FTO genetic variants and risk of obesity and type 2 diabetes: A meta‐analysis of 28,394 Indians

To investigate the magnitude of association of FTO variants with obesity, type 2 diabetes (T2DM), and related traits among Asian Indians.

[1]  Robert J. Goodloe,et al.  The Influence of Obesity-Related Single Nucleotide Polymorphisms on BMI Across the Life Course , 2013, Diabetes.

[2]  E. Ingelsson,et al.  Associations of Variants in FTO and Near MC4R With Obesity Traits in South Asian Indians , 2012, Obesity.

[3]  Nilanjan Chatterjee,et al.  Common Genetic Variants and Central Adiposity Among Asian‐Indians , 2012, Obesity.

[4]  D. Meyre.  Is FTO a type 2 diabetes susceptibility gene? , 2012, Diabetologia.

[5]  S. R. Kulkarni,et al.  Analysis of 32 common susceptibility genetic variants and their combined effect in predicting risk of Type 2 diabetes and related traits in Indians , 2012, Diabetic medicine : a journal of the British Diabetic Association.

[6]  T. Wong,et al.  Replication of 13 obesity loci among Singaporean Chinese, Malay and Asian-Indian populations , 2012, International Journal of Obesity.

[7]  P. Sham,et al.  Association of genetic variation in FTO with risk of obesity and type 2 diabetes with data from 96,551 East and South Asians , 2011, Diabetologia.

[8]  N. Timpson,et al.  Association analysis of 31 common polymorphisms with type 2 diabetes and its related traits in Indian sib pairs , 2011, Diabetologia.

[9]  S. Awasthi,et al.  Association of FTO rs17817449 SNP with obesity and associated physiological parameters in a north Indian population , 2011, Annals of human biology.

[10]  N. Tandon,et al.  Common variants of FTO and the risk of obesity and type 2 diabetes in Indians , 2011, Journal of Human Genetics.

[11]  M. Lai,et al.  FTO gene polymorphisms and obesity risk: a meta-analysis , 2011, BMC medicine.

[12]  N. Timpson,et al.  Associations of FTO and MC4R Variants with Obesity Traits in Indians and the Role of Rural/Urban Environment as a Possible Effect Modifier , 2011, Journal of obesity.

[13]  V. Mohan,et al.  Genetic variations in the FTO gene are associated with type 2 diabetes and obesity in south Indians (CURES-79). , 2011, Diabetes technology & therapeutics.

[14]  Thomas Meitinger,et al.  Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution , 2010, Nature Genetics.

[15]  Tanya M. Teslovich,et al.  Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index , 2010 .

[16]  Ituro Inoue,et al.  Meta-analysis of genetic association studies: methodologies, between-study heterogeneity and winner's curse , 2009, Journal of Human Genetics.

[17]  Laura J. Scott,et al.  Edinburgh Research Explorer Genome-wide association scan meta-analysis identifies three loci influencing adiposity and fat distribution , 2022 .

[18]  R. Gupta,et al.  Consensus statement for diagnosis of obesity, abdominal obesity and the metabolic syndrome for Asian Indians and recommendations for physical activity, medical and surgical management. , 2009, The Journal of the Association of Physicians of India.

[19]  Ellen Kampman,et al.  Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity , 2009, Nature Genetics.

[20]  Christian Gieger,et al.  Six new loci associated with body mass index highlight a neuronal influence on body weight regulation , 2009, Nature Genetics.

[21]  S. R. Kulkarni,et al.  FTO gene variants are strongly associated with type 2 diabetes in South Asian Indians , 2009, Diabetologia.

[22]  Anoop Misra,et al.  Obesity and the metabolic syndrome in developing countries. , 2008, The Journal of clinical endocrinology and metabolism.

[23]  T. Wong,et al.  FTO Variants Are Associated With Obesity in the Chinese and Malay Populations in Singapore , 2008, Diabetes.

[24]  Philippe Froguel,et al.  Common genetic variation near MC4R is associated with waist circumference and insulin resistance , 2008, Nature Genetics.

[25]  Subhajyoti De,et al.  Common variants near MC4R are associated with fat mass, weight and risk of obesity , 2008, Nature Genetics.

[26]  S. Yusuf,et al.  Association between the FTO rs9939609 polymorphism and the metabolic syndrome in a non-Caucasian multi-ethnic sample , 2008, Cardiovascular diabetology.

[27]  Shizhong Han,et al.  Impact of nine common type 2 diabetes risk polymorphisms in Asian Indian Sikhs: PPARG2 (Pro12Ala), IGF2BP2, TCF7L2 and FTO variants confer a significant risk , 2008, BMC Medical Genetics.

[28]  Lisa J. Martin,et al.  Meta‐Analysis of Genome‐wide Linkage Studies in BMI and Obesity , 2007, Obesity.

[29]  James Strait,et al.  Genome-Wide Association Scan Shows Genetic Variants in the FTO Gene Are Associated with Obesity-Related Traits , 2007, PLoS genetics.

[30]  M. Jarvelin,et al.  A Common Variant in the FTO Gene Is Associated with Body Mass Index and Predisposes to Childhood and Adult Obesity , 2007, Science.

[31]  Gary H Lyman,et al.  The strengths and limitations of meta-analyses based on aggregate data , 2005, BMC Medical Research Methodology.

[32]  S. Wild,et al.  Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. , 2004, Diabetes care.

[33]  Pak Chung Sham,et al.  Genetic Power Calculator: design of linkage and association genetic mapping studies of complex traits , 2003, Bioinform..

[34]  P. Deurenberg,et al.  Elevated body fat percentage and cardiovascular risks at low body mass index levels among Singaporean Chinese, Malays and Indians , 2002, Obesity reviews : an official journal of the International Association for the Study of Obesity.

[35]  C. Yajnik.  The lifecycle effects of nutrition and body size on adult adiposity, diabetes and cardiovascular disease , 2002, Obesity reviews : an official journal of the International Association for the Study of Obesity.

[36]  S. Thompson,et al.  Quantifying heterogeneity in a meta‐analysis , 2002, Statistics in medicine.

[37]  S Duval,et al.  Trim and Fill: A Simple Funnel‐Plot–Based Method of Testing and Adjusting for Publication Bias in Meta‐Analysis , 2000, Biometrics.

[38]  G. Smith,et al.  Bias in meta-analysis detected by a simple, graphical test , 1997, BMJ.

[39]  W. Haenszel,et al.  Statistical aspects of the analysis of data from retrospective studies of disease. , 1959, Journal of the National Cancer Institute.