Neural functions of bisecting GlcNAc

[1]  M. Tomás,et al.  Oxidative stress and the amyloid beta peptide in Alzheimer’s disease , 2017, Redox biology.

[2]  Naoyuki Taniguchi,et al.  N-glycan and Alzheimer's disease. , 2017, Biochimica et biophysica acta. General subjects.

[3]  Ajit Varki,et al.  Biological roles of glycans , 2016, Glycobiology.

[4]  N. Taniguchi,et al.  Epigenetic regulation of neural N‐glycomics , 2016, Proteomics.

[5]  K. Ohtsubo,et al.  Disease-associated glycans on cell surface proteins. , 2016, Molecular aspects of medicine.

[6]  N. Taniguchi,et al.  Enzymes for N-Glycan Branching and Their Genetic and Nongenetic Regulation in Cancer , 2016, Biomolecules.

[7]  Keiichiro Suzuki,et al.  Glyco-redox, a link between oxidative stress and changes of glycans: Lessons from research on glutathione, reactive oxygen and nitrogen species to glycobiology. , 2016, Archives of biochemistry and biophysics.

[8]  N. Taniguchi,et al.  Atomic visualization of a flipped-back conformation of bisected glycans bound to specific lectins , 2016, Scientific Reports.

[9]  J. Gu,et al.  Expression of N-Acetylglucosaminyltransferase III Suppresses α2,3-Sialylation, and Its Distinctive Functions in Cell Migration Are Attributed to α2,6-Sialylation Levels* , 2016, The Journal of Biological Chemistry.

[10]  Evan Bolton,et al.  Symbol Nomenclature for Graphical Representations of Glycans. , 2015, Glycobiology.

[11]  N. Taniguchi,et al.  Clec4g (LSECtin) interacts with BACE1 and suppresses Aβ generation , 2015, FEBS letters.

[12]  M. Staufenbiel,et al.  An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease , 2015, EMBO molecular medicine.

[13]  P. Wong,et al.  Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects , 2014, Journal of neurochemistry.

[14]  S. Itohara,et al.  Single App knock-in mouse models of Alzheimer's disease , 2014, Nature Neuroscience.

[15]  Y. Wada,et al.  The Absence of Core Fucose Up-regulates GnT-III and Wnt Target Genes , 2014, The Journal of Biological Chemistry.

[16]  K. Nave,et al.  Bace1 and Neuregulin-1 cooperate to control formation and maintenance of muscle spindles , 2013, The EMBO journal.

[17]  Frank M LaFerla,et al.  Animal models of Alzheimer disease. , 2012, Cold Spring Harbor perspectives in medicine.

[18]  U. Schepers,et al.  Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons , 2012, The EMBO journal.

[19]  Kelley W. Moremen,et al.  Vertebrate protein glycosylation: diversity, synthesis and function , 2012, Nature Reviews Molecular Cell Biology.

[20]  B. de Strooper,et al.  The Neural Cell Adhesion Molecules L1 and CHL1 Are Cleaved by BACE1 Protease in Vivo* , 2012, The Journal of Biological Chemistry.

[21]  C. Haass,et al.  Trafficking and proteolytic processing of APP. , 2012, Cold Spring Harbor perspectives in medicine.

[22]  Y. Sugita,et al.  Structural diversity and changes in conformational equilibria of biantennary complex-type N-glycans in water revealed by replica-exchange molecular dynamics simulation. , 2011, Biophysical journal.

[23]  B. Strooper,et al.  The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics , 2011, Nature Reviews Drug Discovery.

[24]  D. Selkoe,et al.  Resolving controversies on the path to Alzheimer's therapeutics , 2011, Nature Medicine.

[25]  J. Marth,et al.  Pathway to diabetes through attenuation of pancreatic beta cell glycosylation and glucose transport , 2011, Nature Medicine.

[26]  Alison Abbott,et al.  Dementia: A problem for our age , 2011, Nature.

[27]  P. Stanley,et al.  Tumor and Stem Cell Biology Cancer Research The Bisecting GlcNAc on N-Glycans Inhibits Growth Factor Signaling and Retards Mammary Tumor Progression , 2010 .

[28]  N. Taniguchi.  From the γ-glutamyl cycle to the glycan cycle: a road with many turns and pleasant surprises. , 2010, The Journal of Biological Chemistry.

[29]  N. Taniguchi.  From the γ-Glutamyl Cycle to the Glycan Cycle: A Road with Many Turns and Pleasant Surprises , 2009, The Journal of Biological Chemistry.

[30]  K. Ohtsubo,et al.  Core fucose and bisecting GlcNAc, the direct modifiers of the N-glycan core: their functions and target proteins. , 2009, Carbohydrate research.

[31]  Y. Sakurai,et al.  Increased bisecting and core-fucosylated N-glycans on mutant human amyloid precursor proteins , 2008, Glycoconjugate Journal.

[32]  D. Price,et al.  Alteration of BACE1-dependent NRG1/ErbB4 signaling and schizophrenia-like phenotypes in BACE1-null mice , 2008, Proceedings of the National Academy of Sciences.

[33]  P. Wong,et al.  Bace1 modulates myelination in the central and peripheral nervous system , 2006, Nature Neuroscience.

[34]  P. Saftig,et al.  Control of Peripheral Nerve Myelination by the ß-Secretase BACE1 , 2006, Science.

[35]  Naoyuki Taniguchi,et al.  Decoding sugar functions by identifying target glycoproteins. , 2006, Current opinion in structural biology.

[36]  J. Marth,et al.  Glycosylation in Cellular Mechanisms of Health and Disease , 2006, Cell.

[37]  Rudi D'Hooge,et al.  Phenotypic and Biochemical Analyses of BACE1- and BACE2-deficient Mice* , 2005, Journal of Biological Chemistry.

[38]  L. Tsai,et al.  BACE1 Suppression by RNA Interference in Primary Cortical Neurons* , 2004, Journal of Biological Chemistry.

[39]  P. Stanley,et al.  Truncated, InactiveN-Acetylglucosaminyltransferase III (GlcNAc-TIII) Induces Neurological and Other Traits Absent in Mice That Lack GlcNAc-TIII* , 2002, The Journal of Biological Chemistry.

[40]  G. Struhl,et al.  Nicastrin is required for Presenilin-mediated transmembrane cleavage in Drosophila , 2001, Nature Cell Biology.

[41]  Y. Ikeda,et al.  Down-regulation of the alpha-Gal epitope expression in N-glycans of swine endothelial cells by transfection with the N-acetylglucosaminyltransferase III gene. Modulation of the biosynthesis of terminal structures by a bisecting GlcNAc. , 2001, The Journal of biological chemistry.

[42]  Ruedi Aebersold,et al.  Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and βAPP processing , 2000, Nature.

[43]  J. Dennis,et al.  Suppression of tumor growth and metastasis in Mgat5-deficient mice , 2000, Nature Medicine.

[44]  Carolyn R. Bertozzi,et al.  Essentials of Glycobiology , 1999 .

[45]  Naoyuki Taniguchi,et al.  Expression of α1‐6 fucosyltransferase in rat tissues and human cancer cell lines , 1997 .

[46]  J. Marth,et al.  Isolation, characterization and inactivation of the mouse Mgat3 gene: the bisecting N-acetylglucosamine in asparagine-linked oligosaccharides appears dispensable for viability and reproduction. , 1997, Glycobiology.

[47]  S. Fujii,et al.  Remodeling of cell surface glycoproteins by N-acetylglucosaminyltransferase III gene transfection: modulation of metastatic potentials and down regulation of hepatitis B virus replication. , 1996, Glycobiology.

[48]  Y. Matsuzawa,et al.  Aberrant Glycosylation of E-cadherin Enhances Cell-Cell Binding to Suppress Metastasis* , 1996, The Journal of Biological Chemistry.

[49]  N. Taniguchi,et al.  Suppression of lung metastasis of B16 mouse melanoma by N-acetylglucosaminyltransferase III gene transfection. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[50]  J. Rommens,et al.  Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene , 1995, Nature.

[51]  D. Pollen,et al.  Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease , 1995, Nature.

[52]  T. Miyatake,et al.  N-Linked Oligosaccharide of β-Amyloid Precursor Protein (βAPP) of C6 Glioma-Cells: Putative Regulatory Role in βAPP Processing , 1995 .

[53]  J. Gu,et al.  Purification and characterization of UDP-N-acetylglucosamine: alpha-6-D-mannoside beta 1-6N-acetylglucosaminyltransferase (N-acetylglucosaminyltransferase V) from a human lung cancer cell line. , 1993, Journal of biochemistry.

[54]  N. Taniguchi,et al.  Purification, cDNA cloning, and expression of UDP-N-acetylglucosamine: beta-D-mannoside beta-1,4N-acetylglucosaminyltransferase III from rat kidney. , 1992, The Journal of biological chemistry.

[55]  S. Fujii,et al.  Structural heterogeneity of sugar chains in immunoglobulin G. Conformation of immunoglobulin G molecule and substrate specificities of glycosyltransferases. , 1990, The Journal of biological chemistry.

[56]  H. Schachter,et al.  Biosynthetic controls that determine the branching and microheterogeneity of protein-bound oligosaccharides. , 1986, Biochemistry and cell biology = Biochimie et biologie cellulaire.

[57]  N. Taniguchi,et al.  Bisecting GlcNAc modification stabilizes BACE1 protein under oxidative stress conditions. , 2016, The Biochemical journal.

[58]  Naoyuki Taniguchi,et al.  Glycans and cancer: role of N-glycans in cancer biomarker, progression and metastasis, and therapeutics. , 2015, Advances in cancer research.

[59]  J. Gu,et al.  Mannosyl (Beta-1,4-)-Glycoprotein Beta-1,4-N-Acetylglucosaminyltransferase (MGAT3); β1,4-N-Acetylglucosaminyltransferase III (GnT-III, GlcNAcT-III) , 2014 .

[60]  D. Selkoe.  Alzheimer's disease. , 2011, Cold Spring Harbor perspectives in biology.

[61]  N. Taniguchi,et al.  Protective effect of N-glycan bisecting GlcNAc residues on beta-amyloid production in Alzheimer's disease. , 2010, Glycobiology.

[62]  N. Hayashi,et al.  Expression of alpha1-6 fucosyltransferase in rat tissues and human cancer cell lines. , 1997, International journal of cancer.

[63]  T. Miyatake,et al.  N-linked oligosaccharide of beta-amyloid precursor protein (beta APP) of C6 glioma cells: putative regulatory role in beta APP processing. , 1995, Biochemical and biophysical research communications.

[64]  Shigeru FujiiS,et al.  Structural Heterogeneity of Sugar Chains in Immunoglobulin G , 1990 .