transplant registry. United Network for Organ Sharing. , 1995, Clinical transplants.

[103]  L. Wein,et al.  Structure-Function Analysis of Angiotensin I-converting Enzyme Using Monoclonal Antibodies , 1994 .

[104]  P. Corvol,et al.  Distribution of plasma angiotensin I-converting enzyme levels in healthy men: relationship to environmental and hormonal parameters. , 1991, The Journal of laboratory and clinical medicine.

[105]  V. Muzykantov,et al.  Lung is the target organ for a monoclonal antibody to angiotensin-converting enzyme. , 1991, Laboratory investigation; a journal of technical methods and pathology.

[106]  Tzartos Sj.  Myasthenia gravis studied by monoclonal antibodies to the acetylcholine receptor. , 1988 .

[107]  L. Shingarova,et al.  Tandem arrangement of genes coding for tumor necrosis factor (TNF-alpha) and lymphotoxin (TNF-beta) in the human genome. , 1986, Cold Spring Harbor symposia on quantitative biology.

[108]  S. Danilov,et al.  Mitogen-induced disorganization of capillary-like structures formed by human large vessel endothelial cells in vitro. , 1986, Tissue & cell.

[109]  Rømer Fk.  Clinical and biochemical aspects of sarcoidosis. With special reference to angiotensin-converting enzyme (ACE). , 1984 .