Pharmacokinetics of oral acyclovir (Zovirax) in the eye.

Patients due for cataract extraction received 5 doses of 400 mg acyclovir (Zovirax) orally during the 24 hours prior to surgery. Aqueous humour levels of acyclovir (mean 3.26 microM) were well above the normal ED50 range for herpes simplex virus type 1, and showed a significant correlation with plasma concentrations (mean 8.74 microM). There was also a correlation between the age of the patient and the concentration of acyclovir in the plasma. Oral acyclovir was well tolerated.

[1]  S. Isenberg,et al.  Intraocular antiviral penetration. , 1982, Archives of ophthalmology.

[2]  D. Easty,et al.  Isolation of herpes simplex virus from the cornea in chronic stromal keratitis. , 1982, The British journal of ophthalmology.

[3]  J. Oosterhuis,et al.  Acyclovir and trifluorothymidine in herpetic keratitis: a multicentre trial. , 1982, The British journal of ophthalmology.

[4]  G. Elion,et al.  Mechanism of action and selectivity of acyclovir. , 1982, The American journal of medicine.

[5]  J. V. D. van der Meer,et al.  Acyclovir in severe herpes virus infections. , 1982, The American journal of medicine.

[6]  R. Whitley,et al.  Pharmacokinetics of acyclovir in humans following intravenous administration. A model for the development of parenteral antivirals. , 1982, The American journal of medicine.

[7]  P. de Miranda,et al.  Overview of acyclovir pharmacokinetic disposition in adults and children. , 1982, The American journal of medicine.

[8]  J. Kingham,et al.  Intraocular antiviral penetration. , 1982, Archives of ophthalmology.

[9]  J. Colin,et al.  [Superficial herpes simplex keratitis. Double-blind comparative trial of acyclovir and idoxuridine (author's transl)]. , 1981, La Nouvelle presse medicale.

[10]  R. T. Walker,et al.  Comparative efficacy of antiherpes drugs against different strains of herpes simplex virus. , 1980, The Journal of infectious diseases.

[11]  P. de Miranda,et al.  A sensitive radioimmunoassay for the antiviral agent BW248U [9-(2-hydroxyethoxymethyl)guanine]. , 1979, Analytical biochemistry.

[12]  C. Crumpacker,et al.  Growth Inhibition by Acycloguanosine of Herpesviruses Isolated from Human Infections , 1979, Antimicrobial Agents and Chemotherapy.

[13]  H. Schaeffer,et al.  Selectivity of action of an antiherpetic agent, 9-(2-hydroxyethoxymethyl) guanine. , 1977, Proceedings of the National Academy of Sciences of the United States of America.

[14]  A. Kanai,et al.  Herpetic iritis: demonstration of virus in the anterior chamber by fluorescent antibody techniques and electron microscopy. , 1971, American journal of ophthalmology.

[15]  N. Rice,et al.  Symposium on certain forms of infective kerato-uveitis or uveitis. I. An approach to the problem, and the technique of anterior chamber tap. , 1969, Transactions of the ophthalmological societies of the United Kingdom.

[16]  T. E. Moore,et al.  Structural changes in chronic herpetic keratitis. Studied by light and electron microscopy. , 1968, Archives of ophthalmology.

[17]  T. Iwamoto,et al.  Electron microscope observation of herpes-like particles in the iris. , 1968, Archives of ophthalmology.