A Core Human Primary Tumor Angiogenesis Signature Identifies the Endothelial Orphan Receptor ELTD1 as a Key Regulator of Angiogenesis
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Demin Li | Francesca M. Buffa | Roger Patient | Hee Dong Han | Heather Dalton | Adrian L. Harris | Gabriel Lopez-Berestein | A. Harris | J. Tuynman | A. Banham | A. Sood | E. Bridges | Ji-Liang Li | G. Lopez-Berestein | Cheng Han | F. Buffa | S. Wu | H. Han | R. Patient | L. Mangala | Anil K. Sood | Sunila Pradeep | Lingegowda S. Mangala | M. Masiero | Filipa C. Simões | C. Snell | T. Peterkin | S. Pradeep | Demin Li | H. Dalton | N. Mortensen | Cameron Snell | Ji-Liang Li | Alison H. Banham | Jurriaan B. Tuynman | Tessa Peterkin | Massimo Masiero | Filipa Costa Simões | Esther Bridges | Sherry Yen-Yao Wu | Cheng Han | Neil Mortensen | Tessa Peterkin
[1] Zhen-ping Zhu,et al. Development of angiogenesis inhibitors to vascular endothelial growth factor receptor 2. Current status and future perspective. , 2005, Frontiers in bioscience : a journal and virtual library.
[2] Wen Shi,et al. Delta-like 4 Notch ligand regulates tumor angiogenesis, improves tumor vascular function, and promotes tumor growth in vivo. , 2007, Cancer research.
[3] Thomas Quertermous,et al. The embryonic angiogenic factor Del1 accelerates tumor growth by enhancing vascular formation. , 2002, Microvascular research.
[4] K. Kinzler,et al. Genes expressed in human tumor endothelium. , 2000, Science.
[5] A. Harris,et al. Crosstalk of VEGF and Notch pathways in tumour angiogenesis: therapeutic implications. , 2009, Frontiers in bioscience.
[6] A. Harris,et al. Vascular Biology , Atherosclerosis and Endothelium Biolog y Expression of Vascular Notch Ligand Delta-Like 4 and Inflammatory Markers in Breast Cancer , 2010 .
[7] T. Koyama,et al. The GPCR modulator protein RAMP2 is essential for angiogenesis and vascular integrity. , 2008, The Journal of clinical investigation.
[8] T. Nechiporuk,et al. ETL, a Novel Seven-transmembrane Receptor That Is Developmentally Regulated in the Heart , 2001, The Journal of Biological Chemistry.
[9] T. Kume,et al. The Foxc2 Transcription Factor Regulates Angiogenesis via Induction of Integrin β3 Expression* , 2008, Journal of Biological Chemistry.
[10] H. Stuhlmann,et al. EGFL7: a unique angiogenic signaling factor in vascular development and disease. , 2012, Blood.
[11] B. Scheithauer,et al. Endoglin (CD105): a review of its role in angiogenesis and tumor diagnosis, progression and therapy. , 2011, Anticancer research.
[12] Holger Gerhardt,et al. Angiogenesis: a team effort coordinated by notch. , 2009, Developmental cell.
[13] M. Newton,et al. Fundamental differences in cell cycle deregulation in human papillomavirus-positive and human papillomavirus-negative head/neck and cervical cancers. , 2007, Cancer research.
[14] S. Mousa,et al. Studies with an Orally Bioavailable αV Integrin Antagonist in Animal Models of Ocular Vasculopathy: Retinal Neovascularization in Mice and Retinal Vascular Permeability in Diabetic Rats , 2008, Journal of Pharmacology and Experimental Therapeutics.
[15] Olivier Poch,et al. Identification of genes associated with tumorigenesis and metastatic potential of hypopharyngeal cancer by microarray analysis , 2004, Oncogene.
[16] H. DeLisser,et al. Angiogenesis in platelet endothelial cell adhesion molecule-1-null mice. , 2009, The American journal of pathology.
[17] J. Mably,et al. An Acyltransferase Controls the Generation of Hematopoietic and Endothelial Lineages in Zebrafish , 2008, Circulation research.
[18] E. Lundberg,et al. Towards a knowledge-based Human Protein Atlas , 2010, Nature Biotechnology.
[19] A. Fukamizu,et al. Identification and functional analysis of endothelial tip cell–enriched genes , 2022 .
[20] Sergi Ferré,et al. GPCR homomers and heteromers: a better choice as targets for drug development than GPCR monomers? , 2009, Pharmacology & therapeutics.
[21] Heather Verkade,et al. Genetic and cellular analyses of zebrafish atrioventricular cushion and valve development , 2005, Development.
[22] Z. Nagy,et al. of Identification of novel vascular markers through gene expression profiling of tumor-derived endothelium , 2008 .
[23] F. Hsieh,et al. Germ‐line transmission of a myocardium‐specific GFP transgene reveals critical regulatory elements in the cardiac myosin light chain 2 promoter of zebrafish , 2003, Developmental dynamics : an official publication of the American Association of Anatomists.
[24] R. Tibshirani,et al. Significance analysis of microarrays applied to the ionizing radiation response , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[25] P. Hall,et al. An expression signature for p53 status in human breast cancer predicts mutation status, transcriptional effects, and patient survival. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[26] T. Mcclanahan,et al. Microarray analysis of primary endothelial cells challenged with different inflammatory and immune cytokines. , 2005, Cytokine.
[27] H. Stuhlmann,et al. Targeted Vezf1-Null Mutation Impairs Vascular Structure Formation During Embryonic Stem Cell Differentiation , 2010, Arteriosclerosis, thrombosis, and vascular biology.
[28] Marie Joseph,et al. Gene Signatures of Progression and Metastasis in Renal Cell Cancer , 2005, Clinical Cancer Research.
[29] Christophe Dussert,et al. Targeting adrenomedullin receptors with systemic delivery of neutralizing antibodies inhibits tumor angiogenesis and suppresses growth of human tumor xenografts in mice , 2009, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[30] Gavin Thurston,et al. Dll4-Notch signaling as a therapeutic target in tumor angiogenesis , 2011, Vascular cell.
[31] Fabian Kiessling,et al. Vascular normalization in Rgs5-deficient tumours promotes immune destruction , 2008, Nature.
[32] A. Villers,et al. Vascular endocan (ESM‐1) is markedly overexpressed in clear cell renal cell carcinoma , 2010, Histopathology.
[33] A. Sobel,et al. The Journal of Biological Chemistry. , 2009, Nutrition reviews.
[34] Hongliang Li,et al. Augmented Cardiac Hypertrophy in Response to Pressure Overload in Mice Lacking ELTD1 , 2012, PloS one.
[35] David E. Gloriam,et al. The human and mouse repertoire of the adhesion family of G-protein-coupled receptors. , 2004, Genomics.
[36] Dov Stekel,et al. The University of Birmingham ( Live System ) A novel method of differential gene expression analysis using multiple cDNA libraries applied to the identification of tumour endothelial genes , 2016 .
[37] Clifford A. Meyer,et al. Genome-wide analysis of estrogen receptor binding sites , 2006, Nature Genetics.
[38] A. Harris,et al. DLL4-Notch signaling mediates tumor resistance to anti-VEGF therapy in vivo. , 2011, Cancer research.
[39] L. Giacomelli,et al. CD105 is a marker of tumour vasculature and a potential target for the treatment of head and neck squamous cell carcinoma. , 2010, Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology.
[40] Nathan D. Lawson,et al. Notch signalling limits angiogenic cell behaviour in developing zebrafish arteries , 2007, Nature.
[41] P. Carmeliet,et al. Differential Endothelial Transcriptomics Identifies Semaphorin 3G as a Vascular Class 3 Semaphorin , 2011, Arteriosclerosis, thrombosis, and vascular biology.
[42] A. Griffioen,et al. In silico analysis of angiogenesis associated gene expression identifies angiogenic stage related profiles. , 2005, Biochimica et biophysica acta.
[43] G. Thurston,et al. VEGF and Delta-Notch: interacting signalling pathways in tumour angiogenesis , 2008, British Journal of Cancer.
[44] Holger Gerhardt,et al. Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis , 2007, Nature.
[45] M. Maio,et al. Targeting cancer vasculature via endoglin/CD105: a novel antibody-based diagnostic and therapeutic strategy in solid tumours. , 2010, Cardiovascular research.
[46] J. Madri,et al. Lack of platelet endothelial cell adhesion molecule-1 attenuates foreign body inflammation because of decreased angiogenesis. , 2003, The American journal of pathology.
[47] C. Sorenson,et al. Attenuation of retinal vascular development and neovascularization in PECAM-1-deficient mice. , 2008, Developmental biology.
[48] H. Moch,et al. Tissue microarray (TMA) technology: miniaturized pathology archives for high‐throughput in situ studies , 2001, The Journal of pathology.
[49] A. Molinolo,et al. Viral G protein-coupled receptor up-regulates Angiopoietin-like 4 promoting angiogenesis and vascular permeability in Kaposi's sarcoma , 2010, Proceedings of the National Academy of Sciences.
[50] M. Abe,et al. Vascular Endothelial Zinc Finger 1 Is Involved in the Regulation of Angiogenesis: Possible Contribution of Stathmin/OP18 as a Downstream Target Gene , 2004, Arteriosclerosis, thrombosis, and vascular biology.
[51] D. Hanahan,et al. Hallmarks of Cancer: The Next Generation , 2011, Cell.
[52] Gavin Thurston,et al. Haploinsufficiency of delta-like 4 ligand results in embryonic lethality due to major defects in arterial and vascular development. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[53] Yi Zhou,et al. Mutant-specific gene programs in the zebrafish. , 2005, Blood.
[54] K. Moulton,et al. E-selectin is required for the antiangiogenic activity of endostatin. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[55] Ronald J Moore,et al. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. , 2005, Journal of proteome research.
[56] A. Harris,et al. Large meta-analysis of multiple cancers reveals a common, compact and highly prognostic hypoxia metagene , 2010, British Journal of Cancer.
[57] Experimental Cell Research , 1949, Nature.
[58] E. Dejana,et al. Endothelial cadherins and tumor angiogenesis. , 2006, Experimental cell research.
[59] Peter Carmeliet,et al. VEGF as a Key Mediator of Angiogenesis in Cancer , 2005, Oncology.
[60] Pengcheng Zhu,et al. Emerging Roles of Angiopoietin-like 4 in Human Cancer , 2012, Molecular Cancer Research.
[61] B. Göttgens,et al. The SCL gene specifies haemangioblast development from early mesoderm , 1998, The EMBO journal.
[62] Gurpreet W. Tang,et al. Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes , 2009, Nature.
[63] Markus Thomas,et al. The role of the Angiopoietins in vascular morphogenesis , 2009, Angiogenesis.
[64] S. Germain,et al. Alteration of Developmental and Pathological Retinal Angiogenesis in angptl4-deficient Mice* , 2011, The Journal of Biological Chemistry.
[65] M. Engelse,et al. Differential gene expression analysis of tubule forming and non-tubule forming endothelial cells: CDC42GAP as a counter-regulator in tubule formation , 2007, Angiogenesis.
[66] Gianluca Bontempi,et al. Predicting prognosis using molecular profiling in estrogen receptor-positive breast cancer treated with tamoxifen , 2008, BMC Genomics.
[67] P. Carmeliet,et al. Molecular mechanisms and clinical applications of angiogenesis , 2011, Nature.
[68] Jeong Won Lee,et al. Targeted Gene Silencing Using RGD-Labeled Chitosan Nanoparticles , 2010, Clinical Cancer Research.
[69] D. Driscoll,et al. Novel Roles of GATA1 in Regulation of Angiogenic Factor AGGF1 and Endothelial Cell Function* , 2009, The Journal of Biological Chemistry.
[70] L. Zanetta,et al. Expression of von Willebrand factor, an endothelial cell marker, is up‐regulated by angiogenesis factors: A potential method for objective assessment of tumor angiogenesis , 2000, International journal of cancer.
[71] E. Larsson,et al. Identification of a Core Set of 58 Gene Transcripts With Broad and Specific Expression in the Microvasculature , 2008, Arteriosclerosis, thrombosis, and vascular biology.
[72] Shuo Lin,et al. Identification of novel vascular endothelial-specific genes by the microarray analysis of the zebrafish cloche mutants. , 2005, Blood.
[73] A. Hartmann,et al. Endocan is upregulated on tumor vessels in invasive bladder cancer where it mediates VEGF-A-induced angiogenesis. , 2013, Cancer research.
[74] K. Park,et al. Involvement of E-selectin in recruitment of endothelial progenitor cells and angiogenesis in ischemic muscle. , 2007, Blood.
[75] S. Gordon,et al. The EGF-TM7 family: a postgenomic view , 2003, Immunogenetics.
[76] E. Jubeli,et al. E-selectin as a target for drug delivery and molecular imaging. , 2012, Journal of controlled release : official journal of the Controlled Release Society.
[77] Tasuku Honjo,et al. Haploinsufficient lethality and formation of arteriovenous malformations in Notch pathway mutants. , 2004, Genes & development.
[78] Janet Rossant,et al. Dosage-sensitive requirement for mouse Dll4 in artery development. , 2004, Genes & development.
[79] Rakesh K. Jain,et al. Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases , 2011, Nature Reviews Drug Discovery.
[80] T. Seidler,et al. Overexpression of Integrin &bgr;5 Enhances the Paracrine Properties of Circulating Angiogenic Cells via Src Kinase–Mediated Activation of STAT3 , 2010, Arteriosclerosis, thrombosis, and vascular biology.
[81] R. Bicknell,et al. Slits and Roundabouts in cancer, tumour angiogenesis and endothelial cell migration , 2008, Angiogenesis.
[82] Marie-José Goumans,et al. Endoglin in angiogenesis and vascular diseases , 2008, Angiogenesis.
[83] G. Calin,et al. Regulation of tumor angiogenesis by EZH2. , 2010, Cancer cell.
[84] B. Seon,et al. Anti‐endoglin monoclonal antibodies are effective for suppressing metastasis and the primary tumors by targeting tumor vasculature , 2009, International journal of cancer.
[85] J Zhang,et al. Angiogenic Factor AGGF1 Promotes Therapeutic Angiogenesis in a Mouse Limb Ischemia Model , 2012, PloS one.
[86] P. Szafranski,et al. Identification of an angiogenic factor that when mutated causes susceptibility to Klippel–Trenaunay syndrome , 2004, Nature.
[87] Bin Tean Teh,et al. Two Distinct Types of Blood Vessels in Clear Cell Renal Cell Carcinoma Have Contrasting Prognostic Implications , 2007, Clinical Cancer Research.
[88] A. Griffioen,et al. Gene expression of tumor angiogenesis dissected: specific targeting of colon cancer angiogenic vasculature. , 2006, Blood.
[89] H. Ishikura,et al. Expression of regulator of G protein signalling protein 5 (RGS5) in the tumour vasculature of human renal cell carcinoma , 2004, The Journal of pathology.
[90] H. Augustin,et al. Transcriptional profiling of human glioblastoma vessels indicates a key role of VEGF‐A and TGFβ2 in vascular abnormalization , 2012, The Journal of pathology.
[91] Liz Y. Han,et al. Chronic stress promotes tumor growth and angiogenesis in a mouse model of ovarian carcinoma , 2006, Nature Medicine.
[92] B. Weinstein,et al. Angiogenic network formation in the developing vertebrate trunk , 2003, Development.
[93] Adam L. Bermange,et al. Endothelial signalling by the Notch ligand Delta-like 4 restricts angiogenesis , 2007, Development.
[94] Crispin J. Miller,et al. Relation of a hypoxia metagene derived from head and neck cancer to prognosis of multiple cancers. , 2007, Cancer research.
[95] Cory B. Giles,et al. ELTD1, a potential new biomarker for gliomas. , 2013, Neurosurgery.
[96] Yi-Lin Yan,et al. Double fluorescent in situ hybridization to zebrafish embryos. , 1996, Trends in genetics : TIG.
[97] Pierre Corvol,et al. Angiopoietin-like 4 is a proangiogenic factor produced during ischemia and in conventional renal cell carcinoma. , 2003, The American journal of pathology.
[98] X. Liu,et al. Over-Expression of the Endocan Gene in Endothelial Cells from Hepatocellular Carcinoma is Associated with Angiogenesis and Tumour Invasion , 2010, The Journal of international medical research.
[99] R. Swann,et al. Vascular Endothelial Growth Factor Receptors VEGFR-2 and VEGFR-3 Are Localized Primarily to the Vasculature in Human Primary Solid Cancers , 2010, Clinical Cancer Research.
[100] M. van Engeland,et al. VHL and HIF signalling in renal cell carcinogenesis , 2010, The Journal of pathology.
[101] Thomas Korff,et al. Integration of Endothelial Cells in Multicellular Spheroids Prevents Apoptosis and Induces Differentiation , 1998, The Journal of cell biology.
[102] S. Seaman,et al. Genes that distinguish physiological and pathological angiogenesis. , 2007, Cancer cell.