Wireless-Powering Deep Brain Stimulation Platform Based on 1D-Structured Magnetoelectric Nanochains Applied in Antiepilepsy Treatment.

Electrical deep brain stimulation (DBS) is a top priority for pharmacoresistant epilepsy treatment, while less-invasive wireless DBS is an urgent priority but challenging. Herein, we developed a conceptual wireless DBS platform to realize local electric stimulation via 1D-structured magnetoelectric Fe3O4@BaTiO3 nanochains (FBC). The FBC was facilely synthesized via magnetic-assisted interface coassembly, possessing a higher electrical output by inducing larger local strain from the anisotropic structure and strain coherence. Subsequently, wireless magnetoelectric neuromodulation in vitro was synergistically achieved by voltage-gated ion channels and to a lesser extent, the mechanosensitive ion channels. Furthermore, FBC less-invasively injected into the anterior nucleus of the thalamus (ANT) obviously inhibited acute and continuous seizures under magnetic loading, exhibiting excellent therapeutic effects in suppressing both high voltage electroencephalogram signals propagation and behavioral seizure stage and neuroprotection of the hippocampus mediated via the Papez circuit similar to conventional wired-in DBS. This work establishes an advanced antiepilepsy strategy and provides a perspective for other neurological disorder treatment.

[1]  G. Lur,et al.  Magnetic-field-synchronized wireless modulation of neural activity by magnetoelectric nanoparticles , 2022, Brain Stimulation.

[2]  L. Covolan,et al.  Deep brain stimulation of the anterior thalamus attenuates PTZ kindling with concomitant reduction of adenosine kinase expression in rats , 2022, Brain Stimulation.

[3]  Aviad Hai,et al.  In silico assessment of electrophysiological neuronal recordings mediated by magnetoelectric nanoparticles , 2022, Scientific Reports.

[4]  F. Gao,et al.  Ni3C/Ni Nanochains for Electrochemical Sensing of Glucose , 2021, ACS Applied Nano Materials.

[5]  Hongsong Fan,et al.  Magnetoelectric Nanoparticles Incorporated Biomimetic Matrix for Wireless Electrical Stimulation and Nerve Regeneration , 2021, Advanced healthcare materials.

[6]  Ming Wu,et al.  Strain engineered nano-ferroelectrics for high-efficiency piezocatalytic overall water splitting. , 2021, Angewandte Chemie.

[7]  Carmen C. Mayorga-Martinez,et al.  Magnetically Driven Micro and Nanorobots , 2021, Chemical reviews.

[8]  J. Cheon,et al.  Non-contact long-range magnetic stimulation of mechanosensitive ion channels in freely moving animals , 2021, Nature Materials.

[9]  Y. Temel,et al.  Nonresonant powering of injectable nanoelectrodes enables wireless deep brain stimulation in freely moving mice , 2021, Science Advances.

[10]  Alberto Salleo,et al.  How is flexible electronics advancing neuroscience research? , 2020, Biomaterials.

[11]  M. Landry,et al.  Mitigation of Carbon Nanotube Neurosensor Induced Transcriptomic and Morphological Changes in Mouse Microglia with Surface Passivation. , 2020, ACS nano.

[12]  Lei Kong,et al.  Self‐Adaptive Magnetic Photonic Nanochain Cilia Arrays , 2020, Advanced Functional Materials.

[13]  Jia-Hao Liu,et al.  Electromagnetized‐Nanoparticle‐Modulated Neural Plasticity and Recovery of Degenerative Dopaminergic Neurons in the Mid‐Brain , 2020, Advanced materials.

[14]  P. Anikeeva,et al.  Magnetic Vortex Nanodiscs Enable Remote Magnetomechanical Neural Stimulation. , 2020, ACS nano.

[15]  Jonghwa Park,et al.  Ferroelectric Multilayer Nanocomposites with Polarization and Stress Concentration Structures for Enhanced Triboelectric Performances. , 2020, ACS nano.

[16]  Alireza Gharabaghi,et al.  Desynchronization of temporal lobe theta-band activity during effective anterior thalamus deep brain stimulation in epilepsy , 2020, NeuroImage.

[17]  M. G. Christiansen,et al.  Transgene-free remote magnetothermal regulation of adrenal hormones , 2020, Science Advances.

[18]  Yu Chen,et al.  Construction of Pepstatin A-Conjugated ultrasmall SPIONs for targeted positive MR imaging of epilepsy-overexpressed P-glycoprotein. , 2019, Biomaterials.

[19]  Julien Francisco Zaldivar-Jolissaint,et al.  Pulse generator battery life in deep brain stimulation: out with the old… in with the less durable? , 2019, Acta Neurochirurgica.

[20]  Suneil K. Kalia,et al.  Deep brain stimulation: potential for neuroprotection , 2018, Annals of clinical and translational neurology.

[21]  G. Worrell,et al.  High-frequency stimulation of anterior nucleus of thalamus desynchronizes epileptic network in humans , 2018, Brain : a journal of neurology.

[22]  Jiacan Su,et al.  A Magnetic‐Field Guided Interface Coassembly Approach to Magnetic Mesoporous Silica Nanochains for Osteoclast‐Targeted Inhibition and Heterogeneous Nanocatalysis , 2018, Advanced materials.

[23]  I. Scheffer,et al.  Epilepsy , 2018, Nature Reviews Disease Primers.

[24]  Kenji F. Tanaka,et al.  Near-infrared deep brain stimulation via upconversion nanoparticle–mediated optogenetics , 2018, Science.

[25]  Y. Temel,et al.  Deep brain stimulation of the anterior nucleus of the thalamus for drug-resistant epilepsy , 2018, Neurosurgical Review.

[26]  Raag D. Airan,et al.  Neuromodulation with nanoparticles , 2017, Science.

[27]  Daniel S. Kohane,et al.  External triggering and triggered targeting strategies for drug delivery , 2017 .

[28]  A. Cukiert,et al.  Deep brain stimulation targeting in refractory epilepsy , 2017, Epilepsia.

[29]  Yang Zou,et al.  Biodegradable triboelectric nanogenerator as a life-time designed implantable power source , 2016, Science Advances.

[30]  N. Wenderoth,et al.  A technical guide to tDCS, and related non-invasive brain stimulation tools , 2016, Clinical Neurophysiology.

[31]  Guanyu Zhu,et al.  Potential Protective Effects of Chronic Anterior Thalamic Nucleus Stimulation on Hippocampal Neurons in Epileptic Monkeys , 2015, Brain Stimulation.

[32]  Angelo Auricchio,et al.  Feasibility, safety, and short-term outcome of leadless ultrasound-based endocardial left ventricular resynchronization in heart failure patients: results of the wireless stimulation endocardially for CRT (WiSE-CRT) study. , 2014, Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology.

[33]  Annika Lüttjohann,et al.  A revised Racine's scale for PTZ-induced seizures in rats , 2009, Physiology & Behavior.

[34]  M. Sperling,et al.  Refractory seizures: Try additional antiepileptic drugs (after two have failed) or go directly to early surgery evaluation? , 2009, Epilepsia.

[35]  OUP accepted manuscript , 2022, Cerebral Cortex.