Improvement of Eustachian Tube Function by Tissue-Engineered Regeneration of Mastoid Air Cells

Most cases of chronic otitis media (OMC) are associated with poor development of the mastoid air cells (MACs) and poor Eustachian tube (ET) function. We have previously reported that MAC regeneration can effectively eliminate intractable OMC. In this study, we assessed the ability of regenerated MACs to restore normal gas exchange function and contribute to improved ET function.

[1]  Y. Yamamoto Gas exchange function through the middle ear mucosa in piglets: comparative study of normal and inflamed ears. , 1999, Acta oto-laryngologica.

[2]  A. Bilgili,et al.  Evaluation of the mastoid air cell system by high resolution computed tomography: three-dimensional multiplanar volume rendering technique , 2003, The Journal of Laryngology & Otology.

[3]  W. Doyle The mastoid as a functional rate-limiter of middle ear pressure change. , 2007, International journal of pediatric otorhinolaryngology.

[4]  F. Ikarashi,et al.  Carbon dioxide exchange via the mucosa in healthy middle ear. , 1999, Archives of otolaryngology--head & neck surgery.

[5]  高橋 晴雄 The middle ear : the role of ventilation in disease and surgery , 2001 .

[6]  H. Toda,et al.  Gas Exchange Function Through the Mastoid Mucosa in Ears After Surgery , 1997, The Laryngoscope.

[7]  Federico Marchetti,et al.  Burden of Disease Caused by Otitis Media: Systematic Review and Global Estimates , 2012, PloS one.

[8]  J. Dirckx,et al.  Middle Ear Pressure Regulation-Complementary Active Actions of the Mastoid and the Eustachian Tube , 2010, Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology.

[9]  K. Omori,et al.  Regeneration of Mastoid Air Cells in Clinical Applications by In Situ Tissue Engineering , 2005, The Laryngoscope.

[10]  K. Shakesheff,et al.  Development of a porous poly(DL‐lactic acid‐co‐glycolic acid)‐based scaffold for mastoid air‐cell regeneration , 2013, The Laryngoscope.

[11]  K. Omori,et al.  Tissue engineering for the regeneration of the mastoid air cells: A preliminary in vitro study , 2004, Acta oto-laryngologica. Supplementum.

[12]  K. Omori,et al.  Regeneration of mastoid air cells: Clinical applications , 2004, Acta oto-laryngologica. Supplementum.