论文信息 - Optimization of a coded aperture coherent scatter spectral imaging system for medical imaging

Optimization of a coded aperture coherent scatter spectral imaging system for medical imaging

Coherent scatter X-ray imaging is a technique that provides spatially-resolved information about the molecular structure of the material under investigation, yielding material-specific contrast that can aid medical diagnosis and inform treatment. In this study, we demonstrate a coherent-scatter imaging approach based on the use of coded apertures (known as coded aperture coherent scatter spectral imaging1, 2) that enables fast, dose-efficient, high-resolution scatter imaging of biologically-relevant materials. Specifically, we discuss how to optimize a coded aperture coherent scatter imaging system for a particular set of objects and materials, describe and characterize our experimental system, and use the system to demonstrate automated material detection in biological tissue.

David J. Brady | Joel A. Greenberg | Anuj J. Kapadia | Manu N. Lakshmanan

[1] R D Speller,et al. X-ray scatter signatures for normal and neoplastic breast tissues. , 1999, Physics in medicine and biology.

[2] Ricardo Tadeu Lopes,et al. Coherent scattering characteristics of normal and pathological breast human tissues , 2004 .

[3] Ian A Cunningham,et al. Bone-composition imaging using coherent-scatter computed tomography: assessing bone health beyond bone mineral density. , 2006, Medical physics.

[4] Chrysoula Theodorakou,et al. The classification of secondary colorectal liver cancer in human biopsy samples using angular dispersive x-ray diffraction and multivariate analysis. , 2009, Physics in medicine and biology.

[5] Taha Sochi,et al. Reconstructive colour X-ray diffraction imaging--a novel TEDDI imaging method. , 2009, The Analyst.

[6] D. Brady,et al. Snapshot molecular imaging using coded energy-sensitive detection. , 2013, Optics express.

[7] Wael M. Elshemey,et al. X-ray scattering signatures of β-thalassemia , 2009 .

[8] David J. Brady,et al. Coding and sampling for compressive x-ray diffraction tomography , 2013, Optics & Photonics - Optical Engineering + Applications.

[9] Ehsan Samei,et al. Experimental implementation of coded aperture coherent scatter spectral imaging of cancerous and healthy breast tissue samples , 2015, Medical Imaging.

[10] P C Johns,et al. X-ray coherent scattering form factors of tissues, water and plastics using energy dispersion. , 2011, Physics in medicine and biology.