Image Sequence Processing Using Factor Analysis And Compartmental Modelling

Factor Analysis of Dynamic Structures (FADS) has been developed since ten years in the medical imaging field to process dynamic image sequences. Its aim is to estimate the different underlying physiological mechanisms. This paper summarises the conventional FADS algorithm and discusses its limitations. A priori information has been used by several authors in order to improve the estimations. After a critical review of these approaches, we propose an original way of introducing constraints, which is based on the a priori knowledge of the physiological data. It is applied to the study of 99mTc HMDP early kinetics in osseous tissues.

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