Foxp3, Regulatory T Cell, and Autoimmune Diseases

[1]  G. Kaplan,et al.  Novel CD8+ T-Cell Subsets Demonstrating Plasticity in Patients with Inflammatory Bowel Disease , 2016, Inflammatory bowel diseases.

[2]  Junfei Jin,et al.  CD8+ Tregs promote GVHD prevention and overcome the impaired GVL effect mediated by CD4+ Tregs in mice , 2016, Oncoimmunology.

[3]  N. Ishimaru,et al.  Role of regulatory T cell in the pathogenesis of inflammatory bowel disease. , 2016, World journal of gastroenterology.

[4]  D. Klatzmann,et al.  The promise of low-dose interleukin-2 therapy for autoimmune and inflammatory diseases , 2015, Nature Reviews Immunology.

[5]  D. Klatzmann,et al.  Human and Mouse CD8+CD25+FOXP3+ Regulatory T Cells at Steady State and during Interleukin-2 Therapy , 2015, Front. Immunol..

[6]  Yuxin Feng,et al.  Post-transplant high-dose cyclophosphamide for the prevention of graft-versus-host disease. , 2015, Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.

[7]  R. Talaat,et al.  Th1/Th2/Th17/Treg cytokine imbalance in systemic lupus erythematosus (SLE) patients: Correlation with disease activity. , 2015, Cytokine.

[8]  H. Tagawa,et al.  Downregulated expression of miR-155, miR-17, and miR-181b, and upregulated expression of activation-induced cytidine deaminase and interferon-α in PBMCs from patients with SLE , 2015, Modern rheumatology.

[9]  G. Burmester,et al.  Rapid induction of clinical remission by low-dose interleukin-2 in a patient with refractory SLE , 2015, Annals of the rheumatic diseases.

[10]  D. Klatzmann,et al.  Selective IL-2 Responsiveness of Regulatory T Cells Through Multiple Intrinsic Mechanisms Supports the Use of Low-Dose IL-2 Therapy in Type 1 Diabetes , 2015, Diabetes.

[11]  S. Sakaguchi,et al.  Epigenetic control of thymic Treg‐cell development , 2015, European journal of immunology.

[12]  K. Ghosh,et al.  Effect of Proinflammatory Cytokines (IL-6, TNF-α, and IL-1β) on Clinical Manifestations in Indian SLE Patients , 2014, Mediators of inflammation.

[13]  M. Kaplan,et al.  The inflammasome and lupus: another innate immune mechanism contributing to disease pathogenesis? , 2014, Current opinion in rheumatology.

[14]  S. Sakaguchi,et al.  TREG-cell therapies for autoimmune rheumatic diseases , 2014, Nature Reviews Rheumatology.

[15]  B. Li,et al.  Critical role of all-trans retinoic acid in stabilizing human natural regulatory T cells under inflammatory conditions , 2014, Proceedings of the National Academy of Sciences.

[16]  B. Li,et al.  PIM1 Kinase Phosphorylates the Human Transcription Factor FOXP3 at Serine 422 to Negatively Regulate Its Activity under Inflammation* , 2014, The Journal of Biological Chemistry.

[17]  R. Remus,et al.  CD49d- Treg Cells with High Suppressive Capacity are Remarkably Less Efficient on Activated CD45RA- than on Naive CD45RA+ Teff Cells , 2014, Cellular Physiology and Biochemistry.

[18]  S. Xiong,et al.  Interleukin-6 promotes systemic lupus erythematosus progression with Treg suppression approach in a murine systemic lupus erythematosus model , 2014, Clinical Rheumatology.

[19]  M. Battaglia,et al.  Sirolimus-based graft-versus-host disease prophylaxis promotes the in vivo expansion of regulatory T cells and permits peripheral blood stem cell transplantation from haploidentical donors , 2014, Leukemia.

[20]  C. Riccardi,et al.  GILZ promotes production of peripherally induced Treg cells and mediates the crosstalk between glucocorticoids and TGF-β signaling. , 2014, Cell reports.

[21]  Tzei-Yi Lin,et al.  CD8+ Treg Cells Associated with Decreasing Disease Activity after Intravenous Methylprednisolone Pulse Therapy in Lupus Nephritis with Heavy Proteinuria , 2014, PloS one.

[22]  Y. Iwakura,et al.  Excess IL-1 Signaling Enhances the Development of Th17 Cells by Downregulating TGF-β–Induced Foxp3 Expression , 2014, The Journal of Immunology.

[23]  Tingting Wang,et al.  Hydroxychloroquine decreases the upregulated frequencies of Tregs in patients with oral lichen planus , 2014, Clinical Oral Investigations.

[24]  M. Ehrenstein,et al.  B cell resistance to Fas-mediated apoptosis contributes to their ineffective control by regulatory T cells in rheumatoid arthritis , 2013, Annals of the rheumatic diseases.

[25]  J. Bluestone,et al.  Self-antigen-driven activation induces instability of regulatory T cells during an inflammatory autoimmune response. , 2013, Immunity.

[26]  Nam-Soon Kim,et al.  Phosphorylation of FOXP3 by LCK Downregulates MMP9 Expression and Represses Cell Invasion , 2013, PloS one.

[27]  S. Zheng,et al.  The ubiquitin ligase Stub1 negatively modulates regulatory T cell suppressive activity by promoting degradation of the transcription factor Foxp3. , 2013, Immunity.

[28]  H. Ovaa,et al.  Stabilization of the transcription factor Foxp3 by the deubiquitinase USP7 increases Treg-cell-suppressive capacity. , 2013, Immunity.

[29]  Chunxia Chen,et al.  Foxp3 Protein Stability Is Regulated by Cyclin-dependent Kinase 2* , 2013, The Journal of Biological Chemistry.

[30]  Yichun Hu,et al.  Patients with antineutrophil cytoplasmic antibody-associated vasculitis have defective Treg cell function exacerbated by the presence of a suppression-resistant effector cell population. , 2013, Arthritis and rheumatism.

[31]  Xuetao Cao,et al.  CD11chighCD8+ Regulatory T Cell Feedback Inhibits CD4 T Cell Immune Response via Fas Ligand–Fas Pathway , 2013, The Journal of Immunology.

[32]  S. Sakaguchi,et al.  Development and maintenance of regulatory T cells. , 2013, Immunity.

[33]  B. Prakken,et al.  Editorial: Quality or quantity? Unraveling the role of Treg cells in rheumatoid arthritis. , 2013, Arthritis and rheumatism.

[34]  G. Riemekasten,et al.  CD4+Foxp3+ regulatory T cells prolong drug-induced disease remission in (NZBxNZW) F1 lupus mice , 2013, Arthritis Research & Therapy.

[35]  Zachary D. Smith,et al.  DNA methylation: roles in mammalian development , 2013, Nature Reviews Genetics.

[36]  H. Nie,et al.  Phosphorylation of FOXP3 controls regulatory T cell function and is inhibited by TNF-α in rheumatoid arthritis , 2013, Nature Medicine.

[37]  L. Luznik,et al.  Post-transplantation cyclophosphamide for tolerance induction in HLA-haploidentical bone marrow transplantation. , 2012, Seminars in oncology.

[38]  K. Nakai,et al.  T cell receptor stimulation-induced epigenetic changes and Foxp3 expression are independent and complementary events required for Treg cell development. , 2012, Immunity.

[39]  D. Isenberg,et al.  Th17 cells are restrained by Treg cells via the inhibition of interleukin-6 in patients with rheumatoid arthritis responding to anti-tumor necrosis factor antibody therapy. , 2012, Arthritis and rheumatism.

[40]  Scott A. Shaffer,et al.  Transcription factor Foxp3 and its protein partners form a complex regulatory network , 2012, Nature Immunology.

[41]  Xiaomin Song,et al.  Structural and biological features of FOXP3 dimerization relevant to regulatory T cell function. , 2012, Cell reports.

[42]  E. Greer,et al.  Histone methylation: a dynamic mark in health, disease and inheritance , 2012, Nature Reviews Genetics.

[43]  Herman Waldmann,et al.  Plasticity of Foxp3(+) T cells reflects promiscuous Foxp3 expression in conventional T cells but not reprogramming of regulatory T cells. , 2012, Immunity.

[44]  Xia Li,et al.  Roles of Pro- and Anti-Inflammatory Cytokines in the Pathogenesis of SLE , 2012, Journal of biomedicine & biotechnology.

[45]  C. Hsieh,et al.  Selection of regulatory T cells in the thymus , 2012, Nature Reviews Immunology.

[46]  N. Das,et al.  Cytokine imbalance in systemic lupus erythematosus: a study on northern Indian subjects , 2012, Lupus.

[47]  M. Sanak,et al.  Imbalance between Th17 and regulatory T-cells in systemic lupus erythematosus. , 2012, Folia histochemica et cytobiologica.

[48]  Y. Wan,et al.  Requirements of transcription factor Smad-dependent and -independent TGF-β signaling to control discrete T-cell functions , 2012, Proceedings of the National Academy of Sciences.

[49]  C. Kallenberg,et al.  Disturbed Th1, Th2, Th17 and T(reg) balance in patients with systemic lupus erythematosus. , 2011, Clinical immunology.

[50]  P. Boor,et al.  Human plasmacytoid dendritic cells induce CD8+LAG‐3+Foxp3+CTLA‐4+ regulatory T cells that suppress allo‐reactive memory T cells , 2011, European journal of immunology.

[51]  W. Leonard,et al.  Modulation of cytokine receptors by IL-2 broadly regulates differentiation into helper T cell lineages , 2011, Nature Immunology.

[52]  Ke Wu,et al.  IL-17+ Regulatory T Cells in the Microenvironments of Chronic Inflammation and Cancer , 2011, The Journal of Immunology.

[53]  L. Fainboim,et al.  Mechanisms involved in the expansion of Tregs during pregnancy: role of IL-2/STAT5 signalling. , 2011, Journal of reproductive immunology.

[54]  D. Roopenian,et al.  CD8+ T regulatory cells express the Ly49 Class I MHC receptor and are defective in autoimmune prone B6-Yaa mice , 2011, Proceedings of the National Academy of Sciences.

[55]  G. Hämmerling,et al.  Myelin-Reactive, TGF-β–Induced Regulatory T Cells Can Be Programmed To Develop Th1-Like Effector Function but Remain Less Proinflammatory Than Myelin-Reactive Th1 Effectors and Can Suppress Pathogenic T Cell Clonal Expansion In Vivo , 2010, The Journal of Immunology.

[56]  J. Smolen,et al.  Pathogenetic aspects of systemic lupus erythematosus with an emphasis on regulatory T cells. , 2010, Journal of autoimmunity.

[57]  P. Jouk,et al.  Identification of new FOXP3 mutations and prenatal diagnosis of IPEX syndrome , 2010, Prenatal diagnosis.

[58]  S. Robson,et al.  Nucleosome-Interacting Proteins Regulated by DNA and Histone Methylation , 2010, Cell.

[59]  C. Lau,et al.  The Relation of Interleukin 17 (IL-17) and IL-23 to Th1/Th2 Cytokines and Disease Activity in Systemic Lupus Erythematosus , 2010, The Journal of Rheumatology.

[60]  S. Zheng,et al.  Cutting Edge: All-Trans Retinoic Acid Sustains the Stability and Function of Natural Regulatory T Cells in an Inflammatory Milieu , 2010, The Journal of Immunology.

[61]  B. Ni,et al.  Reduced FOXP3 expression causes IPEX syndrome onset: An implication from an IPEX patient and his disease-free twin brother. , 2010, Clinical immunology.

[62]  D. Hafler,et al.  FOXP3+ regulatory T cells in the human immune system , 2010, Nature Reviews Immunology.

[63]  S. Zheng,et al.  The imbalance between regulatory and IL-17-secreting CD4+ T cells in lupus patients , 2010, Clinical Rheumatology.

[64]  Ming O. Li,et al.  Transforming growth factor-beta signaling curbs thymic negative selection promoting regulatory T cell development. , 2010, Immunity.

[65]  B. Flourié,et al.  Therapy with anti‐TNF&agr; antibody enhances number and function of Foxp3+ regulatory T cells in inflammatory bowel diseases , 2010, Inflammatory bowel diseases.

[66]  A. Rudensky,et al.  Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate , 2010, Nature.

[67]  P. Krammer,et al.  CD127(low/-) and FoxP3(+) expression levels characterize different regulatory T-cell populations in human peripheral blood. , 2010, The Journal of investigative dermatology.

[68]  A. Scheffold,et al.  Homeostatic imbalance of regulatory and effector T cells due to IL-2 deprivation amplifies murine lupus , 2009, Proceedings of the National Academy of Sciences.

[69]  S. Ghosh,et al.  Nuclear factor-kappaB modulates regulatory T cell development by directly regulating expression of Foxp3 transcription factor. , 2009, Immunity.

[70]  E. d'Hennezel,et al.  FOXP3 forkhead domain mutation and regulatory T cells in the IPEX syndrome. , 2009, The New England journal of medicine.

[71]  G. Lal,et al.  Epigenetic mechanisms of regulation of Foxp3 expression. , 2009, Blood.

[72]  T. Huizinga,et al.  De Novo Generation and Enhanced Suppression of Human CD4+CD25+ Regulatory T Cells by Retinoic Acid1 , 2009, The Journal of Immunology.

[73]  T. Nomura,et al.  Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor. , 2009, Immunity.

[74]  E. Eisenstein,et al.  The Treg/Th17 Cell Balance: A New Paradigm for Autoimmunity , 2009, Pediatric Research.

[75]  Ying C. Song,et al.  Anti‐ribosomal phosphoprotein autoantibody triggers interleukin‐10 overproduction via phosphatidylinositol 3‐kinase‐dependent signalling pathways in lipopolysaccharide‐activated macrophages , 2009, Immunology.

[76]  D. Littman,et al.  Identification of IL-17-producing FOXP3+ regulatory T cells in humans , 2009, Proceedings of the National Academy of Sciences.

[77]  T. Chatila,et al.  A Central Role for Induced Regulatory T Cells in Tolerance Induction in Experimental Colitis1 , 2009, The Journal of Immunology.

[78]  Yong Zhao,et al.  The significantly enhanced frequency of functional CD4+CD25+Foxp3+ T regulatory cells in therapeutic dose aspirin-treated mice. , 2009, Transplant immunology.

[79]  E. Vigorito,et al.  Cutting Edge: The Foxp3 Target miR-155 Contributes to the Development of Regulatory T Cells1 , 2009, The Journal of Immunology.

[80]  Linjiang Zhu,et al.  A low interleukin-2 receptor signaling threshold supports the development and homeostasis of T regulatory cells. , 2009, Immunity.

[81]  B. Malissen,et al.  Heterogeneity of natural Foxp3+ T cells: A committed regulatory T-cell lineage and an uncommitted minor population retaining plasticity , 2009, Proceedings of the National Academy of Sciences.

[82]  D. Levy,et al.  Epigenetic Regulation of Foxp3 Expression in Regulatory T Cells by DNA Methylation1 , 2009, The Journal of Immunology.

[83]  Kristen J. Monte,et al.  Increased number and function of FoxP3 regulatory T cells during experimental arthritis. , 2008, Arthritis and rheumatism.

[84]  V. Kuchroo,et al.  IL-4 inhibits TGF-β-induced Foxp3+ T cells and, together with TGF-β, generates IL-9+ IL-10+ Foxp3− effector T cells , 2008, Nature Immunology.

[85]  M. Farrar,et al.  IL-2, -7, and -15, but Not Thymic Stromal Lymphopoeitin, Redundantly Govern CD4+Foxp3+ Regulatory T Cell Development1 , 2008, The Journal of Immunology.

[86]  A. Rudensky,et al.  Dicer-dependent microRNA pathway safeguards regulatory T cell function , 2008, The Journal of experimental medicine.

[87]  Michael T. McManus,et al.  Selective miRNA disruption in T reg cells leads to uncontrolled autoimmunity , 2008, The Journal of experimental medicine.

[88]  Lars Rogge,et al.  Faculty Opinions recommendation of IL-21 and TGF-beta are required for differentiation of human T(H)17 cells. , 2008 .

[89]  Chen Dong,et al.  Molecular antagonism and plasticity of regulatory and inflammatory T cell programs. , 2008, Immunity.

[90]  A. Ho,et al.  Reduced CD4+,CD25- T cell sensitivity to the suppressive function of CD4+,CD25high,CD127 -/low regulatory T cells in patients with active systemic lupus erythematosus. , 2008, Arthritis and rheumatism.

[91]  J. Smolen,et al.  Quantitative and qualitative deficiencies of regulatory T cells in patients with systemic lupus erythematosus (SLE). , 2008, International immunology.

[92]  E. Barillot,et al.  A critical function for transforming growth factor-β, interleukin 23 and proinflammatory cytokines in driving and modulating human TH-17 responses , 2008, Nature Immunology.

[93]  K. Kretschmer,et al.  DNA methylation controls Foxp3 gene expression , 2008, European journal of immunology.

[94]  A. Kulkarni,et al.  A critical function for TGF-β signaling in the development of natural CD4+CD25+Foxp3+ regulatory T cells , 2008, Nature Immunology.

[95]  T. Nomura,et al.  Regulatory T Cells and Immune Tolerance , 2008, Cell.

[96]  D. Littman,et al.  The differentiation of human TH-17 cells requires transforming growth factor-β and induction of the nuclear receptor RORγt , 2008, Nature Immunology.

[97]  K. Venken,et al.  Natural Naive CD4+CD25+CD127low Regulatory T Cell (Treg) Development and Function Are Disturbed in Multiple Sclerosis Patients: Recovery of Memory Treg Homeostasis during Disease Progression1 , 2008, The Journal of Immunology.

[98]  C. June,et al.  Cutting Edge: Foxp3-Mediated Induction of Pim 2 Allows Human T Regulatory Cells to Preferentially Expand in Rapamycin1 , 2008, The Journal of Immunology.

[99]  F. Cominelli,et al.  A CD8+/CD103high T Cell Subset Regulates TNF-Mediated Chronic Murine Ileitis1 , 2008, The Journal of Immunology.

[100]  M. Aringer,et al.  The role of tumor necrosis factor-alpha in systemic lupus erythematosus , 2008, Arthritis research & therapy.

[101]  C. Kuo,et al.  The quantitative analysis of peripheral blood FOXP3‐expressing T cells in systemic lupus erythematosus and rheumatoid arthritis patients , 2007, European journal of clinical investigation.

[102]  M. Sela,et al.  The role of CD8+CD28− regulatory cells in suppressing myasthenia gravis-associated responses by a dual altered peptide ligand , 2007, Proceedings of the National Academy of Sciences.

[103]  E. Shevach,et al.  Induction of FOXP3 expression in naive human CD4+FOXP3 T cells by T-cell receptor stimulation is transforming growth factor-beta dependent but does not confer a regulatory phenotype. , 2007, Blood.

[104]  C. Suh,et al.  Cytokine IL-6 and IL-10 as Biomarkers in Systemic Lupus Erythematosus , 2007, Journal of Clinical Immunology.

[105]  D. Fox,et al.  Regulatory T cell defects in rheumatoid arthritis. , 2007, Arthritis and rheumatism.

[106]  A. Rudensky,et al.  Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells , 2007, Nature.

[107]  Edgar Schmitt,et al.  Epigenetic Control of the foxp3 Locus in Regulatory T Cells , 2007, PLoS biology.

[108]  M. Battaglia,et al.  Rapamycin Promotes Expansion of Functional CD4+CD25+FOXP3+ Regulatory T Cells of Both Healthy Subjects and Type 1 Diabetic Patients1 , 2006, The Journal of Immunology.

[109]  J. Hillebrands,et al.  A Regulatory CD4+ T Cell Subset in the BB Rat Model of Autoimmune Diabetes Expresses Neither CD25 Nor Foxp31 , 2006, The Journal of Immunology.

[110]  R. Steinman,et al.  Expansion of FOXP3high regulatory T cells by human dendritic cells (DCs) in vitro and after injection of cytokine-matured DCs in myeloma patients. , 2006, Blood.

[111]  I. T. Ten Berge,et al.  CD103 Is a Marker for Alloantigen-Induced Regulatory CD8+ T Cells , 2006, The Journal of Immunology.

[112]  H. Zinger,et al.  IL-1Β-deficient mice are resistant to induction of experimental SLE , 2006 .

[113]  A. Rudensky,et al.  Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[114]  R. J. Hocking,et al.  TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. , 2006, Immunity.

[115]  G. Doria,et al.  IL-4 Modulation of CD4+CD25+ T Regulatory Cell-Mediated Suppression1 , 2005, The Journal of Immunology.

[116]  M. Battaglia,et al.  Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells. , 2005, Blood.

[117]  A. Singer,et al.  CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2 , 2005, Nature Immunology.

[118]  R. Doerge,et al.  Reversible Histone Acetylation and Deacetylation Mediate Genome-Wide, Promoter-Dependent and Locus-Specific Changes in Gene Expression During Plant Development , 2005, Genetics.

[119]  C. Akdis,et al.  Glucocorticoids upregulate FOXP3 expression and regulatory T cells in asthma. , 2004, The Journal of allergy and clinical immunology.

[120]  C. Gordon,et al.  Interleukin (IL)‐10, IL‐1ra and IL‐12 profiles in active and quiescent systemic lupus erythematosus: could longitudinal studies reveal patient subgroups of differing pathology? , 2004, Clinical and experimental immunology.

[121]  Y. Kawamoto,et al.  Essential Roles of CD8+CD122+ Regulatory T Cells in the Maintenance of T Cell Homeostasis , 2004, The Journal of experimental medicine.

[122]  D. Isenberg,et al.  Compromised Function of Regulatory T Cells in Rheumatoid Arthritis and Reversal by Anti-TNFα Therapy , 2004, The Journal of experimental medicine.

[123]  G. Freeman,et al.  CD4 CD25 T Regulatory Cells Dependent on ICOS Promote Regulation of Effector Cells in the Prediabetic Lesion , 2004 .

[124]  L-L Fung,et al.  Decreased CD4+CD25+ T Cells in Peripheral Blood of Patients with Systemic Lupus Erythematosus , 2004, Scandinavian journal of immunology.

[125]  R. Noelle,et al.  Cd4+Cd25+ Immune Regulatory Cells Are Required for Induction of Tolerance to Alloantigen via Costimulatory Blockade , 2001, The Journal of experimental medicine.

[126]  F. Powrie,et al.  IL-10 Is Required for Regulatory T Cells to Mediate Tolerance to Alloantigens In Vivo1 , 2001, The Journal of Immunology.

[127]  Ana Cumano,et al.  CD25+ CD4+ T Cells Regulate the Expansion of Peripheral CD4 T Cells Through the Production of IL-101 , 2001, The Journal of Immunology.

[128]  L. Klareskog,et al.  Cytokine production, serum levels and disease activity in systemic lupus erythematosus. , 2000, Clinical and experimental rheumatology.

[129]  J. Bluestone,et al.  B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes. , 2000, Immunity.

[130]  J. Ragnaud,et al.  Th1 (IL‐2, interferon‐gamma (IFN‐γ)) and Th2 (IL‐10, IL‐4) cytokine production by peripheral blood mononuclear cells (PBMC) from patients with systemic lupus erythematosus (SLE) , 1999, Clinical and experimental immunology.

[131]  M. Toda,et al.  Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. , 1995, Journal of immunology.

[132]  M. Linker‐Israeli Cytokine abnormalities in human lupus. , 1992, Clinical immunology and immunopathology.

[133]  M. Linker-Israeli,et al.  Elevated levels of endogenous IL-6 in systemic lupus erythematosus. A putative role in pathogenesis. , 1991, Journal of immunology.

[134]  J. Wang,et al.  Increased apoptosis induction in CD4+ CD25+ Foxp3+ T cells contributes to enhanced disease activity in patients with rheumatoid arthritis through IL-10 regulation. , 2014, European review for medical and pharmacological sciences.

[135]  E. Mohamed,et al.  The role of interleukins 4, 17 and interferon gamma as biomarkers in patients with Systemic Lupus Erythematosus and their correlation with disease activity , 2014 .

[136]  D. Bunch,et al.  ANCA-associated Vasculitis Patients Have Defective Treg Function Exacerbated by Presence of a Suppression-Resistant Effector Population , 2013 .

[137]  Ruth I. Tennen,et al.  Lysine methylation of the NF-κB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-κB signaling , 2011, Nature Immunology.

[138]  C. Simionescu,et al.  Cytokine panel and histopathological aspects in the systemic lupus erythematosus. , 2010, Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie.

[139]  Shimon Sakaguchi,et al.  Regulatory T cells exert checks and balances on self tolerance and autoimmunity , 2010, Nature Immunology.

[140]  M. Sultan,et al.  Assessment of Proinflammatory Th1 Cytokines (IL18-IFN ) and Th2 Cytokine (IL13) Concentrations in patients with Autoimmune Rheumatic Diseases (Systemic Lupus Erythematosus, Rheumatoid Artharitis and Systemic Sclerosis) , 2010 .

[141]  A. Torgashina,et al.  Reduced number and function of CD4+CD25highFoxP3+ regulatory T cells in patients with systemic lupus erythematosus. , 2007, Advances in experimental medicine and biology.

[142]  H. Zinger,et al.  IL-1 beta-deficient mice are resistant to induction of experimental SLE. , 2006, European cytokine network.

[143]  D. Galas,et al.  Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse , 2001, Nature Genetics.

[144]  M. Jordan Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide , 2001, Nature Immunology.