What is the importance of the immunological synapse?

The immunological synapse (IS) has proved to be a stimulating concept, particularly in provoking discussion on the similarity of intercellular communication controlling disparate biological processes. Recent studies have clarified some of the underlying molecular mechanisms and functions of the IS. For both T cells and natural killer (NK) cells, assembly of the IS can be described in stages with distinct cytoskeletal requirements. Functions of the IS vary with circumstance and include directing secretion and integrating positive and negative signals to determine the extent of response.

[1]  Bo Dupont,et al.  Cutting Edge: Differential Segregation of the Src Homology 2-Containing Protein Tyrosine Phosphatase-1 Within the Early NK Cell Immune Synapse Distinguishes Noncytolytic from Cytolytic Interactions1 , 2002, The Journal of Immunology.

[2]  P. Parham,et al.  Stress management: MHC class I and class I-like molecules as reporters of cellular stress. , 2003, Immunity.

[3]  B. Freiberg,et al.  Formation of supramolecular activation clusters on fresh ex vivo CD8+ T cells after engagement of the T cell antigen receptor and CD8 by antigen-presenting cells , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[4]  H. Maniar,et al.  Visualization of signaling pathways and cortical cytoskeleton in cytolytic and noncytolytic natural killer cell immune synapses , 2002, Immunological reviews.

[5]  P. Marrack,et al.  Complex and dynamic redistribution of NF-kappaB signaling intermediates in response to T cell receptor stimulation. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[6]  Clemens Utzny,et al.  Lytic versus stimulatory synapse in cytotoxic T lymphocyte/target cell interaction: Manifestation of a dual activation threshold , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[7]  I. Verma.  The Common Thread: A Story of Science, Politics, Ethics and the Human Genome , 2002, Nature Medicine.

[8]  M. Bonneville,et al.  Uncoupling between immunological synapse formation and functional outcome in human gamma delta T lymphocytes. , 2003, Journal of immunology.

[9]  Leo M. Carlin,et al.  Intercellular Transfer and Supramolecular Organization of Human Leukocyte Antigen C at Inhibitory Natural Killer Cell Immune Synapses 〉 , 2001, The Journal of experimental medicine.

[10]  Steffen Jung,et al.  Spatial Organization of Signal Transduction Molecules in the NK Cell Immune Synapses During MHC Class I-Regulated Noncytolytic and Cytolytic Interactions , 2001, The Journal of Immunology.

[11]  Patricia L. Widder,et al.  A Novel Adaptor Protein Orchestrates Receptor Patterning and Cytoskeletal Polarity in T-Cell Contacts , 1998, Cell.

[12]  A. Lanzavecchia,et al.  Different responses are elicited in cytotoxic T lymphocytes by different levels of T cell receptor occupancy , 1996, The Journal of experimental medicine.

[13]  H. Kupfer,et al.  Imaging immune cell interactions and functions: SMACs and the Immunological Synapse. , 2003, Seminars in immunology.

[14]  R. Biassoni,et al.  Human NK cells and their receptors. , 2002, Microbes and infection.

[15]  L. Lanier,et al.  Virus-driven evolution of natural killer cell receptors. , 2002, Microbes and infection.

[16]  L. Mátyus,et al.  Kv1.3 potassium channels are localized in the immunological synapse formed between cytotoxic and target cells. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[17]  Charles A. Janeway,et al.  Receptor-directed focusing of lymphokine release by helper T cells , 1988, Nature.

[18]  Michael J. Byrne,et al.  Wiskott–Aldrich syndrome protein is required for NK cell cytotoxicity and colocalizes with actin to NK cell-activating immunologic synapses , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[19]  M. Norcross,et al.  A synaptic basis for T-lymphocyte activation. , 1984, Annales d'immunologie.

[20]  M. Bonneville,et al.  Uncoupling between Immunological Synapse Formation and Functional Outcome in Human γδ T Lymphocytes , 2003, The Journal of Immunology.

[21]  H. Yin,et al.  Regulation of Sustained Actin Dynamics by the TCR and Costimulation as a Mechanism of Receptor Localization , 2003, The Journal of Immunology.

[22]  T. Hamblin,et al.  Adaptor protein 3–dependent microtubule-mediated movement of lytic granules to the immunological synapse , 2003, Nature Immunology.

[23]  O. Mandelboim,et al.  The human natural killer cell immune synapse. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[24]  L. Collinson,et al.  Cell Surface Organization of Stress-inducible Proteins ULBP and MICA That Stimulate Human NK Cells and T Cells via NKG2D , 2004, The Journal of experimental medicine.

[25]  W. Paul,et al.  Lymphocyte responses and cytokines , 1994, Cell.

[26]  D. Davis,et al.  Assembly of the immunological synapse for T cells and NK cells. , 2002, Trends in immunology.

[27]  H. Eisen,et al.  Evidence that a single peptide-MHC complex on a target cell can elicit a cytolytic T cell response. , 1996, Immunity.

[28]  G. Griffiths,et al.  The immunological synapse of CTL contains a secretory domain and membrane bridges. , 2001, Immunity.

[29]  Arup K Chakraborty,et al.  The Immunological Synapse Balances T Cell Receptor Signaling and Degradation , 2003, Science.

[30]  Jay T. Groves,et al.  Synaptic pattern formation during cellular recognition , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[31]  D. Goulding,et al.  The Size of the Synaptic Cleft and Distinct Distributions of Filamentous Actin, Ezrin, CD43, and CD45 at Activating and Inhibitory Human NK Cell Immune Synapses 12 , 2003, The Journal of Immunology.

[32]  Colin R. F. Monks,et al.  Three-dimensional segregation of supramolecular activation clusters in T cells , 1998, Nature.

[33]  B. Plougastel,et al.  Immune functions encoded by the natural killer gene complex , 2003, Nature Reviews Immunology.

[34]  N. Burroughs,et al.  Differential segregation in a cell-cell contact interface: the dynamics of the immunological synapse. , 2002, Biophysical journal.

[35]  Mark M. Davis,et al.  Direct observation of ligand recognition by T cells , 2002, Nature.

[36]  S. Bromley,et al.  Identification of self through two-dimensional chemistry and synapses. , 2001, Annual review of cell and developmental biology.

[37]  D. Raulet.  Roles of the NKG2D immunoreceptor and its ligands , 2003, Nature Reviews Immunology.

[38]  Michael Loran Dustin,et al.  Cytotoxic T lymphocytes form an antigen-independent ring junction. , 2004, The Journal of clinical investigation.

[39]  R. Germain,et al.  T-cell signaling: The importance of receptor clustering , 1997, Current Biology.

[40]  S. Dzik,et al.  The immunological synapse: A molecular machine controlling T cell activation , 2000 .

[41]  P. Bongrand,et al.  Intercellular transfer of antigen‐presenting cell determinants onto T cells: molecular mechanisms and biological significance , 2002, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[42]  A. Trautmann,et al.  ERM proteins regulate cytoskeleton relaxation promoting T cell–APC conjugation , 2004, Nature Immunology.

[43]  Mark M Davis,et al.  Continuous T cell receptor signaling required for synapse maintenance and full effector potential , 2003, Nature Immunology.

[44]  Eric O Long,et al.  Vav1 Dephosphorylation by the Tyrosine Phosphatase SHP-1 as a Mechanism for Inhibition of Cellular Cytotoxicity , 2003, Molecular and Cellular Biology.

[45]  Mitsuhiro Osame,et al.  Spread of HTLV-I Between Lymphocytes by Virus-Induced Polarization of the Cytoskeleton , 2003, Science.

[46]  Hans-Hermann Gerdes,et al.  Nanotubular Highways for Intercellular Organelle Transport , 2004, Science.

[47]  D. Zaller,et al.  Staging and resetting T cell activation in SMACs , 2002, Nature Immunology.

[48]  Watt W. Webb,et al.  Imaging coexisting fluid domains in biomembrane models coupling curvature and line tension , 2003, Nature.

[49]  Michael Loran Dustin,et al.  T Cell Receptor Signaling Precedes Immunological Synapse Formation , 2002, Science.

[50]  J. Schatzle,et al.  Stepwise cytoskeletal polarization as a series of checkpoints in innate but not adaptive cytolytic killing , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[51]  M. Neuberger,et al.  B cells acquire antigen from target cells after synapse formation , 2001, Nature.

[52]  M. Jackson,et al.  TCR-Mediated internalization of peptide-MHC complexes acquired by T cells. , 1999, Science.

[53]  Stephen Luntz,et al.  The Common Thread , 2002 .

[54]  D. McDonald,et al.  Recruitment of HIV and Its Receptors to Dendritic Cell-T Cell Junctions , 2003, Science.