First-in-human assessment of safety and immunogenicity of low and high doses of Plasmodium falciparum malaria protein 013 (FMP013) administered intramuscularly with ALFQ adjuvant in healthy malaria-naïve adults.
暂无分享,去创建一个
N. Waters | Z. Beck | G. Matyas | E. Bergmann-Leitner | E. Angov | J. Moon | D. Lanar | S. Dutta | M. Rao | V. Ngauy | L. Soisson | J. Regules | E. Duncan | P. Robben | X. Quinn | Kristen M. Merino | Lei Zhu | J. Bolton | Xiaoyan Zou | Jack N Hutter | Christine Lee | M. Hamer | Heather Galli | Dallas R. Brown
[1] M. Lievens,et al. A phase IIA extension study evaluating the effect of booster vaccination with a fractional dose of RTS,S/AS01E in a controlled human malaria infection challenge. , 2021, Vaccine.
[2] A. Dicko,et al. Seasonal Malaria Vaccination with or without Seasonal Malaria Chemoprevention. , 2021, The New England journal of medicine.
[3] O. Traoré,et al. Efficacy of a low-dose candidate malaria vaccine, R21 in adjuvant Matrix-M, with seasonal administration to children in Burkina Faso: a randomised controlled trial , 2021, The Lancet.
[4] S. Chaudhury,et al. Multiplex serological assay for establishing serological profiles of polymorphic, closely related peptide antigens , 2021, MethodsX.
[5] Pengfei Wang. Natural and Synthetic Saponins as Vaccine Adjuvants , 2021, Vaccines.
[6] M. Travassos,et al. Low dose recombinant full-length circumsporozoite protein-based Plasmodium falciparum vaccine is well-tolerated and highly immunogenic in phase 1 first-in-human clinical testing. , 2021, Vaccine.
[7] D. Wirth,et al. Breadth of humoral immune responses to the C-terminus of the circumsporozoite protein is associated with protective efficacy induced by the RTS,S malaria vaccine. , 2021, Vaccine.
[8] Dianne J Terlouw,et al. Cost-effectiveness and public health impact of RTS,S/AS01 E malaria vaccine in Malawi, using a Markov static model , 2020, Wellcome open research.
[9] Linda A. Murray,et al. A Phase IIa Controlled Human Malaria Infection and Immunogenicity Study of RTS,S/AS01E and RTS,S/AS01B Delayed Fractional Dose Regimens in Malaria-Naive Adults , 2020, The Journal of infectious diseases.
[10] Z. Beck,et al. Army Liposome Formulation (ALF) family of vaccine adjuvants , 2020, Expert review of vaccines.
[11] Z. Beck,et al. Comparison of immunogenicity and safety outcomes of a malaria vaccine FMP013/ALFQ in rhesus macaques (Macaca mulatta) of Indian and Chinese origin , 2019, Malaria Journal.
[12] C. Sauboin,et al. Economic Impact of Introducing the RTS,S Malaria Vaccine: Cost-Effectiveness and Budget Impact Analysis in 41 Countries , 2019, MDM policy & practice.
[13] N. Waters,et al. Safety, toxicity and immunogenicity of a malaria vaccine based on the circumsporozoite protein (FMP013) with the adjuvant army liposome formulation containing QS21 (ALFQ). , 2019, Vaccine.
[14] S. Chaudhury,et al. Identification of Immune Signatures of Novel Adjuvant Formulations Using Machine Learning , 2018, Scientific Reports.
[15] Kwaku Poku Asante,et al. Baseline exposure, antibody subclass, and hepatitis B response differentially affect malaria protective immunity following RTS,S/AS01E vaccination in African children , 2018, BMC Medicine.
[16] R. A. van den Berg,et al. Cellular and molecular synergy in AS01-adjuvanted vaccines results in an early IFNγ response promoting vaccine immunogenicity , 2017 .
[17] A. Wallqvist,et al. Delayed fractional dose regimen of the RTS,S/AS01 malaria vaccine candidate enhances an IgG4 response that inhibits serum opsonophagocytosis , 2017, Scientific Reports.
[18] N. Waters,et al. Liposomes containing monophosphoryl lipid A and QS-21 serve as an effective adjuvant for soluble circumsporozoite protein malaria vaccine FMP013. , 2017, Vaccine.
[19] A. Hill,et al. Enhancing protective immunity to malaria with a highly immunogenic virus-like particle vaccine , 2017, Scientific Reports.
[20] Anthony D. May,et al. Rhesus macaque and mouse models for down-selecting circumsporozoite protein based malaria vaccines differ significantly in immunogenicity and functional outcomes , 2017, Malaria Journal.
[21] N. Waters,et al. Fractional Third and Fourth Dose of RTS,S/AS01 Malaria Candidate Vaccine: A Phase 2a Controlled Human Malaria Parasite Infection and Immunogenicity Study. , 2016, The Journal of infectious diseases.
[22] Juliana K. Wambua,et al. Seven-Year Efficacy of RTS,S/AS01 Malaria Vaccine among Young African Children. , 2016, The New England journal of medicine.
[23] Jason A. Regules,et al. Circulating follicular T helper cells and cytokine profile in humans following vaccination with the rVSV-ZEBOV Ebola vaccine , 2016, Scientific Reports.
[24] A. Wallqvist,et al. The biological function of antibodies induced by the RTS,S/AS01 malaria vaccine candidate is determined by their fine specificity , 2016, Malaria Journal.
[25] Z. Beck,et al. Liposomal adjuvants for human vaccines , 2016, Expert opinion on drug delivery.
[26] Trevor Bedford,et al. Genetic Diversity and Protective Efficacy of the RTS,S/AS01 Malaria Vaccine. , 2015, The New England journal of medicine.
[27] Michael D. Porter,et al. Head-to-Head Comparison of Soluble vs. Qβ VLP Circumsporozoite Protein Vaccines Reveals Selective Enhancement of NANP Repeat Responses , 2015, PloS one.
[28] Z. Beck,et al. Differential immune responses to HIV-1 envelope protein induced by liposomal adjuvant formulations containing monophosphoryl lipid A with or without QS21. , 2015, Vaccine.
[29] Shinn-Jang Hwang,et al. Efficacy of an adjuvanted herpes zoster subunit vaccine in older adults. , 2015, The New England journal of medicine.
[30] Z. Beck,et al. Detection of liposomal cholesterol and monophosphoryl lipid A by QS-21 saponin and Limulus polyphemus amebocyte lysate. , 2015, Biochimica et biophysica acta.
[31] Michael D. Porter,et al. IgG2 Antibodies against a Clinical Grade Plasmodium falciparum CSP Vaccine Antigen Associate with Protection against Transgenic Sporozoite Challenge in Mice , 2014, PloS one.
[32] Joe D. Cohen,et al. Evaluation of the immune response to RTS,S/AS01 and RTS,S/AS02 adjuvanted vaccines , 2014, Human vaccines & immunotherapeutics.
[33] T. Richie,et al. Towards an optimized inhibition of liver stage development assay (ILSDA) for Plasmodium falciparum , 2013, Malaria Journal.
[34] S. Meshnick,et al. Comparative population structure of Plasmodium falciparum circumsporozoite protein NANP repeat lengths in Lilongwe, Malawi , 2013, Scientific Reports.
[35] D. Carucci,et al. DNA Prime/Adenovirus Boost Malaria Vaccine Encoding P. falciparum CSP and AMA1 Induces Sterile Protection Associated with Cell-Mediated Immunity , 2013, PloS one.
[36] Michael B. Doud,et al. Unexpected fold in the circumsporozoite protein target of malaria vaccines , 2012, Proceedings of the National Academy of Sciences.
[37] C. Ockenhouse,et al. The RTS,S vaccine candidate for malaria , 2011, Expert review of vaccines.
[38] V. A. Stewart,et al. Randomized, double-blind, phase 2a trial of falciparum malaria vaccines RTS,S/AS01B and RTS,S/AS02A in malaria-naive adults: safety, efficacy, and immunologic associates of protection. , 2009, The Journal of infectious diseases.
[39] P. Sinnis,et al. The Plasmodium circumsporozoite protein is proteolytically processed during cell invasion , 2005, The Journal of experimental medicine.
[40] M. Moser,et al. The adjuvant monophosphoryl lipid A increases the function of antigen-presenting cells. , 2000, International immunology.
[41] Joe D. Cohen,et al. A preliminary evaluation of a recombinant circumsporozoite protein vaccine against Plasmodium falciparum malaria. RTS,S Malaria Vaccine Evaluation Group. , 1997, The New England journal of medicine.
[42] J. Sadoff,et al. Safety, immunogenicity, and efficacy of a recombinantly produced Plasmodium falciparum circumsporozoite protein-hepatitis B surface antigen subunit vaccine. , 1995, The Journal of infectious diseases.
[43] S. Hoffman,et al. SAFETY AND EFFICACY OF A RECOMBINANT DNA PLASMODIUM FALCIPARUM SPOROZOITE VACCINE , 1987, The Lancet.
[44] R. Schwarz,et al. Strain variation in the circumsporozoite protein gene of Plasmodium falciparum. , 1987, Molecular and biochemical parasitology.
[45] V. Nussenzweig,et al. Circumsporozoite proteins of malaria parasites contain a single immunodominant region with two or more identical epitopes , 1983, The Journal of experimental medicine.
[46] V. Nussenzweig,et al. Circumsporozoite proteins of human malaria parasites Plasmodium falciparum and Plasmodium vivax , 1982, The Journal of experimental medicine.