Biodegradable thermoreversible gelling PLGA-g-PEG copolymers

The thermogelling aqueous solution of poly(DL-lactic acid-co-glycolic acid) grafted with poly(ethylene glycol)s is developed, and the elegant instrumental methods to determine sol–gel transition temperature and the method to control gel duration are reported.

[1]  Sung Wan Kim,et al.  Thermoreversible Gelation of PEG−PLGA−PEG Triblock Copolymer Aqueous Solutions , 1999 .

[2]  D. Wirtz,et al.  Reversible hydrogels from self-assembling artificial proteins. , 1998, Science.

[3]  C. Booth,et al.  Association properties of diblock copolymers of ethylene oxide and 1,2-butylene oxide in aqueous solution. Copolymers with oxyethylene-block lengths in the range 100-400 chain units. , 1999 .

[4]  Anna Gutowska,et al.  Thermogelling Biodegradable Polymers with Hydrophilic Backbones: PEG-g-PLGA , 2000 .

[5]  Y. Bae,et al.  Drug release from biodegradable injectable thermosensitive hydrogel of PEG-PLGA-PEG triblock copolymers. , 2000, Journal of controlled release : official journal of the Controlled Release Society.

[6]  M. Malmsten,et al.  Self-assembly in aqueous block copolymer solutions , 1992 .

[7]  J. Vacanti,et al.  Soft-Tissue Augmentation with Injectable Alginate and Syngeneic Fibroblasts , 2000, Plastic and reconstructive surgery.

[8]  T. A. Hatton,et al.  Micellization of poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) triblock copolymers in aqueous solutions: Thermodynamics of copolymer association , 1994 .

[9]  Sung Wan Kim,et al.  Biodegradable thermosensitive micelles of PEG-PLGA-PEG triblock copolymers , 1999 .

[10]  A. Hoffman,et al.  Site-specific polymer-streptavidin bioconjugate for pH-controlled binding and triggered release of biotin. , 2000, Bioconjugate chemistry.

[11]  H. Hoffmann,et al.  The aggregation behavior of poly-(oxyethylene)-poly-(oxypropylene)-poly-(oxyethylene)-block-copolymers in aqueous solution , 1990 .