Design and syntheses of some iminosugar derivatives as potential immunosuppressants

Eleven new iminosugar derivatives were synthesized and the effects of these synthetic iminosugars on proliferation of the mouse splenocytes were evaluated by the cell counting kit-8 (CCK-8) assay. The preliminary structure–activity relationships were deduced from the experimental data. It was found that iminosugar 14 (IC50 = 22 μM) and its C-5 epimer 15 (IC50 = 45 μM) displayed the strongest inhibitory effects, and might hold potential as immunosuppressive agents.

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