Human oculomotor function: Reliability and diurnal variation

To provide information on test-retest reliability for seven oculomotor paradigms currently used in studies of schizophrenia and other neuropsychiatric conditions, we tested eight controls at four weekly intervals, twice in the morning (8-10 AM) and twice in the afternoon (3-5 PM). Intraclass correlation coefficients were significant (p < .05) for both AM and PM pairs of measures as well as for mean AM and PM pairs for closed-loop pursuit gain, open-loop pursuit gain (using velocity as the measure), saccadic frequency during pursuit and fixation, visually and nonvisually guided saccadic latency and velocity, antisaccadic latency, and premature reflexive saccades during the memory-guided saccade task. Acceleration as a measure of open-loop gain (for slower targets) and accuracy of saccades to a moving target were only reliable at PM testing time. Nonvisually guided saccadic accuracy and inappropriate reflexive saccades during the antisaccade task were not reliable, possibly due to the narrow range of values for these measures. Except for approximately 10% fewer saccades during pursuit and fixation in the morning, there were no consistent diurnal differences. These findings suggest that, in a small sample of subjects, most measures of oculomotor function are stable across time and may reflect underlying neurophysiologic traits.

[1]  D. Lykken,et al.  Eye tracking and psychopathology. New procedures applied to a sample of normal monozygotic twins. , 1979, Archives of general psychiatry.

[2]  R. Leigh,et al.  The neurology of eye movements , 1984 .

[3]  G. Pearlson,et al.  Oculomotor performance in obsessive-compulsive disorder. , 1992, The American journal of psychiatry.

[4]  E. Smeraldi,et al.  Combined measure of smooth pursuit eye movements and ventricle-brain ratio in schizophrenic disorders , 1987, Psychiatry Research.

[5]  S Matthysse,et al.  Eye tracking dysfunction and schizophrenia: a critical perspective. , 1993, Schizophrenia bulletin.

[6]  D. Lykken,et al.  Two-year retest stability of eye tracking performance and a comparison of electro-oculographic and infrared recording techniques: evidence of EEG in the electro-oculogram. , 1981, Psychophysiology.

[7]  M Versino,et al.  Quantitative evaluation of saccadic and smooth pursuit eye movements. Is it reliable? , 1993, Investigative ophthalmology & visual science.

[8]  L. Siever,et al.  Smooth pursuit eye movement disorder and its psychobiologic correlates in unmedicated schizophrenics , 1986, Biological Psychiatry.

[9]  R. Abrams,et al.  Ocular motor abnormalities in human immunodeficiency virus infection , 1991, Annals of neurology.

[10]  J. Sweeney,et al.  Pursuit eye movement dysfunction in obsessive-compulsive disorder , 1992, Psychiatry Research.

[11]  A. Richens,et al.  Saccadic eye movement analysis as a measure of drug effects on human psychomotor performance. , 1984, British journal of clinical pharmacology.

[12]  C. Rashbass,et al.  The relationship between saccadic and smooth tracking eye movements , 1961, The Journal of physiology.

[13]  D J Nutt,et al.  Saccadic eye movement parameters in normal subjects. , 1993, Electroencephalography and clinical neurophysiology.

[14]  E. J. Morris,et al.  Visual motion processing and sensory-motor integration for smooth pursuit eye movements. , 1987, Annual review of neuroscience.

[15]  J. Sweeney,et al.  Smooth-pursuit eye movement dysfunction and liability for schizophrenia: implications for genetic modeling. , 1992, Journal of abnormal psychology.

[16]  W. Iacono,et al.  Smooth-pursuit eye tracking in first-episode psychotic patients and their relatives. , 1992, Journal of abnormal psychology.

[17]  N. Rozendaal,et al.  Subjective cognitive dysfunction, eye tracking, and slow brain potentials in schizophrenic and schizoaffective patients , 1988, Biological Psychiatry.

[18]  J. Bartko Measurement and reliability: statistical thinking considerations. , 1991, Schizophrenia bulletin.

[19]  Daniel W. Hommer,et al.  A quantitative analysis of saccades and smooth pursuit during visual pursuit tracking A comparison of schizophrenics with normals and substance abusing controls , 1992, Schizophrenia Research.

[20]  J. Jesberger,et al.  Effect of typical antipsychotic medications and clozapine on smooth pursuit performance in patients with schizophrenia , 1992, Psychiatry Research.

[21]  L. Stark,et al.  The main sequence, a tool for studying human eye movements , 1975 .

[22]  D. Overton,et al.  Eye-tracking performance in psychiatric patients. , 1974, Biological psychiatry.

[23]  D. Campion,et al.  SPEM impairment in drug-naive schizophrenic patients: Evidence for a trait marker , 1992, Biological Psychiatry.