Modulation of lemniscal input during conditioned arm movements in the monkey

SummaryModulation of sensory transmission in the lemniscal system was investigated in 2 monkeys trained to perform a simple elbow flexion in response to an auditory cue. Evoked responses to peripheral stimulation were recorded in the medial lemniscus, sensory thalamus (ventral posterior lateral nucleus, caudal division, VPLc) and somatosensory cortex. Simultaneous recordings were made from the cortex and either the medial lemniscus or VPLc. At all recording sites, evoked responses to natural (air puff) or electrical, percutaneous stimulation were depressed prior to and during active movement. The time course of the depression was similar at all three levels; the magnitude of the decrease during movement was most pronounced at the cortical level. Cortical evoked responses to central stimulation of effective sites in either the medial lemniscus or VPLc were decreased during, but not before, the onset of movement. The decrease was less than that seen for peripheral evoked potentials. Passive movement of the forearm significantly decreased all but the lemniscal evoked potential. The results indicate that there is a centrally mediated suppression of somatosensory transmission prior to, and during movement, occurring at the level of the first relay, the dorsal column nuclei. During movement, reafferent signals from the moving arm decrease transmission at the thalamocortical level.

[1]  D. Giblin,et al.  SOMATOSENSORY EVOKED POTENTIALS IN HEALTHY SUBJECTS AND IN PATIENTS WITH LESIONS OF THE NERVOUS SYSTEM * † , 1964, Annals of the New York Academy of Sciences.

[2]  J. Walsh,et al.  RESPONSIVENESS IN THE VISUAL SYSTEM DURING VARIOUS PHASES OF SLEEP AND WAKING. , 1965, Experimental neurology.

[3]  E. Evarts.  Pyramidal tract activity associated with a conditioned hand movement in the monkey. , 1966, Journal of neurophysiology.

[4]  M. L. Sotgiu,et al.  Control by brain stem reticular formation of sensory transmission in Burdach nucleus. Analysis of single units. , 1969, Brain research.

[5]  Y. Lamarre,et al.  A stereotaxic method for repeated sessions of central unit recording in the paralyzed or moving animal. , 1970, Revue canadienne de biologie.

[6]  A. Towe,et al.  Afferent inhibition in the cuneate nucleus of the rhesus monkey. , 1971, Brain research.

[7]  M. Coulmance,et al.  Modifications des potentiels evoques corticaux somesthesiques durant des mouvements actifs et passifs chez l'homme , 1972 .

[8]  J. Coquery,et al.  Altérations des potentiels évoqués sur le cortex somesthésique du chat durant un mouvement conditionné , 1972 .

[9]  E V Evarts,et al.  Contrasts between activity of precentral and postcentral neurons of cerebral cortex during movement in the monkey. , 1972, Brain research.

[10]  C. Ghez,et al.  Inhibition of afferent transmission in cuneate nucleus during voluntary movement in the cat. , 1972, Brain research.

[11]  J. D. Coulter,et al.  Sensory transmission through lemniscal pathway during voluntary movement in the cat. , 1974, Journal of neurophysiology.

[12]  E V Evarts,et al.  Precentral and postcentral cortical activity in association with visually triggered movement. , 1974, Journal of neurophysiology.

[13]  R. Cooper,et al.  Inhibition of cortical evoked potentials and sensation by self-initiated movement in man , 1975, Nature.

[14]  S P Wise,et al.  Size, laminar and columnar distribution of efferent cells in the sensory‐motor cortex of monkeys , 1977, The Journal of comparative neurology.

[15]  E. G. Jones,et al.  Intracortical connectivity of architectonic fields in the somatic sensory, motor and parietal cortex of monkeys , 1978, The Journal of comparative neurology.

[16]  D. Pandya,et al.  Cortico‐cortical connections of somatic sensory cortex (areas 3, 1 and 2) in the rhesus monkey , 1978, The Journal of comparative neurology.

[17]  Y. Lamarre,et al.  Activity of postcentral cortical neurons of the monkey during conditioned movements of a deafferented limb , 1979, Brain Research.

[18]  E. Fetz,et al.  Responses of identified cells in postcentral cortex of awake monkeys during comparable active and passive joint movements. , 1980, Journal of neurophysiology.

[19]  J Hyvärinen,et al.  Influence of attentive behavior on neuronal responses to vibration in primary somatosensory cortex of the monkey. , 1980, Journal of neurophysiology.

[20]  E Favale,et al.  Proprioceptive modulation of somatosensory evoked potentials during active or passive finger movements in man. , 1981, Journal of neurology, neurosurgery, and psychiatry.

[21]  Y Lamarre,et al.  Patterns of muscular and motor cortical activity during a simple arm movement in the monkey. , 1981, Canadian journal of physiology and pharmacology.

[22]  J. Rothwell,et al.  Gating of somatosensory evoked potentials during different kinds of movement in man. , 1981, Brain : a journal of neurology.

[23]  Donald J. Woodward,et al.  Modulation of sensory responsiveness of single somatosensory cortical cells during movement and arousal behaviors , 1981, Experimental Neurology.

[24]  Edward V. Evarts,et al.  Pyramidal tract neurons in somatosensory cortex: central and peripheral inputs during voluntary movement , 1982, Brain Research.

[25]  J. Chapin,et al.  Somatic sensory transmission to the cortex during movement: Gating of single cell responses to touch , 1982, Experimental Neurology.

[26]  J. Hyvärinen,et al.  Effects of attention on multiunit responses to vibration in the somatosensory regions of the monkey's brain. , 1982, Electroencephalography and clinical neurophysiology.

[27]  J. Cole,et al.  Timing of corticofugal actions on the gracile and cuneate nuclei of the cat. , 1983, The Journal of physiology.

[28]  Y. Lamarre,et al.  Fast ballistic arm movements triggered by visual, auditory, and somesthetic stimuli in the monkey. I. Activity of precentral cortical neurons. , 1983, Journal of neurophysiology.

[29]  G. Lamb.  Tactile discrimination of textured surfaces: psychophysical performance measurements in humans. , 1983, The Journal of physiology.

[30]  R. Nelson.  Responsiveness of monkey primary somatosensory cortical neurons to peripheral stimulation depends on ‘motor-set’ , 1984, Brain Research.

[31]  R. Giuffrida,et al.  Effect of microstimulation of movement-evoking cortical foci on the activity of neurons on the dorsal column nuclei. , 1985, Somatosensory research.

[32]  B L Whitsel,et al.  Sensorimotor cortical projections to the primate cuneate nucleus , 1985, The Journal of comparative neurology.

[33]  Y. Lamarre,et al.  Activity of dentate neurons during arm movements triggered by visual, auditory, and somesthetic stimuli in the monkey. , 1986, Journal of neurophysiology.

[34]  Y. Lamarre,et al.  Comparative Timing of Neuronal Discharge in Cortical and Cerebellar Structures During a Simple Arm Movement in the Monkey , 1986 .

[35]  M. Bentivoglio,et al.  Corticospinal neurons with branching axons to the dorsal column nuclei in the monkey , 1986, The Journal of comparative neurology.

[36]  Modulation of somatosensory input to sensory cortex produced by intracortical microstimulation of motor cortex in the monkey , 1986 .

[37]  L. Cohen,et al.  Localization, timing and specificity of gating of somatosensory evoked potentials during active movement in man. , 1987, Brain : a journal of neurology.

[38]  C. E. Chapman,et al.  Sensory perception during movement in man , 2004, Experimental Brain Research.

[39]  S. Nakamura,et al.  Pyramidal tract control over cutaneous and kinesthetic sensory transmission in the cat thalamus , 1975, Experimental Brain Research.

[40]  C. Ghez,et al.  Modulation of sensory transmission in cat lemniscal system during voluntary movement , 2004, Pflügers Archiv.