A novel thermo-responsive drug delivery system with positive controlled release.

[1]  Toyoichi Tanaka,et al.  Volume phase transition in a nonionic gel , 1984 .

[2]  E. Cussler,et al.  Gels as size selective extraction solvents , 1984 .

[3]  Allan S. Huffman,et al.  Thermally reversible hydrogels: II. Delivery and selective removal of substances from aqueous solutions , 1986 .

[4]  Allan S. Hoffman,et al.  Applications of thermally reversible polymers and hydrogels in therapeutics and diagnostics , 1987 .

[5]  T. Okano,et al.  Thermo-sensitive polymers as on-off switches for drug release , 1987 .

[6]  Toyoichi Tanaka,et al.  Kinetics of discontinuous volume-phase transition of gels , 1988 .

[7]  Teruo Okano,et al.  Insulin permeation through thermo-sensitive hydrogels , 1989 .

[8]  Shozaburo Saito,et al.  Phase Transition of N-Substituted Acrylamide Gels , 1990 .

[9]  Teruo Okano,et al.  Temperature dependence of swelling of crosslinked poly(N,N′-alkyl substituted acrylamides) in water , 1990 .

[10]  T. Okano,et al.  Thermo-Responsive Polymeric Hydrogels and Their Application to Pulsatile Drug Release , 1991 .

[11]  S. Gehrke,et al.  Synthesis of fast response, temperature-sensitive poly(N-isopropylacrylamide) gel , 1991 .

[12]  Allan S. Hoffman,et al.  Environmentally Sensitive Polymers and Hydrogels , 1991 .

[13]  Toyoichi Tanaka,et al.  NMR study of poly(N-isopropylacrylamide) gels near phase transition , 1991 .

[14]  H. G. Schild Poly(N-isopropylacrylamide): experiment, theory and application , 1992 .

[15]  Paul Yager,et al.  Synthesis and characterization of thermally reversible macroporous poly(N‐isopropylacrylamide) hydrogels , 1992 .

[16]  Jan Feijen,et al.  Effect of comonomer hydrophilicity and ionization on the lower critical solution temperature of N-isopropylacrylamide copolymers , 1993 .

[17]  R. Zhuo,et al.  Synthesis of Thermal Phase Separating Reactive Polymers and Their Applications in Immobilized Enzymes , 1993 .

[18]  T. Okano,et al.  Dynamic contact angle measurement of temperature-responsive surface properties for poly(N-isopropylacrylamide) grafted surfaces , 1994 .

[19]  T. Okano,et al.  Influence of Freely Mobile Grafted Chain Length on Dynamic Properties of Comb-Type Grafted Poly(N-isopropylacrylamide) Hydrogels , 1995 .

[20]  T. Okano,et al.  Comb-type grafted hydrogels with rapid deswelling response to temperature changes , 1995, Nature.

[21]  P. C. Rieke,et al.  Reversible Surface Properties of Glass Plate and Capillary Tube Grafted by Photopolymerization of N-Isopropylacrylamide , 1998 .

[22]  Chi Wu,et al.  Comparison of the Coil-to-Globule and the Globule-to-Coil Transitions of a Single Poly(N-isopropylacrylamide) Homopolymer Chain in Water , 1998 .

[23]  Kiyotaka Sakai,et al.  Rapid Deswelling Response of Poly(N-isopropylacrylamide) Hydrogels by the Formation of Water Release Channels Using Poly(ethylene oxide) Graft Chains , 1998 .

[24]  Ron,et al.  Temperature-responsive gels and thermogelling polymer matrices for protein and peptide delivery. , 1998, Advanced drug delivery reviews.

[25]  R. Zhuo,et al.  A novel method to prepare a fast responsive, thermosensitive poly(N-isopropylacrylamide) hydrogel , 1999 .

[26]  T. Park Temperature modulated protein release from pH/temperature-sensitive hydrogels. , 1999, Biomaterials.

[27]  R. Zhuo,et al.  Synthesis and characterization of a novel thermosensitive gel with fast response , 1999 .

[28]  Chi Wu,et al.  Light-Scattering Study of Coil-to-Globule Transition of a Poly(N-isopropylacrylamide) Chain in Deuterated Water , 1999 .

[29]  R. Zhuo,et al.  Preparation of fast responsive, temperature-sensitive poly(N-isopropylacrylamide) hydrogel , 1999 .

[30]  Y. Jeong,et al.  Core-shell type polymeric nanoparticles composed of poly(L-lactic acid) and poly(N-isopropylacrylamide). , 2000, International journal of pharmaceutics.

[31]  R. Zhuo,et al.  Preparation of fast responsive, thermally sensitive poly(N-isopropylacrylamide) gel , 2000 .

[32]  R Langer,et al.  Responsive polymeric delivery systems. , 2001, Advanced drug delivery reviews.

[33]  R. Zhuo,et al.  Dynamic Properties of Temperature-Sensitive Poly(N-isopropylacrylamide) Gel Cross-Linked through Siloxane Linkage , 2001 .

[34]  Teruo Okano,et al.  Hydrogels: Swelling, Drug Loading, and Release , 1992, Pharmaceutical Research.