Effects of Olaquindox and Cyadox on Immunity of Piglets Orally Inoculated with Escherichia coli

A 2×3 factorial arrangement of treatments was used to determine the effects of olaquindox and cyadox on immune response of Landrace×Large-White geld piglets that had been orally given 10 10 CFU of Escherichia coli (E. coli, O139:K88). Factors included (1) E. coli inoculation or control, and (2) no antimicrobials, 100 mg/kg olaquindox and 100 mg/kg cyadox in the basal diet respectively. E. coli inoculums were orally administered 7 days after the diets were supplemented with olaquindox and cyadox. The effects of the two antimicrobials were assessed in terms of: (1) average daily gain (ADG), (2) systemic immune response (the number of white blood cells and lymphocytes, leukocyte bactericidal capacity, lymphocyte proliferation response to PHA, immunoglobulin concentrations, and total serous hemolytic complement activity), and (3) intestinal mucosal immunity including the number of intraepithelial lymphocytes (IELs) and immunoglobulin A secreting cells (ASCs) in the intestinal lamina propria. E. coli inoculation reduced ADG (p 0.05). The data suggest that olaquindox and cyadox suppress E. coli-induced immune activation, especially intestinal mucosal immune activation, which may be involved in the observed growth promotion. (Asian-Aust. J. Anim. Sci. 2005. Vol 18, No. 9 : 1320-1325)

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