VEGF and Delta-Notch: interacting signalling pathways in tumour angiogenesis

[1]  Jianzhong Huang,et al.  A notch1 ectodomain construct inhibits endothelial notch signaling, tumor growth, and angiogenesis. , 2008, Cancer research.

[2]  Christopher C W Hughes,et al.  TNF primes endothelial cells for angiogenic sprouting by inducing a tip cell phenotype. , 2008, Blood.

[3]  Arndt F. Siekmann,et al.  Modulation of VEGF signalling output by the Notch pathway , 2008, BioEssays : news and reviews in molecular, cellular and developmental biology.

[4]  Adrian L Harris,et al.  Regulation of multiple angiogenic pathways by Dll4 and Notch in human umbilical vein endothelial cells. , 2008, Microvascular research.

[5]  M. Skobe,et al.  Notch alters VEGF responsiveness in human and murine endothelial cells by direct regulation of VEGFR-3 expression. , 2007, The Journal of clinical investigation.

[6]  R. Adams,et al.  Regulation of vascular morphogenesis by Notch signaling. , 2007, Genes & development.

[7]  Weidong Jiang,et al.  Inhibition of Dll4-mediated signaling induces proliferation of immature vessels and results in poor tissue perfusion. , 2007, Blood.

[8]  Tracy T Batchelor,et al.  VEGF-targeted cancer therapy strategies: current progress, hurdles and future prospects. , 2007, Trends in molecular medicine.

[9]  Gavin Thurston,et al.  The Delta paradox: DLL4 blockade leads to more tumour vessels but less tumour growth , 2007, Nature Reviews Cancer.

[10]  Adam L. Bermange,et al.  Endothelial signalling by the Notch ligand Delta-like 4 restricts angiogenesis , 2007, Development.

[11]  G. Thurston,et al.  Delta-like ligand 4 (Dll4) is induced by VEGF as a negative regulator of angiogenic sprouting , 2007, Proceedings of the National Academy of Sciences.

[12]  Antonio Duarte,et al.  The Notch ligand Delta-like 4 negatively regulates endothelial tip cell formation and vessel branching , 2007, Proceedings of the National Academy of Sciences.

[13]  Holger Gerhardt,et al.  Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis , 2007, Nature.

[14]  Nathan D. Lawson,et al.  Notch signalling limits angiogenic cell behaviour in developing zebrafish arteries , 2007, Nature.

[15]  Gavin Thurston,et al.  Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis , 2006, Nature.

[16]  Minhong Yan,et al.  Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis , 2006, Nature.

[17]  A. Villemain,et al.  The role of the vascular endothelial growth factor-Delta-like 4 ligand/Notch4-ephrin B2 cascade in tumor vessel remodeling and endothelial cell functions. , 2006, Cancer research.

[18]  A. Harris,et al.  Up-Regulation of Endothelial Delta-like 4 Expression Correlates with Vessel Maturation in Bladder Cancer , 2006, Clinical Cancer Research.

[19]  S. Ylä-Herttuala,et al.  Biology of vascular endothelial growth factors , 2006, FEBS letters.

[20]  Adrian L Harris,et al.  Up-regulation of delta-like 4 ligand in human tumor vasculature and the role of basal expression in endothelial cell function. , 2005, Cancer research.

[21]  Z. Werb,et al.  Endothelial expression of constitutively active Notch4 elicits reversible arteriovenous malformations in adult mice. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[22]  T. Giordano,et al.  Crosstalk between tumor and endothelial cells promotes tumor angiogenesis by MAPK activation of Notch signaling. , 2005, Cancer cell.

[23]  Gavin Thurston,et al.  Haploinsufficiency of delta-like 4 ligand results in embryonic lethality due to major defects in arterial and vascular development. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[24]  Tasuku Honjo,et al.  Haploinsufficient lethality and formation of arteriovenous malformations in Notch pathway mutants. , 2004, Genes & development.

[25]  Janet Rossant,et al.  Dosage-sensitive requirement for mouse Dll4 in artery development. , 2004, Genes & development.

[26]  J. Kitajewski,et al.  Notch Signaling in Primary Endothelial Cells , 2003, Annals of the New York Academy of Sciences.

[27]  J. Folkman.  Role of angiogenesis in tumor growth and metastasis. , 2002, Seminars in oncology.

[28]  Christopher C W Hughes,et al.  Notch activation during endothelial cell network formation in vitro targets the basic HLH transcription factor HESR-1 and downregulates VEGFR-2/KDR expression. , 2002, Microvascular research.

[29]  B. Weinstein,et al.  sonic hedgehog and vascular endothelial growth factor act upstream of the Notch pathway during arterial endothelial differentiation. , 2002, Developmental cell.

[30]  R Bicknell,et al.  Delta4, an endothelial specific notch ligand expressed at sites of physiological and tumor angiogenesis. , 2001, Differentiation; research in biological diversity.

[31]  M. Fishman,et al.  Gridlock signalling pathway fashions the first embryonic artery , 2001, Nature.

[32]  J. Campos-Ortega,et al.  Notch signaling is required for arterial-venous differentiation during embryonic vascular development. , 2001, Development.

[33]  J. Rossant,et al.  Vascular patterning defects associated with expression of activated Notch4 in embryonic endothelium , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[34]  Raphael Kopan,et al.  Notch signaling: from the outside in. , 2000, Developmental biology.

[35]  J. Sundberg,et al.  Notch signaling is essential for vascular morphogenesis in mice. , 2000, Genes & development.

[36]  G. Weinmaster,et al.  Embryonic lethality and vascular defects in mice lacking the Notch ligand Jagged1. , 1999, Human molecular genetics.

[37]  A. Fischer,et al.  Hypoxia-mediated activation of Dll4-Notch-Hey2 signaling in endothelial progenitor cells and adoption of arterial cell fate. , 2007, Experimental cell research.

[38]  S. Ekker,et al.  Distinct requirements for zebrafish angiogenesis revealed by a VEGF-A morphant. , 2000, Yeast.

[39]  N. Ferrara,et al.  Role of Vascular Endothelial Growth Factor in Regulation of Angiogenesis , 1999 .