Amyloid beta as a regulator of lipid homeostasis.

[1]  P. Kelly,et al.  Amyloid precursor protein knockdown by siRNA impairs spontaneous alternation in adult mice , 2007, Journal of neurochemistry.

[2]  Melissa Cain,et al.  β-secretase processing of the Alzheimer’s amyloid protein precursor (APP) , 2007, Journal of Molecular Neuroscience.

[3]  T. Hartmann,et al.  Therapeutic perspectives in Alzheimer's disease. , 2012, Recent patents on CNS drug discovery.

[4]  C. Pietrzik,et al.  Functional Role of the Low-Density Lipoprotein Receptor-Related Protein in Alzheimer’s Disease , 2006, Neurodegenerative Diseases.

[5]  Jae Woong Lee,et al.  Mutant presenilin 2 causes abnormality in the brain lipid profile in the development of Alzheimer’s disease , 2006, Archives of pharmacal research.

[6]  Lars-Olof Wahlund,et al.  Omega-3 fatty acid treatment in 174 patients with mild to moderate Alzheimer disease: OmegAD study: a randomized double-blind trial. , 2006, Archives of neurology.

[7]  H. Tanila,et al.  Impact of different saturated fatty acid, polyunsaturated fatty acid and cholesterol containing diets on beta-amyloid accumulation in APP/PS1 transgenic mice , 2006, Neurobiology of Disease.

[8]  T. Hartmann,et al.  Altered membrane fluidity and lipid raft composition in presenilin‐deficient cells , 2006, Acta neurologica Scandinavica. Supplementum.

[9]  B. Kriem,et al.  Soluble oligomers of amyloid-β peptide induce neuronal apoptosis by activating a cPLA2-dependent sphingomyelinase-ceramide pathway , 2006, Neurobiology of Disease.

[10]  S. Hébert,et al.  Regulated intramembrane proteolysis of amyloid precursor protein and regulation of expression of putative target genes , 2006, EMBO reports.

[11]  J. Winderickx,et al.  Ceramide involvement in apoptosis and apoptotic diseases. , 2006, Mini reviews in medicinal chemistry.

[12]  J. Hartmann Therapeutic Perspectives in Alzheimers Disease , 2006 .

[13]  B. Strooper,et al.  Regulation of cholesterol and sphingomyelin metabolism by amyloid-β and presenilin , 2005, Nature Cell Biology.

[14]  R. Paro,et al.  Homo‐ and heterodimerization of APP family members promotes intercellular adhesion , 2005, The EMBO journal.

[15]  M. Heneka,et al.  Inhibition of Glycosphingolipid Biosynthesis Reduces Secretion of the β-Amyloid Precursor Protein and Amyloid β-Peptide*[boxs] , 2005, Journal of Biological Chemistry.

[16]  F. Checler,et al.  Presenilin-Dependent Transcriptional Control of the Aβ-Degrading Enzyme Neprilysin by Intracellular Domains of βAPP and APLP , 2005, Neuron.

[17]  Patrick Browne,et al.  Atorvastatin for the treatment of mild to moderate Alzheimer disease: preliminary results. , 2005, Archives of neurology.

[18]  Takashi Morihara,et al.  A Diet Enriched with the Omega-3 Fatty Acid Docosahexaenoic Acid Reduces Amyloid Burden in an Aged Alzheimer Mouse Model , 2005, The Journal of Neuroscience.

[19]  W. Gan,et al.  Defective Neuromuscular Synapses in Mice Lacking Amyloid Precursor Protein (APP) and APP-Like Protein 2 , 2005, The Journal of Neuroscience.

[20]  K. Pahan,et al.  Fibrillar Amyloid-β Peptides Kill Human Primary Neurons via NADPH Oxidase-mediated Activation of Neutral Sphingomyelinase , 2004, Journal of Biological Chemistry.

[21]  V. Rodwell,et al.  The 3-hydroxy-3-methylglutaryl coenzyme-A (HMG-CoA) reductases , 2004, Genome Biology.

[22]  P. Wong,et al.  Association of γ-Secretase with Lipid Rafts in Post-Golgi and Endosome Membranes* , 2004, Journal of Biological Chemistry.

[23]  Jochen Herms,et al.  Cortical dysplasia resembling human type 2 lissencephaly in mice lacking all three APP family members , 2004 .

[24]  Valérie Wilquet,et al.  Amyloid-beta precursor protein processing in neurodegeneration , 2004, Current Opinion in Neurobiology.

[25]  K. Beyreuther,et al.  GM1 ganglioside regulates the proteolysis of amyloid precursor protein , 2004, Molecular Psychiatry.

[26]  Takashi Morihara,et al.  Docosahexaenoic Acid Protects from Dendritic Pathology in an Alzheimer's Disease Mouse Model , 2004, Neuron.

[27]  R. Nitsch,et al.  The APP intracellular domain forms nuclear multiprotein complexes and regulates the transcription of its own precursor , 2004, Journal of Cell Science.

[28]  Kai Simons,et al.  Model systems, lipid rafts, and cell membranes. , 2004, Annual review of biophysics and biomolecular structure.

[29]  A. Prochiantz,et al.  Soluble form of amyloid precursor protein regulates proliferation of progenitors in the adult subventricular zone , 2004, Development.

[30]  T. Südhof,et al.  Binding of F-spondin to amyloid-β precursor protein: A candidate amyloid-β precursor protein ligand that modulates amyloid-β precursor protein cleavage , 2004 .

[31]  M. Mattson,et al.  Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's disease , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[32]  Y. Suh,et al.  C‐terminal fragments of amyloid precursor protein exert neurotoxicity by inducing glycogen synthase kinase‐3β expression , 2003 .

[33]  N. Hooper,et al.  Exclusively targeting β-secretase to lipid rafts by GPI-anchor addition up-regulates β-site processing of the amyloid precursor protein , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[34]  P. Vito,et al.  Autosomal Recessive Hypercholesterolemia Protein Interacts with and Regulates the Cell Surface Level of Alzheimer's Amyloid β Precursor Protein* , 2003, Journal of Biological Chemistry.

[35]  R. Turner,et al.  X11α modulates secretory and endocytic trafficking and metabolism of amyloid precursor protein: mutational analysis of the yenpty sequence , 2003, Neuroscience.

[36]  K. Miyazawa,et al.  A Scaffold Protein JIP-1b Enhances Amyloid Precursor Protein Phosphorylation by JNK and Its Association with Kinesin Light Chain 1* , 2003, Journal of Biological Chemistry.

[37]  A. Goffinet,et al.  Reelin and brain development , 2003, Nature Reviews Neuroscience.

[38]  Wickliffe C Abraham,et al.  Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory , 2003, Progress in Neurobiology.

[39]  C. Masters,et al.  The Transmembrane Domain of the Amyloid Precursor Protein in Microsomal Membranes Is on Both Sides Shorter than Predicted* , 2003, The Journal of Biological Chemistry.

[40]  C. Haass,et al.  Amyloidogenic processing of the Alzheimer β-amyloid precursor protein depends on lipid rafts , 2003, The Journal of cell biology.

[41]  C. Lemere,et al.  Novel Therapeutic Approach for the Treatment of Alzheimer's Disease by Peripheral Administration of Agents with an Affinity to β-Amyloid , 2003, The Journal of Neuroscience.

[42]  K. Handa,et al.  Glycosphingolipid‐dependent cross‐talk between glycosynapses interfacing tumor cells with their host cells: essential basis to define tumor malignancy , 2002, FEBS letters.

[43]  Simon C Watkins,et al.  Disabled‐2 exhibits the properties of a cargo‐selective endocytic clathrin adaptor , 2002, The EMBO journal.

[44]  J. Dichgans,et al.  Treatment with simvastatin in normocholesterolemic patients with Alzheimer's disease: A 26‐week randomized, placebo‐controlled, double‐blind trial , 2002, Annals of neurology.

[45]  U. Igbavboa,et al.  Brain membrane cholesterol domains, aging and amyloid beta-peptides , 2002, Neurobiology of Aging.

[46]  J. Goldstein,et al.  Cholesterol addition to ER membranes alters conformation of SCAP, the SREBP escort protein that regulates cholesterol metabolism. , 2002, Molecular cell.

[47]  Alfred H. Merrill,et al.  De Novo Sphingolipid Biosynthesis: A Necessary, but Dangerous, Pathway* , 2002, The Journal of Biological Chemistry.

[48]  Christopher K. Glass,et al.  Exchange of N-CoR Corepressor and Tip60 Coactivator Complexes Links Gene Expression by NF-κB and β-Amyloid Precursor Protein , 2002, Cell.

[49]  Y. Kirino,et al.  Interaction of Alzheimer's β-Amyloid Precursor Family Proteins with Scaffold Proteins of the JNK Signaling Cascade* , 2002, The Journal of Biological Chemistry.

[50]  P. Pelicci,et al.  Tyrosine Phosphorylation of the β-Amyloid Precursor Protein Cytoplasmic Tail Promotes Interaction with Shc* , 2002, The Journal of Biological Chemistry.

[51]  J. Leverenz,et al.  Diet-induced hypercholesterolemia enhances brain A&bgr; accumulation in transgenic mice , 2002, Neuroreport.

[52]  S. Younkin,et al.  Cholesterol-Dependent γ-Secretase Activity in Buoyant Cholesterol-Rich Membrane Microdomains , 2002, Neurobiology of Disease.

[53]  Kenneth Rockwood,et al.  Use of lipid-lowering agents, indication bias, and the risk of dementia in community-dwelling elderly people. , 2002, Archives of neurology.

[54]  C. Masters,et al.  The intramembrane cleavage site of the amyloid precursor protein depends on the length of its transmembrane domain , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[55]  M. Mercken,et al.  A Cholesterol-Lowering Drug Reduces β-Amyloid Pathology in a Transgenic Mouse Model of Alzheimer's Disease , 2001, Neurobiology of Disease.

[56]  B. Hyman,et al.  Acyl-coenzyme A: cholesterol acyltransferase modulates the generation of the amyloid β-peptide , 2001, Nature Cell Biology.

[57]  D. Riddell,et al.  Compartmentalization of β-secretase (Asp2) into low-buoyant density, noncaveolar lipid rafts , 2001, Current Biology.

[58]  J Tuomilehto,et al.  Midlife vascular risk factors and Alzheimer's disease in later life: longitudinal, population based study , 2001, BMJ.

[59]  B. Winblad,et al.  Effects of apolipoprotein E (apoE) isoforms, β-amyloid (Aβ) and apoE/Aβ complexes on Protein Kinase C-α (PKC-α) translocation and amyloid precursor protein (APP) processing in human SH-SY5Y neuroblastoma cells and fibroblasts , 2001, Neurochemistry International.

[60]  E. Kojro,et al.  Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the α-secretase ADAM 10 , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[61]  C. Bergmann,et al.  Simvastatin strongly reduces levels of Alzheimer's disease β-amyloid peptides Aβ42 and Aβ40 in vitro and in vivo , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[62]  Y. Ihara,et al.  Accumulation and Aggregation of Amyloid β-Protein in Late Endosomes of Niemann-Pick Type C Cells* , 2001, The Journal of Biological Chemistry.

[63]  Howard Riezman,et al.  Protein Sorting upon Exit from the Endoplasmic Reticulum , 2001, Cell.

[64]  P. Pelicci,et al.  Numb Is an Endocytic Protein , 2000, The Journal of cell biology.

[65]  E. Ikonen,et al.  How cells handle cholesterol. , 2000, Science.

[66]  H Jick,et al.  Statins and the risk of dementia , 2000, The Lancet.

[67]  H. Lipp,et al.  Mice with Combined Gene Knock-Outs Reveal Essential and Partially Redundant Functions of Amyloid Precursor Protein Family Members , 2000, The Journal of Neuroscience.

[68]  A. Futerman,et al.  Ceramide as a second messenger: sticky solutions to sticky problems. , 2000, Trends in cell biology.

[69]  G. Celesia,et al.  Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors. , 2000, Archives of neurology.

[70]  Kai Simons,et al.  Lipid rafts and signal transduction , 2000, Nature Reviews Molecular Cell Biology.

[71]  Rong Wang,et al.  Hypercholesterolemia Accelerates the Alzheimer's Amyloid Pathology in a Transgenic Mouse Model , 2000, Neurobiology of Disease.

[72]  B. Strooper,et al.  Proteolytic processing and cell biological functions of the amyloid precursor protein. , 2000, Journal of cell science.

[73]  Y. Hannun,et al.  Effects of sphingosine and other sphingolipids on protein kinase C. , 2000, Methods in enzymology.

[74]  Ramin Homayouni,et al.  Disabled-1 Binds to the Cytoplasmic Domain of Amyloid Precursor-Like Protein 1 , 1999, The Journal of Neuroscience.

[75]  C. Masters,et al.  Neurite-outgrowth regulating functions of the amyloid protein precursor of Alzheimer's disease. , 1999, Journal of Alzheimer's disease : JAD.

[76]  R Brookmeyer,et al.  Projections of Alzheimer's disease in the United States and the public health impact of delaying disease onset. , 1998, American journal of public health.

[77]  P. Lansbury,et al.  A detergent-insoluble membrance compartment contains Aβ in vivo , 1998, Nature Medicine.

[78]  B. Strooper,et al.  Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[79]  D. Brown,et al.  Structure of detergent-resistant membrane domains: does phase separation occur in biological membranes? , 1997, Biochemical and biophysical research communications.

[80]  U. Igbavboa,et al.  Lipid Binding to Amyloid β‐Peptide Aggregates: Preferential Binding of Cholesterol as Compared with Phosphatidylcholine and Fatty Acids , 1997, Journal of neurochemistry.

[81]  R. Doms,et al.  Alzheimer's Aβ(1–42) is generated in the endoplasmic reticulum/intermediate compartment of NT2N cells , 1997, Nature Medicine.

[82]  C. Masters,et al.  Distinct sites of intracellular production for Alzheimer's disease Aβ40/42 amyloid peptides , 1997, Nature Medicine.

[83]  M. Ball,et al.  Water-soluble A(N-40, N-42) Oligomers in Normal and Alzheimer Disease Brains (*) , 1996, The Journal of Biological Chemistry.

[84]  M. White,et al.  PTB Domains of IRS-1 and Shc Have Distinct but Overlapping Binding Specificities (*) , 1995, The Journal of Biological Chemistry.

[85]  M. Seike,et al.  The reeler gene-associated antigen on cajal-retzius neurons is a crucial molecule for laminar organization of cortical neurons , 1995, Neuron.

[86]  L. Svennerholm,et al.  Membrane Lipids of Adult Human Brain: Lipid Composition of Frontal and Temporal Lobe in Subjects of Age 20 to 100 Years , 1994, Journal of neurochemistry.

[87]  J. Haines,et al.  Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. , 1993, Science.

[88]  K. Simons,et al.  Glycosphingolipid-enriched, detergent-insoluble complexes in protein sorting in epithelial cells. , 1993, Biochemistry.

[89]  P. Lansbury,et al.  The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease. , 1993, Biochemistry.

[90]  I. Nishimoto,et al.  Alzheimer amyloid protein precursor complexes with brain GTP-binding protein Go , 1993, Nature.

[91]  J. Talan-Hranilović,et al.  Cortical distribution of gangliosides in Alzheimer's disease , 1992, Neurochemistry International.

[92]  K. Blennow,et al.  Gangliosides in cerebrospinal fluid in 'probable Alzheimer's disease'. , 1991, Archives of neurology.

[93]  J. Talan-Hranilović,et al.  Brain gangliosides in Alzheimer's disease. , 1990, Journal fur Hirnforschung.