Vitix®– a new treatment for vitiligo?

It has been demonstrated that a reduction in epidermal H 2 O 2 levels correlates with a cessation of the disease in 95% of affected individuals in association with extensive repigmentation. 4,7,8 Moreover, it has been shown that the reduction in epidermal H 2 O 2 levels induced by a low-dose, narrow-band, ultraviolet-B (UV-B)-activated pseudocatalase (PC-KUS) decreases systemic H 2 O 2 stress, underlining the importance of H 2 O 2 transfer from the epidermal compartment to the vascular system. 6,9

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[2]  N. J. Gibbons,et al.  Perturbed 6-tetrahydrobiopterin recycling via decreased dihydropteridine reductase in vitiligo: more evidence for H2O2 stress. , 2004, The Journal of investigative dermatology.

[3]  E. Camera,et al.  Alterations of mitochondria in peripheral blood mononuclear cells of vitiligo patients. , 2003, Pigment cell research.

[4]  K. Schallreuter,et al.  Rapid initiation of repigmentation in vitiligo with Dead Sea climatotherapy in combination with pseudocatalase (PC‐KUS) , 2002, International journal of dermatology.

[5]  J. Wood,et al.  In vitro and in vivo identification of ‘pseudocatalase’ activity in Dead Sea water using Fourier transform Raman spectroscopy , 2002 .

[6]  M. Falchi,et al.  Mitochondrial impairment in peripheral blood mononuclear cells during the active phase of vitiligo. , 2001, The Journal of investigative dermatology.

[7]  R. Dummer,et al.  Epidermal H(2)O(2) accumulation alters tetrahydrobiopterin (6BH4) recycling in vitiligo: identification of a general mechanism in regulation of all 6BH4-dependent processes? , 2001, The Journal of investigative dermatology.

[8]  E Panzig,et al.  In vivo and in vitro evidence for hydrogen peroxide (H2O2) accumulation in the epidermis of patients with vitiligo and its successful removal by a UVB-activated pseudocatalase. , 1999, The journal of investigative dermatology. Symposium proceedings.

[9]  S. Passi,et al.  Increased sensitivity to peroxidative agents as a possible pathogenic factor of melanocyte damage in vitiligo. , 1997, The Journal of investigative dermatology.

[10]  J. Wood,et al.  Treatment of vitiligo with a topical application of pseudocatalase and calcium in combination with short-term UVB exposure: a case study on 33 patients. , 1995, Dermatology.