Levamisole-Induced Vasculitis

Levamisole-contaminated cocaine is an increasingly reported cause of a syndrome characterized by vasculitic skin lesions and immunologic abnormalities. With approximately 70% of cocaine in the United States now contaminated with levamisole, the incidence of this syndrome is likely to increase. We report two cases of this syndrome and review its clinical presentation, course, and prognosis.

[1]  H. Rennke,et al.  Contaminated cocaine and antineutrophil cytoplasmic antibody-associated disease. , 2011, Clinical journal of the American Society of Nephrology : CJASN.

[2]  N. Craft,et al.  Characteristic purpura of the ears, vasculitis, and neutropenia--a potential public health epidemic associated with levamisole-adulterated cocaine. , 2011, Journal of the American Academy of Dermatology.

[3]  J. Lipoff,et al.  A novel cutaneous vasculitis syndrome induced by levamisole-contaminated cocaine , 2011, Clinical Rheumatology.

[4]  U. Specks.  The growing complexity of the pathology associated with cocaine use. , 2011, Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases.

[5]  J. Osterloh,et al.  Levamisole: A Dangerous New Cocaine Adulterant , 2010, Clinical pharmacology and therapeutics.

[6]  G. Jacquet,et al.  A Confirmed Case of Agranulocytosis after Use of Cocaine Contaminated with Levamisole , 2010, Journal of Medical Toxicology.

[7]  V. Majithia,et al.  Cocaine use and its rheumatic manifestations: a case report and discussion , 2007, Clinical Rheumatology.

[8]  Augustine S. Lee,et al.  Antineutrophil cytoplasmic antibodies reacting with human neutrophil elastase as a diagnostic marker for cocaine-induced midline destructive lesions but not autoimmune vasculitis. , 2004, Arthritis and rheumatism.

[9]  F. Facchetti,et al.  Cocaine-induced midline destructive lesions: clinical, radiographic, histopathologic, and serologic features and their differentiation from Wegener granulomatosis. , 2001, Medicine.

[10]  A. Edefonti,et al.  Purpura of the ears: a distinctive vasculopathy with circulating autoantibodies complicating long‐term treatment with levamisole in children , 1999, The British journal of dermatology.