Preparative method for isosilybin isolation based on enzymatic kinetic resolution of silymarin mixture

[1]  V. Křen,et al.  Narrow-bore core-shell particles and monolithic columns in the analysis of silybin diastereoisomers. , 2011, Journal of separation science.

[2]  V. Křen,et al.  Large-scale separation of silybin diastereoisomers using lipases , 2010 .

[3]  Qipeng Yuan,et al.  Isolation and purification of silychristin, silydianin and taxifolin in the co-products of the silybin refined process from the silymarin by high-speed counter-current chromatography , 2010 .

[4]  R. Agarwal,et al.  Large-scale isolation of flavonolignans from Silybum marianum extract affords new minor constituents and preliminary structure-activity relationships. , 2010, Planta medica.

[5]  V. Křen,et al.  Enzymatic kinetic resolution of silybin diastereoisomers. , 2010, Journal of natural products.

[6]  V. Křen,et al.  Chemoenzymatic preparative separation of silybins A and B , 2009 .

[7]  R. Agarwal,et al.  Isosilibinin inhibits advanced human prostate cancer growth in athymic nude mice: Comparison with silymarin and silibinin , 2008, International journal of cancer.

[8]  R. Agarwal,et al.  Gram-scale purification of flavonolignan diastereoisomers from Silybum marianum (Milk Thistle) extract in support of preclinical in vivo studies for prostate cancer chemoprevention. , 2007, Planta medica.

[9]  R. Agarwal,et al.  Isosilybin B and isosilybin A inhibit growth, induce G1 arrest and cause apoptosis in human prostate cancer LNCaP and 22Rv1 cells. , 2007, Carcinogenesis.

[10]  V. Křen,et al.  Silybin and silymarin--new and emerging applications in medicine. , 2007, Current medicinal chemistry.

[11]  R. Večeřa,et al.  Effect of silymarin and its polyphenolic fraction on cholesterol absorption in rats. , 2006, Pharmacological research.

[12]  R. Agarwal,et al.  Milk thistle and prostate cancer: differential effects of pure flavonolignans from Silybum marianum on antiproliferative end points in human prostate carcinoma cells. , 2005, Cancer research.

[13]  D. Y. Lee,et al.  Molecular structure and stereochemistry of silybin A, silybin B, isosilybin A, and isosilybin B, Isolated from Silybum marianum (milk thistle). , 2003, Journal of natural products.

[14]  Nam-Cheol Kim,et al.  Complete isolation and characterization of silybins and isosilybins from milk thistle (Silybum marianum). , 2003, Organic & biomolecular chemistry.

[15]  P. Morazzoni,et al.  Silybum marianum (Carduus marianus) , 1995 .

[16]  H. Becker,et al.  CALLUS– UND SUSPENSIONSKULTUREN VON SILYBUM MARIANUM , 1977 .