DEVELOPMENT AND VALIDATION OF SIMULTANEOUS EQU ATION METHOD FOR THE ESTIMATION OF CEFIXIME AND OFLOXACIN IN PURE AND IN TABLET FORMULATION

This paper describes developed and validated UV spectrophotometry method for the simultaneous estimation of Ofloxacin and Cef ixime in a combined dosage form by Simultaneous equation method. This method utilize methanol as solvent. In this method UV spectra of Ofloxacin and Cefixime were recorded, from the overlay spectra the wavelength selected for the simultaneous equation method were 235nm for Ofloxacin and 290 nm for Cefexime, where the linearity ranges for both the drugs were 5 - 30 µg / ml. The correlation coefficient of Ofloxacin and Cefexime was found to be 0.9999 and 0.9998 respectively. The results of analysis of this method have been valid ated statistical ly and recovery studies confirmed the accuracy of the proposed method.