Biological monitoring of the occupational exposure to halothane (fluothane) in operating room personnel.

The concentration of halothane (fluothane) in the ambient atmosphere was determined in five operating theaters of two hospitals in Italy. The concentrations of halothane in the ambient air exceeded the NIOSH recommended time-weighted average exposure levels (median value: 10.38 mg/m3). Halothane was detected in the urine of 58 exposed subjects (anesthetists, surgeons, and nurses). A significant correlation was found between the halothane concentration in urine produced during the shift (Cu, micrograms/L) and halothane environmental concentration (CI, mg/m3) (Cu = 0.242 x CI + 3.51) (N = 58; r = 0.92; p less than 0.0001). The results show that the urinary halothane concentration can be used as an appropriate biological exposure index. The biological values proposed are: 92 micrograms/L, corresponding to a 50 ppm of environmental exposure; 6.5 micrograms/L, corresponding to 2 ppm of environmental exposure and 3.9 micrograms/L, corresponding to a 0.5 ppm of environmental exposure.

[1]  A. Trevisan,et al.  Biological monitoring of nitrous oxide exposure in surgical areas. , 1990, American journal of industrial medicine.

[2]  E. Capodaglio,et al.  Evaluation of exposure to isoflurane (Forane): environmental and biological measurements in operating room personnel. , 1988, Journal of toxicology and environmental health.

[3]  E. Capodaglio,et al.  Nitrous Oxide (N2O) in Urine as Biological Index of Exposure in Operating Room Personnel , 1988 .

[4]  E. Capodaglio,et al.  The urinary concentration of solvents as a biological indicator of exposure: proposal for the biological equivalent exposure limit for nine solvents. , 1987, American Industrial Hygiene Association journal.

[5]  Wilson Hk.  Breath analysis. Physiological basis and sampling techniques. , 1986 .

[6]  J. Ekstrand,et al.  Plasma Fluoride and Bromide Concentrations during Occupational Exposure to Enflurane or Halothane , 1985 .

[7]  O. Stenqvist,et al.  Urinary N2O as a measure of biologic exposure to nitrous oxide anaesthetic contamination. , 1983, The Annals of occupational hygiene.

[8]  J. Trudell,et al.  Binding of Halothane‐free Radicals to Fatty Acids Following: UV Irradiation , 1982, Anesthesiology.

[9]  P. Temmerman,et al.  Anaesthetic health hazards among belgian nurses and physicians , 1981, International archives of occupational and environmental health.

[10]  C. Hinds,et al.  Blood concentrations of nitrous oxide in theatre personnel. , 1980, British journal of anaesthesia.

[11]  Edward J. Driscoll,et al.  Occupational Disease in Dentistry and Chronic Exposure to Trace Anesthetic Gases , 1980 .

[12]  P. Duvaldestin,et al.  Halothane Biotransformation in Anesthetists , 1979, Anesthesiology.

[13]  P. Tomlin.  Health problems of anaesthetists and their families in the West Midlands. , 1979, British medical journal.

[14]  R. Knill-Jones,et al.  Is there a health hazard in anaesthetic practice? , 1978, British journal of anaesthesia.

[15]  M. Vessey.  Epidemiological studies of the occupational hazards of anaesthesia‐a review * , 1978, Anaesthesia.

[16]  G. Chamberlain,et al.  OUTCOME OF PREGNANCY AMONG WOMEN IN ANÆSTHETIC PRACTICE , 1977, The Lancet.

[17]  Göthe Cj.  Narcotic gases as occupational risk. What can we do to eliminate the risks , 1976 .

[18]  B. Hitt,et al.  Metabolism and Renal Effects of Enflurane in Man , 1976, Anesthesiology.

[19]  B. Brown,et al.  A survey of anesthetic health hazards among dentists. , 1975, The Journal of the American Dental Association (1939).

[20]  R. Gibbons,et al.  Comparative Toxicities of Halothane, Isoflurane, and Diethyl Ether at Subanesthetic Concentrations in Laboratory Animals , 1975, Anesthesiology.

[21]  L. Chang,et al.  Ultrastructural changes in the kidney following chronic exposure to low levels of halothane. , 1975, The American journal of pathology.

[22]  R. G. Cornell,et al.  Birth Defects among Children of Nurse‐anesthetists , 1974, Anesthesiology.

[23]  Wilson Ws,et al.  Letter: Retinal xanthoma. , 1974 .

[24]  R. G. Cornell,et al.  Effects of Low Concentrations of Nitrous Oxide on Rat Pregnancy , 1973, Anesthesiology.

[25]  P. Götell,et al.  [Exposure of nurse anesthetists to halothane]. , 1972, Lakartidningen.

[26]  R. Knill-Jones,et al.  ANÆSTHETIC PRACTICE AND PREGNANCY: Controlled Survey of Women Anæsthetists in the United Kingdom , 1972 .

[27]  G. Klatskin,et al.  Recurrent hepatitis attributable to halothane sensitization in an anesthetist. , 1969, The New England journal of medicine.

[28]  D. Bruce,et al.  Causes of death among anesthesiologists: a 20-year survey. , 1968, Anesthesiology.

[29]  I. Ahlgren,et al.  HALOTHANE HEPATITIS IN AN ANÆSTHETIST , 1966 .