Cerebral amyloidosis, ageing and Alzheimer's disease; A contribution from studies on Down's syndrome

Observations concerning the time course of deposition of amyloid within the brain substance and blood vessels in persons, of different ages, with Down's syndrome are used to provide a perspective on the nature of the process of cerebral amyloidosis in Alzheimer's disease.

[1]  D. Selkoe,et al.  Beta-amyloid precursor protein of Alzheimer disease occurs as 110- to 135-kilodalton membrane-associated proteins in neural and nonneural tissues. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[2]  J. Hardy,et al.  An integrative hypothesis concerning the pathogenesis and progression of Alzheimer's disease , 1986, Neurobiology of Aging.

[3]  D. Mann,et al.  The pattern of acquisition of plaques and tangles in the brains of patients under 50 years of age with Down's syndrome , 1989, Journal of the Neurological Sciences.

[4]  J. Morrison,et al.  Localization of amyloid beta protein messenger RNA in brains from patients with Alzheimer's disease. , 1987, Science.

[5]  David M. A. Mann,et al.  The pathological association between down syndrome and Alzheimer disease , 1988, Mechanisms of Ageing and Development.

[6]  A. Mooradian Effect of aging on the blood-brain barrier , 1988, Neurobiology of Aging.

[7]  R. Tanzi,et al.  Amyloid protein precursor messenger RNAs: differential expression in Alzheimer's disease. , 1988, Science.

[8]  K. Grzeschik,et al.  The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor , 1987, Nature.

[9]  G. Glenner,et al.  Evidence of amyloid beta-protein immunoreactive early plaque lesions in Down's syndrome brains. , 1989, Laboratory investigation; a journal of technical methods and pathology.

[10]  K. Ogomori,et al.  Beta-protein amyloid is widely distributed in the central nervous system of patients with Alzheimer's disease. , 1989, The American journal of pathology.

[11]  C. Bouras,et al.  Down patients: Extracellular preamyloid deposits precede neuritic degeneration and senile plaques , 1989, Neuroscience Letters.

[12]  G. Glenner,et al.  Morphology and distribution of plaque and related deposits in the brains of Alzheimer's disease and control cases. An immunohistochemical study using amyloid beta-protein antibody. , 1989, Laboratory investigation; a journal of technical methods and pathology.

[13]  D. Mann,et al.  AN ANALYSIS OF THE MORPHOLOGY OF SENILE PLAQUES IN DOWN'S SYNDROME PATIENTS OF DIFFERENT AGES USING IMMUNOCYTOCHEMICAL AND LECTIN HISTOCHEMICAL TECHNIQUES , 1989, Neuropathology and applied neurobiology.

[14]  R. Martins,et al.  Neuronal origin of a cerebral amyloid: neurofibrillary tangles of Alzheimer's disease contain the same protein as the amyloid of plaque cores and blood vessels. , 1985, The EMBO journal.

[15]  H. Wiśniewski,et al.  Discrepancy between Alzheimer‐Type Neuropathology and Dementia in Persons with Down's Syndrome a , 1986, Annals of the New York Academy of Sciences.