Comparison of two optimizing algorithms for cerebral blood flow analysis using the intravenous 133Xe wash-out method.

The analysis of cerebral blood flow data using intravenous injection and inhalation of 133Xe requires a correction for the arterial recirculation. With a multi-exponential transfer function a problem exists in estimating the non-linear parameters. In this paper conventional two-compartmental blood flow indices from the intravenous 133Xe clearance method are calculated using Marquardt and variable metric optimizing algorithms. Close agreement was found between these two methods in that they yield similar values for the cerebral transfer function.

[1]  N. Lassen,et al.  Tracer kinetic methods in medical physiology , 1979 .

[2]  J. Seylaz,et al.  Measurement of regional cerebral blood flow by intravenous injection of Xe133. , 1979, Medical progress through technology.

[3]  D. Marquardt.  An Algorithm for Least-Squares Estimation of Nonlinear Parameters , 1963 .

[4]  G. Austin,et al.  Description and early results of an intravenous radioisotope technique for measuring regional cerebral blood flow in man. , 1972, European neurology.

[5]  D. Wyper,et al.  Two minute slope inhalation technique for cerebral blood flow measurement in man. 1. Method. , 1976, Journal of neurology, neurosurgery, and psychiatry.

[6]  T. Kallanranta,et al.  An intravenous isotope method for measuring regional cerebral blood flow (rCBF) and volume (rCBV). , 1977, Physics in medicine and biology.

[7]  J. Risberg,et al.  Regional Cerebral Blood Flow by 133Xenon Inhalation: Preliminary Evaluation of an Initial Slope Index in Patients with Unstable Flow Compartments , 1975, Stroke.

[8]  L. Symon,et al.  An intravenous 133Xenon clearance technique for measuring cerebral blood flow , 1979, Journal of the Neurological Sciences.

[9]  W. Obrist,et al.  Regional cerebral blood flow estimated by 133-xenon inhalation. , 1975, Stroke.

[10]  R. Fletcher,et al.  A New Approach to Variable Metric Algorithms , 1970, Comput. J..

[11]  J. Meyer.  Improved Method for Noninvasive Measurement of Regional Cerebral Blood Flow by 133Xenon Inhalation Part II: Measurements in Health and Disease , 1978, Stroke.