Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression
暂无分享,去创建一个
T. Tuschl | D. Patel | A. Stamford | V. Kuryavyi | M. Michino | W. Xie | P. Meinke | A. Jennings | Rei Okamoto | C. Adura | J. F. Glickman | D. Tomita | P. Meinke | T. Kamei | T. Imaeda | T. Gogakos | P. Gao | Michael Miller | S. Hashizume | T. Kuroita | W. Xie | L. Lama | Lavoisier Ramos-Espiritu | Y. Asano | J. Steinberg | J. Aida | Lavoisier S. Ramos-Espiritu
[1] G. Turcatti,et al. Targeting STING with covalent small-molecule inhibitors , 2018, Nature.
[2] N. Gray,et al. Structure of the Human cGAS–DNA Complex Reveals Enhanced Control of Immune Surveillance , 2018, Cell.
[3] Modi Wang,et al. Suramin potently inhibits cGAMP synthase, cGAS, in THP1 cells to modulate IFN-β levels. , 2018, Future medicinal chemistry.
[4] M. Ascano,et al. Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice , 2017, Nature Communications.
[5] D. Lin,et al. Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polarization assay , 2017, PloS one.
[6] L. Zender,et al. Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence , 2017, Nature Cell Biology.
[7] Martin A. M. Reijns,et al. cGAS surveillance of micronuclei links genome instability to innate immunity , 2017, Nature.
[8] Dennis E Discher,et al. Mitotic progression following DNA damage enables pattern recognition within micronuclei , 2017, Nature.
[9] Zhijian J. Chen,et al. cGAS is essential for cellular senescence , 2017, Proceedings of the National Academy of Sciences.
[10] D. Bose,et al. An RNA-Based Fluorescent Biosensor for High-Throughput Analysis of the cGAS-cGAMP-STING Pathway. , 2016, Cell chemical biology.
[11] G. Hartmann,et al. Discriminating self from non-self in nucleic acid sensing , 2016, Nature Reviews Immunology.
[12] C. Steegborn,et al. Discovery of LRE1 as a specific and allosteric inhibitor of soluble adenylyl cyclase , 2016, Nature chemical biology.
[13] R. Silverman,et al. Activation of RNase L is dependent on OAS3 expression during infection with diverse human viruses , 2016, Proceedings of the National Academy of Sciences.
[14] D. Pisetsky. Anti-DNA antibodies — quintessential biomarkers of SLE , 2016, Nature Reviews Rheumatology.
[15] Zhijian J. Chen,et al. Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases , 2015, Proceedings of the National Academy of Sciences.
[16] Elizabeth E Gray,et al. Cutting Edge: cGAS Is Required for Lethal Autoimmune Disease in the Trex1-Deficient Mouse Model of Aicardi–Goutières Syndrome , 2015, The Journal of Immunology.
[17] Zhigang Zhang,et al. Modulation of the cGAS-STING DNA sensing pathway by gammaherpesviruses , 2015, Proceedings of the National Academy of Sciences.
[18] H. Virgin,et al. The Cytosolic Sensor cGAS Detects Mycobacterium tuberculosis DNA to Induce Type I Interferons and Activate Autophagy. , 2015, Cell host & microbe.
[19] J. An,et al. Cutting Edge: Antimalarial Drugs Inhibit IFN-β Production through Blockade of Cyclic GMP-AMP Synthase–DNA Interaction , 2015, The Journal of Immunology.
[20] R. Means,et al. Mitochondrial DNA Stress Primes the Antiviral Innate Immune Response , 2014, Nature.
[21] Senlin Li,et al. The E3 ubiquitin ligase AMFR and INSIG1 bridge the activation of TBK1 kinase by modifying the adaptor STING. , 2014, Immunity.
[22] T. Decker,et al. Listeria monocytogenes induces IFNβ expression through an IFI16‐, cGAS‐ and STING‐dependent pathway , 2014, The EMBO journal.
[23] V. Hornung,et al. OAS proteins and cGAS: unifying concepts in sensing and responding to cytosolic nucleic acids , 2014, Nature Reviews Immunology.
[24] G. Barber,et al. Cytosolic-DNA-Mediated, STING-Dependent Proinflammatory Gene Induction Necessitates Canonical NF-κB Activation through TBK1 , 2014, Journal of Virology.
[25] Nan Yan,et al. Cyclic GMP-AMP Synthase Is an Innate Immune Sensor of HIV and Other Retroviruses , 2013, Science.
[26] Zhijian J. Chen,et al. Cyclic GMP-AMP containing mixed phosphodiester linkages is an endogenous high-affinity ligand for STING. , 2013, Molecules and Cells.
[27] V. Hornung,et al. cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING , 2013, Nature.
[28] Roger A. Jones,et al. Cyclic [G(2′,5′)pA(3′,5′)p] Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP Synthase , 2013, Cell.
[29] Zhijian J. Chen,et al. Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA , 2013, Science.
[30] Zhijian J. Chen,et al. Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway , 2013, Science.
[31] G. Barber,et al. STING manifests self DNA-dependent inflammatory disease , 2012, Proceedings of the National Academy of Sciences.
[32] P. Zwart,et al. Towards automated crystallographic structure refinement with phenix.refine , 2012, Acta crystallographica. Section D, Biological crystallography.
[33] J. Hiscott,et al. Orchestrating the interferon antiviral response through the mitochondrial antiviral signaling (MAVS) adapter. , 2011, Current opinion in immunology.
[34] Sarah E. Ewald,et al. Nucleic acid recognition by the innate immune system. , 2011, Annual review of immunology.
[35] J. Baell,et al. New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassays. , 2010, Journal of medicinal chemistry.
[36] G. Barber,et al. STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity , 2009, Nature.
[37] Xiaoping Zhou,et al. ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization , 2009, Proceedings of the National Academy of Sciences.
[38] T. Mogensen. Pathogen Recognition and Inflammatory Signaling in Innate Immune Defenses , 2009, Clinical Microbiology Reviews.
[39] Y. Li,et al. The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation. , 2008, Immunity.
[40] Randy J. Read,et al. Phaser crystallographic software , 2007, Journal of applied crystallography.
[41] D. Barnes,et al. Mutations in the gene encoding the 3′-5′ DNA exonuclease TREX1 cause Aicardi-Goutières syndrome at the AGS1 locus , 2006, Nature Genetics.
[42] R. Glen,et al. Molecular similarity: a key technique in molecular informatics. , 2004, Organic & biomolecular chemistry.
[43] Conrad C. Huang,et al. UCSF Chimera—A visualization system for exploratory research and analysis , 2004, J. Comput. Chem..
[44] T. Okabe,et al. High-throughput screening with quantitation of ATP consumption: a universal non-radioisotope, homogeneous assay for protein kinase. , 2004, Assay and drug development technologies.
[45] Phillip Jeffrey,et al. The Practice of Medicinal Chemistry , 2004 .
[46] Thomas D. Y. Chung,et al. A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays , 1999, Journal of biomolecular screening.
[47] P. Emsley,et al. Features and development of Coot , 2010, Acta crystallographica. Section D, Biological crystallography.
[48] P. Dansette,et al. Biotransformations Leading to Toxic Metabolites: Chemical Aspect , 2008 .
[49] Vincent B. Chen,et al. Acta Crystallographica Section D Biological , 2001 .