论文信息 - A Trip from a Tube to a Chip Applied Micro and Nanotechnology in Biotechnology, Veterinary and Life Sciences

A Trip from a Tube to a Chip Applied Micro and Nanotechnology in Biotechnology, Veterinary and Life Sciences

More than 200 known diseases are transmitted via foods or food products. In the United States, food-borne diseases are responsible for 76 million cases of illness, 32,500 cases of hospitalisation and 5000 cases of death yearly. The ongoing increase in worldwide trade in livestock, food, and food products in combination with increase in human mobility (business- and leisure travel, emigration etc.) will increase the risk of emergence and spreading of such pathogens. There is therefore an urgent need for development of rapid, efficient and reliable methods for detection and identification of such pathogens.

[1] Mogens Madsen,et al. Development of a PCR assay suitable for Campylobacter spp. mass screening programs in broiler production , 2001 .

[2] F J Blanco,et al. Fabrication of SU-8 multilayer microstructures based on successive CMOS compatible adhesive bonding and releasing steps. , 2005, Lab on a chip.

[3] P. Telleman,et al. Development of a sensitive DNA microarray suitable for rapid detection of Campylobacter spp. , 2003, Molecular and cellular probes.

[4] Ivan R. Perch-Nielsen,et al. Detection of a putative virulence cadF gene of Campylobacter jejuni obtained from different sources using a microfabricated PCR chip , 2005 .

[5] J. El-Ali,et al. Simulation and experimental validation of a SU-8 based PCR thermocycler chip with integrated heaters and temperature sensor , 2004 .

[6] J. El-Ali,et al. Removal of PCR inhibitors using dielectrophoresis as a selective filter in a microsystem. , 2003, Lab on a chip.

[7] Pieter Telleman,et al. Use of Culture, PCR Analysis, and DNA Microarrays for Detection of Campylobacter jejuni and Campylobacter coli from Chicken Feces , 2004, Journal of Clinical Microbiology.