Chemerin level in pregnancies complicated by preeclampsia and its relation with disease severity and neonatal outcomes

Abstract The aims of this prospective study were to detect maternal serum chemerin level in patients with preeclampsia and investigate its association with disease severity and neonatal outcomes. Maternal serum chemerin levels were significantly elevated in severe preeclamptic women (394.72 ± 100.01 ng/ml) compared to mild preeclamptic women (322.11 ± 37.60 ng/ml) and healthy pregnant women (199.96 ± 28.05 ng/ml) (p = .001). Maternal serum chemerin levels were positively correlated with systolic and diastolic blood pressure, C-reactive protein levels, homeostasis model assessment of insulin resistance, proteinuria, AST, ALT, and duration of hospitalisation. Gestational week at delivery, birthweight, and APGAR scores at 1 and 5 min were negatively correlated with maternal serum chemerin level. A maternal serum chemerin level of >252.0 ng/ml indicated preeclampsia with 95.5% sensitivity and 95.7% specificity. There was a positive correlation between maternal serum chemerin level and severity of preeclampsia. Additionally, adverse neonatal outcomes were significantly associated with high maternal serum chemerin levels.

[1]  J. Kingdom,et al.  Preeclampsia , 2016, Canadian Medical Association Journal.

[2]  Mei Peng,et al.  Chemerin plays a protective role by regulating human umbilical vein endothelial cell-induced nitric oxide signaling in preeclampsia , 2015, Endocrine.

[3]  Yan Jin,et al.  The predictive value of the first-trimester maternal serum chemerin level for pre-eclampsia , 2014, Peptides.

[4]  J. Rourke,et al.  Towards an integrative approach to understanding the role of chemerin in human health and disease , 2013, Obesity reviews : an official journal of the International Association for the Study of Obesity.

[5]  R. Rehman,et al.  Elevated Chemerin Levels in Pakistani Men: An Interrelation with Metabolic Syndrome Phenotypes , 2013, PloS one.

[6]  A. Malamitsi‐Puchner,et al.  Cord blood chemerin and obestatin levels in large for gestational age infants , 2013, The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians.

[7]  R. Hemi,et al.  Chemerin is present in human cord blood and is positively correlated with birthweight. , 2012, American journal of obstetrics and gynecology.

[8]  H. Ozkol,et al.  Evaluation of the Relationship Between Adenosine Deaminase, Myeloperoxidase, Cholinesterase, Preeclampsia Severity, and Neonatal Outcomes , 2012, Clinical and experimental hypertension.

[9]  M. Kurdoğlu,et al.  Metastin levels in pregnancies complicated by pre-eclampsia and their relation with disease severity , 2012, The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians.

[10]  S. Parlee,et al.  Chemerin: a potential endocrine link between obesity and type 2 diabetes , 2012, Endocrine.

[11]  C. Diéguez,et al.  Expression and regulation of chemerin during rat pregnancy. , 2012, Placenta.

[12]  Weiqing Wang,et al.  The association of serum chemerin level with risk of coronary artery disease in Chinese adults , 2012, Endocrine.

[13]  D. Schust,et al.  Preeclampsia: multiple approaches for a multifactorial disease , 2012, Disease Models & Mechanisms.

[14]  M. Parmentier,et al.  Chemerin and its receptors in leukocyte trafficking, inflammation and metabolism. , 2011, Cytokine & growth factor reviews.

[15]  M. Fasshauer,et al.  Serum levels of the adipokine chemerin are increased in preeclampsia during and 6months after pregnancy , 2011, Regulatory Peptides.

[16]  Mi-kyung Kim,et al.  Relationship between Chemerin Levels and Cardiometabolic Parameters and Degree of Coronary Stenosis in Korean Patients with Coronary Artery Disease , 2011, Diabetes & metabolism journal.

[17]  G. Pilu,et al.  Persistence of increased uterine artery resistance in the third trimester and pregnancy outcome , 2010, Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology.

[18]  Jian Zhang,et al.  Cloning of porcine chemerin, ChemR23 and GPR1 and their involvement in regulation of lipogenesis. , 2010, BMB reports.

[19]  M. Fasshauer,et al.  Circulating Levels of the Adipokine Chemerin in Gestational Diabetes Mellitus , 2010, Hormone Research in Paediatrics.

[20]  H. Tilg,et al.  Effect of bariatric surgery on circulating chemerin levels , 2010, European journal of clinical investigation.

[21]  M. Parmentier,et al.  Mouse ChemR23 Is Expressed in Dendritic Cell Subsets and Macrophages, and Mediates an Anti-Inflammatory Activity of Chemerin in a Lung Disease Model1 , 2009, The Journal of Immunology.

[22]  P. Arner,et al.  Chemerin Is a Novel Adipocyte-Derived Factor Inducing Insulin Resistance in Primary Human Skeletal Muscle Cells , 2009, Diabetes.

[23]  M. Reiser,et al.  Chemerin is associated with markers of inflammation and components of the metabolic syndrome but does not predict coronary atherosclerosis. , 2009, European journal of endocrinology.

[24]  F. Figueras,et al.  Reference ranges for uterine artery mean pulsatility index at 11–41 weeks of gestation , 2008, Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology.

[25]  D. Greaves,et al.  Synthetic chemerin-derived peptides suppress inflammation through ChemR23 , 2008, The Journal of experimental medicine.

[26]  P. Zimmet,et al.  Chemerin is a novel adipokine associated with obesity and metabolic syndrome. , 2007, Endocrinology.

[27]  E. Butcher,et al.  Chemerin, a Novel Adipokine That Regulates Adipogenesis and Adipocyte Metabolism* , 2007, Journal of Biological Chemistry.

[28]  E. Butcher,et al.  NMR assignment of human chemerin, a novel chemoattractant , 2007, Biomolecular NMR assignments.

[29]  Marc Parmentier,et al.  Specific Recruitment of Antigen-presenting Cells by Chemerin, a Novel Processed Ligand from Human Inflammatory Fluids , 2003, The Journal of experimental medicine.

[30]  T. Yamaguchi,et al.  Selection of cDNAs encoding putative type II membrane proteins on the cell surface from a human full-length cDNA bank. , 1999, Gene.

[31]  M. Beaufils.  Pregnancy Hypertension , 1992, International Journal of Technology Assessment in Health Care.

[32]  Qiong Lei,et al.  Serum levels of the adipokine chemerin in preeclampsia , 2011, Journal of perinatal medicine.