Development of a Pilot Plant Facility for the Conversion of Renewables in Biotechnological Processes

The experience of recent years has shown that a swift transfer of new biotechnological processes into practice often fails due to the lack of a reference facility that can be used for multiple applications. Besides the basic research there is a need for investigations at different scales from the laboratory to the industrial scale. The construction of a pilot plant facility for the production of lactic acid at the Leibniz Institute for Agricultural Engineering Potsdam‐Bornim (ATB) consequently fills a gap in the various phases of bioprocess engineering from applied fundamental via application research to the launch of biotechnological processes in practice. An example of a biorefinery is presented, which produces 10 t lactic acid in 200 days per year. The steps of project development from the idea and concept up to the planning and installation of the plant are described. First results for the manufacture of lactic acid from rye wholemeal illustrate the conformity with existing investigations. Further research may lead to an increase in the long‐term stability of the fermentation and to an adaptation of the process to the demands of product quality. The availability of product samples should familiarize interested partners in industry with the specific product requirements and win them as cooperation partners for research projects.

[1]  S. Rakshit,et al.  Direct fermentative production of lactic acid on cassava and other starch substrates , 1997, Biotechnology Letters.

[2]  Guido Zacchi,et al.  An economic evaluation of the fermentative production of lactic acid from wheat flour , 2000 .

[3]  Kamalesh K. Sirkar,et al.  Membrane in a reactor: A functional perspective , 1999 .

[4]  Seung-Hyeon Moon,et al.  Lactic acid recovery from fermentation broth using one‐stage electrodialysis , 2001 .

[6]  Alex Patist,et al.  Fermentation goes large-scale , 2003 .

[7]  David F. Ollis,et al.  Biochemical Engineering Fundamentals , 1976 .

[8]  Seung-Hyeon Moon,et al.  Lactic acid recovery using two-stage electrodialysis and its modelling , 1998 .

[9]  V. Kasche,et al.  Aufarbeitung von Bioprodukten , 2000 .

[10]  R. P. John,et al.  Production of L(+) lactic acid from cassava starch hydrolyzate by immobilized Lactobacillus delbrueckii , 2007, Journal of basic microbiology.

[11]  C. Berthold,et al.  Biotechnological Conversion of Sugar and Starchy Crops into Lactic Acid , 1998 .

[12]  Production of Lactic Acid from Barley: Strain Selection, Phenotypic and Medium Optimization , 2006 .

[13]  Hwa-Won Ryu,et al.  Lactic acid production from agricultural resources as cheap raw materials. , 2005, Bioresource technology.

[14]  Y. Linko,et al.  Simultaneous liquefaction, saccharification, and lactic acid fermentation on barley starch , 1996 .

[15]  Mathieu Bailly,et al.  Production of organic acids by bipolar electrodialysis: realizations and perspectives , 2002 .

[16]  C. Nolasco-Hipólito,et al.  Synchronized fresh cell bioreactor system for continuous L-(+)-lactic acid production using Lactococcus lactis IO-1 in hydrolysed sago starch. , 2002, Journal of bioscience and bioengineering.