Early detection research program at the NCI

The Early Detection Branch, Division of Cancer Prevention and Control, National Cancer Institute, has created a program called The Early Detection Research Network (EDRN). EDRN's mission is to support translational research leading to early detection of cancer. The objectives are to (i) establish a network of institutions with the facilities, resources, personnel and interest to undertake biomarker research in early cancer detection; (ii) advance the understanding of the molecular basis of tumorigenesis in relation to screening, early detection and risk assessment; (iii) identify potential biomarkers that can be used as outcome measures or as intermediate end‐points for cancer screening studies and (iv) respond to late‐breaking developments in the field of biomarkers in a timely fashion. This program has the singular purpose of studying biologic, molecular and genetic markers relevant to the early detection of prostate, colorectal, lung, head and neck, bladder and breast cancers. © 1996 Wiley‐Liss, Inc.

[1]  Y. Nakamura,et al.  Screening guidelines and premorbid diagnosis of familial adenomatous polyposis using linkage. , 1991, Gastroenterology.

[2]  D. Ward,et al.  Mutation in the DNA mismatch repair gene homologue hMLH 1 is associated with hereditary non-polyposis colon cancer , 1994, Nature.

[3]  A. Feinberg,et al.  Hypomethylation of DNA from benign and malignant human colon neoplasms. , 1985, Science.

[4]  C. Boland,et al.  Genetics, natural history, tumor spectrum, and pathology of hereditary nonpolyposis colorectal cancer: an updated review. , 1993, Gastroenterology.

[5]  R. Fleischmann,et al.  Mutation of a mutL homolog in hereditary colon cancer. , 1994, Science.

[6]  T. Smyrk,et al.  Differential diagnosis of hereditary nonpolyposis colorectal cancer (Lynch syndrome I and Lynch syndrome II) , 1988, Diseases of the colon and rectum.

[7]  J. Young,et al.  Follow-up study of patients with benign mucosal polyps discovered by proctosigmoidoscopy , 1974, Diseases of the colon and rectum.

[8]  W. J. Brammar,et al.  Alterations to either c-erbB-2(neu) or c-myc proto-oncogenes in breast carcinomas correlate with poor short-term prognosis. , 1987, Oncogene.

[9]  B. Vogelstein,et al.  p53 mutations in human cancers. , 1991, Science.

[10]  G. Riou,et al.  Overexpression of either c-myc or c-erbB-2/neu proto-oncogenes in human breast carcinomas: correlation with poor prognosis. , 1988, Oncogene research.

[11]  Margaret Robertson,et al.  Identification and characterization of the familial adenomatous polyposis coli gene , 1991, Cell.

[12]  J. Moore,et al.  Elevated expression of the c-myc oncoprotein correlates with poor prognosis in head and neck squamous cell carcinoma. , 1989, Oncogene.

[13]  K. Kinzler,et al.  Identification of a gene located at chromosome 5q21 that is mutated in colorectal cancers. , 1991, Science.

[14]  R. Fleischmann,et al.  Mutations of two P/WS homologues in hereditary nonpolyposis colon cancer , 1994, Nature.

[15]  B. Vogelstein,et al.  Prevalence of ras gene mutations in human colorectal cancers , 1987, Nature.

[16]  Robin J. Leach,et al.  Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer , 1993, Cell.

[17]  A. Morrison,et al.  Relationship of polyps to cancer of the large intestine. , 1992, Journal of the National Cancer Institute.

[18]  Kathleen R. Cho,et al.  Identification of a chromosome 18q gene that is altered in colorectal cancers. , 1990, Science.

[19]  Y. Nakamura,et al.  Genetic alterations during colorectal-tumor development. , 1988, The New England journal of medicine.

[20]  L. Melton,et al.  Colorectal polyps and the risk of subsequent carcinoma. , 1986, Mayo Clinic proceedings.

[21]  W. Kimberling,et al.  Hereditary ovarian carcinoma. Biomarker studies , 1985, Cancer.

[22]  S. Dawsey,et al.  Validation of intermediate end points in cancer research. , 1990, Journal of the National Cancer Institute.