Opioid receptor types and membrane ion channels

Abstract Activation of μ- or δ-receptor types causes an increase in a potassium conductance of the neuronal membrane. On a given neurone, this potassium conductance may be identical to the one activated by α 2 -adrenoceptor agonists and somatostatin, but it is not known whether μ and δ-receptors co-exist on the same neurone. Activation of receptors of the κ type has a quite different effect: it causes a reduction in a voltage-dependent calcium conductance. Receptors of the κ type can co-exist with those of the μ (or δ) type. In both cases the net result is a reduction in the rate of neuronal discharge, and a reduction in the amount of transmitter released by each action potential.

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