Partial-Hepatectomized (70%) Model Shows a Correlation between Hepatocyte Growth Factor Levels and Beta-Cell Mass

One of the best-known Greek myths of all time is the tragedy of the Titan Prometheus, who stole fire from Olympus to deliver it to the human race. Furious, Zeus demands that Prometheus is chained to a rock at the peak of the Caucasus and condemns him to have the liver eternally devoured by an eagle. Every time that the eagle finished eating the liver from Prometheus, the liver was regenerated and the eagle began all over again. Then, it is not today what science knows the liver’s ability to regenerate and its importance for the human body.

[1]  F. Moreau,et al.  Early Effects of Liver Regeneration on Endocrine Pancreas: In Vivo Change in Islet Morphology and In Vitro Assessment of Systemic Effects on β-Cell Function and Viability in the Rat Model of Two-Thirds Hepatectomy , 2014, Hormone and Metabolic Research.

[2]  M. Saad,et al.  Insulin-Resistance-Associated Compensatory Mechanisms of Pancreatic Beta Cells: A Current Opinion , 2013, Front. Endocrinol..

[3]  J. Carvalheira,et al.  Hepatocyte growth factor plays a key role in insulin resistance-associated compensatory mechanisms. , 2012, Endocrinology.

[4]  Jean S. Campbell,et al.  Liver regeneration. , 2012, Journal of hepatology.

[5]  Nathaniel K. Chan,et al.  Partial hepatectomy improves the outcome of intraportal islet transplantation by promoting revascularization , 2012, Islets.

[6]  S. Thorgeirsson,et al.  β-Cell-Specific Ablation of the Hepatocyte Growth Factor Receptor Results in Reduced Islet Size, Impaired Insulin Secretion, and Glucose Intolerance , 2005 .

[7]  A. F. Stewart,et al.  Hepatocyte Growth Factor Overexpression in the Islet of Transgenic Mice Increases Beta Cell Proliferation, Enhances Islet Mass, and Induces Mild Hypoglycemia* , 2000, The Journal of Biological Chemistry.

[8]  M. Neurath,et al.  Partial Hepatectomy Affects Pancreatic Size and Function in Rats , 1993, Pancreas.

[9]  T. Hirano,et al.  Morphological and Functional Discrepancies in Endocrine Pancreas After Partial Hepatectomy in Dogs , 1991, HPB surgery : a world journal of hepatic, pancreatic and biliary surgery.

[10]  M. Rao,et al.  DNA synthesis in exocrine and endocrine pancreas after partial hepatectomy in Syrian golden hamsters , 1986, Experientia.

[11]  G. Michalopoulos.  Liver regeneration after partial hepatectomy: critical analysis of mechanistic dilemmas. , 2010, The American journal of pathology.

[12]  G. Higgins,et al.  Experimental pathology of the liver : I. Restoration of the liver of the while rat following surgical removal. , 1931 .

[13]  G. Higgins,et al.  Experimental pathology of the liver , 1931 .