论文信息 - Identification of cancer drug sensitivity biomarkers

Identification of cancer drug sensitivity biomarkers

Anti-cancer therapies have different responses to different patients. There is a need to identify biomarkers for effectiveness of drugs beside the biomarkers for the diseases like cancer to advance the field personalized medicine. We have used a panel of cancer cell lines from Genomics of Drug Sensitivity in Cancer (GDSC) to capture the sensitivity of drugs. By combining the genetic information such as mutations, copy number variations and gene expression levels from Catalogue of Somatic Mutations in Cancer (COSMIC) and The Cancer Genome ATLAS (TCGA) for the afore mentioned cell lines, we are able to identify genomic features associated with the sensitivity of the drugs.

[1] A. Gelman. Scaling regression inputs by dividing by two standard deviations , 2008, Statistics in medicine.

[2] S. Ramaswamy,et al. Systematic identification of genomic markers of drug sensitivity in cancer cells , 2012, Nature.

[3] Emanuel J. V. Gonçalves,et al. A Landscape of Pharmacogenomic Interactions in Cancer , 2016, Cell.

[4] Mingming Jia,et al. COSMIC: exploring the world's knowledge of somatic mutations in human cancer , 2014, Nucleic Acids Res..

[5] Jae K. Lee,et al. Genomancy: predicting tumour response to cancer therapy based on the oracle of genetics , 2009, Current oncology.

[6] Nci Dream Community. A community effort to assess and improve drug sensitivity prediction algorithms , 2014 .

[7] Luís Torgo,et al. Data Mining with R: Learning with Case Studies , 2010 .

[8] Steven A. Roberts,et al. Mutational heterogeneity in cancer and the search for new cancer-associated genes , 2013 .

[9] Sridhar Ramaswamy,et al. Genomics of Drug Sensitivity in Cancer (GDSC): a resource for therapeutic biomarker discovery in cancer cells , 2012, Nucleic Acids Res..

[10] Laura M. Heiser,et al. A community effort to assess and improve drug sensitivity prediction algorithms , 2014, Nature Biotechnology.