Protective effect of the HLA-Bw4I80 epitope and the killer cell immunoglobulin-like receptor 3DS1 gene against the development of hepatocellular carcinoma in patients with hepatitis C virus infection.

The aim of the present study was to investigate, in 152 Spanish patients infected with hepatitis C virus (HCV), the possibility that killer cell immunoglobulin-like receptors (KIRs) influence progression to hepatocellular carcinoma. KIRs are related to the activation and inhibition of natural killer cells and may play an important role in the innate response against infection with such viruses as HCV. We found that the human leukocyte antigen-Bw4I80 epitope and the KIR3DS1 gene were more frequent in HCV carriers than in patients with hepatocellular carcinoma. Moreover, these associations were not independent of each other--the KIR3DS1/Bw4I80 genotype clearly was also more frequent in HCV carriers (odds ratio, 24.22).

[1]  Salim I. Khakoo,et al.  HLA and NK Cell Inhibitory Receptor Genes in Resolving Hepatitis C Virus Infection , 2004, Science.

[2]  L. Rodrigo,et al.  Extended human leukocyte antigen haplotype EH18.1 influences progression to hepatocellular carcinoma in patients with hepatitis C virus infection. , 2004, The Journal of infectious diseases.

[3]  Eric Vivier,et al.  Inhibitory NK-cell receptors on T cells: witness of the past, actors of the future , 2004, Nature Reviews Immunology.

[4]  J. Hoofnagle.  Course and outcome of hepatitis C , 2002, Hepatology.

[5]  Michael J. Wilson,et al.  Cutting Edge: Susceptibility to Psoriatic Arthritis: Influence of Activating Killer Ig-Like Receptor Genes in the Absence of Specific HLA-C Alleles1 , 2002, The Journal of Immunology.

[6]  Keith Hoots,et al.  Epistatic interaction between KIR3DS1 and HLA-B delays the progression to AIDS , 2002, Nature Genetics.

[7]  J. Goedert,et al.  HLA-Cw*04 and Hepatitis C Virus Persistence , 2002, Journal of Virology.

[8]  C. Vilches,et al.  Genotyping of human killer-cell immunoglobulin-like receptor genes by polymerase chain reaction with sequence-specific primers: an update. , 2002, Tissue antigens.

[9]  H. Mochizuki,et al.  Decrease of CD56+T cells and natural killer cells in cirrhotic livers with hepatitis C may be involved in their susceptibility to hepatocellular carcinoma , 2000, Hepatology.

[10]  Jun Wu,et al.  Immunoreceptor DAP12 bearing a tyrosine-based activation motif is involved in activating NK cells , 1998, Nature.

[11]  H. Rivera,et al.  Impairment of natural killer (NK) cytotoxic activity in hepatitis C virus (HCV) infection , 1997, Clinical and experimental immunology.

[12]  G. Ferrara,et al.  NK3-specific natural killer cells are selectively inhibited by Bw4- positive HLA alleles with isoleucine 80 , 1994, The Journal of experimental medicine.

[13]  E. Ciccone,et al.  P58 molecules as putative receptors for major histocompatibility complex (MHC) class I molecules in human natural killer (NK) cells. Anti-p58 antibodies reconstitute lysis of MHC class I-protected cells in NK clones displaying different specificities , 1993, The Journal of experimental medicine.

[14]  Peter Parham,et al.  KIR: diverse, rapidly evolving receptors of innate and adaptive immunity. , 2002, Annual review of immunology.

[15]  L. Lanier,et al.  Regulation of T cell lymphokine production by killer cell inhibitory receptor recognition of self HLA class I alleles , 1996, The Journal of experimental medicine.