Post mortem studies of systemic candidiasis: I. Diagnostic validity of precipitin reaction and probable origin of sensitization to cytoplasmic candidal antigens.

Precipitating antibodies against a cytoplasmic extract of Candida albicans (“S” antigen) were demonstrated during life in 14 of 17 patients who revealed systemic candidal infection Post mortem. No false positive precipitin reactions were observed. Three false negative reactions are attributed to terminal or disease-related anergy.The precipitin reaction proved diagnostically more reliable than mycologic evidence of infection. However, no diagnostic test at present available reflects adequately the extent and severity of the infection in a given case. Both were considerable in the present series, in whom on the average three internal organs were involved per patient.The macrophages of the reticuloendothelial system are implicated in the destruction of Candida and release of the cytoplasmic antigens that induce the precipitin response.The yeast phase of Candida appears to be the invasive form, and neither tubes nor mycelia seem to be essential in evoking the inflammatory or necrotic tissue changes that char...

[1]  P. Kozinn,et al.  Diagnosis and therapy of systemic candidiasis. , 1969, Sabouraudia.

[2]  E. Henderson,et al.  Serologic diagnosis of disseminated candidiasis in patients with acute leukemia. , 1968, Annals of internal medicine.

[3]  D. Sulitzeanu.  Affinity of antigen for white cells and its relation to the induction of antibody formation. , 1968, Bacteriological reviews.

[4]  L. Montes,et al.  Ultrastructural Features of Host-Parasite Relationship in Oral Candidiasis , 1968, Journal of bacteriology.

[5]  N. Esterly.  Serum antibody titers to Candida albicans utilizing an immunofluorescent technic. , 1968, American journal of clinical pathology.

[6]  Seelig Ms.  The rationale for preventing antibacterial-induced fungal overgrowth. , 1968 .

[7]  F. Hargreave,et al.  Candida albicans precipitins in respiratory disease in man. , 1968, The Journal of allergy.

[8]  D. Rifkind,et al.  Systemic fungal infections complicating renal transplantation and immunosuppressive therapy: Clinical, microbiologic, neurologic and pathologic features , 1967 .

[9]  P. Kozinn,et al.  Serodiagnosis of systemic candidiasis. , 1967, The Journal of infectious diseases.

[10]  C. Taschdjian,et al.  The susceptibility to moniliasis in children with endocrine hypofunction. , 1967, Transactions of the Association of American Physicians.

[11]  G. Gresham.  Experimentally induced Candida infections. , 1966 .

[12]  G. Thorbecke,et al.  PHAGOCYTOSIS OF THE ANTIGEN, A CRUCIAL STEP IN THE INDUCTION OF THE PRIMARY RESPONSE. , 1965, Proceedings of the National Academy of Sciences of the United States of America.

[13]  P. Kozinn,et al.  Immune studies in candidiasis. 3. Precipitating antibodies in systemic candidiasis. , 1964, Sabouraudia.

[14]  D. Mackenzie.  Morphogenesis of Candida albicans in vivo. , 1964, Sabouraudia.

[15]  P. Kozinn,et al.  Immune studies relating to candidiasis. II. Experimental and preliminary clinical studies on antibody formation in systemic candidiasis. , 1964, Sabouraudia.

[16]  D. Louria,et al.  Behavior of Candida Cells Within Leukocytes.∗ , 1964, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[17]  M. Solotorovsky,et al.  Fluorescent antibody studies of pathogenesis in experimental Candida albicans infections of mice. , 1962, Journal of immunology.

[18]  G. Gresham,et al.  Studies of the invasive, mycelial form of Candida albicans. , 1961, Sabouraudia.