Statistical tools for linkage analysis and genetic association studies
暂无分享,去创建一个
[1] Scott M. Williams,et al. Traversing the conceptual divide between biological and statistical epistasis: systems biology and a more modern synthesis. , 2005, BioEssays : news and reviews in molecular, cellular and developmental biology.
[2] Jacqueline K. Wittke-Thompson,et al. Rational inferences about departures from Hardy-Weinberg equilibrium. , 2005, American journal of human genetics.
[3] P. Donnelly,et al. Genome-wide strategies for detecting multiple loci that influence complex diseases , 2005, Nature Genetics.
[4] Gary K. Chen,et al. Association testing in a linked region using large pedigrees. , 2005, American Journal of Human Genetics.
[5] M. Daly,et al. Genome-wide association studies for common diseases and complex traits , 2005, Nature Reviews Genetics.
[6] D. Clayton,et al. Genome-wide association studies: theoretical and practical concerns , 2005, Nature Reviews Genetics.
[7] Pak Sham,et al. Properties of Structured Association Approaches to Detecting Population Stratification , 2005, Human Heredity.
[8] D. Schaid. Evaluating associations of haplotypes with traits , 2004, Genetic epidemiology.
[9] Jason Cooper,et al. Use of unphased multilocus genotype data in indirect association studies , 2004, Genetic epidemiology.
[10] T. Niu. Algorithms for inferring haplotypes , 2004, Genetic epidemiology.
[11] Jonathan L Haines,et al. Genetics, statistics and human disease: analytical retooling for complexity. , 2004, Trends in genetics : TIG.
[12] Frank Dudbridge,et al. Efficient computation of significance levels for multiple associations in large studies of correlated data, including genomewide association studies. , 2004, American journal of human genetics.
[13] Andrew P Morris,et al. Linkage disequilibrium mapping via cladistic analysis of single-nucleotide polymorphism haplotypes. , 2004, American journal of human genetics.
[14] A. Morris,et al. Little loss of information due to unknown phase for fine-scale linkage-disequilibrium mapping with single-nucleotide-polymorphism genotype data. , 2004, American journal of human genetics.
[15] Shaun Purcell,et al. Epistasis in Quantitative Trait Locus Linkage Analysis: Interaction or Main Effect? , 2004, Behavior genetics.
[16] Lon R. Cardon,et al. The complex interplay among factors that influence allelic association , 2004, Nature Reviews Genetics.
[17] Dmitri V Zaykin,et al. Diagnostic polymorphisms in the mitochondrial cytochrome b gene allow discrimination between cattle, sheep, goat, roe buck and deer by PCR-RFLP , 2004, BMC Genetics.
[18] Juliet M Chapman,et al. Detecting Disease Associations due to Linkage Disequilibrium Using Haplotype Tags: A Class of Tests and the Determinants of Statistical Power , 2003, Human Heredity.
[19] J. Ott,et al. Mathematical multi-locus approaches to localizing complex human trait genes , 2003, Nature Reviews Genetics.
[20] Christopher A. Haiman,et al. Choosing Haplotype-Tagging SNPS Based on Unphased Genotype Data Using a Preliminary Sample of Unrelated Subjects with an Example from the Multiethnic Cohort Study , 2003, Human Heredity.
[21] Mario Falchi,et al. Identification of a novel gene and a common variant associated with uric acid nephrolithiasis in a Sardinian genetic isolate. , 2003, American journal of human genetics.
[22] L. Wasserman,et al. On the identification of disease mutations by the analysis of haplotype similarity and goodness of fit. , 2003, American journal of human genetics.
[23] G. Abecasis,et al. Using haplotype blocks to map human complex trait loci. , 2003, Trends in genetics : TIG.
[24] Joseph D Terwilliger,et al. Confounding, ascertainment bias, and the blind quest for a genetic ‘fountain of youth’ , 2003, Annals of medicine.
[25] Kathryn Roeder,et al. Evolutionary‐based association analysis using haplotype data , 2003, Genetic epidemiology.
[26] S. Rich,et al. Challenges and strategies for investigating the genetic complexity of common human diseases. , 2002, Diabetes.
[27] H. Stefánsson,et al. Neuregulin 1 and susceptibility to schizophrenia. , 2002, American journal of human genetics.
[28] Eleanor Feingold,et al. Regression-based quantitative-trait-locus mapping in the 21st century. , 2002, American journal of human genetics.
[29] Shaun Purcell,et al. Powerful regression-based quantitative-trait linkage analysis of general pedigrees. , 2002, American journal of human genetics.
[30] Steuart Rorke,et al. Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness , 2002, Nature.
[31] John S Witte,et al. Point: population stratification: a problem for case-control studies of candidate-gene associations? , 2002, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.
[32] S. Gabriel,et al. The Structure of Haplotype Blocks in the Human Genome , 2002, Science.
[33] R. Myers,et al. Candidate-gene approaches for studying complex genetic traits: practical considerations , 2002, Nature Reviews Genetics.
[34] N. E. Morton,et al. The first linkage disequilibrium (LD) maps: Delineation of hot and cold blocks by diplotype analysis , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[35] D. Schaid,et al. Score tests for association between traits and haplotypes when linkage phase is ambiguous. , 2002, American journal of human genetics.
[36] J Blangero,et al. Large upward bias in estimation of locus-specific effects from genomewide scans. , 2001, American journal of human genetics.
[37] T. Mackay. The genetic architecture of quantitative traits. , 2001, Annual review of genetics.
[38] J. Ott,et al. Trimming, weighting, and grouping SNPs in human case-control association studies. , 2001, Genome research.
[39] Frank Dudbridge,et al. Haplotype tagging for the identification of common disease genes , 2001, Nature Genetics.
[40] W S Watkins,et al. Population genomics: a bridge from evolutionary history to genetic medicine. , 2001, Human molecular genetics.
[41] M. Daly,et al. High-resolution haplotype structure in the human genome , 2001, Nature Genetics.
[42] C. Sabatti,et al. Bayesian analysis of haplotypes for linkage disequilibrium mapping. , 2001, Genome research.
[43] E. Lander,et al. On the allelic spectrum of human disease. , 2001, Trends in genetics : TIG.
[44] J. H. Moore,et al. Multifactor-dimensionality reduction reveals high-order interactions among estrogen-metabolism genes in sporadic breast cancer. , 2001, American journal of human genetics.
[45] B. Rannala,et al. High-resolution multipoint linkage-disequilibrium mapping in the context of a human genome sequence. , 2001, American journal of human genetics.
[46] Mourad Sahbatou,et al. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease , 2001, Nature.
[47] N. Laird,et al. The family based association test method: strategies for studying general genotype–phenotype associations , 2001, European Journal of Human Genetics.
[48] C. Sing,et al. A combinatorial partitioning method to identify multilocus genotypic partitions that predict quantitative trait variation. , 2001, Genome research.
[49] Siavash Ghaffari,et al. A candidate prostate cancer susceptibility gene at chromosome 17p , 2001, Nature Genetics.
[50] Mariza de Andrade,et al. Comparison of Multivariate Tests for Genetic Linkage , 2001, Human Heredity.
[51] R C Elston,et al. Transmission/disequilibrium tests for quantitative traits , 2001, Genetic epidemiology.
[52] E J Hollox,et al. Lactase haplotype diversity in the Old World. , 2001, American journal of human genetics.
[53] Tom H. Lindner,et al. Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus , 2000, Nature Genetics.
[54] D J Balding,et al. Bayesian fine-scale mapping of disease loci, by hidden Markov models. , 2000, American journal of human genetics.
[55] E. Martin,et al. A test for linkage and association in general pedigrees: the pedigree disequilibrium test. , 2000, American journal of human genetics.
[56] P. Donnelly,et al. Inference of population structure using multilocus genotype data. , 2000, Genetics.
[57] P. Sham,et al. Power of linkage versus association analysis of quantitative traits, by use of variance-components models, for sibship data. , 2000, American journal of human genetics.
[58] H H Göring,et al. Linkage analysis in the presence of errors IV: joint pseudomarker analysis of linkage and/or linkage disequilibrium on a mixture of pedigrees and singletons when the mode of inheritance cannot be accurately specified. , 2000, American journal of human genetics.
[59] K Roeder,et al. Haplotype fine mapping by evolutionary trees. , 2000, American journal of human genetics.
[60] G. Abecasis,et al. A general test of association for quantitative traits in nuclear families. , 2000, American journal of human genetics.
[61] Mario Pirastu,et al. Population choice in mapping genes for complex diseases , 1999, Nature Genetics.
[62] K. Roeder,et al. Genomic Control for Association Studies , 1999, Biometrics.
[63] P. Sham,et al. Model-Free Analysis and Permutation Tests for Allelic Associations , 1999, Human Heredity.
[64] D. Clayton,et al. A generalization of the transmission/disequilibrium test for uncertain-haplotype transmission. , 1999, American journal of human genetics.
[65] M. McPeek,et al. Assessment of linkage disequilibrium by the decay of haplotype sharing, with application to fine-scale genetic mapping. , 1999, American journal of human genetics.
[66] S E Hodge,et al. Direct power comparisons between simple LOD scores and NPL scores for linkage analysis in complex diseases. , 1999, American journal of human genetics.
[67] C I Amos,et al. Comparison of linkage-disequilibrium methods for localization of genes influencing quantitative traits in humans. , 1999, American journal of human genetics.
[68] N M Laird,et al. A discordant-sibship test for disequilibrium and linkage: no need for parental data. , 1998, American journal of human genetics.
[69] K. Weiss,et al. Linkage disequilibrium mapping of complex disease: fantasy or reality? , 1998, Current opinion in biotechnology.
[70] M. Ehm,et al. Detecting marker-disease association by testing for Hardy-Weinberg disequilibrium at a marker locus. , 1998, American journal of human genetics.
[71] N E Morton,et al. Tests and estimates of allelic association in complex inheritance. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[72] E. Boerwinkle,et al. Haplotype structure and population genetic inferences from nucleotide-sequence variation in human lipoprotein lipase. , 1998, American journal of human genetics.
[73] J. Terwilliger,et al. Mapping Genes through the Use of Linkage Disequilibrium Generated by Genetic Drift: ‘Drift Mapping’ in Small Populations with No Demographic Expansion , 1998, Human Heredity.
[74] L. Almasy,et al. Multipoint quantitative-trait linkage analysis in general pedigrees. , 1998, American journal of human genetics.
[75] A Collins,et al. Mapping a disease locus by allelic association. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[76] W. Ewens,et al. A sibship test for linkage in the presence of association: the sib transmission/disequilibrium test. , 1998, American journal of human genetics.
[77] D. Weeks,et al. Comparison of nonparametric statistics for detection of linkage in nuclear families: single-marker evaluation. , 1997, American journal of human genetics.
[78] S. Heath. Markov chain Monte Carlo segregation and linkage analysis for oligogenic models. , 1997, American journal of human genetics.
[79] D Rabinowitz,et al. A transmission disequilibrium test for quantitative trait loci. , 1997, Human heredity.
[80] L. Almasy,et al. Bivariate quantitative trait linkage analysis: Pleiotropy versus co‐incident linkages , 1997, Genetic epidemiology.
[81] J. Blangero,et al. Power of variance component linkage analysis to detect epistasis , 1997, Genetic Epidemiology.
[82] N Risch,et al. The Future of Genetic Studies of Complex Human Diseases , 1996, Science.
[83] D W Fulker,et al. An improved multipoint sib-pair analysis of quantitative traits , 1996, Behavior genetics.
[84] K Lange,et al. Descent graphs in pedigree analysis: applications to haplotyping, location scores, and marker-sharing statistics. , 1996, American journal of human genetics.
[85] L. Sandkuijl,et al. Perspectives of identity by descent (IBD) mapping in founder populations , 1995, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.
[86] E. Lander,et al. Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results , 1995, Nature Genetics.
[87] N. Risch,et al. A comparison of linkage disequilibrium measures for fine-scale mapping. , 1995, Genomics.
[88] L. Excoffier,et al. Maximum-likelihood estimation of molecular haplotype frequencies in a diploid population. , 1995, Molecular biology and evolution.
[89] E M Wijsman,et al. A familial Alzheimer's disease locus on chromosome 1 , 1995, Science.
[90] D. Curtis,et al. An extended transmission/disequilibrium test (TDT) for multi‐allele marker loci , 1995, Annals of human genetics.
[91] N Risch,et al. Extreme discordant sib pairs for mapping quantitative trait loci in humans. , 1995, Science.
[92] A. Templeton,et al. A cladistic analysis of phenotypic associations with haplotypes inferred from restriction endonuclease mapping or DNA sequencing. V. Analysis of case/control sampling designs: Alzheimer's disease and the apoprotein E locus. , 1995, Genetics.
[93] J. Terwilliger. A powerful likelihood method for the analysis of linkage disequilibrium between trait loci and one or more polymorphic marker loci. , 1995, American journal of human genetics.
[94] D. Curtis,et al. Monte Carlo tests for associations between disease and alleles at highly polymorphic loci , 1995, Annals of human genetics.
[95] S A Seuchter,et al. Two-locus disease models with two marker loci: the power of affected-sib-pair tests. , 1994, American journal of human genetics.
[96] M. Boehnke,et al. Limits of resolution of genetic linkage studies: implications for the positional cloning of human disease genes. , 1994, American journal of human genetics.
[97] C. Amos. Robust variance-components approach for assessing genetic linkage in pedigrees. , 1994, American journal of human genetics.
[98] A. Whittemore,et al. A class of tests for linkage using affected pedigree members. , 1994, Biometrics.
[99] J Halpern,et al. Probability of gene identity by descent: computation and applications. , 1994, Biometrics.
[100] Nelson B. Freimer,et al. Genome screening by searching for shared segments: mapping a gene for benign recurrent intrahepatic cholestasis , 1994, Nature Genetics.
[101] N. Schork,et al. Two-trait-locus linkage analysis: a powerful strategy for mapping complex genetic traits. , 1993, American journal of human genetics.
[102] A. Chapelle,et al. Disease gene mapping in isolated human populations: the example of Finland. , 1993, Journal of medical genetics.
[103] W. Ewens,et al. Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM). , 1993, American journal of human genetics.
[104] P. Holmans,et al. Asymptotic properties of affected-sib-pair linkage analysis. , 1993, American journal of human genetics.
[105] J. Terwilliger,et al. A haplotype-based 'haplotype relative risk' approach to detecting allelic associations. , 1992, Human heredity.
[106] M. King,et al. Linkage of early-onset familial breast cancer to chromosome 17q21. , 1990, Science.
[107] N. Risch,et al. Linkage strategies for genetically complex traits. III. The effect of marker polymorphism on analysis of affected relative pairs. , 1990, American journal of human genetics.
[108] K. Weiss,et al. Admixture as a tool for finding linked genes and detecting that difference from allelic association between loci. , 1988, Proceedings of the National Academy of Sciences of the United States of America.
[109] C. Falk,et al. Haplotype relative risks: an easy reliable way to construct a proper control sample for risk calculations , 1987, Annals of human genetics.
[110] E. Boerwinkle,et al. The use of measured genotype information in the analysis of quantitative phenotypes in man. II. The role of the apolipoprotein E polymorphism in determining levels, variability, and covariability of cholesterol, betalipoprotein, and triglycerides in a sample of unrelated individuals. , 1987, American journal of medical genetics.
[111] E. Lander,et al. Construction of multilocus genetic linkage maps in humans. , 1987, Proceedings of the National Academy of Sciences of the United States of America.
[112] C. Bonaïti‐pellié,et al. Effects of misspecifying genetic parameters in lod score analysis. , 1986, Biometrics.
[113] J. Ott. Analysis of Human Genetic Linkage , 1985 .
[114] C. Sing,et al. Role of the apolipoprotein E polymorphism in determining normal plasma lipid and lipoprotein variation. , 1985, American journal of human genetics.
[115] R. Elston,et al. A comparison of sib‐pair linkage tests for disease susceptibility loci , 1985, Genetic epidemiology.
[116] D. Botstein,et al. Construction of a genetic linkage map in man using restriction fragment length polymorphisms. , 1980, American journal of human genetics.
[117] R. Elston,et al. The investigation of linkage between a quantitative trait and a marker locus , 1972, Behavior genetics.
[118] R. Elston,et al. A general model for the genetic analysis of pedigree data. , 1971, Human heredity.
[119] H. Harris,et al. GENETICAL STUDIES ON HUMAN RED CELL ACID PHOSPHATASE. , 1964, American journal of human genetics.
[120] N. Morton. Sequential tests for the detection of linkage. , 1955, American journal of human genetics.
[121] L. Penrose. THE DETECTION OF AUTOSOMAL LINKAGE IN DATA WHICH CONSIST OF PAIRS OF BROTHERS AND SISTERS OF UNSPECIFIED PARENTAGE , 1935 .